Journal of Pharmaceutical Negative Results最新文献

{"title":"Knowledge, Attitude, Perception, And Awareness Regarding Benign Prostatic Hyperplasia And Prostate Cancer Among Men Older Than 40 Years - An Online Cross Sectional Study","authors":"Somasundaram P, Nirenjen S, Shanmugasundaram P","doi":"10.47750/pnr.2022.13.s08.480","DOIUrl":"https://doi.org/10.47750/pnr.2022.13.s08.480","url":null,"abstract":"Aim: The purpose of this study is to assess the knowledge, attitude, perception and to create awareness regarding Benign prostatic hyperplasia and prostate cancer among men older than 40 years. \u0000Objectives: To determine the perception and understanding regarding benign prostatic hyperplasia and prostate cancer among men older than 40 years of age. To provide information regarding benign prostatic hyperplasia and prostate cancer. \u0000Study design: This study is design as a online cross sectional study. \u0000Study Duration: The study will be carried from the month of August (2021) to April (2022) – 9 months. \u0000Study Instruments: The study instrument is developed and carried out with the use of self-developed questionnaire after a thorough literature analysis which will be assessed and validated by Physicians. \u0000Statistical Analysis: Microsoft sheet and SPSS software version 24 will be used for statistical analysis of the data. Descriptive analysis of quantitative variables will be done by using mean, standard deviation, and Chi-square test. \u0000Conclusion: The results of this study suggest that the men population in Chennai lack knowledge regarding prostate disease. This study recommends widespread public health campaigns using the mass media, hospitals, and religious centres to improve knowledge, attitude and screening practices regarding prostatic diseases.","PeriodicalId":16728,"journal":{"name":"Journal of Pharmaceutical Negative Results","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47876141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence And Intensity Of Human Schistosomiasis In Selected Rural Communities Of Mecha District And Bahir Dar Town Administration, West Gojjam, Northwestern Ethiopia","authors":"A. Getu","doi":"10.47750/pnr.2022.13.s01.289","DOIUrl":"https://doi.org/10.47750/pnr.2022.13.s01.289","url":null,"abstract":"The study was conducted in Selected Rural Communities of Mecha District and Bahir Dar Town Administration, West Gojjam, Northwestern Ethiopia, to determine the prevalence and intensity of human schistosomiasis. A total of 490 stool and urine specimens were collected using stool cup and test tubes respectively. The overall prevalence and intensity of Schistosoma mansoni was 10.4% and 128.03 eggs per gram of stool (EPG) respectively. The prevalence of infection ranging from 7.8% in Wotet Abay Peasant Associations to 12.9% Kudmi Peasant Associations. The prevalence of Schistosoma mansoni infection among males and females was 13.2% and 7.5%, respectively, and the intensity of infection was 132.37 EPG and 120.42 EPG, respectively. The prevalence of Schistosoma mansoni infection among different age groups ranging from 3.9% in ≥ 30 years to 20.5% in 10-14 years whereas, the intensity of infection was ranging from 89.47 EPG in ≥ 30 years to 168.22 EPG in 10-14 years. It signifies the fact that the age groups 10-14 and 15-19 years are the highest risk groups. It is recommended that to control schistosomiasis in the areas should target at the youngest segment of the population.","PeriodicalId":16728,"journal":{"name":"Journal of Pharmaceutical Negative Results","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45245880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation Of Random Forest Model on Influenza Like Illness ILI Surveillance Based on Patients Attending Fever OPD During COVID 19 Pandemic at Tertiary Care Hospital In Raigad District Maharashtra India","authors":"Mr Raut","doi":"10.47750/pnr.2022.13.S08.488","DOIUrl":"https://doi.org/10.47750/pnr.2022.13.S08.488","url":null,"abstract":"Introduction: The machine learning and artificial intelligence tools, party and random forest can be used to evaluate surveillance data for better outcomes. The primary objective of the study was to evaluate the utility and reliability of machine learning and artificial intelligence model primary data for the Influenzas Like illness (ILI) Surveillance of patients attending fever OPD in a tertiary care hospital during covid 19 pandemic. The secondary objective was to estimate model statistics to measure the effect of parameters. \u0000Methodology: This is a secondary data analysis study based on surveillance data in the tertiary care hospital attached to medical college. The data of 3723 cases was collected by Surveillance team for Influenzas