Journal of Pediatric Gastroenterology and Nutrition最新文献_第10页

How do we define normal bowel frequency from newborn to teens?: A Bayesian meta-analysis. 我们如何定义从新生儿到青少年的正常排便频率？：贝叶斯元分析。

IF 2.4 3区医学

Journal of Pediatric Gastroenterology and Nutrition Pub Date : 2024-12-29 DOI: 10.1002/jpn3.12432

Sachith Munasinghe, Supun Manathunga, Wathsala Hathagoda, Chandrani Kuruppu, Priyanga Ranasinghe, Niranga M Devanarayana, Desiree F Baaleman, Marc A Benninga, Shaman Rajindrajith

{"title":"How do we define normal bowel frequency from newborn to teens?: A Bayesian meta-analysis.","authors":"Sachith Munasinghe, Supun Manathunga, Wathsala Hathagoda, Chandrani Kuruppu, Priyanga Ranasinghe, Niranga M Devanarayana, Desiree F Baaleman, Marc A Benninga, Shaman Rajindrajith","doi":"10.1002/jpn3.12432","DOIUrl":"https://doi.org/10.1002/jpn3.12432","url":null,"abstract":"Objectives: Defecation disorders are a common pediatric problem and bowel frequency is crucial in identifying them. The aim of this analysis is to define normal bowel frequencies in healthy children ranging from newborns to adolescents.Methods: A literature search was conducted using MEDLINE, SCOPUS, EMBASE, Cochrane Library, and Web of Science from their inception to February 2024, aiming to identify studies reporting bowel habits of healthy children (0-18 years). A Bayesian distribution modeling approach was adopted to pool the mean frequency of bowel opening using inverse-variance weighing. A subgroup analysis and a meta-regression were performed with Bayesian generalized additive mixed distributional models. The methodological quality of the articles was evaluated using the Newcastle-Ottawa Scale modified for cross-sectional studies.Results: Seventeen studies were included in the analysis, including 22,698 children aged from 0 to 18 years. The subgroup meta-analysis showed mean bowel frequencies for newborns, 1-6 months, 6-12 months, 1-2 years, 2-5 years, and over 5 years are 3.24 (95% credible interval [CrI]: 2.83-3.63), 1.99 (95% CrI: 1.77-2.19), 1.66 (95% CrI: 1.45-1.88), 1.53 (95% CrI: 1.37-1.7), 1.15 (95% CrI: 0.99-1.31), and 1.02 (95% CrI 0.88-1.18), respectively. Between studies, heterogeneity demonstrated a near-normal distribution with a mean of 0.16 and a 95% CrI of 0.04-0.28. The variance of the distribution of mean bowel frequency reduced with age.Discussion: In this Bayesian meta-analysis, we found that younger children have a higher bowel frequency. The reported bowel frequencies for each age group could serve as normal values in clinical practice to differentiate health and disease.","PeriodicalId":16694,"journal":{"name":"Journal of Pediatric Gastroenterology and Nutrition","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FISPGHAN statement on the global public health impact of metabolic dysfunction-associated steatotic liver disease. FISPGHAN关于代谢功能障碍相关脂肪变性肝病全球公共卫生影响的声明。

IF 2.4 3区医学

Journal of Pediatric Gastroenterology and Nutrition Pub Date : 2024-12-27 DOI: 10.1002/jpn3.12399

Tania Mitsinikos, Marion M Aw, Robert Bandsma, Marcela Godoy, Samar H Ibrahim, Jake P Mann, Iqbal Memon, Neelam Mohan, Nezha Mouane, Gilda Porta, Elvira Verduci, Stavra Xanthakos

