Journal of Personalized Medicine最新文献

{"title":"Comparative Evaluation of Deep Learning Models for Diagnosis of Helminth Infections.","authors":"Omid Mirzaei, Ahmet Ilhan, Emrah Guler, Kaya Suer, Boran Sekeroglu","doi":"10.3390/jpm15030121","DOIUrl":"10.3390/jpm15030121","url":null,"abstract":"<p><p>(1) <b>Background</b>: Helminth infections are a widespread global health concern, with Ascaris and taeniasis representing two of the most prevalent infestations. Traditional diagnostic methods, such as egg-based microscopy, are fraught with challenges, including subjectivity and low throughput, often leading to misdiagnosis. This study evaluates the efficacy of advanced deep learning models in accurately classifying <i>Ascaris lumbricoides</i> and <i>Taenia saginata</i> eggs from microscopic images, proposing a technologically enhanced approach for diagnostics in clinical settings. (2) <b>Methods</b>: Three state-of-the-art deep learning models, ConvNeXt Tiny, EfficientNet V2 S, and MobileNet V3 S, are considered. A diverse dataset comprising images of Ascaris, Taenia, and uninfected eggs was utilized for training and validating these models by performing multiclass experiments. (3) <b>Results</b>: All models demonstrated high classificatory accuracy, with ConvNeXt Tiny achieving an F1-score of 98.6%, followed by EfficientNet V2 S at 97.5% and MobileNet V3 S at 98.2% in the experiments. These results prove the potential of deep learning in streamlining and improving the diagnostic process for helminthic infections. The application of deep learning models such as ConvNeXt Tiny, EfficientNet V2 S, and MobileNet V3 S shows promise for efficient and accurate helminth egg classification, potentially significantly enhancing the diagnostic workflow. (4) <b>Conclusion</b>: The study demonstrates the feasibility of leveraging advanced computational techniques in parasitology and points towards a future where rapid, objective, and reliable diagnostics are standard.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 3","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Perception of Illness in People with Advanced Chronic Kidney Disease.","authors":"Miquel Sitjar-Suñer, Rosa Suñer-Soler, Afra Masià-Plana, Bernat Carles Serdà-Ferrer, Xavier Pericot-Mozo, Glòria Reig-Garcia","doi":"10.3390/jpm15030120","DOIUrl":"10.3390/jpm15030120","url":null,"abstract":"<p><p><b>Background/objectives</b>: Chronic kidney disease (CKD) has become an important public health issue; however, there are few investigations regarding the perception of CKD in its advanced stages. Personalized medicine approaches, which take into account knowledge of the disease, symptoms and treatment responses, can improve the perception of the disease and help control the progression of CKD. This study aimed to describe illness perception in people with advanced CKD in primary healthcare settings. <b>Methods</b>: A cross-sectional and multicenter descriptive study was conducted amongst a sample of 189 people over 18 years of age with advanced CKD and a glomerular filtration rate between 15 and 29 mL/min/1.73 m² in three community health centers, including rural and urban areas, during 2023. Data on sociodemographic and clinical variables were collected through an ad hoc questionnaire and those on the perception of disease through the Brief Illness Perception Questionnaire. Nurses at the centers collected data from the study. <b>Results</b>: The mean age was 79.7, and all participants suffered from another chronic condition in addition to CKD. The mean total score for perception of the disease was 44.02 points, and the dimensions of the duration of treatment control and understanding had the highest evaluations. Men had a greater perception in the dimensions of concern (<i>p</i> = 0.023) and understanding (<i>p</i> = 0.006). The dimension of consequences showed a correlation with identity (Spearman's Rho 0.688; <i>p</i> = 0.001), and concern about the disease was associated with emotional response (Spearman's Rho 0.689; <i>p</i> < 0.001). A higher number of hospital admissions was associated with a higher score on the questionnaire (B = 4.93; <i>p</i> < 0.001; CI: 3.01-6.84) in a multiple linear regression. <b>Conclusions</b>: Participants in this study with advanced CKD had low illness perception; women expressed less concern in understanding their health status. Higher symptom burden was linked to greater illness perception, greater emotional impact, and increased hospital admissions.