The impact of obesity on development of cardiovascular diseases: Mini review

Abstract

Obesity is considered to be a chronic metabolic disorder closely connected to the chronically low inflammation characterized by significant changes in the levels of adipokines and proinflammatory cytokines, as well as other molecules that have an impact on cardiovascular function. Therefore, obesity (especially central obesity) is considered to be a significant risk factor for the development of cardiovascular diseases, atherosclerosis, coronary artery disease, hypertension and left ventricular dysfunction being some of them. The increased accumulation of fat tissue around the heart and in the blood vessels, the increased levels of oxidative stress and the inflammatory state mutually interact in the process of cardiovascular disease occurrence. Lowering the amount of body weight could significantly contribute to reduction of cardiovascular diseases and the subsequent complications.