Journal of Personalized Medicine最新文献

{"title":"Association of MMP-8 -799C/T Polymorphism with Peri-Implantitis: A Cross-Sectional Study.","authors":"Ioannis Fragkioudakis, Christine Kottaridi, Aikaterini-Elisavet Doufexi, Konstantinos Papadimitriou, Leonidas Batas, Dimitra Sakellari","doi":"10.3390/jpm15050182","DOIUrl":"10.3390/jpm15050182","url":null,"abstract":"<p><p><b>Purpose</b>: This study explored the relationship between matrix metalloproteinase-8 (MMP-8) gene polymorphisms (-799C/T, -381A/G, and +17C/G) and peri-implantitis, examining clinical parameters including the probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP). <b>Methods</b>: This cross-sectional study involved 120 participants categorized into peri-implantitis and healthy implant groups according to the 2018 classification criteria for periodontal and peri-implant diseases. Saliva samples were analyzed for MMP-8 polymorphisms using polymerase chain reaction (PCR) and Sanger sequencing. Statistical analyses were conducted to evaluate genotype- and allele-specific risks and their associations with clinical parameters. <b>Results</b>: Among the 95 samples analyzed, the -799C/T polymorphism was significantly associated with peri-implantitis, with T allele carriers having a higher diagnosis rate (odds ratio: 3.04, <i>p</i> = 0.010). Although T allele carriers exhibited higher mean values for the probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP), these differences were not statistically significant across genotypes. No associations were found between the -381A/G and +17C/G polymorphisms and peri-implantitis clinical parameters. <b>Conclusions</b>: The -799C/T polymorphism, specifically the T allele, is strongly linked to peri-implantitis, indicating its potential as a genetic marker for disease susceptibility. Further research is required to investigate the role of MMP-8 polymorphisms in peri-implant diseases and to advance the development of personalized diagnostic tools.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 5","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12113233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Central Nervous System Metastases from Primary Lung Carcinoma: Significance of RNA Fusion Testing and Early Versus Late Metastases.","authors":"Michelle Garlin Politis, Mahesh Mansukhani, Benjamin O Herzberg, Lanyi N Chen, Mark Stoopler, Maelle Saliba, Markus Siegelin, Zhe Zhu, Joshua Sonett, Brian S Henick, Simon K Cheng, Swarnali Acharyya, Catherine A Shu, Michael L Miller, Benjamin Izar, Helen Fernandes, Susan Hsiao, Anjali Saqi","doi":"10.3390/jpm15050181","DOIUrl":"10.3390/jpm15050181","url":null,"abstract":"<p><p><b>Background/Objectives:</b> While the genomic landscape of primary lung carcinomas is well characterized, there is a relative scarcity of fusion data on corresponding central nervous system (CNS) metastases. This study aimed to elucidate the molecular profiles of CNS metastases to (1) assess the significance of a combined DNA-reflex RNA fusion testing approach and (2) compare the mutational landscape between patients who present initially [early (≤2 months)] with CNS metastases and those who develop CNS metastases thereafter [late (>2 months)]. <b>Methods</b>: We performed a retrospective search of CNS metastases of adenocarcinoma of probable lung origin interrogated by targeted DNA-reflex RNA next-generation sequencing (NGS). The DNA NGS panel included the driver mutations <i>EGFR</i>, <i>BRAF</i>, <i>KRAS</i>, <i>MET</i>, and <i>ERBB2</i>. RNA NGS included <i>ALK</i>, <i>RET</i>, <i>ROS1</i>, and <i>MET</i>. Additionally, mutational profiles were examined between those with early versus late CNS metastases. <b>Results:</b> Of the 58 patients, 44 (75.9%) had mutations or alterations, including 34 identified by DNA NGS [<i>EGFR</i> (<i>n</i> = 17; 50.0%), <i>KRAS</i> (<i>n</i> = 15; 44.1%), <i>MET</i> (<i>n</i> = 2; 5.9%)] and 10/24 by RNA NGS [<i>ALK</i> (<i>n</i> = 7; 70%), <i>MET</i> (<i>n</i> = 2; 20%), <i>ROS1</i> (<i>n</i> = 1; 10%)]. Of all patients, 32 (55%) presented with early and 26 (45%) with late CNS metastases. Although patients with early metastases had worse survival compared to those with late metastases (<i>p</i> < 0.001), there were no statistically significant differences in the mutational profiles between the two cohorts. <b>Conclusions</b>: A significant proportion of CNS metastases without driver mutations identified by DNA NGS had targetable alterations identified by RNA NGS (10/24, 41.7%). In summary, a combined DNA with reflex RNA fusion testing approach plays a significant role in detecting and potentially managing CNS metastases. Comprehensive prospective studies are essential to elucidate the differences between early and late CNS metastases.