Journal of Pediatric Gastroenterology and Nutrition最新文献_第8页

The Nancy Histopathological Index has limited value in predicting clinical outcomes in newly diagnosed pediatric patients with ulcerative colitis. 南希组织病理学指数在预测新诊断的儿科溃疡性结肠炎患者的临床结果方面价值有限。

IF 2.4 3区医学

Journal of Pediatric Gastroenterology and Nutrition Pub Date : 2025-01-01 Epub Date: 2024-11-14 DOI: 10.1002/jpn3.12416

Yaniv Faingelernt, Irit Birger, Sara Morgenstern, Eyal Cohen-Sela, Manar Matar, Yael Weintraub, Raanan Shamir, Dror S Shouval

{"title":"The Nancy Histopathological Index has limited value in predicting clinical outcomes in newly diagnosed pediatric patients with ulcerative colitis.","authors":"Yaniv Faingelernt, Irit Birger, Sara Morgenstern, Eyal Cohen-Sela, Manar Matar, Yael Weintraub, Raanan Shamir, Dror S Shouval","doi":"10.1002/jpn3.12416","DOIUrl":"10.1002/jpn3.12416","url":null,"abstract":"The Nancy Histological Index (NHI) is used to score histologic disease activity in patients with ulcerative colitis (UC). Our goal was to assess the utility of NHI at diagnosis in predicting clinical outcomes in pediatric patients with UC, in comparison to clinical and endoscopic scores. We retrospectively reviewed data at diagnosis of 106 children with UC (59 [55.7%] females; median age 14.4 [11.2-15.9] years, median Pediatric Ulcerative Colitis Activity Index [PUCAI] 35 [25-55]). During a follow-up of 116 (55-171) weeks, 33 patients (31.1%) required azathioprine therapy, and 32 (30.2%) were escalated to anti-tumor necrosis factor alpha (anti-TNFa). The PUCAI and Mayo endoscopic scores at diagnosis were significantly associated with escalation to anti-TNFa (p = 0.036 and p = 0.02, respectively), but not with initiation of azathioprine or subsequent acute severe colitis (ASC) events. However, the NHI was not associated with subsequent immunomodulators or anti-TNFa therapy (p = 0.42 and p = 0.78, respectively), nor with future ASC events (p = 0.70). In conclusion, the NHI failed to predict clinical outcomes in newly diagnosed pediatric patients with UC.","PeriodicalId":16694,"journal":{"name":"Journal of Pediatric Gastroenterology and Nutrition","volume":" ","pages":"141-146"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Handgrip strength and health outcomes in hospitalized children or children with chronic disease: A systematic review. 住院儿童或慢性病患儿的握力与健康状况：系统综述。

IF 2.4 3区医学

Journal of Pediatric Gastroenterology and Nutrition Pub Date : 2025-01-01 Epub Date: 2024-11-22 DOI: 10.1002/jpn3.12406

Liesbet Verbrugghe, Alice Larue, Hanne Delcourt, Yvan Vandenplas, Koen Huysentruyt

{"title":"Handgrip strength and health outcomes in hospitalized children or children with chronic disease: A systematic review.","authors":"Liesbet Verbrugghe, Alice Larue, Hanne Delcourt, Yvan Vandenplas, Koen Huysentruyt","doi":"10.1002/jpn3.12406","DOIUrl":"10.1002/jpn3.12406","url":null,"abstract":"Handgrip strength (HGS) is a simple measurement of maximum voluntary muscle strength and is widely used as a single indicator of overall muscle strength. This systematic review summarized the evidence about the relation between HGS and health outcomes in hospitalized children or chronically ill children. The primary outcome was the number of hospital days in a 2-month period for outpatients and the length of hospital stay for inpatients. After a systematic search in PubMed, Embase, Lilacs, and the Cochrane Library, 9282 unique papers were screened, 24 included. Studies assessed HGS in children with cystic fibrosis, neuromuscular disease, chronic kidney disease, type 1 diabetes mellitus, asthma, cardiac disease, juvenile idiopathic arthritis, intestinal failure, surgical patients, and a mixed hospitalized population. One study reported that children experienced a decline in HGS during hospitalization which was associated with prolonged hospital stay. Another reported no relation with the number of hospital days in 5 years. No studies reported on the association between HGS and infectious complications or antibiotic use. We did find a positive correlation between HGS and quality of life, different nutritional parameters and inflammatory biochemical markers. We concluded that the relation between HGS and hospital stay in children is poorly studied. HGS showed promise as a functional biomarker for children with chronic health conditions when inflammation is involved, but more attention should be paid to the methodological aspects of assessing HGS.","PeriodicalId":16694,"journal":{"name":"Journal of Pediatric Gastroenterology and Nutrition","volume":" ","pages":"218-237"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142687281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endomysial antibodies or anti-tissue transglutaminase type 2 IgA antibodies as a confirmatory test in children with celiac disease. 内含物抗体或抗组织转谷氨酰胺酶 2 型 IgA 抗体作为乳糜泻患儿的确诊试验。