Like Illness (ILI) under Department of Community Medicine in Fever OPD during covid pandemic from 23 March 2020 to 30 June 2020. Data consisted (11) variables. Data was analysed using R Software (4.2.2). Machine learning (ML) and Artificial Intelligence tool party and random forest were applied. \u0000Results: The random forest model performed better than Party model with model accuracy of 0.9557, AUC of random forest model were 87.4% (sensitivity 0.9533, specificity 0.9685), 89.7% (sensitivity 0.9059, specificity 0.9957) and 88.3% (Sensitivity 0.965, Specificity 0.9527) for confirmed, probable and suspected with different cut-offs. The model found Severity of Patient (Mild, Moderate, Severe), the day of Fever OPD Visit, nature of illness (is asymptomatic?) and age of patient as the most significant factors in decreasing order by mean decrease in Accuracy while the Severity of Patient (Mild, Moderate, Severe), the day of Fever OPD Visit, age of patient and number of symptomatic Complaint (NOC) were found the most significant factors in decreasing order by mean decrease in Gini to predict Covid-19 Test Results. \u0000Conclusions: The party algorithm was consistent for train and test dataset while for the random forest results were good on train dataset while same model had seen difficulty in prediction class for the test dataset.","PeriodicalId":16728,"journal":{"name":"Journal of Pharmaceutical Negative Results","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42372977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence Of Adeno Associated Virus Vector Receptor AAVR And Co-Receptors And Their Mutations On Tropism And Transduction Of Adeno Associated Virus During Gene Therapy A Review Tirthal Rai Usha Adiga Deepika Kamath M","authors":"Tirthal Rai, U. Adiga, Deepika Kamath","doi":"10.47750/pnr.2022.13.s08.489","DOIUrl":"https://doi.org/10.47750/pnr.2022.13.s08.489","url":null,"abstract":"Gene therapy is an experimental treatment being investigated to correct defective genes that are responsible for disease development. To treat cancer and genetic illnesses, researchers are looking into a variety of gene therapy techniques. Finding a proper vector to transfer DNA into tissues is one of the most difficult aspects of gene therapy. Some gene therapy vectors have issues with infecting both quiescent and dividing cells, provoking an immunological response, lack of indefinite expression, and reproducible high titre. The adenovirus, retrovirus, and recombinant modified adeno-associated virus are top contenders for gene therapy vectors (rAAV). The issues with gene therapy may be resolved by the adeno associated virus (AAV). Hemophilia is a condition which may be benefited by the gene therapy using AAV as vector. Aim of this review is to emphasize on the role of adeno associated virus receptors(AAVR)  and co-receptors in tropism and transduction of adeno associated virus(AAV) in the gene therapy of hemophilia In Vitro as well as In Vivo. \u0000 ","PeriodicalId":16728,"journal":{"name":"Journal of Pharmaceutical Negative Results","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48234588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Key Aspects Of The Development Of The Menstrual And Ovarian Cycle In Adolescent Girls","authors":"ASHUROVA NIGORA GAFUROVNA","doi":"10.47750/pnr.2022.13.s09.800","DOIUrl":"https://doi.org/10.47750/pnr.2022.13.s09.800","url":null,"abstract":"To determine the causative factors that are etiological factors in the development of menstrual-ovarian cycle disorders in the structure of gynecological pathology among adolescent girls in the Bukhara region and develop recommendations for the early prevention of reproductive dysfunctions. Violation of the harmony of development, lagging pace and timing of the development of secondary sexual characteristics, later than the “menarche” to a certain extent determines the low level of their reproductive health, which dictates the need for a thorough integrated approach and timely correction of premorbid conditions in adolescence. However, already today, starting from adolescence, we can use the possibilities of preventing the above pathologies to really provide, on a population scale, individualized preconception training for each girl and girl, aimed at strengthening the reproductive potential of the country.","PeriodicalId":16728,"journal":{"name":"Journal of Pharmaceutical Negative Results","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49665873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation And Evaluation Polyherbal Gel Against Staphylococcus Aureus Bacteria Causing Skin Disease","authors":"Rohini Sharma, D. Ahuja","doi":"10.47750/pnr.2022.13.s07.561","DOIUrl":"https://doi.org/10.47750/pnr.2022.13.s07.561","url":null,"abstract":"Objective: Over past few years, herbal drugs have been gradually shown a revival of interest for the use of medicinal plants to be used against various disorders. Not limited to developing countries but developed areas are also inclined towards the use because herbal medicines as they have been reported to be safe with least adverse effects especially in comparison to the synthetic drugs. Aim of this research is to formulate and evaluate polyherbal gel against bacteria. \u0000Method: In the present study we have prepared a topical gel formulation  which is comprised of  combined drug aqueous extract of  Murraya Koeniggi, Eucalyptus globulus, Dodonaea viscosa and Mentha spicata in a concentration of 19.2% respectively in a base. The base was prepared by using carbapol 940, propylene glycol-400, glycerine, honey, propylparaben, EDTA, triethanolamine and required amount of water in a quantity sufficient to prepare 100g. The prepared formulation were evaluated for its antimicrobial activity by agar well diffusion technique against S. aureus, Gram positive bacteria by using agar well diffusion method. Further, the formulation was also undergone physical evaluation for appearance and homogeneity, pH, viscosity and rheological studies, spreadability, skin irritation test (Patch test) and washability. \u0000Result: The results of the study revealed that the formulated gel has shown better zone of inhibition against staphylococcus aureus bacteria causing skin disease.   \u0000Conclusion: Based on our research, it could be concluded that this formulations possess a positive antimicrobial activity and can be used safely on human skin.","PeriodicalId":16728,"journal":{"name":"Journal of Pharmaceutical Negative Results","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46266313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognosis Of Idiopathic Parkinsonism Using Support Vector Machine And Random Forest Classifiers","authors":"Raghavendra M Devadas, Vani Ashok Hiremani","doi":"10.47750/pnr.2022.13.s08.571","DOIUrl":"https://doi.org/10.47750/pnr.2022.13.s08.571","url":null,"abstract":"Many of individuals all over the world suffer with Idiopathic Parkinsonism (IP) which is more common in people over 50. Even today, despite numerous technological developments and breakthroughs, early disease identification is still difficult. This calls for the development of machine learning-based automatic methods that assist doctors in accurately identifying this disease in its early stages. This research paper's main goal is to give a thorough analysis of and comparison of the current machine learning methods used for IP detection. In order to compare and determine which of the two classifiers is the most effective and accurate for classifying IP, this paper discusses Support Vector Machine and Random Forest on a dataset. Accuracy and Kappa scores for support vector machine is 85.6% and 0.814. Accuracy 86.45% and kappa score of 0.81 was found in random forest.","PeriodicalId":16728,"journal":{"name":"Journal of Pharmaceutical Negative Results","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44300107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge On Menstrual Stem Cell Banking Among Nursing Students :Descriptive Study- South Coastal, Karnataka India","authors":"Akhila Pathrose, EV Nishitha, Nithyashree, Asst.Professor","doi":"10.47750/pnr.2022.13.s08.614","DOIUrl":"https://doi.org/10.47750/pnr.2022.13.s08.614","url":null,"abstract":"Background: Given that stem cells may be extracted from it, menstrual blood is regarded as the ideal waste to use. Women have a special opportunity to gather and store stem cells that can be extracted from the body's menstrual blood thanks to menstrual stem cell banking. It might be kept for later use in addiction to this. In this study, we evaluate nursing students' understanding of menstrual stem cell banking. The purpose of the study is to assess nursing students' understanding about menstrual stem cell banking. \u0000Material and Method: To measure knowledge regarding menstrual stem cell banking, 134 nursing students were chosen using a non-probability purposive sampling technique. A quantitative, descriptive research design was used to carry out the study. An organised knowledge questionnaire was used to obtain the information. \u0000Result: The majority of nursing students (89.6%) had average awareness about menstrual stem cell banking, according to the study. 