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 5","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12112828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalized Care in Advance Care Planning with Cancer and Chronic Progressive Diseases Using the Go Wish Game.","authors":"Sara Alquati, Marta Perin, Simona Sacchi, Ludovica De Panfilis, Silvia Tanzi","doi":"10.3390/jpm15050180","DOIUrl":"10.3390/jpm15050180","url":null,"abstract":"<p><p><b>Background:</b> The Go Wish Game (GWG) is a card game designed to ease Advance Care Planning (ACP) discussions. It helps patients to consider their values and priorities, and to share them with families and healthcare professionals (HPs). Despite a general appreciation of the GWG, mechanisms related to its implementation have been poorly investigated. <b>Objective</b>: to determine optimal strategies for integration of the GWG into clinical practice and to investigate the experiences of a Palliative Care Unit (PCU) trained in the use of the GWG. <b>Methods</b>: We performed a descriptive qualitative study. Data were collected through a focus group (FG) and we followed the thematic analysis. The PCU's team described their experience using the GWG focusing on 15 patients (9 oncological, 6 non-oncological) patients, managed by the PCU. <b>Results</b>: Our data revealed five main themes, along with their subthemes: (1) personalizing the GWG proposal; (2) the role of the caregiver; (3) organizational aspects; (4) meaning of the GWG in clinical practice, and (5) dealing with patient's priorities. Comparison of real-life cases has led to the identification of specific facilitators and barriers that can hinder or promote the use of the GWG for personalized medicine. <b>Conclusions</b>: Findings suggest that certain aspects still require attention in GWG implementation, particularly regarding the training and competencies (communicative, relational, ethical) of the healthcare professionals, and the process leading to the proposal of the GWG to the patient.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 5","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12112847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Depression in Hemodialysis, Peritoneal Dialysis, and Kidney Transplant Patients: A Systematic Review with Meta-Analysis.","authors":"Gloria M Zaragoza-Fernández, José C De La Flor, Verónica Fernández Abreu, Elisa Iglesias Castellano, Laura Rodríguez-Barbero Requena, Rafael Fernández Castillo","doi":"10.3390/jpm15050179","DOIUrl":"10.3390/jpm15050179","url":null,"abstract":"<p><p><b>Background:</b> Depression is a common comorbidity in patients with chronic kidney disease undergoing renal replacement therapy. This meta-analysis compares depression prevalence across hemodialysis, peritoneal dialysis, and kidney transplantation, considering mean age, treatment duration, comorbidities (diabetes and hypertension), and measurement instruments. <b>Methods:</b> A systematic review and meta-analysis of 16 studies involving 26,301 participants was conducted in accordance with PRISMA guidelines and registered in PROSPERO. It analyzed observational studies (2000-2024) on depression in patients receiving hemodialysis, peritoneal dialysis, or kidney transplantation. Data extraction included sample size, mean age, treatment duration, comorbidities, and measurement instruments. Random-effects models calculated the standardized mean differences and pooled prevalence estimates. Heterogeneity (Cochran's Q, I²) and publication bias (Egger's test) were assessed. <b>Results:</b> Depression prevalence was 35.56% (95% CI: 34.2-37.0%) in hemodialysis, 35.09% (95% CI: 33.5-36.7%) in peritoneal dialysis, and 25.33% (95% CI: 24.0-26.6%) in kidney transplant recipients. No significant differences were found between hemodialysis and peritoneal dialysis. Mean age, treatment duration, comorbidities, and measurement instruments were not significantly associated with depression prevalence. <b>Conclusions:</b> Kidney transplantation is linked to a lower depression prevalence than dialysis, while no significant differences exist between hemodialysis and peritoneal dialysis. These findings highlight the need to ensure timely transplantation access and enhance psychological support for dialysis patients. Further research should explore psychosocial factors and targeted interventions to improve mental health in this population.