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 3","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protocol for Converting DICOM Files to STL Models Using 3D Slicer and Ultimaker Cura.","authors":"Malena Pérez-Sevilla, Fernando Rivas-Navazo, Pedro Latorre-Carmona, Darío Fernández-Zoppino","doi":"10.3390/jpm15030118","DOIUrl":"10.3390/jpm15030118","url":null,"abstract":"<p><p><b>Background/Objectives</b>: 3D printing has become an invaluable tool in medicine, enabling the creation of precise anatomical models for surgical planning and medical education. This study presents a comprehensive protocol for converting DICOM files into three-dimensional models and their subsequent transformation into GCODE files ready for 3D printing. <b>Methods</b>: We employed the open-source software \"3D Slicer\" for the initial conversion of the DICOM files, capitalising on its robust capabilities in segmentation and medical image processing. An optimised workflow was developed for the precise and efficient conversion of medical images into STL models, ensuring high fidelity in anatomical structures. The protocol was validated through three case studies, achieving elevated structural fidelity based on deviation analysis between the STL models and the original DICOM data. Furthermore, the segmentation process preserved morphological accuracy within a narrow deviation range, ensuring the reliable replication of anatomical features for medical applications. Our protocol provides an effective and accessible approach to generating 3D anatomical models with enhanced accuracy and reproducibility. In later stages, we utilised the \"Ultimaker Cura\" software to generate customised GCODE files tailored to the specifications of the 3D printer. <b>Results</b>: Our protocol offers an effective, accessible, and more accurate solution for creating 3D anatomical models from DICOM images. Furthermore, the versatility of this approach allows for its adaptation to various 3D printers and materials, expanding its utility in the medical and scientific community. <b>Conclusions</b>: This study presents a robust and reproducible approach for converting medical data into physical three-dimensional objects, paving the way for a wide range of applications in personalised medicine and advanced clinical practice. The selection of sample datasets from the 3D Slicer repository ensures standardisation and reproducibility, allowing for independent validation of the proposed workflow without ethical or logistical constraints related to patient data access. However, we acknowledge that future work could expand upon this by incorporating real patient datasets and benchmarking the protocol against alternative segmentation methods and software packages to further assess performance across different clinical scenarios. Essentially, this protocol can be particularly characterised by its commitment to open-source software and low-cost solutions, making advanced 3D modelling accessible to a wider audience. By leveraging open-access tools such as \"3D Slicer\" and \"Ultimaker Cura\", we democratise the creation of anatomical models, ensuring that institutions with limited resources can also benefit from this technology, promoting innovation and inclusivity in medical sciences and education.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 3","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Basivertebral Nerve Ablation for Chronic Low Back Pain: A Narrative Review.","authors":"Sujeivan Mahendram, Paul J Christo","doi":"10.3390/jpm15030119","DOIUrl":"10.3390/jpm15030119","url":null,"abstract":"<p><p>Chronic low back pain has traditionally been thought to stem from intervertebral disc degeneration. However, emerging evidence over the last few decades has revealed other contributing sources. One such etiology of chronic non-radiating axial low back pain has been attributed to vertebral end plate disruption and degeneration, leading to basivertebral nerve-mediated nociception. These degenerative events, described as Modic changes on MRI, provide a means of diagnosis and offer personalized treatment options, like minimally invasive radiofrequency ablation, to help address this source of low back pain. This review focuses on recent advancements, rationale, efficacy, and safety profile intraosseous basivertebral nerve ablation in the treatment of vertebrogenic back pain, and discusses current knowledge gaps that may help guide future research in the field.