Journal of Pharmaceutical Negative Results最新文献

{"title":"An Analysis Of Socio-Cultural Factors Affecting Gender Inequality With A Role In Mental Health","authors":"Melika keyghobadi","doi":"10.47750/pnr.2023.14.03.371","DOIUrl":"https://doi.org/10.47750/pnr.2023.14.03.371","url":null,"abstract":"Women's needs and expectations in society are changing and evolving now as a result of efforts to reclaim their lost rights and achieve gender justice. In order to understand the cultural-social aspects that contribute to gender disparity, the current research has looked into factors including patriarchal ideology, gender stereotypes, gender socialization, and others. Feminists' conceptions of gender inequality, and Bourdieu's theory have all been used in this study. 385 individuals were chosen as a sample from the married women in Isfahan city who are the statistical population for this study and range in age from 20 to 49. Quota sampling is the technique used in this study. The research's findings show that there is a high level of gender disparity, especially in the economic and cultural spheres, and that there is no correlation between gender stereotypes and inequality, adherence to the patriarchal ideology, or societal norms and inequality. Inequality and gender tolerance exist in the connection.","PeriodicalId":16728,"journal":{"name":"Journal of Pharmaceutical Negative Results","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47612102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DRBAC-Healthchain (DRBAC-HC): Decentralized Role Based Access Control Framework For Achieving Security And Privacy Using Blockchain In Healthcare System","authors":"Avani Dadhania, Dr. Hiren Patel","doi":"10.47750/pnr.2023.14.03.368","DOIUrl":"https://doi.org/10.47750/pnr.2023.14.03.368","url":null,"abstract":"With the Internet of Things' (IoTs) rapid expansion, effect, and potential, the healthcare industry is shifting to a new paradigm that permits wearable devices to collect patient medical data and use it for monitoring and diagnosis. Tamper-proof data and avoidance of the centralized record-keeping mechanism are crucial requirements in any wellness system due to its exigent and precise necessity of data requests. Along with the same, transactions’ auditability and revocation of access rights upon certain records for specific stakeholders are also a few of the other prerequisites in the medical segment. Blockchain, as a distributed ledger, offers a solution for securely storing data while providing transparency in transactions and interactions among stakeholders. Synchronous interaction among patient, doctor, pharmacy, consultant, hospital, etc. with all possible data security is another concern that could be resolved through the usage of Blockchain’s smart contracts wherein interaction among these stakeholders is permitted in a traceable and irreversible mode. The purpose of this paper is to discuss the potential use of Blockchain technology in the healthcare sector to achieve data security, transparency, and reliability without the involvement of a trusted third party. In terms of security and privacy, we survey and provide an exhaustive review of Blockchain-based access control systems for the healthcare system. In addition, for the healthcare system, we propose and implemented a decentralized role-based access control model based on Ethereum smart contract.","PeriodicalId":16728,"journal":{"name":"Journal of Pharmaceutical Negative Results","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46584154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect Of Surface Treatment And Thermocycling On Bond Strength Between Silicon Soft Denture Lining And Acrylic Resin Denture Base","authors":"Ariyani , Syafrinani , Chairunnisa R and Febriani","doi":"10.47750/pnr.2023.14.03.369","DOIUrl":"https://doi.org/10.47750/pnr.2023.14.03.369","url":null,"abstract":"Introduction: Silicon Soft Denture Liner (SDL) is often used along with heat polymerization acrylic resin (PMMA) as an obturator material because it can cover the undercut area in a broad defect for long term and painlessly. Despite that, silicon SDL and PMMA have different molecular structures so that they have a low bond strength. Long-term use can also affect the bond strength, so there is a need to increase the bond strength between PMMA and SDL. A method to increase the bond strength is surface treatment. This study is conducted to determine the effect of surface treatment and thermocycling on the bond strength of PMMA and Silicon SDL. Methods: The study used 40 samples (8 groups) divided into 4 groups based on the surface treatments, namely no surface treatment, sandblast, adhesive primer and combination, and further divided into two groups of thermocycling and without thermocycling treatment. The bond strength between PMMA and SDL was tested with tensile test by using Universal Testing Machine (UTM). Results: One-way ANOVA analysis showed there were significant differences of the bond strength among all groups (p <0.05) where the adhesive primer showed the highest value in all treatment groups. Conclusion: There is an effect of surface treatment and thermocycling on the bond strength between the PMMA and SDL, where the adhesive primer as a surface treatment material shows the highest bond strength of all.","PeriodicalId":16728,"journal":{"name":"Journal of Pharmaceutical Negative Results","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42810930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer Therapy","authors":"Sukanta Satapathy","doi":"10.47750/pnr.2023.14.02.429","DOIUrl":"https://doi.org/10.47750/pnr.2023.14.02.429","url":null,"abstract":"Cancer is a threat to humanity in this era. The new cases are sharply increasing. The cancer death also a major problem of the recent time. In this review the various treatment options available are described. The cancer types also explained. The WHO data of various new cases of cancer are depicted in the form of graph. The alternate therapies are reviewed .These alternate therapies are a hope now for the future cancer therapy. The future prospects of cancer therapy also