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 5","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12113119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Scoping Review of Precision Medicine in Breast Reconstruction (2011-2025).","authors":"Zain Aryanpour, Alec S McCranie, Jason W Yu, Julian Winocour, Katie G Egan, David Mathes, Christodoulos Kaoutzanis","doi":"10.3390/jpm15050178","DOIUrl":"10.3390/jpm15050178","url":null,"abstract":"<p><p><b>Background:</b> Personalization of medical care is a significant topic of interest. Precision medicine denotes customized medical treatments based on individual genetic, molecular, and/or biomarker data. We conducted a scoping review to identify studies exploring precision medicine in breast reconstruction. <b>Objectives:</b> (1) To map the existing literature, (2) to identify key concepts, and (3) to discuss current and future clinical implications of precision medicine in breast reconstruction. <b>Eligibility criteria:</b> Indexed journal articles (primary research studies) relating to precision medicine in breast reconstruction written in the English language. <b>Sources of evidence:</b> Medline (via Pubmed), Web of Science, and the Cochrane Library. <b>Charting methods:</b> Data charting of selected studies was performed independently by two reviewers using Microsoft Excel. Any discrepancies in data charting were addressed through inter-reviewer discussion and/or expert review. <b>Results:</b> Of 321 initial records, 9 studies that were published between 2011 and 2025 were included in the final review. Eight studies focused predominantly on genomics, and one study focused predominantly on targeted therapies. Genomic-based studies were frequently implemented to evaluate patient risk and inform clinical decision-making, while targeted therapies were used to optimize reconstructive outcomes through cell-based therapies. <b>Conclusions:</b> There is a limited but emerging body of literature on precision medicine in breast reconstruction. Genomic data are the driving force of precision medicine in breast reconstruction, and multiple potential avenues exist to achieve translational applications in the short-term period. Future efforts should focus on translating known genomic data into real-time clinical applications and investing in precision-based research for targeted therapies and regenerative medicine in breast reconstruction.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 5","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12113009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteomics in Diagnostic Evaluation and Treatment of Breast Cancer: A Scoping Review.","authors":"Menelaos Zafrakas, Ioannis Gavalas, Panayiota Papasozomenou, Christos Emmanouilides, Maria Chatzidimitriou","doi":"10.3390/jpm15050177","DOIUrl":"10.3390/jpm15050177","url":null,"abstract":"<p><p><b>Objectives:</b> The aim of this scoping review was to delineate the current role and possible applications of proteomics in personalized breast cancer diagnostic evaluation and treatment. <b>Methods:</b> A comprehensive search in PubMed/MEDLINE and Scopus/EMBASE was conducted, according to the PRISMA-ScR guidelines. Inclusion criteria: proteomic studies of specimens from breast cancer patients, clinically relevant studies and clinical studies. Exclusion criteria: in silico, in vitro and studies in animal models, review articles, case reports, case series, comments, editorials, and articles in language other than English. The study protocol was registered in the Open Science Framework. <b>Results:</b> In total, 1093 records were identified, 170 papers were retrieved and 140 studies were selected for data extraction. Data analysis and synthesis of evidence showed that most proteomic analyses were conducted in breast tumor specimens (n = 77), followed by blood samples (n = 48), and less frequently in other biologic material taken from breast cancer patients (n = 19). The most commonly used methods were liquid chromatography-tandem mass spectrometry (LC-MS/MS), followed by Matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF), Surface-Enhanced Laser Desorption/Ionization Time-of-Flight (SELDI-TOF) and Reverse Phase Protein Arrays (RPPA). <b>Conclusions:</b> The present review provides a thorough map of the published literature reporting clinically relevant results yielded from proteomic studies in various biological samples from different subgroups of breast cancer patients. This analysis shows that, although proteomic methods are not currently used in everyday practice to guide clinical decision-making, nevertheless numerous proteins identified by proteomics could be used as biomarkers for personalized diagnostic evaluation and treatment of breast cancer patients.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 5","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12113354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalized Medical Approach in Gastrointestinal Surgical Oncology: Current Trends and Future Perspectives.","authors":"Dae Hoon Kim","doi":"10.3390/jpm15050175","DOIUrl":"10.3390/jpm15050175","url":null,"abstract":"<p><p>Advances in artificial intelligence (AI), multi-omic profiling, and sophisticated imaging technologies have significantly advanced personalized medicine in gastrointestinal surgical oncology. These technological innovations enable precise patient stratification, tailored surgical strategies, and individualized therapeutic approaches, thereby significantly enhancing clinical outcomes. Despite remarkable progress, challenges persist, including the standardization and integration of diverse data types, ethical concerns regarding patient privacy, and rigorous clinical validation of predictive models. Addressing these challenges requires establishing international standards for data interoperability, such as Fast Healthcare Interoperability Resources, and adopting advanced security methods, such as homomorphic encryption, to facilitate secure multi-institutional data sharing. Moreover, ensuring model transparency and explainability through techniques such as explainable AI is critical for fostering trust among clinicians and patients. The successful integration of these advanced technologies necessitates strong multidisciplinary collaboration among surgeons, radiologists, geneticists, pathologists, and oncologists. Ultimately, the continued development and effective implementation of these personalized medical strategies complemented by human expertise promise a transformative shift toward patient-centered care, improving long-term outcomes for patients with gastrointestinal cancer.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 5","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12112797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association of Assisted Reproductive Technology with Placental and Umbilical Abnormalities.","authors":"Antonios Siargkas, Ioannis Tsakiridis, Sonia Giouleka, Petya Chaveeva, Maria Mar Gil, Walter Plasencia, Catalina De Paco Matallana, Efstratios M Kolibianakis, Themistoklis Dagklis","doi":"10.3390/jpm15050176","DOIUrl":"10.3390/jpm15050176","url":null,"abstract":"<p><p><b>Objective:</b> Global utilization of assisted reproductive technology (ART) is increasing; however, it is associated with adverse perinatal outcomes. Placental and umbilical cord abnormalities contribute significantly to these negative outcomes. However, it remains unclear whether ART independently increases the risk of such abnormalities. This study aimed to investigate the association between ART and key umbilico-placental abnormalities, after adjustment for confounders. <b>Methods:</b> In this retrospective cohort study, singleton pregnancies receiving routine antenatal care (January 2015 to June 2024) at the 3rd Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Greece, were analyzed. Pregnancies conceived via ART were compared to those conceived spontaneously. To investigate placental and cord anomalies, this study employed multiple logistic regression. This approach adjusted for various confounders, including maternal age, BMI, parity, smoking status, history of previous cesarean section, diabetes mellitus, and thyroid disease. <b>Results:</b> This study included a total of 13,854 singleton pregnancies, of which 647 were conceived via ART. ART was significantly associated with an increased risk of placenta previa (aOR 1.99, 95% CI 1.10-3.61), low-lying placenta (aOR 1.71, 95% CI 1.38-2.11), bilobate placenta (aOR 2.81, 95% CI 1.92-4.11), single umbilical artery (aOR 2.62, 95% CI 1.022-6.715), marginal (aOR 1.63, 95% CI 1.32-2.01) and velamentous cord insertion (aOR 3.13, 95% CI 1.98-4.95), and vasa previa (aOR 5.51, 95% CI 1.28-23.76). <b>Conclusions:</b> ART-conceived pregnancies appear to carry a higher risk for certain placental and umbilical cord abnormalities, potentially contributing to adverse perinatal outcomes. Further studies are required to investigate the pathophysiology underlying these associations.