Journal of Pediatric Gastroenterology and Nutrition最新文献

{"title":"Eosinophilic esophagitis associated with infliximab therapy in pediatric patients with inflammatory bowel disease.","authors":"Meng-Che Wu, Jonathan N Glickman, Harland S Winter","doi":"10.1002/jpn3.70007","DOIUrl":"https://doi.org/10.1002/jpn3.70007","url":null,"abstract":"","PeriodicalId":16694,"journal":{"name":"Journal of Pediatric Gastroenterology and Nutrition","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How does bovine milk-based fortification alter the oxidant-antioxidant profile of breast milk in preterm infants?","authors":"Ozge Aydemir, Yusuf Aydemir, Ozge Surmeli Onay","doi":"10.1002/jpn3.70008","DOIUrl":"https://doi.org/10.1002/jpn3.70008","url":null,"abstract":"<p><strong>Objectives: </strong>Fortification of breast milk (BM) is recommended to enhance protein, vitamin, and mineral content, supporting improved growth in preterm infants. However, the impact of fortification on the oxidant-antioxidant balance in BM has not been previously studied. This study aims to evaluate the effects of fortification with a bovine milk-based fortifier on the total antioxidant capacity (TAC) and total oxidant status (TOS) in preterm BM.</p><p><strong>Methods: </strong>In this prospective cohort study, transitional milk (TM) (6-10 days postpartum) and mature milk (MM) (>15 days postpartum) samples were collected from mothers of preterm infants receiving fortified BM. TAC and TOS were measured in BM samples before and after fortification. The oxidative stress index (OSI), defined as the TOS-to-TAC ratio, was used to assess oxidative stress levels.</p><p><strong>Results: </strong>Seventy-five BM samples from 59 preterm infants, with a mean gestational age of 31.4 ± 2.8 weeks, were analyzed. TAC levels were consistent between TM and MM of the preterm infants. TOS levels and OSI were lower in TM compared to MM (p = 0.019 and p = 0.033, respectively). Fortification led to increased TAC and TOS in both TM (p < 0.001 each) and MM (p < 0.001 each). The OSI was higher in fortified TM (p = 0.032) compared to unfortified TM, while OSI remained unchanged in fortified MM (p = 0.39).</p><p><strong>Conclusions: </strong>Preterm TM exhibits a more favorable oxidant-antioxidant profile compared to MM. Fortification elevates both TAC and TOS in preterm BM. In MM, the oxidant-antioxidant balance is maintained post-fortification; however, in TM, the increase in TOS exceeds that of TAC, resulting in a higher OSI.</p>","PeriodicalId":16694,"journal":{"name":"Journal of Pediatric Gastroenterology and Nutrition","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric endoscopic ultrasound-guided liver biopsy: 3-year experience.","authors":"Talia S Schwartz, Marialena Mouzaki, Lara Berklite, Oscar F Lopez-Nunez, Alexander Miethke, Stavra A Xanthakos, David S Vitale","doi":"10.1002/jpn3.70001","DOIUrl":"https://doi.org/10.1002/jpn3.70001","url":null,"abstract":"<p><strong>Objectives: </strong>Liver biopsy is the gold standard for diagnosing and staging liver diseases. Endoscopic ultrasound-guided liver biopsy (EUS-LB) has been reported in adults with equivalent or better safety profiles than percutaneous liver biopsies. The aim of this study was to retrospectively assess the safety and efficacy of EUS-LB in pediatric patients.</p><p><strong>Methods: </strong>This was a retrospective chart review of consecutive pediatric patients undergoing EUS-LB at Cincinnati Children's Hospital Medical Center from March 2020 to April 2023. Patients ≤21 years old were included. EUS-LB was performed via fine-needle biopsy technique with transduodenal and/or transgastric approach. Histology was independently reviewed by one of two expert pathologists, including length (cm) and complete portal tract (CPT) number per the American Association for the Study of Liver Diseases (AASLD) adequacy criteria. Demographics, clinical data, technical information, diagnostic success, and adverse events were recorded.