Journal of Pharmaceutical Policy and Practice最新文献

{"title":"Real-world effectiveness of aromatase inhibitors and fulvestrant in HR+/HER2- advanced breast cancer: a snapshot of the last two years before conventional use of CDK 4/6 inhibitors in a Portuguese institution.","authors":"Maria Inês Teodoro, Alexandra Mayer, Ana da Costa Miranda, Hugo Nunes, Filipa Alves da Costa, António Lourenço","doi":"10.1080/20523211.2023.2296551","DOIUrl":"10.1080/20523211.2023.2296551","url":null,"abstract":"<p><strong>Background: </strong>Monotherapy with aromatase inhibitors and fulvestrant were the standard-of-care for hormone receptor-positive (HR+)/human epidermal growth factor receptor-type2 negative (HER2-) advanced breast cancer, before integration of cyclin-dependent kinase 4/6 inhibitors. Effectiveness data is essential for regulatory action, but little is known about real-world use of aromatase inhibitors and fulvestrant.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted resorting to data from a cancer registry to identify adult women with HR+/HER- advanced breast cancer exposed to aromatase inhibitors or fulvestrant (31 May 2017-31 March 2019) at the main oncology hospital in Portugal. Cases were updated with follow-up until death or cut-off (31 March 2021) and pseudoanonymized data extracted. Primary outcome was overall survival (OS) and secondary time to treatment failure (TTF), estimated using survival analysis and compared with published trials.</p><p><strong>Results: </strong>192 patients were distributed by subgroups according to the medicine. Letrozole: OS 30.8 (95% confidence interval (CI) 20.6-41.4); TTF 11.2 (95%CI 8.7-13.7). Exemestane: OS 22.1 (95%CI 9.7-34.6); TTF 6.0 (95%CI 4.1-7.8). Fulvestrant: OS 21.6 (95%CI 16.5-26.7); TTF 5.6 (95%CI 4.5-6.6).</p><p><strong>Conclusions: </strong>Estimated effectiveness (OS) of letrozole and fulvestrant was, respectively, 3.2-3.5 months lower than reported. The clinical meaning seems uncertain and may be explained a higher proportion of worse prognostic characteristics in patients treated in the real-world.</p>","PeriodicalId":16740,"journal":{"name":"Journal of Pharmaceutical Policy and Practice","volume":"17 1","pages":"2296551"},"PeriodicalIF":4.2,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10798277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139512714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detecting manuscripts written by generative AI and AI-assisted technologies in the field of pharmacy practice.","authors":"Ammar Abdulrahman Jairoun, Faris El-Dahiyat, Ghaleb A ElRefae, Sabaa Saleh Al-Hemyari, Moyad Shahwan, Samer H Zyoud, Khawla Abu Hammour, Zaheer-Ud-Din Babar","doi":"10.1080/20523211.2024.2303759","DOIUrl":"10.1080/20523211.2024.2303759","url":null,"abstract":"<p><p>Generative AI can be a powerful research tool, but researchers must employ it ethically and transparently. This commentary addresses how the editors of pharmacy practice journals can identify manuscripts generated by generative AI and AI-assisted technologies. Editors and reviewers must stay well-informed about developments in AI technologies to effectively recognise AI-written papers. Editors should safeguard the reliability of journal publishing and sustain industry standards for pharmacy practice by implementing the crucial strategies outlined in this editorial. Although obstacles, including ignorance, time constraints, and protean AI strategies, might hinder detection efforts, several facilitators can help overcome those obstacles. Pharmacy practice journal editors and reviewers would benefit from educational programmes, collaborations with AI experts, and sophisticated plagiarism-detection techniques geared toward accurately identifying AI-generated text. Academics and practitioners can further uphold the integrity of published research through transparent reporting and ethical standards. Pharmacy practice journal staffs can sustain academic rigour and guarantee the validity of scholarly work by recognising and addressing the relevant barriers and utilising the proper enablers. Navigating the changing world of AI-generated content and preserving standards of excellence in pharmaceutical research and practice requires a proactive strategy of constant learning and community participation.