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 5","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12113098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-Term Changes in Tear Film Stability and Tear Volume Following the Application of Various DED Management Options in a Healthy Young Population.","authors":"Belén Sabucedo-Villamarin, Jacobo Garcia-Queiruga, Laura Cacabelos-Torres, Maria J Giraldez, Eva Yebra-Pimentel, Hugo Pena-Verdeal","doi":"10.3390/jpm15050173","DOIUrl":"10.3390/jpm15050173","url":null,"abstract":"<p><p><b>Background:</b> To determine short-term changes in tear film volume and stability after various treatments for dry eye disease in healthy participants. <b>Methods:</b> 36 healthy participants aged from 18 to 35 years were recruited for a single-session examination and randomly assigned to one of three treatment groups (1:1:1 treatment, 1:1 eye): Group 1 (artificial tears 'Comfort Drops'), Group 2 (eyelid wipes 'Systane Lid Wipes'), and Group 3 (ocular bath 'Acuaiss'). Tear Meniscus Height (TMH) was assessed at baseline, 2, 5, 10, 15, and 20 min, and Non-Invasive Break-Up Time (NIBUT) at baseline, 2, 10, and 20 min, all using the OCULUS Keratograph 5M by one examiner. <b>Results:</b> Of the initially recruited participants, 35 were analyzed; one was excluded for reflex tearing. Group 1 (n = 12) showed a significant TMH increase at 2 min compared to 10 and 20 min (Friedman, <i>p</i> = 0.004; Bonferroni, <i>p</i> ≤ 0.028). Group 3 (n = 12) showed a significant increase at 2 and 5 min compared to baseline and decrease at 10 min against 2 and 5 min (Friedman, <i>p</i> < 0.001; Bonferroni, <i>p</i> ≤ 0.034). Group 2 (n = 11) showed no significant changes over time (Friedman, <i>p</i> = 0.108). NIBUT showed no significant differences at any time-point in any group (Friedman, <i>p</i> ≥ 0.231). Basal TMH differed between groups (ANOVA, <i>p</i> = 0.048), but post hoc analysis found no significance (Bonferroni, all <i>p</i> ≥ 0.088). No significant differences in TMH at other time-points (Kruskal-Wallis/ANOVA, <i>p</i> ≥ 0.265) or in NIBUT between groups (Kruskal-Wallis/ANOVA, <i>p</i> = 0.108) were found. <b>Conclusions</b>: In healthy participants, artificial tears and ocular baths temporarily increase TMH, while eyelid wipes do not. Neither has an immediate impact on NIBUT.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 5","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12112829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalized Surgical Approach for Nonunion of the Second Metatarsal Fracture and Post-Traumatic Metatarsalgia: A Case Report and Literature Review.","authors":"Roberto Bevoni, Elena Artioli, Marco Di Ponte, Silvio Caravelli, Massimiliano Mosca","doi":"10.3390/jpm15050174","DOIUrl":"10.3390/jpm15050174","url":null,"abstract":"<p><p>Nonunion of the second metatarsal presents a significant clinical challenge, often leading to pain, functional impairment, and deformity. Various treatment strategies have been described in the literature, tailored to the patient's specific characteristics. To provide a comprehensive overview of the available therapeutic options, a literature review was conducted. In this context, this article aims to present an innovative and personalized surgical technique for patients with nonunion and an altered metatarsal formula following a proximal shaft fracture of the second metatarsal. This technique enables the simultaneous consolidation of the nonunion and restoration of metatarsal alignment, with favorable clinical, functional, and radiological outcomes observed over a three-year follow-up period.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 5","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12113075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}