</p><p><strong>Results: </strong>Eighty-three patients were included in the analysis, with various indications that required liver biopsy. All biopsies achieved diagnostic and technical success, with 77 (93%) meeting both AASLD criteria for adequacy. Most patients (57, 69%) underwent biopsy of both hepatic lobes, with an overall median of two needle passes. Total specimen length was a median of 7.9 cm (interquartile range [IQR] 5.2-10.3), and the median maximum intact specimen was 4.2 cm (IQR 3.1-5.4). The median CPT number was 24 (IQR 17-32) per patient. Four mild adverse events (5%) occurred; none involved bleeding.</p><p><strong>Conclusions: </strong>EUS-LB was well tolerated and yielded samples that were technically and diagnostically successful in a pediatric population, with comparable safety to percutaneous liver biopsy.</p>","PeriodicalId":16694,"journal":{"name":"Journal of Pediatric Gastroenterology and Nutrition","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protein and energy digestibility in preterm infants fed fortified human milk.","authors":"Susanne Soendergaard Kappel, Per Torp Sangild, Gitte Zachariassen, Julie Hvid Andersen, Kirsten Kørup Rasmussen, Palle Bekker Jeppesen, Lise Aunsholt","doi":"10.1002/jpn3.70000","DOIUrl":"https://doi.org/10.1002/jpn3.70000","url":null,"abstract":"<p><strong>Objectives: </strong>The objective of the present study is to determine whether the apparent nutrient digestibility differs between very preterm infants fortified with bovine colostrum (BC) compared to those fortified with a conventional fortifier (CF), building on previous findings that BC was associated with looser stools and reduced need for laxatives in very preterm infants (VPI).</p><p><strong>Methods: </strong>We conducted a 24-h digestibility balance study in 10 VPIs to assess the retention of protein, energy, and wet-weight following the intake of fortified human milk and collection of faecal excretions. Infants (n = 5) were matched by gestational age and birthweight.</p><p><strong>Results: </strong>In the 10 infants, the mean gestational age and birthweight were 28 ± 1 weeks and 899 ± 182 g, respectively. Infants fortified with BC had a higher faecal energy loss compared with infants fortified with CF (BC: 178 [range 111-205] vs. CF: 153 [96-235] kJ/kg, p < 0.05). No differences (p > 0.05) were found for wet-weight intake (421 [360-427] vs. 494 [328-500] kJ/kg), relative absorption of protein (60 [33-75] vs. 50 [33-75]%) or absolute protein absorption (249 [159-310) vs. 281 [210-347]).</p><p><strong>Conclusion: </strong>Nutrient absorption was similar between groups although higher energy loss indicates reduced overall digestibility of BC versus CF, however, with a large variation within each group. Studies on more infants are required to confirm these results. A 24-h digestibility balance study can successfully be used to assess nutrient and energy retention in preterm infants.</p>","PeriodicalId":16694,"journal":{"name":"Journal of Pediatric Gastroenterology and Nutrition","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intestinal histopathology in pediatric PSC-IBD: Characterization of phenotype and assessment of the Nancy Index.","authors":"Rebecca Little, Juan Putra, Binita M Kamath, Anne M Griffiths, Amanda Ricciuto, Iram Siddiqui","doi":"10.1002/jpn3.12434","DOIUrl":"10.1002/jpn3.12434","url":null,"abstract":"<p><strong>Objectives: </strong>We aimed to characterize the histologic gut phenotype of pediatric primary sclerosing cholangitis (PSC)-associated inflammatory bowel disease (IBD) against non-PSC colitis, and to assess Nancy Index (NI) performance in pediatric PSC-IBD.</p><p><strong>Methods: </strong>Single-center retrospective cohort study including children diagnosed with PSC-IBD or non-PSC colitis (ulcerative colitis [UC] or IBD-unclassified) from 2000 to 2018, with diagnostic intestinal biopsies. Biopsies were re-reviewed by two independent pathologists who assessed microscopic disease distribution, NI scores, and specific histological features in the right and left colons, overall and stratified by endoscopic severity (moderate-severe vs. no more than mild). We examined NI inter-rater reliability with Fleiss' weighted (quadratic) kappa and NI construct validity against global endoscopic severity (Spearman correlation) and clinical outcomes (logistic regression).