explained.","PeriodicalId":16728,"journal":{"name":"Journal of Pharmaceutical Negative Results","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43040765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contact Lens Wearer’s Outlook Towards Recommended Replacement Schedule of Contact Lens in Mumbai","authors":"Mansi Mehta, Kalika L. Bandamwar, Ph.D. Scholar","doi":"10.47750/pnr.2023.14.s01.194","DOIUrl":"https://doi.org/10.47750/pnr.2023.14.s01.194","url":null,"abstract":"Background: Non-compliance is one of the major reasons of CL related complications. Various research studies have been done over the past three decades to find reasons for patient non-compliances. Use of CLs over the recommended replacement schedule has been one of the major reasons leading to CLs complications. It is evident that the CLs user are often unaware of their non-compliance towards lens care and maintenance regimen. Even after introduction of daily disposable lenses and one-step multipurpose solution non-compliance towards CLs use is still a major problem in CLs patients. The complications due to patient noncompliance can be sometimes irreversible. This research will help us understand CL user reasons of intentionally or unintentionally being non-compliant to recommended replacement frequency. \u0000Method: All CL users willing to share their experience participated in this questionnaire based online survey which was designed with the help of focused group discussion. \u0000Results: Most of the CL wearer prefer buying pairs for at least 6 months at a time. Almost 80% of CL wearers do not replace their CL as per MRRF. 70% of those who participated wore CL for more than 10 hours per day. The male and female ratio is almost equal in the participants participated in the research. \u0000Conclusion: Research done in the past suggest incomplete knowledge imparted to the wearer or CL forgetting the instructions given to them at dispensing. Research also suggest some CL wearer knowingly are non-compliant to MRRF. This study tries to find loopholes in a CL practice by finding reasons of non-compliance as per CL wearers prospective and probable suggestion from the user itself. An ECP is a paramedical person who has the right to prescribe them, whether according to MRRF or as per their knowledge of the patient’s ocular status. For e.g., an antibiotic medicine is supposed to be prescribed for 3 days or 5 days, once or twice is decided by the medical practitioner prescribing. As this research shows over 50% of the CL wearer said that their 'ECP said its okay'.","PeriodicalId":16728,"journal":{"name":"Journal of Pharmaceutical Negative Results","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44272760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2-(((4h-1,2,4-Triazol-4-Yl)Imino)Methyl)Phenol Derived Schiff Bases And Their Pharmacological Importance","authors":"Bilal Ahmad Dar","doi":"10.47750/pnr.2023.14.s01.101","DOIUrl":"https://doi.org/10.47750/pnr.2023.14.s01.101","url":null,"abstract":"A facile method has been developed for the synthesis of Schiff bases derived from 4-Amino-1,2,4-triazole with 2-Hydroxybenzaldehyde (Salicylaldehyde) and their complexes with the Mn(II) and V(III) have been synthesized. Derived Metal complexes shown that they have a greater impact than their parent medications. Elemental analysis, IR, and ESR XRD studies have been used to characterize the prepared complexes. The results of the spectroscopic investigations suggested that the metal complexes' have octahedral geometry and the presence of the azomethine nitrogen group in coordination with the metal ion have been projected. Schiff bases and their derived metal complexes have potent biological potential (Antibacterial).","PeriodicalId":16728,"journal":{"name":"Journal of Pharmaceutical Negative Results","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70924645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eye Care Practitioner’s Perception to Replacement Schedule of Contact Lenses","authors":"Mansi Mehta, Kalika L. Bandamwar","doi":"10.47750/pnr.2023.14.s01.193","DOIUrl":"https://doi.org/10.47750/pnr.2023.14.s01.193","url":null,"abstract":"Background: Non-compliance to manufactures recommended replacement frequency is expected to result in ocular complications. While many reports the percentage of people who are non- compliant, only some report pay attention to the care and maintenance instructions that eye care practitioners provide to their patients. The goal of this study is to draw attention to the instructions imparted by eye care practitioner to their user and explore the measure taken by them to reduce contact lens non-compliance. \u0000Method: Eye care practitioner from Mumbai who were willing to provide consent and share their experience participated in this anonymous online survey which was designed with the help of focused group discussion with a panel of experts. \u0000Results: Majority of eye care practitioner had 5 years or more clinical experience in the field of contact lens. About 81% contact lens users in their practice were between the age of 20-29 years. These eye care practitioners believed their contact lens user non-compliant to replacement schedule of contact lens, was 35% due to forgetting the actual day of replacement, 46% as they forget to reorder their lenses, 33% believe to do this to save money, 41% believe contact lens user have lack of time and 36% believe they don’t change their lenses as there is no discomfort in continuing. Of all 55% of eye care practitioner agree in giving written information, SMS or telephonic reminder and agreed that increase in follow up would improve compliance. However, 57% of eye care practitioner strongly agree that contact lens practice should be restricted to Eye care practitioner only to increase compliance in contact lens users. \u0000Conclusion: Reminders to follow up and to buy contact lens as per their previous purchase can help in reducing majority of non-compliance to replacement schedule. In addition, eye care practitioner strongly agrees to restrict contact lens practice to Eye care practitioner only.","PeriodicalId":16728,"journal":{"name":"Journal