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 3","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of A Levonorgestrel-Releasing Intrauterine System Versus Hysteroscopic Treatment for Abnormal Uterine Bleeding in Women with Cesarean Scar Defects: A Systematic Review and Meta-Analysis.","authors":"Athanasios Douligeris, Nikolaos Kathopoulis, Konstantinos Kypriotis, Dimitrios Zacharakis, Anastasia Prodromidou, Anastasia Mortaki, Ioannis Chatzipapas, Themos Grigoriadis, Athanasios Protopapas","doi":"10.3390/jpm15030117","DOIUrl":"10.3390/jpm15030117","url":null,"abstract":"<p><p><b>Background/Objectives</b>: To assess the effectiveness of the levonorgestrel-releasing intrauterine device (LNG-IUD) compared to hysteroscopic resection for managing women with symptomatic cesarean scar defects (CSDs). <b>Methods</b>: This systematic review and meta-analysis followed PRISMA guidelines. A comprehensive search of four electronic databases was conducted to identify studies comparing LNG-IUD with hysteroscopic management for symptomatic CSDs. Studies reporting outcomes of bleeding and spotting days and effectiveness rates were included. Quality assessment was performed using the ROBINS-I and RoB-2 tools. <b>Results</b>: Three studies involving 344 patients met the inclusion criteria. At 6 months, LNG-IUD use significantly reduced total bleeding days (MD -4.13; 95% CI: -5.17 to -3.09; <i>p</i> < 0.00001) and spotting days (MD 1.90; 95% CI: 0.43 to 3.37; <i>p</i> = 0.01) compared to hysteroscopic treatment. By 12 months, LNG-IUD demonstrated superior effectiveness (OR 3.46; 95% CI: 1.53 to 7.80; <i>p</i> = 0.003), with fewer total bleeding days (MD -5.69; 95% CI: -6.55 to -4.83; <i>p</i> < 0.00001) and spotting days (MD 3.09; 95% CI: 1.49 to 4.69; <i>p</i> = 0.0002). Approximately 50% of LNG-IUD users experienced amenorrhea within 1 year. <b>Conclusions</b>: LNG-IUD offers a minimally invasive and effective alternative to hysteroscopic resection for women with symptomatic CSD and no desire for future pregnancies. Its role should be considered in clinical practice, but further research is needed to validate these findings and define its long-term benefits and limitations.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 3","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Actinomycosis of the Stomach: A Review of the Literature for A Rare Entity.","authors":"Afroditi Ziogou, Ilias Giannakodimos, Alexios Giannakodimos, Evangelia Mitakidi, Nikolaos Charalampakis, Petros Ioannou","doi":"10.3390/jpm15030116","DOIUrl":"10.3390/jpm15030116","url":null,"abstract":"<p><p><b>Background/Objectives:</b> Primary gastric actinomycosis is extremely rare and only a limited number of cases are published in the literature. Actinomycosis is caused by anaerobic Gram-positive bacteria; these microorganisms are members of the normal human microbiome and occasionally lead to infection, especially in immunocompromised patients or patients subjected to abdominal surgery. Advances in personalized medicine, including tailored antimicrobial therapy based on individual patient profiles, may enhance treatment efficacy and reduce unnecessary interventions. <b>Methods:</b> A review was performed through a literature search of the PubMed/MedLine and Scopus databases. <b>Results:</b> A total of 27 patients were included, 15 males (55.56%) and 12 (44.44%) females, with a mean age of 55.11 ± 17.48 years. Among the included patients, 25.93% had a history of abdominal surgery. Abdominal pain (73.08%), weight loss (40.74%), nausea or vomiting (30.77%) and fever (19.23%) constitute the most commonly reported clinical manifestations. Endoscopy (59.26%), computed tomography (48.15%), ultrasonography (22.22%) and magnetic resonance imaging (11.11%) assisted in indicating the primary lesion. Diagnosis was achieved preoperatively in 66.66% of patients, via endoscopy and biopsy (51.85%) or via cultures (14.81%), while nine cases (33.33%) were diagnosed postoperatively. The therapeutic approaches included antimicrobial administration (32%), surgery (24%) or both (44%). The most widely used antimicrobial was penicillin (77.78%) and the mean duration of antimicrobial treatment was 5.85 months. The protocol for this review was registered in Prospero (ID:CRD42025649532). <b>Conclusions:</b> Due to the divergent clinical presentation of primary gastric actinomycosis, clinicians should be aware of this rare entity in order to establish diagnosis in a timely manner and provide prompt and effective treatment.