</p>","PeriodicalId":16740,"journal":{"name":"Journal of Pharmaceutical Policy and Practice","volume":"17 1","pages":"2303759"},"PeriodicalIF":4.2,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10791078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139478562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers to access of maternal health commodities among pregnant women in public health facilities in Ubungo Municipal Council, Tanzania","authors":"Doris Mollel, G. Kagashe, D. Asingizwe, Stany Banzimana, S. M. Maru, François Niragire","doi":"10.1080/20523211.2023.2300457","DOIUrl":"https://doi.org/10.1080/20523211.2023.2300457","url":null,"abstract":"","PeriodicalId":16740,"journal":{"name":"Journal of Pharmaceutical Policy and Practice","volume":"39 20","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139442776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical pharmacists’ interventions for preventing adverse events in critically ill neonates in Qatar: an economic impact analysis","authors":"Ola Yakti, D. Al-Badriyeh, M. Rijims, Mohammed Abdelaal, O. Alsoukhni, M. Al Hail, P. Abdulrouf, Wessam El-Kassem, Fouad F. Abounahia, R. Kaddoura, D. Abushanab","doi":"10.1080/20523211.2023.2291508","DOIUrl":"https://doi.org/10.1080/20523211.2023.2291508","url":null,"abstract":"","PeriodicalId":16740,"journal":{"name":"Journal of Pharmaceutical Policy and Practice","volume":"69 9","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139452713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of prices, availability and affordability of essential medicines in Juba County, South Sudan.","authors":"Justin Deng, Augustino Ting Mayai, Egide Kayitare, Theoneste Ntakirutimana, Omary Swallehe, Thomas Bizimana","doi":"10.1186/s40545-023-00675-5","DOIUrl":"10.1186/s40545-023-00675-5","url":null,"abstract":"<p><strong>Background: </strong>Access to safe, effective, affordable, and high-quality medications has been included in the Sustainable Development Goals (SDGs) of the United Nations as a crucial step towards attaining universal health coverage. Access to medicines is a fundamental human right. If medicines are accessible and affordable, they save lives by reducing mortality and morbidity associated with acute and chronic diseases. WHO recommends that all countries voluntarily reach the minimum target of 80% availability of medicines by 2025. The primary purpose of this research is to assess access to essential medicines in Juba County, South Sudan.</p><p><strong>Methods: </strong>This study was undertaken using the standard World Health Organization/Health Action International Organization (WHO/HAI) approach for surveying the prices, availability, and affordability of medicines. A survey was conducted in six payams of Juba County, South Sudan, and 55 health facilities were assessed.</p><p><strong>Results: </strong>Prices for generic medicines were better in faith-based health facilities with a median price ratio of 1.95. Private pharmacies and private clinics had MPRs of 4.64 and 4.32, respectively. Local prices were high compared to International referent prices. Availability of medicines was highest in the faith-based health facilities (65.5%) and slightly lower in private pharmacies (55.4%), private clinics (57.7%) and public (50.4%) sectors. Most of the surveyed medicines were unaffordable. The medicines needed to treat non-communicable diseases cost up to 33.7-day wages for one full course of treatment.</p><p><strong>Conclusions: </strong>In South Sudan, medicines are poorly available in all sectors. Medicines are affordable in the public sector but Most medicines are unaffordable in private pharmacies, private clinics and faith-based health facilities. Poor medicines availability in the public sector contributes to the overall unaffordability of medicines in all the other sectors.</p>","PeriodicalId":16740,"journal":{"name":"Journal of Pharmaceutical Policy and Practice","volume":"16 1","pages":"172"},"PeriodicalIF":4.2,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10757353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139074408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacist-led vaccination services in the Middle East.","authors":"Faten Naif Aldajani, Mohammed Aldosari","doi":"10.1186/s40545-023-00664-8","DOIUrl":"10.1186/s40545-023-00664-8","url":null,"abstract":"<p><p>Successful Vaccine uptake relies heavily on the effectiveness of vaccination services. Expanding the scope of pharmacists' involvement in vaccination services can significantly improve vaccination coverage. The level of pharmacists' engagement in immunization services varies globally. The aim of this paper is to describe the current role of pharmacists in vaccination services in the Middle Eastern countries. The provision of vaccination services by pharmacists in the region has evolved notably in recent years. The extent of pharmacists' involvement in immunization services varies from one country to another in the region. They play a more active role in the delivery of vaccinations, not only facilitating but also administering vaccines. Future studies on pharmacist-led vaccination services in these countries are necessary to assess the value of the expanded practice of pharmacists in this field, especially due to the scarcity of evidence.