IF 2.4 3区医学

Journal of Pediatric Gastroenterology and Nutrition Pub Date : 2025-01-01 Epub Date: 2024-10-13 DOI: 10.1002/jpn3.12383

Amir Ben-Tov, Tomer Achler, Rochelle Fayngor, Raanan Shamir, Lia Supino, Yael Weintraub, Anat Yerushalmy-Feler, Shlomi Cohen

引用次数: 0

Pain management in pediatric acute pancreatitis: An area of need. 小儿急性胰腺炎的疼痛治疗：需求领域。

IF 2.4 3区医学

Journal of Pediatric Gastroenterology and Nutrition Pub Date : 2025-01-01 Epub Date: 2024-11-22 DOI: 10.1002/jpn3.12417

Amit S Grover, Michael Wilschanski

引用次数: 0

Response to letter to the editor: Formula modifications to the Crohn's disease exclusion diet do not affect therapy success in pediatric Crohn's disease. 回复致编辑的信：克罗恩病排除饮食的配方调整不会影响小儿克罗恩病的治疗成功率。

IF 2.4 3区医学

Journal of Pediatric Gastroenterology and Nutrition Pub Date : 2025-01-01 Epub Date: 2024-11-22 DOI: 10.1002/jpn3.12413

Emma Landorf, Paul Hammond, Rammy Abu-Assi, Samuel Ellison, Terry Boyle, Annabel Comerford, Richard Couper

引用次数: 0

The association of human milk intake and outcomes in biliary atresia. 人奶摄入量与胆道闭锁后遗症的关系。

IF 2.4 3区医学

Journal of Pediatric Gastroenterology and Nutrition Pub Date : 2025-01-01 Epub Date: 2024-11-11 DOI: 10.1002/jpn3.12403

Mary Elizabeth M Tessier, Jeremy M Schraw, Stacey Beer, Sanjiv Harpavat, M Kyle Jensen, John C Magee, Vicky Ng, Michael E Scheurer, Sarah A Taylor, Benjamin L Shneider

{"title":"The association of human milk intake and outcomes in biliary atresia.","authors":"Mary Elizabeth M Tessier, Jeremy M Schraw, Stacey Beer, Sanjiv Harpavat, M Kyle Jensen, John C Magee, Vicky Ng, Michael E Scheurer, Sarah A Taylor, Benjamin L Shneider","doi":"10.1002/jpn3.12403","DOIUrl":"10.1002/jpn3.12403","url":null,"abstract":"Objectives: Human milk intake has many benefits which could influence outcomes in biliary atresia (BA). However, the role of human milk in BA has not been examined. We hypothesized that human milk intake would be associated with improved outcomes in BA.Methods: We assessed the impact of any human milk (AHM) as compared to formula only (FO) intake before Kasai portoenterostomy (KP) on outcomes in 447 infants with BA using the PROBE database (NCT00061828) post hoc. The primary outcome was clearance of jaundice (COJ = total bilirubin (TB) < 2 mg/dL by 3 months post-KP). Secondary outcomes included 2-year survival with native liver (SNL), bilirubin levels, cholangitis, ascites, and growth. We assessed the fecal microbiome (n = 8) comparing AHM versus FO.Results: At baseline, 211 infants received AHM and 215 received FO. 53.9% of AHM and 50.5% of FO achieved COJ (p = NS). SNL was insignificantly increased in AHM (odds ratio = 1.47, 95% confidence interval: 1.00-2.12, p = 0.053). TB decreased in AHM from 4 weeks to 3 months post-KP [4.8-4.0 mg/dL (p = 0.01)] unlike the FO group (4.9-4.9 mg/dL, p = 0.4). At 3 months post-KP, AHM infants had greater weight gain (1.88 ± 0.66 vs. 1.57 ± 0.73 kg, p < 0.001) and mid-upper arm circumference (12.9 ± 1.4 vs. 12.2 ± 1.7 cm, p < 0.001). Other secondary outcomes were not different. Microbiome differences were seen between AHM and FO.Conclusions: Human milk intake in infants with BA did not significantly improve COJ or SNL. However, growth parameters were improved, and TB 3 months post-KP was decreased. Thus, human milk intake should not be discouraged. Prospective studies with detailed assessment of human milk intake are needed.","PeriodicalId":16694,"journal":{"name":"Journal of Pediatric Gastroenterology and Nutrition","volume":" ","pages":"163-173"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacological management of pediatric metabolic dysfunction-associated steatotic liver disease. 儿科代谢功能障碍相关脂肪肝的药物治疗。