{"title":"FISPGHAN statement on the global public health impact of metabolic dysfunction-associated steatotic liver disease.","authors":"Tania Mitsinikos, Marion M Aw, Robert Bandsma, Marcela Godoy, Samar H Ibrahim, Jake P Mann, Iqbal Memon, Neelam Mohan, Nezha Mouane, Gilda Porta, Elvira Verduci, Stavra Xanthakos","doi":"10.1002/jpn3.12399","DOIUrl":"https://doi.org/10.1002/jpn3.12399","url":null,"abstract":"As rates of obesity rise worldwide, incidence of metabolic dysfunction-associated steatotic liver disease (MASLD), formerly referred to as nonalcoholic fatty liver disease, is increasing, worsening the burden of healthcare systems. The council of the Federation of International Societies for Pediatric Gastroenterology, Hepatology, and Nutrition (FISPGHAN) identified the topic of MASLD epidemiology, treatment, and prevention as a global priority issue to be addressed by an expert team, with the goal to describe feasible and evidence-based actions that may contribute to reducing MASLD risk. The FISPGHAN member societies nominated experts in the field. The FISPGHAN council selected and appointed members of the expert team and a chair. The subtopics included in this manuscript were chosen through a consensus of the experts involved. We review the epidemiology, natural history, and screening and management. We further expand to relevant public health measures aimed at MASLD prevention, including identifying interventions that could reduce risk factors (environmental and iatrogenic), optimize maternal and newborn health, and support healthier lifestyles for older children and adolescents on a local, national, and international scale. While recognizing that various aspects of population health and public policy can shape MASLD risk, we also review what we can do on an individual level to support our patients to reduce the significant burden of this ever rising disease in pediatrics.","PeriodicalId":16694,"journal":{"name":"Journal of Pediatric Gastroenterology and Nutrition","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical effects of pediatric commercial food-based formulas: A systematic review. 小儿商业食品配方奶粉的临床效果：系统综述。

IF 2.4 3区医学

Journal of Pediatric Gastroenterology and Nutrition Pub Date : 2024-12-27 DOI: 10.1002/jpn3.12450

Judy-April Murayi, Elizabeth Evenson, Chelsea Britton, Alison Gehred, Praveen S Goday

引用次数: 0

A step closer to bridging the knowledge gap in pediatric cyclic vomiting syndrome. 缩小小儿周期性呕吐综合征的知识差距又近了一步。

IF 2.4 3区医学

Journal of Pediatric Gastroenterology and Nutrition Pub Date : 2024-12-24 DOI: 10.1002/jpn3.12447

Jermie J Gandhi, Julie Khlevner

引用次数: 0

Intestinal ultrasound at diagnosis of pediatric inflammatory bowel disease compared to endoscopy. 肠道超声诊断小儿炎性肠病与内窥镜的比较。

IF 2.4 3区医学

Journal of Pediatric Gastroenterology and Nutrition Pub Date : 2024-12-24 DOI: 10.1002/jpn3.12444

Hamza Hassan Khan, Martha M Munden, Leslie H Spence, Richard H Jones, Jordan Whatley, Carmine Suppa

{"title":"Intestinal ultrasound at diagnosis of pediatric inflammatory bowel disease compared to endoscopy.","authors":"Hamza Hassan Khan, Martha M Munden, Leslie H Spence, Richard H Jones, Jordan Whatley, Carmine Suppa","doi":"10.1002/jpn3.12444","DOIUrl":"https://doi.org/10.1002/jpn3.12444","url":null,"abstract":"Objectives: Intestinal ultrasound (IU) has emerged as an alternative to detect bowel wall inflammation. The aim of this study was to compare IU findings to clinical disease, fecal calprotectin (FC), and endoscopic findings in newly diagnosed pediatric inflammatory bowel disease (IBD) patients.Methods: This study was a 1-year, single-center, prospective study. Any pediatric patient undergoing colonoscopy could be recruited. Following ileo-colonoscopy, subjects were divided into two groups: patients diagnosed with IBD and patients without IBD. Participants had an IU within 1 month. Endoscopists and radiologists were blinded to each other. The IU findings were compared with clinical disease activity, FC, and endoscopic findings.Results: A total of 50 subjects were enrolled in the study; 29 (58%) were females, median age was 13.5 years, and 25 (50%) were diagnosed with IBD. IU sensitivity was 76%, specificity 84%, positive predictive value (PPV) 83%, and negative predictive value (NPV) 78%. For detection of moderate to severe disease, sensitivity, specificity, PPV, and NPV were 91.3%, 86.21%, 84%, and 92.6%, respectively. A significant correlation was noted between IU and FC, Mayo score, and Simple Endoscopic Score (0.513, 0.565, and 0.731, respectively). Pediatric Ulcerative Colitis Activity Index and Pediatric Crohn's Disease Activity Index scores had Pearson correlations of 0.070 and -0.159, respectively.Conclusions: IU can be considered a screening tool for pediatric IBD. It has reasonable sensitivity, specificity, PPV, and NPV, particularly for moderate-to-severe disease. The severity noted on IU correlated with FC and endoscopic disease activity but did not correlate with clinical disease activity.","PeriodicalId":16694,"journal":{"name":"Journal of Pediatric Gastroenterology and Nutrition","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term outcome of pediatric acute severe colitis: A prospective 5-year follow-up of the PRASCO trial. 儿童急性严重结肠炎的长期预后：PRASCO试验的前瞻性5年随访。