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 3","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune Checkpoint Inhibitor-Induced Insidiously Progressive, Fatal Interstitial Lung Disease.","authors":"Nobuhiro Kanaji, Naoki Watanabe, Takuya Inoue, Hitoshi Mizoguchi, Yuta Komori, Yasuhiro Ohara, Norimitsu Kadowaki","doi":"10.3390/jpm15030115","DOIUrl":"10.3390/jpm15030115","url":null,"abstract":"<p><p><b>Background/Objectives:</b> Immune checkpoint inhibitors (ICIs) cause interstitial lung diseases (ILDs) as a type of immune-related adverse event (irAE). The characteristics of ICI-ILD are diverse. The objective of this study is to investigate the clinical features of ICI-ILD, with particular emphasis on insidiously progressive ICI-ILD. <b>Methods:</b> We retrospectively analyzed 232 patients with advanced lung cancer who were treated with ICIs (including combination therapy with cytotoxic agents). <b>Results:</b> IrAEs were observed in 85 patients (36.6%). The most frequent irAE was ICI-ILD (41 patients, 17.7% of all patients). The occurrence of ICI-ILD was associated with a significantly better response compared to the non-irAE group (response rates: 88% vs. 33%), longer progression-free survival (PFS) (median: 17.5 vs. 3.0 months), and longer overall survival (median: 52.6 vs. 16.6 months), respectively. However, six patients died from ICI-ILD, which could be divided into two patterns: early-onset ICI-ILD in three patients (median PFS: 1.2 months), and insidiously progressive ICI-ILD in three patients. In the latter type, ICI-ILD developed unnoticed, progressed insidiously, and led to respiratory failure (median PFS: 7.2 months). The non-organizing pneumonia pattern and a weak response to corticosteroid therapy were also common findings. On average, six cycles of ICI treatment were administered between the time when ICI-ILD became retrospectively recognizable and the discontinuation of ICI treatment. During this period, C-reactive protein levels and the extent of ILD involvement gradually increased. <b>Conclusions:</b> Insidiously progressive ICI-ILD can lead to fatal outcomes. Early discontinuation of ICIs upon recognition of this type of ICI-ILD may improve patient outcomes.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 3","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Immunological Role of the Microbial Composition of the Appendix and the Associated Risks of Appendectomies.","authors":"Tarequl Islam, Md Shahjalal Sagor, Noshin Tabassum Tamanna, Md Kamrul Islam Bappy, Danishuddin, Md Azizul Haque, Maximilian Lackner","doi":"10.3390/jpm15030112","DOIUrl":"10.3390/jpm15030112","url":null,"abstract":"<p><p>The appendix, an integral part of the large intestine, may serve two purposes. First of all, it is a concentration of lymphoid tissue that resembles Peyer's patches. It is also the main location in the body for the creation of immunoglobulin A (IgA), which is essential for controlling intestinal flora's density and quality. Second, the appendix constitutes a special place for commensal bacteria in the body because of its location and form. Inflammation of the appendix, brought on by a variety of infectious agents, including bacteria, viruses, or parasites, is known as appendicitis. According to a number of studies, the consequences of appendectomies may be more subtle, and may relate to the emergence of heart disease, inflammatory bowel disease (IBD), and Parkinson's disease (PD), among other unexpected illnesses. A poorer prognosis for recurrent <i>Clostridium difficile</i> infection is also predicted by the absence of an appendix. Appendectomies result in gut dysbiosis, which consequently causes different disease outcomes. In this review, we compared the compositional differences between the appendix and gut microbiome, the immunological role of appendix and appendix microbiome (AM), and discussed how appendectomy is linked to different disease consequences.