</p><p><strong>Results: </strong>Fifty children with PSC-IBD and 81 colitis controls were included. Histologically, pancolitis (84% vs. 55%), right colon-predominant colitis (48% vs. 3%), and backwash ileitis (53% vs. 12%) (all p < 0.01) were significantly more common in PSC-IBD; histologic rectal sparing occurred at similar rates (6% vs. 10%, p = 0.54). Lamina propria-predominant neutrophils, prominent eosinophilic infiltration (left colon), and surface villiform change (right colon) were more common in PSC-IBD than colitis controls (p < 0.01). NI showed excellent inter-rater reliability (kappa > 0.9) and correlated moderately with global endoscopic severity but poorly with clinical activity in PSC-IBD.</p><p><strong>Conclusions: </strong>Pediatric PSC-IBD has a distinct histologic phenotype that largely mirrors the endoscopic phenotype in distribution and includes a greater frequency of features not included in conventional UC histologic activity indices. Future work should investigate whether a PSC-IBD-specific index incorporating these features is warranted.</p>","PeriodicalId":16694,"journal":{"name":"Journal of Pediatric Gastroenterology and Nutrition","volume":" ","pages":"290-299"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric gastrostomy tube referral patterns and postoperative use: A single-center experience.","authors":"Derek J Krinock, Krista J Stephenson, Madison G Whaley, Allison Wells, Lindsey L Wolf, Melvin S Dassinger","doi":"10.1002/jpn3.12428","DOIUrl":"10.1002/jpn3.12428","url":null,"abstract":"<p><strong>Objectives: </strong>Practice variability exists regarding the timing of gastrostomy tube (GT) placement in patients unable to maintain adequate oral nutrition. We sought to assess patient factors predictive of longer surgical GT use to inform patient selection.</p><p><strong>Methods: </strong>We conducted a single-center, retrospective cohort study including children ≤18 years who underwent surgical GT placement from June 1, 2018 to June 1, 2021 at a children's hospital. Bivariate and logistic regression analyses were performed to assess the impact of referral patterns, operative indications, and patient comorbidities on the length of GT use.</p><p><strong>Results: </strong>Four hundred fifty-eight children underwent GT placement. Median age at placement was 5 months (interquartile range [IQR]: 2-12) and 52% were male. Fifty-six percent were referred from a neonatal intensive care unit;/cardiovascular intensive care unit provider before initial hospital discharge and 19% were outpatient referrals. Forty-six percent were premature and 50% exhibited oropharyngeal dysphagia. The median duration of nasogastric (NGT) feeding before GT placement was 36.5 days (IQR: 16-64). In those with GT removal (n = 140), the median duration of use was 269 days (IQR: 144-474), with 23% of the cohort no longer utilizing the GT within 12 months of placement. Patients with congenital lung disease (odds ratio [OR]: 3.03, p = 0.002) and genetic anomalies excluding isolated Trisomy 21 (OR: 3.57, p = 0.003) were more likely to require prolonged GT use.</p><p><strong>Conclusions: </strong>Nearly a quarter of children attain full oral feeding within a year of GT placement. The identified factors predictive of prolonged GT use suggest early placement in these patients. Continuing NGT feeds in other patients may decrease the morbidity of unnecessary GT placement.</p>","PeriodicalId":16694,"journal":{"name":"Journal of Pediatric Gastroenterology and Nutrition","volume":" ","pages":"326-335"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of gastrointestinal acute graft-versus-host disease in children undergoing hematopoietic stem cell transplantation.","authors":"Kritiya Rattanaseksan, Usanarat Anurathapan, Pornthep Tanpowpong","doi":"10.1002/jpn3.12425","DOIUrl":"10.1002/jpn3.12425","url":null,"abstract":"<p><strong>Objectives: </strong>Graft-versus-host disease (GVHD) commonly affects the gastrointestinal (GI) tract among children who undergo hematopoietic stem cell transplantation (HSCT). Studies concerning GI-acute GVHD (aGVHD) in developing countries are limited. Therefore, our aims were (1) to demonstrate clinical characteristics, endoscopic and histopathological findings in children with GI-aGVHD post-HSCT and (2) to compare features, risk factors, and clinical outcomes of children with GI-aGVHD versus non GI-aGVHD.