IF 2.4 3区医学

Journal of Pediatric Gastroenterology and Nutrition Pub Date : 2024-12-24 DOI: 10.1002/jpn3.12442

Dan Lachman, Esther Orlanski-Meyer, Raffi Lev-Tzion, Oren Ledder, Amit Assa, Zivia Shavit-Brunschwig, Baruch Yerushalmi, Marina Aloi, Anne M Griffiths, Lindsey Albenberg, Itzhak Bar-Or, Kaija-Leena Kolho, Dror S Shouval, Shlomi Cohen, Dan Turner, Ohad Atia

{"title":"Long-term outcome of pediatric acute severe colitis: A prospective 5-year follow-up of the PRASCO trial.","authors":"Dan Lachman, Esther Orlanski-Meyer, Raffi Lev-Tzion, Oren Ledder, Amit Assa, Zivia Shavit-Brunschwig, Baruch Yerushalmi, Marina Aloi, Anne M Griffiths, Lindsey Albenberg, Itzhak Bar-Or, Kaija-Leena Kolho, Dror S Shouval, Shlomi Cohen, Dan Turner, Ohad Atia","doi":"10.1002/jpn3.12442","DOIUrl":"https://doi.org/10.1002/jpn3.12442","url":null,"abstract":"Objectives: The PRASCO trial reported the short-term superiority of an antibiotic cocktail plus intravenous corticosteroids (IVCS) over IVCS alone in children with acute severe colitis (ASC). Here, we report the extension of the PRASCO trial and the long-term outcomes of the antibiotic cocktail in ASC.Methods: This prospective follow-up of the PRASCO trial documented disease outcomes and treatments annually through 5 years. The primary outcome was colectomy, and the secondary outcome was escalation to biologics, analyzed descriptively.Results: A total of 26 children were included (12 receiving IVCS and 14 receiving IVCS + antibiotics), 19% of whom underwent colectomy during the follow-up period. The estimated probability of colectomy at 3, 6, and 12 months from admission were 7.1%, 7.1%, and 21% with IVCS + antibiotics and 0%, 8.3%, and 17% with IVCS. No children required colectomy after the first year of follow-up. The estimated probability of escalating to biologics were 66%, 77%, and 77% after 1, 2, and 3 years with IVCS + antibiotics and 42%, 51%, and 76% with IVCS. Clinical remission was higher in the IVCS + antibiotics group at each timepoint (e.g., 30% vs. 11% at 5-years). Delta of Pediatric Ulcerative Colitis Activity Index (PUCAI) score from baseline to day three of admission predicted future escalation to biologics (area under curves (AUC) 0.84 [95%CI 0.59-1.0]).Conclusion: While adding antibiotics to IVCS may provide better short-term outcomes, the long-term benefits were comparable to IVCS alone. At 5 years, about one-fifth of children had undergone colectomy, and almost four-fifths had escalated to biologics, particularly during the first year after admission.","PeriodicalId":16694,"journal":{"name":"Journal of Pediatric Gastroenterology and Nutrition","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and sequelae of asymptomatic Clostridioides difficile colonization in children with inflammatory bowel disease. 炎症性肠病儿童无症状艰难梭菌定植的患病率和后遗症。

IF 2.4 3区医学

Journal of Pediatric Gastroenterology and Nutrition Pub Date : 2024-12-20 DOI: 10.1002/jpn3.12439

Seth A Reasoner, Lisa S Zhang, Rachel Bernard, Kathryn M Edwards, Maribeth R Nicholson

引用次数: 0

Determining the time to cholangiocarcinoma in pediatric-onset PSC-IBD. 确定小儿腹腔镜胆管癌的发病时间。

IF 2.4 3区医学

Journal of Pediatric Gastroenterology and Nutrition Pub Date : 2024-12-20 DOI: 10.1002/jpn3.12443

Batul Kaj-Carbaidwala, Johan Fevery, Douglas G Adler, Annika Bergquist, Lissy de Ridder, Mark Deneau, Corinne Gower-Rousseau, Roger W Chapman, Kate D Lynch, Catherine A M Stedman, David C Wilson, Uzma Shah, Lipika Goyal, Harland S Winter, Jochen K Lennerz