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 3","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Small Cell Lung Cancer Patients with Skip-N2 Metastases Have Similar Survival to N1 Patients-A Multicenter Analysis.","authors":"Georg Schlachtenberger, Simon Schallenberg, Fabian Doerr, Hruy Menghesha, Christopher Gaisendrees, Andres Amorin, Alberto Lopez-Pastorini, Reinhard Büettner, Alexander Quaas, David Horst, Frederick Klauschen, Nikolaj Frost, Jens C Rueckert, Jens Neudecker, Khosro Hekmat, Matthias B Heldwein","doi":"10.3390/jpm15030113","DOIUrl":"10.3390/jpm15030113","url":null,"abstract":"<p><p><b>Introduction:</b> Nodal involvement is one of the most important prognostic factors in NSCLC. Skip-N2 metastasis (N0N2), which is N2 metastasis in the absence of N1 metastasis, occurs in approximately 20-30% of patients. According to the International Association for the Study of Lung Cancer, N1 and N0N2 patients may have comparable long-term survival, considering their similar tumor stages. However, this conclusion remains controversial. Therefore, we carried out this multicenter study to examine the long-term survival and disease-free interval (DFI) of N0N2- and N1 patients. <b>Methods:</b> One-, three-, and five-year survival rates were measured. Kaplan-Meier curves and a Cox proportional hazards model assessed survival and were used to identify prognostic factors for overall survival. <b>Results:</b> Between January 2010 and December 2020, 273 N0N2 and N1 patients were included in our analysis. Of those patients, 77 showed N0N2 and 196 N1. Baseline characteristics did not differ significantly between groups. Between N0N2 and N1 patients, there were no significant differences in one- (<i>p</i> = 0.67), three- (<i>p</i> = 0.20), and five-year (<i>p</i> = 0.27) survival. Furthermore, DFI did not differ between groups (<i>p</i> = 0.45). <b>Conclusions:</b> Our findings indicate that N0N2 patients have a prognosis comparable to that of patients with N1 disease. These results indicate that patients with N0N2 have a similar prognosis to N1 patients. N2-NSCLC is heterogeneous and would benefit from a more precise subdivision and differential treatment in the upcoming UICC 9 classification. The following question remains: are we overtreating N0N2 patients or undertreating N1 patients?</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 3","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalizing Breast Cancer Surgery: Harnessing the Power of ROME (Radiological and Oncoplastic Multidisciplinary Evaluation).","authors":"Liliana Barone Adesi, Marzia Salgarello, Alba Di Leone, Giuseppe Visconti, Marco Conti, Paolo Belli, Lorenzo Scardina, Giulio Tarantino, Gianluca Franceschini","doi":"10.3390/jpm15030114","DOIUrl":"10.3390/jpm15030114","url":null,"abstract":"<p><p>Breast cancer treatment has evolved significantly in recent decades, with personalized care models gaining prominence both for the optimization of oncological outcomes and aesthetic results. At the Fondazione Policlinico Universitario Agostino Gemelli IRCCS in Rome, Italy, we have developed a multidisciplinary, evidence-based model for the management of breast cancer patients, called ROME (Radiological and Oncoplastic Multidisciplinary Evaluation). This innovative model integrates the expertise of various specialists in a seamless, patient-centered approach to improve treatment planning and outcomes. ROME involves a collaborative framework between radiologists, oncologists, surgeons, pathologists, oncoplastic specialists and psychologists. The process begins with the detailed radiological evaluation of tumors using advanced imaging techniques, which is then complemented by an oncoplastic assessment to evaluate potential surgical approaches that ensure optimal oncological resections while preserving or enhancing breast aesthetics. The combination of these evaluations allows the team to tailor treatment plans according to the patient's specific clinical profile, including tumor characteristics, genetic factors, and aesthetic considerations. A key feature of the ROME model is the continuous integration of evidence-based guidelines with real-time multidisciplinary input. This enables the personalization of surgical strategies, ensuring that each patient receives a treatment plan that balances the need for effective cancer control with the desire for an optimal aesthetic result. Since its implementation, ROME has demonstrated significant improvements in both oncological and cosmetic outcomes, leading to enhanced patient satisfaction and quality of life. The success of ROME underscores the importance of a holistic and collaborative approach to breast cancer treatment, one that integrates clinical, radiological, and aesthetic perspectives to offer a truly personalized and patient-focused care experience. As evidence continues to accumulate, ROME stands as a model for personalized breast cancer surgery, setting a new standard for care in multidisciplinary oncology settings.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 3","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}