</p><p><strong>Methods: </strong>A retrospective single-center study was conducted on patients receiving the first successful HSCT aged <20 years old between January 2011 and December 2020. The patients were divided into groups with GI-aGVHD (clinically or endoscopy-histopathologically diagnosed) and without GI-aGVHD. Various aforementioned data were recorded to compare the risk factors and clinical outcomes of children with and without GI-aGVHD.</p><p><strong>Results: </strong>Among 246 children post-HSCT, we identified 42 cases (17%) with GI-aGVHD (32 cases with the clinical diagnosis and 10 cases with endoscopy-histopathology confirmed diagnosis) and 204 patients without GI-aGVHD. When compared with children without GI-aGVHD, the GI-aGVHD group had higher rates of hypovolemic shock, renal failure, more extended hospital stays, and deaths (all p < 0.05). The GI-aGVHD group also had a higher proportion of cases with nonhematologic malignancy (odds ratio [OR] = 2.34, 95% confidence interval [CI] = 1.01-5.41, p = 0.047) and cytomegalovirus (CMV) reactivation before the GI-aGVHD episode (OR = 2.22, 95% CI = 1.09-4.51, p = 0.027).</p><p><strong>Conclusions: </strong>GI-aGVHD after HSCT leads to increased morbidity and death. Underlying nonhematologic malignancy and history of CMV reactivation are associated with GI-aGVHD. Direct links between the aforementioned factors and the development of GI-aGVHD merit future studies.</p>","PeriodicalId":16694,"journal":{"name":"Journal of Pediatric Gastroenterology and Nutrition","volume":" ","pages":"271-281"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of colonoscopic versus fluoroscopic colonic manometry catheter placement in children.","authors":"Anna E Leone, Julia M J van der Zande, Shruthi Srinivas, Maria Knaus, Richard J Wood, Mark J Hogan, Marc A Benninga, Raul E Sanchez, Neetu Bali Puri, Karla Vaz, Desale Yacob, Carlo Di Lorenzo, Peter L Lu","doi":"10.1002/jpn3.12429","DOIUrl":"10.1002/jpn3.12429","url":null,"abstract":"<p><strong>Objectives: </strong>Colonic manometry catheter placement can be performed by colonoscopy or fluoroscopy. Our objective was to compare outcomes of colonoscopic to fluoroscopic catheter placement in children based on the extent of colon study and the likelihood of catheter displacement.</p><p><strong>Methods: </strong>Colonic manometry studies performed between May 2015 and May 2022 were reviewed. All studies with catheter placement per rectum were included. Data on patient demographics, medical and surgical history, and information on catheter placement (type of catheter, placement technique, position, and displacement) were recorded.</p><p><strong>Results: </strong>We reviewed 555 studies and included 482 studies performed on 453 children (51% female, median age 10 years, interquartile range: 7-14 years). The catheter was placed during colonoscopy in 274 studies and using fluoroscopy in 208 studies. Children with colonoscopic placement were significantly older (median age 11 vs. 8 years, p < 0.001), more commonly male (55% vs. 41%, p = 0.003), and more commonly had functional constipation (85% vs. 69%, p < 0.001). Children with fluoroscopic placement more often had pediatric intestinal pseudo-obstruction (10% vs. 1%, p < 0.001), a diverting ostomy (21% vs. 7%, p < 0.001), and a cecostomy (10% vs. 4%, p = 0.023). A successful catheter placement (reaching ascending colon) was significantly more common using colonoscopy (49% vs. 23%, p < 0.001). There were no differences in frequency or extent of catheter displacement between colonoscopic and fluoroscopic placement.</p><p><strong>Conclusions: </strong>Colonoscopic placement was superior to fluoroscopic placement in terms of the extent of the colon studied with no differences in frequency of catheter displacement. Colonoscopic placement should be the preferred method in most children with refractory constipation.