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Application of Mass Spectrometry for Signal Transduction Analysis 质谱法在信号转导分析中的应用
Yamaguchi Medical Journal Pub Date : 2015-08-01 DOI: 10.2342/YMJ.64.177
H. Kishi, Sei Kobayashi
{"title":"Application of Mass Spectrometry for Signal Transduction Analysis","authors":"H. Kishi, Sei Kobayashi","doi":"10.2342/YMJ.64.177","DOIUrl":"https://doi.org/10.2342/YMJ.64.177","url":null,"abstract":"","PeriodicalId":166832,"journal":{"name":"Yamaguchi Medical Journal","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129050335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case of ANCA Positive Refractory Otitis Media Started with Otitis Media with Effusion 以积液性中耳炎为首发的ANCA阳性难治性中耳炎1例
Yamaguchi Medical Journal Pub Date : 2015-08-01 DOI: 10.2342/YMJ.64.213
Yosuke Okinaka, K. Sugahara, J. Tsuda, Kuniyoshi Tanaka, Eiju Kanagawa, H. Shimogori, H. Yamashita
{"title":"A Case of ANCA Positive Refractory Otitis Media Started with Otitis Media with Effusion","authors":"Yosuke Okinaka, K. Sugahara, J. Tsuda, Kuniyoshi Tanaka, Eiju Kanagawa, H. Shimogori, H. Yamashita","doi":"10.2342/YMJ.64.213","DOIUrl":"https://doi.org/10.2342/YMJ.64.213","url":null,"abstract":"患 者:41才女性. 主 訴:両側難聴. 現病歴:某年1月頃より軽度の両側難聴,耳痛が出 現し近医耳鼻科で加療された.3月頃より難聴の増 悪を自覚し,5月に総合病院耳鼻咽喉科を紹介され た.同院外来では中耳炎として抗菌薬等を投与され たが,経過中に徐々に左聴力閾値の上昇を認めたた め,7月に精査加療目的に当科を紹介された. 既往歴:特記すべきことなし. 耳内所見:鼓膜は両側とも腫脹・発赤しており,膿 汁の付着を認めた.さらに中耳腔の貯留液が鼓膜よ り透見された(図1a,b). 標準純音聴力検査:前医の初診時には右38.3dB,左 46.7dBと,右軽度,左中等度の難聴を認めた(図1c). 当科初診時の検査結果を示す.右40.0dB,左76.7dB と右中等度,左高度難聴を呈しており,難聴の進行 を認めた(図1d). 耳部CT:両側とも鼓室に軟部陰影を認めたが,乳 山口医学 第64巻 第3号 213頁~216頁,2015年 213","PeriodicalId":166832,"journal":{"name":"Yamaguchi Medical Journal","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125785034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness of Medical Seminars for High-school Students：Results of a Follow-up Survey 高中生医学研讨会的有效性:一项随访调查结果
Yamaguchi Medical Journal Pub Date : 2015-08-01 DOI: 10.2342/YMJ.64.191
Y. Fukuda, Hiroshi Nakamura, Makoto Segawa, Masaaki Abe, A. Taguchi, Mutsuko Miyazaki
{"title":"Effectiveness of Medical Seminars for High-school Students：Results of a Follow-up Survey","authors":"Y. Fukuda, Hiroshi Nakamura, Makoto Segawa, Masaaki Abe, A. Taguchi, Mutsuko Miyazaki","doi":"10.2342/YMJ.64.191","DOIUrl":"https://doi.org/10.2342/YMJ.64.191","url":null,"abstract":"","PeriodicalId":166832,"journal":{"name":"Yamaguchi Medical Journal","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124939199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel Fish-derived Peptides Which Induce Vasorelaxation of Porcine Coronary Arteries 诱导猪冠状动脉血管松弛的新型鱼源肽
Yamaguchi Medical Journal Pub Date : 2015-05-01 DOI: 10.2342/YMJ.64.101
Tomohiko Kimura
{"title":"Novel Fish-derived Peptides Which Induce Vasorelaxation of Porcine Coronary Arteries","authors":"Tomohiko Kimura","doi":"10.2342/YMJ.64.101","DOIUrl":"https://doi.org/10.2342/YMJ.64.101","url":null,"abstract":"血管拡張薬は,虚血性心臓病,高血圧症,心不全 など多くの心血管病に対して,急性期/慢性期を問 わず,頻用されている治療薬である.これらの心血 管病では,急性発症や急性増悪する場合も少なくな いため,日常から摂取可能な食品や食品成分の中か ら,血管弛緩を引き起こす成分が発見できれば,こ れらの心血管病の予防の一助となる可能性が期待さ れる.さらに,同定された食品成分が水溶性であれ ば,注射薬の開発にも繋がると期待される. そこで,食品や食品成分から幅広くスクリーニン グを行い,血管弛緩作用を有する食品成分として, 水溶性の魚類由来ペプチド群(FDPFs)を見出し た.FDPFsは,食用可能なタンパク質分解酵素を 用いて魚類タンパク質から生産されたペプチド群で あり,内膜を除去したブタ冠状動脈平滑筋条片を濃 度依存性に強力かつ持続的に弛緩させた.さらに, タンデム型質量分析計を用いて,FDPFsの中から, 連続性のあるアミノ酸配列を有する4つのペプチド (PG,GPG,VGPG,VGPGG)を同定した.