IF 2.4 3区医学

Journal of Pediatric Gastroenterology and Nutrition Pub Date : 2025-01-01 Epub Date: 2024-11-11 DOI: 10.1002/jpn3.12402

Rasha Abi Radi Abou Jaoudeh, Phillipp Hartmann, Ole Olson, Olga Gupta, Seema Kumar, Samar H Ibrahim, Rima Fawaz, Amal Aqul, Sara Hassan

{"title":"Pharmacological management of pediatric metabolic dysfunction-associated steatotic liver disease.","authors":"Rasha Abi Radi Abou Jaoudeh, Phillipp Hartmann, Ole Olson, Olga Gupta, Seema Kumar, Samar H Ibrahim, Rima Fawaz, Amal Aqul, Sara Hassan","doi":"10.1002/jpn3.12402","DOIUrl":"10.1002/jpn3.12402","url":null,"abstract":"Pediatric obesity, characterized by a body mass index (BMI) at or above the 95th percentile for age, affects a substantial number of children and adolescents worldwide. Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease, represents a prominent hepatic manifestation of obesity and metabolic syndrome, emerging as the most prevalent hepatic disorder among pediatric patients and a significant contributor to liver transplantation in adults. The escalating prevalence of pediatric MASLD mirrors the alarming rise in childhood obesity rates over recent decades. While lifestyle modifications focusing on dietary changes and increased physical activity constitute the cornerstone of MASLD management, achieving and maintaining significant weight reduction remains challenging. Moreover, disease progression often persists despite standard-of-care interventions, warranting exploration into alternative therapeutic strategies. Pharmacological interventions, particularly, glucagon-like peptide-1 receptor agonists (GLP-1RA), have shown promise in addressing pediatric obesity and its associated comorbidities, including MASLD. Recent studies have demonstrated the efficacy of GLP-1RA in inducing weight loss and improving liver enzyme levels, suggesting a potential role in halting disease progression, and reducing the risk of major adverse liver outcomes. This review provides a comprehensive overview of the current pharmacotherapy landscape for pediatric MASLD, with a focus on novel agents such as GLP-1RA. Furthermore, the manuscript proposes a practical algorithm to assist in integrating GLP-1RA into the clinical management of pediatric patients with obesity and MASLD. Despite promising results, further research is warranted to elucidate the long-term efficacy and safety of GLP-1RA in pediatric populations.","PeriodicalId":16694,"journal":{"name":"Journal of Pediatric Gastroenterology and Nutrition","volume":" ","pages":"14-24"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Direct cholangioscopy supporting diagnosis and conservative surgery of a biliary rhabdomyosarcoma in a child. 直接胆道镜辅助诊断儿童胆道横纹肌肉瘤并进行保守手术。

IF 2.4 3区医学

Journal of Pediatric Gastroenterology and Nutrition Pub Date : 2025-01-01 Epub Date: 2024-11-01 DOI: 10.1002/jpn3.12404

Valerio Balassone, Simona Faraci, Mario Brusco, Claudia Mandato, Giuseppe Maria Milano, Marco Spada, Paola De Angelis

引用次数: 0

Dihydroxyacetone phosphate is a novel predictor of hepatic fibrosis in Latino adolescents with obesity. 磷酸二羟丙酮是预测拉丁裔肥胖青少年肝纤维化的新指标。

IF 2.4 3区医学

Journal of Pediatric Gastroenterology and Nutrition Pub Date : 2025-01-01 Epub Date: 2024-11-25 DOI: 10.1002/jpn3.12420

Rachel B Schenker, Cuauhtemoc B Ramirez, Cholsoon Jang, Hooman Allayee, Xueheng Zhao, Kenneth D R Setchell, Rohit Kohli, Michael I Goran