</p>","PeriodicalId":16694,"journal":{"name":"Journal of Pediatric Gastroenterology and Nutrition","volume":" ","pages":"282-289"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Powdered human milk-derived versus bovine milk-derived breastmilk fortification: A multi-centre preterm randomised controlled trial.","authors":"Janet Berrington, Mark Johnson, Shalabh Garg, Christopher Stewart, Christopher Lamb, Jeremy Palmer, Nicholas Embleton","doi":"10.1002/jpn3.12431","DOIUrl":"10.1002/jpn3.12431","url":null,"abstract":"<p><strong>Objective: </strong>To compare faecal calprotectin, plasma amino acids and clinical outcomes in preterm infants receiving powdered human milk-based fortifier (PHMF) compared to powdered bovine milk-based fortifier (PBMF) in preterm infants on an otherwise exclusive human milk diet.</p><p><strong>Methods: </strong>A randomised controlled trial in infants <32 weeks of gestation or <1500 g who only received human milk and had reached full enteral feeds (150 mL/kg/day), without pre-existing gastrointestinal morbidity. Primary outcome was faecal calprotectin within 21 days of starting fortification; secondary outcomes were calprotectin at discharge, plasma amino acids and clinical outcomes, including growth and neonatal morbidities.</p><p><strong>Results: </strong>The trial stopped early after the manufacturer's withdrawal of PHMF. Thirty-one infants were enroled, three without informative sampling, leaving 14 per group. No statistical differences were seen in faecal calprotectin on Day 7 (236 mcg/g PHMF vs. 303 mcg/g PBMF, p = 0.90) or 21 (135 mcg/g PHMF vs. 315 mcg/g PBMF, p = 0.21). Adjusting for gestation and day of life, and including all time points after enrolment to discharge, fortifier type did not impact faecal calprotectin (coefficient estimate -7.13, 95% confidence interval = -172 to 158, p = 0.93). Rates of key neonatal morbidities did not differ. PHMF infants grew more slowly reaching statistical significance in change in weight standard deviation score at discharge compared to PBMF infants (mean (standard deviation) -0.94 (0.7) PHMF vs. -0.24 (0.8) PBMF, p = 0.02).</p><p><strong>Conclusions: </strong>We did not detect reduced gut inflammation as measured by faecal calprotectin in PHMF compared to PBMF but weight gain was slower, of potential clinical importance.</p>","PeriodicalId":16694,"journal":{"name":"Journal of Pediatric Gastroenterology and Nutrition","volume":" ","pages":"336-344"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin and trace element status and growth in children with short bowel syndrome being weaned off parenteral nutrition.","authors":"Jetta Tuokkola, Elina Olkkonen, Riikka Gunnar, Mikko Pakarinen, Laura Merras-Salmio","doi":"10.1002/jpn3.12427","DOIUrl":"10.1002/jpn3.12427","url":null,"abstract":"<p><strong>Objectives: </strong>Children with short bowel syndrome (SBS) are at increased risk of micronutrient deficiencies. We aimed to study weaning off parenteral nutrition (PN) as a risk factor for vitamin and trace element deficiencies and growth deficit.</p><p><strong>Methods: </strong>Children born between 2010 and 2019, treated for SBS in Helsinki University Hospital, were followed for their nutrition, growth, and vitamin and trace element biochemical status. Information on these as well as patient characteristics and intestinal anatomy were collected from electronic patient records.</p><p><strong>Results: </strong>A total of 59 patients with SBS were identified. The weaning period was found to be a risk factor for micronutrient deficiencies and growth. Most frequent deficiencies were detected for vitamin K as suggested by prothrombin time (PT) (91% of patients), vitamin D (70%), and vitamin A (67%). Other deficiencies were less common with 44% for vitamin B12, 25% for selenium, 19% for copper, 24% for zinc, and 11% for vitamin E. For all the studied micronutrients, 3 months before to 1 month postweaning had the highest rate of micronutrient deficiencies, except for vitamin B12, for which the highest proportion of deficiencies presented at 1-6 months postweaning.</p><p><strong>Conclusions: </strong>The weaning period from PN is a risk for micronutrient deficiencies. Regular monitoring and sufficient supplementation are essential for preventing malnutrition.</p>","PeriodicalId":16694,"journal":{"name":"Journal of Pediatric Gastroenterology and Nutrition","volume":" ","pages":"318-325"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}