3.5% of nursing students had inadequate understanding, compared to 7.5% who had adequate knowledge. \u0000Conclusion and interpretation: According to this survey, most nursing students in certain nursing institutions in Mangalore have mediocre awareness of menstrual stem cell banking.","PeriodicalId":16728,"journal":{"name":"Journal of Pharmaceutical Negative Results","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44326176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“A Study To Assess The Level Of Knowledge And Attitude Related To Tooth Avulsion Management Among School Teachers Working In Selected Schools At Mangalore.\"","authors":"Ms Ms.Anu Sebastian, Aparna, Mrs.Navvya","doi":"10.47750/pnr.2022.13.s08.616","DOIUrl":"https://doi.org/10.47750/pnr.2022.13.s08.616","url":null,"abstract":"Smile reveals an individual 's self-confidence.it is also a means of socialization where teeth play a vital role in a pleasant smile and also contributes to each individual's well-being and quality by positivity affecting physical and mental well -being ,appearance and interpersonal relationship children especially school children,face particular health challenges including all health problems related to the stages of their physical and mental development,which makes them especially vulnerable to traumatic dental injuries including the tooth avulsion.\u0000 \u0000Aim of the study:  The study aim to assess the level of knowledge and attitude related to tooth avulsion management among school teachers in selected schools at managlore\".\u0000Material and Method: descriptive research design and quantitative research approach was used for the study among 70 school teachers selected by simple random sampling technique. The data was collected by usingassessing the knowledge and attitude related to tooth avulsion management and demographic Performa.\u0000Result: The result shows that majority 49(70.0%) of them had excellent knowledge,15(21.4%) of them had good knowledge, 4(5.7%)had average knowledge,2(2.9%) of them had poor knowledge regarding tooth avulsion.Majority 66(94.3%) were shown positive attitude and only 4(5.7%) of them have shown neutral attitude towards tooth avulsion.There was a significant association between level of knowledge and selected demographic variables like age, qualification ,experience and source of information.There was no significant association between level of attitude and selected demographic variables\u0000Interpretation and conclusion: The study proved that majority of school teachers have excellent knowledge and had positive attitude towards tooth avulsion","PeriodicalId":16728,"journal":{"name":"Journal of Pharmaceutical Negative Results","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45693182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Approaches For Colon Site-Specific Drug Delivery: An Overview Of Recent Advancements","authors":"Shubham Tyagi, N. G. R. Rao, Anuj Pathak, Aarati Maurya, Irfan Ali, Dr. N.G. Raghavendra Rao","doi":"10.47750/pnr.2022.13.s08.575","DOIUrl":"https://doi.org/10.47750/pnr.2022.13.s08.575","url":null,"abstract":"Nowadays, various routes of administration have been explored for the effective delivery of the drug to the target site. The oral route is considered to be the most convenient for the administration of drugs to patients. But it has a serious drawback in conditions where localized delivery of the drug in the colon is required. The colon-targeted drug delivery system (CDDS) is a potential approach for systemic and topical drug delivery in treating inflammatory bowel diseases such as ulcerative colitis, Crohn’s disease, colon cancer, and amoebiasis. CDDS would provide direct treatment at the site of the disease, reduced dose, and reduced systemic adverse effects. CDDS should be able to release the drug into the colon, indicating that neither drug release nor absorption should take place in the stomach or small intestine, nor should the bioactive agent be degraded there. Instead, the drug should only be released and absorbed when it reaches the colon. The colon is a site for both local and systemic drug delivery. This review mainly compares the primary approaches for CDDS (Colon Specific Drug Delivery) namely prodrugs, pH and time-dependent systems, and microbially triggered systems, which achieved limited success and had limitations as compared with newer CDDS namely pressure-controlled colonic delivery capsules, CODESTM, and osmotic controlled drug delivery systems. The review is also focused on the possible benefits and issues associated with the novel colon-targeted drug delivery system. Recent advancements in various approaches for designing colon-targeted drug delivery systems and their pharmaceutical applications are covered with a particular emphasis on formulation technologies.","PeriodicalId":16728,"journal":{"name":"Journal of Pharmaceutical Negative Results","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47753811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}