Evaluation of the Choroidal Thickness and Retinal Nerve Fiber Layer Thickness in Patients with Vasovagal Syncope.

IF 3 3区 医学 Q2 HEALTH CARE SCIENCES & SERVICES
Hasan B Isleyen, Batur G Kanar, Guzide Akcay, Serdar Demir, Hatice S Kanar, Mehmet V Yazicioglu
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引用次数: 0

Abstract

Aim: The aim of this study was to evaluate choroidal and peripapillary retinal nerve fiber layer (RNFL) thicknesses in individuals with vasovagal syncope (VVS). Method: A total of 67 consecutive patients with VVS and 61 healthy control subjects were enrolled this study. The choroidal thickness (CT) at the fovea, the nasal to fovea thickness, and the temporal to fovea thickness were measured, alongside pRNLFT measurements assessed by swept-source optical coherence tomography (SS-OCT). Results: The mean foveal CT (408.7 ± 92.5 μm vs. 342.1 ± 60.2 μm, p < 0.01), the mean nasal CT (385.2 ± 88.3 μm vs. 329.2 ± 47.6 μm, p < 0.001), and the mean temporal CT (379.5 ± 51.6 μm vs. 321.48 ± 43.2 μm, p < 0.03) were statistically thicker in patients with VVS compared to the healthy controls. There was no statistically significant difference in the global pRNFLT measurements and all quadrants between the study groups. Conclusions: The CT in all regions was found to be thicker in patients with VVS compared to the healthy controls, while there were no differences in pRNFLT values. These results suggest that choroidal circulation might be affected by local neurotransmitter alterations in patients with VVS.

血管迷走神经性晕厥患者脉络膜厚度和视网膜神经纤维层厚度的评价。
目的:本研究的目的是评估血管迷走神经性晕厥(VVS)患者的脉络膜和乳头周围视网膜神经纤维层(RNFL)厚度。方法:选取连续67例VVS患者和61例健康对照者进行研究。测量中央窝脉络膜厚度(CT)、鼻到中央窝厚度、颞到中央窝厚度,并通过扫描源光学相干断层扫描(SS-OCT)评估pRNLFT测量。结果:VVS患者的平均中央凹CT(408.7±92.5 μm比342.1±60.2 μm, p < 0.01)、平均鼻CT(385.2±88.3 μm比329.2±47.6 μm, p < 0.001)、平均颞部CT(379.5±51.6 μm比321.48±43.2 μm, p < 0.03)均较健康对照组厚。在研究组之间,全球pRNFLT测量值和所有象限没有统计学上的显著差异。结论:与健康对照相比,VVS患者各区域CT均增厚,但pRNFLT值无差异。这些结果提示脉络膜循环可能受到VVS患者局部神经递质改变的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Personalized Medicine
Journal of Personalized Medicine Medicine-Medicine (miscellaneous)
CiteScore
4.10
自引率
0.00%
发文量
1878
审稿时长
11 weeks
期刊介绍: Journal of Personalized Medicine (JPM; ISSN 2075-4426) is an international, open access journal aimed at bringing all aspects of personalized medicine to one platform. JPM publishes cutting edge, innovative preclinical and translational scientific research and technologies related to personalized medicine (e.g., pharmacogenomics/proteomics, systems biology). JPM recognizes that personalized medicine—the assessment of genetic, environmental and host factors that cause variability of individuals—is a challenging, transdisciplinary topic that requires discussions from a range of experts. For a comprehensive perspective of personalized medicine, JPM aims to integrate expertise from the molecular and translational sciences, therapeutics and diagnostics, as well as discussions of regulatory, social, ethical and policy aspects. We provide a forum to bring together academic and clinical researchers, biotechnology, diagnostic and pharmaceutical companies, health professionals, regulatory and ethical experts, and government and regulatory authorities.
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