</p>","PeriodicalId":16740,"journal":{"name":"Journal of Pharmaceutical Policy and Practice","volume":"16 1","pages":"171"},"PeriodicalIF":4.2,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10755951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139058452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of the Pharmacist's Stress Scale for Home Care (PSS) and evaluation of its reliability and validity.","authors":"Ayana Kani, Manako Hanya, Hiroyuki Kamei, Kenta Murotani","doi":"10.1186/s40545-023-00610-8","DOIUrl":"10.1186/s40545-023-00610-8","url":null,"abstract":"<p><strong>Background: </strong>As the needs for home care increase, contact with patients and jobs out of the pharmacy such as the patients' homes have increased, and there is concern that the situation increases pharmacists' work-related stress. Stress deteriorates pharmacists' quality of life (QOL) and affects the quality of services they provide. In this study, we developed a scale for the measurement of stress of pharmacists engaged in home care and evaluated it in pharmacists in 3 prefectures of the Tokai district, Japan.</p><p><strong>Methods: </strong>Based on the stress factors of pharmacists in home care extracted by previous studies, a 59-item questionnaire was developed. The questionnaires were sent to 1785 pharmacies engaged in home care in 3 prefectures of the Tokai district, and anonymous responses were obtained from 399 (valid response rate: 22.4%). The answers to each question were scored using 5-point scale (1: I feel no stress to 5: I always feel strong stress).</p><p><strong>Results: </strong>As a result of factor analysis, the Pharmacist's Stress Scale for Home Care (PSS) was prepared with 51 items, i.e., 14 related to the first factor, \"difficulty and feeling of incompetence in patient care\", 9 related to the second factor, \"relationship with superiors and work environment\", 13 related to the third factor, \"burdens related to work load and work contents\", 10 related to the fourth factor, \"communication with patients and families\", and 5 related to the fifth factor, \"communication with other professions\". Cronbach's α coefficients for the entire scale and each factor were ≥ 0.833, and sufficient internal consistency was obtained.</p><p><strong>Conclusions: </strong>The scale developed in this study is considered to be useful for the measurement of stress of pharmacists derived from interpersonal work and home care services. Leaving the job and burnout are expected to be prevented by perceiving the stress level of the pharmacists by themselves using this scale and coping with stress.</p>","PeriodicalId":16740,"journal":{"name":"Journal of Pharmaceutical Policy and Practice","volume":"16 1","pages":"170"},"PeriodicalIF":4.2,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10753843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139048928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cross-sectional assessment of the effects of select training modalities on vaccine cold chain management.","authors":"Aguma Daniel, Joseph Oloro, Innocent Hahirwa, Theogene Rizinde, Marie Francoise Mukanyangezi","doi":"10.1080/20523211.2023.2292717","DOIUrl":"10.1080/20523211.2023.2292717","url":null,"abstract":"<p><strong>Background: </strong>Vaccines offer arguably the most cost-effective public health intervention. Vaccine supply chain management which is a critical building block faces many Human resources challenges mainly due to the special attributes of vaccines.</p><p><strong>Objective: </strong>This study attempted to measure the effect of training on vaccine cold chain handler knowledge and practices.</p><p><strong>Methods: </strong>A cross-sectional research design, using predominantly quantitative data collection techniques, was used. Facilities that have offered vaccination services for more than a year and report through the HMIS system were eligible for selection. Observation checklists and structured questionnaires were used. SPSS was used to analyse data.</p><p><strong>Results: </strong>Vaccine cold chain management among the study group had an average score of 65.33% range (31-85%). The average knowledge score among the study respondents was 62.42% with a range (45-95%). The knowledge of respondents generally increases with an additional increase in the number of training modalities.</p><p><strong>Conclusions: </strong>The status of VCCM is at about 65.33% below the target of 80% set by the EVM. The trainings have an effect on both knowledge of handlers and their practice especially when deployed in a multi-pronged design and thus these trainings need to be aligned to achieve synergy.