{"title":"Dihydroxyacetone phosphate is a novel predictor of hepatic fibrosis in Latino adolescents with obesity.","authors":"Rachel B Schenker, Cuauhtemoc B Ramirez, Cholsoon Jang, Hooman Allayee, Xueheng Zhao, Kenneth D R Setchell, Rohit Kohli, Michael I Goran","doi":"10.1002/jpn3.12420","DOIUrl":"10.1002/jpn3.12420","url":null,"abstract":"Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common pediatric liver disease and can progress to liver fibrosis. Latino adolescents have increased MASLD and fibrosis risk. While fibrosis is diagnosed by biopsy or imaging, more accessible, noninvasive, and economical screening methods are needed. We aimed to use plasma metabolomics/lipidomics to identify potential fibrosis biomarkers in Latino adolescents with obesity.Methods: Liver stiffness (LS) was measured in 93 Latino adolescents with obesity using magnetic resonance elastography. Metabolites and lipids were extracted from plasma and identified on Compound Discoverer. Associations between metabolites/lipids and fibrosis (LS > 2.73 kPa) were determined using linear regression models after covariate adjustment. False discovery rate (FDR) adjusted Pearson's correlations were performed. Analytes yielding significant FDR-adjusted correlations were examined further by receiver operator curve analysis.Results: Mean (±standard deviation) alanine transaminase (ALT) was 45.7(±65.2) IU/L, hepatic fat fraction was 12.7(±9.1)%, and LS was 2.4(±0.3) kPa. We identified 795 metabolites and 413 lipids in plasma, but only one single metabolite, dihydroxyacetone phosphate (DHAP), a marker of triglyceride synthesis, was significantly associated with fibrosis after FDR adjustment (p < 0.05). In terms of predicting fibrosis, ALT had an area under the curve (AUC) of 0.79, and DHAP had an AUC of 0.79. When combined, ALT + DHAP had an AUC of 0.89.Conclusions: The combination of ALT + DHAP may have the potential as an accurate, noninvasive test for liver fibrosis. Our data are limited to Latino children with obesity, and a larger cohort should be examined to further validate this novel biomarker.","PeriodicalId":16694,"journal":{"name":"Journal of Pediatric Gastroenterology and Nutrition","volume":" ","pages":"174-181"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors associated with Helicobacter pylori antimicrobial resistance in a US pediatric cohort. 美国儿科队列中幽门螺旋杆菌抗菌药耐药性的相关因素。

IF 2.4 3区医学

Journal of Pediatric Gastroenterology and Nutrition Pub Date : 2025-01-01 Epub Date: 2024-11-25 DOI: 10.1002/jpn3.12421

Muhammad Riaz, Christina Chan, Christine Andrews, Michael Herzlinger, Enju Liu, Silvana Bonilla

{"title":"Factors associated with Helicobacter pylori antimicrobial resistance in a US pediatric cohort.","authors":"Muhammad Riaz, Christina Chan, Christine Andrews, Michael Herzlinger, Enju Liu, Silvana Bonilla","doi":"10.1002/jpn3.12421","DOIUrl":"10.1002/jpn3.12421","url":null,"abstract":"Objectives: The rising rates of Helicobacter pylori antimicrobial resistance highlight the importance of better understanding its epidemiology in the pediatric population. We aim to study the epidemiological factors associated with antimicrobial resistance in a cohort of US children with H. pylori infection.Methods: A retrospective cohort study of patients in the New England region of the United States between January 15, 2015 and October 15, 2022, with a first-time diagnosis of H. pylori on gastric biopsy and who had antimicrobial resistance data available. Descriptive statistics and logistic regression models were used to determine associations between the patient's demographics, clinical factors, endoscopic findings, and antimicrobial resistance.Results: Out of 273 patients (46% male, median 12.8 years), 118 (43.2%) were resistant to at least one antimicrobial. Clarithromycin resistance (24.5%) was the highest, followed by metronidazole (21.6%), fluoroquinolones (9.9%), rifabutin (3.3%), and amoxicillin (2.6%). Clarithromycin resistance was higher in Asians compared to White individuals (odds ratio [OR]: 4.68, 95% confidence interval [CI]: [2.01-10.89], p < 0.001), and lower in Black compared to White individuals (OR: 0.23, 95% CI: [0.08-0.69], p = 0.01). Antimicrobial resistance to clarithromycin and metronidazole were similar among Hispanics. Asian individuals were more likely to demonstrate one or more antimicrobial resistances compared to White (OR: 3.66, 95% CI: [1.50-8.89], p < 0.001). Compared to individuals from higher household incomes (>$100,000), those from less than $30,000 household incomes had a higher risk of metronidazole resistance (OR: 7.94, 95% CI: [1.83-34.36], p = 0.01).Conclusion: Our study provides novel information concerning the association of H. pylori antimicrobial resistance to race, socioeconomic status, and age in the pediatric population.","PeriodicalId":16694,"journal":{"name":"Journal of Pediatric Gastroenterology and Nutrition","volume":" ","pages":"87-99"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0