of Pharmaceutical Negative Results","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42554508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Study of association of serum lipid profile, IL-6, &amp; ADMA levels with subclinical hypothyroidism”","authors":"None Sandeep Kumar","doi":"10.47750/pnr.2023.14.s01.195","DOIUrl":"https://doi.org/10.47750/pnr.2023.14.s01.195","url":null,"abstract":"Background &amp; Objectives: Subclinical hypothyroidism (SCH) represents the mildest form of thyroid hormone deficiency and may be associated with adverse consequences. SCH is defined as an elevated serum thyrotropin (often referred to as thyroid-stimulating hormone, or TSH) level with normal levels of free thyroxine (FT4) that affects up to 10% of the adult population. The identification of patients with subclinical hypothyroidism having an increased cardiovascular risk is of great importance in the present era. The aim of the study was to evaluate cardiovascular risk factors in patients with subclinical hypothyroidism.&#x0D; Methods: 120 patients with subclinical hypothyroidism and 120 age and gender matched healthy euthyroid controls in the age group of 18-70 years were included in the study. Body mass index (BMI), lipid profile, and levels of serum biomarkers were estimated in both the groups and further compared using student t-test. Lipid profile was also correlated with the serum ADMA &amp; IL-6 and the results were analyzed using Pearson’s correlation coefficient.&#x0D; Results: Patients with subclinical hypothyroidism had significantly higher levels of serum TSH, IL-6 and ADMA. Similarly, serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) were significantly increased and HDL-C was significantly decreased in SCH patients when compared to the same parameters of controls (p<0.001). Significant positive correlations were found among lipid profile and serum IL-6 &amp; ADMA.&#x0D; Conclusions: The present study concluded that the SCH patients presented increased concentrations of cardiovascular disease (CVD) risk factors viz. IL-6, ADMA &amp; lipid profile. The potential benefits of diagnosis and treatment of subclinical hypothyroidism may have possible advantages firstly by preventing the progression to overt hypothyroidism and secondly decrease the risk of death from cardiovascular disease by starting appropriate therapy to improve lipid parameters.&#x0D;","PeriodicalId":16728,"journal":{"name":"Journal of Pharmaceutical Negative Results","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136390346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Citizen Participation And Democratic Practices: An Analysis From The Use Of Social Networks And Schooling","authors":"Jesús Enrique, Morales Rico, Ramsés Daniel Martínez García, Mijael Altamirano Santiago","doi":"10.47750/pnr.2023.14.s01.191","DOIUrl":"https://doi.org/10.47750/pnr.2023.14.s01.191","url":null,"abstract":"There are numerous studies (Norris, 2001; Muñiz, 2015; Díaz and Góngora, 2019) that have declared the importance of the use of social networks and the education of citizens as essential areas to understand civic and democratic participation in issues of sociopolitical interest. . The present work is carried out with the objective of analyzing the association between the variables schooling and use of social networks (YouTube, Facebook and Twitter) to be informed of matters of national interest. For which, a subsample of 20,323 subjects selected from the National Survey of Civic Culture of the year 2020 was used. The selection criterion was to be 18 years old and over. The research hypothesis was that schooling and the use of social networks (Facebook, Twitter and YouTube) are associated in promoting citizen participation in issues of national interest and issues of democratic life. The results showed that, in effect, as the specialized literature points out, there is an association relationship between the variables of interest and citizen participation in issues of sociopolitical interest. To carry out the statistical analysis, the chi2 test was used to determine the association between the study variables, finding a value = 2050.1, with a significance p = 0.05. Therefore, the research hypothesis is verified.","PeriodicalId":16728,"journal":{"name":"Journal of Pharmaceutical Negative Results","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43116454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Political Personalization And Polyarchic Systems: The Opening To Representativeness?","authors":"José Federico de la, Torre Rodríguez, Mijael Altamirano Santiago, Ramsés Daniel, Martínez García","doi":"10.47750/pnr.2023.14.s01.192","DOIUrl":"https://doi.org/10.47750/pnr.2023.14.s01.192","url":null,"abstract":"This paper represents an analytical resource of the phenomenon of political personalization in electoral campaigns, from the accommodation of political forces in polyarchic systems. In this way, it is based on Robert Dahl's proposal by considering that democratic government systems are, rather, polyarchies and that a multitude of interests, starting points and political forces converge in them that have led to a kind of re-understanding. of the relationship of candidates and political parties in order to continue to be valid in the political arena and win the citizen vote. The central thesis of the paper is that political personalization should not only be understood as the maximization of the personal attributes of those who aspire to win electoral contests, but also as a result of the loss of partisan identities in an increasingly plural and diverse sociopolitical context. . Therefore, the main objective of the document is to establish an analytical route that favors the understanding of political personalization as a result of a complex network of political circumstances that have promoted electoral campaigns that tend to maximize personal qualities and attributes within the framework of polyarchic systems.","PeriodicalId":16728,"journal":{"name":"Journal of Pharmaceutical Negative Results","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49490179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}