{"title":"Determining the time to cholangiocarcinoma in pediatric-onset PSC-IBD.","authors":"Batul Kaj-Carbaidwala, Johan Fevery, Douglas G Adler, Annika Bergquist, Lissy de Ridder, Mark Deneau, Corinne Gower-Rousseau, Roger W Chapman, Kate D Lynch, Catherine A M Stedman, David C Wilson, Uzma Shah, Lipika Goyal, Harland S Winter, Jochen K Lennerz","doi":"10.1002/jpn3.12443","DOIUrl":"https://doi.org/10.1002/jpn3.12443","url":null,"abstract":"Primary sclerosing cholangitis (PSC) is a risk factor for cholangiocarcinoma. When a child is diagnosed with both PSC and inflammatory bowel disease (IBD), evidence-based information on counseling families and risk management of developing cholangiocarcinoma is limited. In this case series (PubMed/collaborators), we included patients with PSC-IBD who developed cholangiocarcinoma and contacted authors to determine an event curve specifying the time between the second diagnosis (IBD or PSC) and a diagnosis of cholangiocarcinoma. Review of n = 175 studies resulted in a cohort of n = 21 patients with pediatric-onset PSC-IBD-cholangiocarcinoma. The median time to development of cholangiocarcinoma was 6.95 years from the second diagnosis. Despite the small number, 38% of cholangiocarcinoma developed within the first 2 years, and 47% of patients developed cholangiocarcinoma in the transition period to adult care (age 14-25). Our findings highlight the importance of screening that extends over the so-called transition period from pediatric to adult care.","PeriodicalId":16694,"journal":{"name":"Journal of Pediatric Gastroenterology and Nutrition","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The expanded Child Tax Credit was associated with improved BMI and metabolic outcomes in low-income children. 扩大儿童税收抵免与改善低收入儿童的BMI和代谢结果有关。

IF 2.4 3区医学

Journal of Pediatric Gastroenterology and Nutrition Pub Date : 2024-12-20 DOI: 10.1002/jpn3.12445

Paul Po-Ting Lu, Amy R Mahar, Hal Sitt, Janet Rosenbaum, Renee Bargman, Thomas Wallach

引用次数: 0

Sleep duration among breastfed, goat milk-based or cow's milk-based infant formula-fed infants: Post hoc analyses from a double-blind RCT. 母乳喂养、羊奶喂养或牛奶喂养婴儿的睡眠时间：双盲随机对照试验的事后分析。

IF 2.4 3区医学

Journal of Pediatric Gastroenterology and Nutrition Pub Date : 2024-12-19 DOI: 10.1002/jpn3.12436

Linde van Lee, Yvonne Meijer-Krommenhoek, Tao He, Lucie van der Zee, Henkjan Verkade

{"title":"Sleep duration among breastfed, goat milk-based or cow's milk-based infant formula-fed infants: Post hoc analyses from a double-blind RCT.","authors":"Linde van Lee, Yvonne Meijer-Krommenhoek, Tao He, Lucie van der Zee, Henkjan Verkade","doi":"10.1002/jpn3.12436","DOIUrl":"https://doi.org/10.1002/jpn3.12436","url":null,"abstract":"Objectives: To determine total, night- and daytime sleep duration and waking frequency among infants exclusively fed goat milk-based infant formula (GMF) or cow's milk-based infant formula (CMF) enroled in a randomised controlled trial and compare these to a human milk (HM) fed reference group.Methods: Post hoc analysis from a double-blind randomised controlled trial in 304 healthy term infants was performed. Formula-fed infants were randomly assigned to receive exclusively GMF or CMF for a period of 112 days and compared to a reference group fed HM. Sleep was assessed using a 3-day 24-h diary before the five visits throughout the trial. The association between feeding type and sleep was studied longitudinally and cross-sectionally at the five visits. All models were adjusted for infant sex and study site of enrolment. For associations between formula-fed infants and the non-randomised HM group, additional adjustments were made.Results: Total sleep duration slowly and similarly decreased over the course of study duration for all groups, with a decrease of about an hour between the first and last measurement. Longitudinally, daytime sleep duration was significantly longer for GMF (mean 8.6 h, standard error [SE] 0.17) and HM (8.8, 0.18) fed infants as compared to CMF (8.1, 0.17; p < 0.05). Cross-sectional analyses show that infants fed GMF or HM had higher total sleep duration than infants fed CMF at all visits, with significant differences between the groups at Visits 3 and 4.Conclusions: In infants fed GMF a significantly longer daytime sleep duration and a non-significant trend towards a longer total sleep duration were found when compared to infants fed CMF. These findings suggest that nutrition plays a role in sleep duration.","PeriodicalId":16694,"journal":{"name":"Journal of Pediatric Gastroenterology and Nutrition","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0