</p><p><strong>Abbreviations: </strong>CCE, Cold Chain Equipment; DHIS2, District Health Information Systems 2; DHO, District Health Officer; DPT, Diphtheria, Pertussis, Tetanus; DVS, District Vaccine Stores; EPI, Expanded Program for Immunisation; EVM, Effective Vaccine Management; FEFO, First Expiry First Out; GAVI, Global Alliance for Vaccines and Immunisation; HMIS, Health Information Management Systems; IRC, International Rescue Committee; KII, Key Informant Interview; LIAT, logistics indicator assessment tool; PATH, Program for Appropriate Technology in Health; PHC, Primary Health Care; QPPU, Quantification and Planning and Procurement Unit; SOPs, Standard Operating Procedures; SPSS, Statistical Package for Social Sciences; UNEPI, Uganda National Expanded Program for Immunisation; UNICEF, United Nations Children's Fund; VPD, Vaccine Preventable Diseases; VVM, Vaccine Vial Monitors; WHO, World Health Organisation.</p>","PeriodicalId":16740,"journal":{"name":"Journal of Pharmaceutical Policy and Practice","volume":"17 1","pages":"232-248"},"PeriodicalIF":4.2,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10793629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139485723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Providing anti-retroviral treatment did not achieve the ambition of 'Joint united nations program on HIV/AIDS (UNAIDS) among HIV positive patient in Ethiopia': a systematic review and meta-analysis.","authors":"Tamirat Melis, Tadesse Sahle, Kassahun Haile, Abebe Timerga, Amare Zewdie, Yohannes Wegu, Kebebush Zepire, Jemal Bedewi","doi":"10.1080/20523211.2023.2290672","DOIUrl":"10.1080/20523211.2023.2290672","url":null,"abstract":"<p><strong>Introduction: </strong>Antiretroviral Treatment (ART) has great importance in reducing viral load. Though a global effort was made to suppress viral load, the level of viral load suppression among ART patients is still high in Ethiopia.</p><p><strong>Objective: </strong>This study aims to assess the magnitude and contributing factors for viral load suppression among patients attending ART clinics in Ethiopia.</p><p><strong>Methods: </strong>The articles were searched using different databases using the guideline of reporting systematic review and meta-analysis (PRISMA). A random effect model was used to ascertain the pooled prevalence of viral load suppression in Ethiopia using STATA 14 software.</p><p><strong>Results: </strong>The pooled prevalence of suppressed viral load was 75.25% (95% CI: 68.61-81.89). Having good adherence (OR: 2.71, 95% CI 2.27, 3.15), baseline CD4 count (OR: 1.74, 95% CI 1.53, 1.96), and being female (OR: 1.41, 95% CI 1.04, 1.79) were determinants of pooled estimates of suppressed viral load.</p><p><strong>Conclusion: </strong>The pooled prevalence of suppressed viral load was 75% which is lower than the targeted level by the sustainable development goal (SDG) 2020, which was 90%. Therefore, the stakeholders should be focused on the existing strategies to decrease viral load among ART patients. They should work to adhere to patients for ART treatment.</p>","PeriodicalId":16740,"journal":{"name":"Journal of Pharmaceutical Policy and Practice","volume":"17 1","pages":"2290672"},"PeriodicalIF":4.2,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10793635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139485737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological dynamics of pandemic resilience: a tale of two cultures.","authors":"Shazia Rehman, Erum Rehman, Akhlaq Awan","doi":"10.1080/20523211.2023.2291509","DOIUrl":"10.1080/20523211.2023.2291509","url":null,"abstract":"<p><p>The present work endeavours to explore the experiences of university-level students from Pakistan and Nepal after the COVID-19 outbreak. A comprehensive electronic survey was carried out utilising a meticulous cluster sampling technique encompassing two distinct populations, i.e. Pakistan and Nepal, during the period extending from September 2022 to January 2023. A total of 2496 participants completed the questionnaire (Pakistani population: 55.45% and Nepalese population: 44.55%). We utilised the Mental Health Continuum-Short Form (MHC-SF), Pittsburgh Sleep Quality Index (PSQI), feeling of loneliness (UCLA), interdependent happy scale (IHS), and fear of COVID-19 scale (FCV-19S). Notably, a significant intercultural disparity was observed, particularly concerning the level of COVID-19 fear which was higher among the Nepalese population. However, this particular variable did not demonstrate any significant associations with other variables, except for the social dimension of MHC-SF. There was a negative correlation observed between this variable and IHS within the Pakistani population. Irrespective of the varying degrees of apprehension towards COVID-19 within the two distinct cultural contexts, there exists a significant positive correlation between the assessed psychological assets and individual well-being, as well as the resumption of regular activities after the outbreak.</p>","PeriodicalId":16740,"journal":{"name":"Journal of Pharmaceutical Policy and Practice","volume":"17 1","pages":"2291509"},"PeriodicalIF":4.2,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10793633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139486929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}