これ らのペプチドは生理活性を有するものとして過去に 全く報告のない新規ペプチドであった. FDPFsから同定された新規ペプチドのアミノ酸 配列に従って合成したペプチドは,実際にブタ冠状 動脈平滑筋条片を濃度依存性に弛緩させた.さらに, ペプチド長に応じて血管弛緩作用も増強したため, 最長のVGPGGを認識する新規の受容体の関与が示 唆された.また,この弛緩は,血管平滑筋の細胞質 カルシウムイオン濃度([Ca2+]i)の低下を伴わな かったため,平滑筋収縮のCa2+感受性の低下によ るものと考えられた. FDPFsは強力かつ持続的な血管弛緩作用を有し ていたことから,血管病を予防する有望な食品成分 となり得ると期待される.また,同定ペプチドも同 様な作用を有しており,また水溶性であることから, 注射液などの医薬品への応用が可能となれば,心血 管病の急性期治療へ貢献できる可能性を持っている と期待される.","PeriodicalId":166832,"journal":{"name":"Yamaguchi Medical Journal","volume":"161 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133487968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fascinated by Platelets 对血小板着迷
Yamaguchi Medical Journal Pub Date : 2015-02-01 DOI: 10.2342/YMJ.64.5
K. Okano
{"title":"Fascinated by Platelets","authors":"K. Okano","doi":"10.2342/YMJ.64.5","DOIUrl":"https://doi.org/10.2342/YMJ.64.5","url":null,"abstract":"","PeriodicalId":166832,"journal":{"name":"Yamaguchi Medical Journal","volume":"1939 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129029147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evidence for the Treatment of Hypertension with Combination Therapy and the COPE Trial 联合治疗高血压的证据和COPE试验
Yamaguchi Medical Journal Pub Date : 2015-02-01 DOI: 10.2342/YMJ.64.17
S. Umemoto
{"title":"Evidence for the Treatment of Hypertension with Combination Therapy and the COPE Trial","authors":"S. Umemoto","doi":"10.2342/YMJ.64.17","DOIUrl":"https://doi.org/10.2342/YMJ.64.17","url":null,"abstract":"","PeriodicalId":166832,"journal":{"name":"Yamaguchi Medical Journal","volume":"116 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126712709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Action of Sex Hormone for Proliferative Fibrocellular Tissue Formation in Refractory Vitreoretinal Diseases 性激素对难治性玻璃体视网膜疾病增生性纤维细胞组织形成的作用
Yamaguchi Medical Journal Pub Date : 2015-02-01 DOI: 10.2342/YMJ.64.11
K. Kimura
{"title":"Action of Sex Hormone for Proliferative Fibrocellular Tissue Formation in Refractory Vitreoretinal Diseases","authors":"K. Kimura","doi":"10.2342/YMJ.64.11","DOIUrl":"https://doi.org/10.2342/YMJ.64.11","url":null,"abstract":"","PeriodicalId":166832,"journal":{"name":"Yamaguchi Medical Journal","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124188502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
医学生のロールモデル：２年生を対象にした「ロールモデルを探す」授業の試み 医学生的榜样:以二年级学生为对象的“寻找榜样”课程的尝试
Yamaguchi Medical Journal Pub Date : 2014-11-01 DOI: 10.2342/YMJ.63.275
吉治 福田
{"title":"医学生のロールモデル：２年生を対象にした「ロールモデルを探す」授業の試み","authors":"吉治 福田","doi":"10.2342/YMJ.63.275","DOIUrl":"https://doi.org/10.2342/YMJ.63.275","url":null,"abstract":"","PeriodicalId":166832,"journal":{"name":"Yamaguchi Medical Journal","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134339103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
重症熱性血小板減少症候群（SFTS）様の症状を呈した患者における抗SFTSウイルス抗体の検討 对重症热性血小板减少综合征(SFTS)样症状患者的抗SFTS病毒抗体的研究
Yamaguchi Medical Journal Pub Date : 2014-11-01 DOI: 10.2342/YMJ.63.257
亜希 石堂, 徹 重岡, 貴元 富永, 泰子 末廣, 秀悦 福士, 昌幸 下島, 政幸 西條, 徹夫 高橋
{"title":"重症熱性血小板減少症候群（SFTS）様の症状を呈した患者における抗SFTSウイルス抗体の検討","authors":"亜希 石堂, 徹 重岡, 貴元 富永, 泰子 末廣, 秀悦 福士, 昌幸 下島, 政幸 西條, 徹夫 高橋","doi":"10.2342/YMJ.63.257","DOIUrl":"https://doi.org/10.2342/YMJ.63.257","url":null,"abstract":"","PeriodicalId":166832,"journal":{"name":"Yamaguchi Medical Journal","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116592233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
早期体験実習（early exposure）としての高齢者施設体験実習の現状と課題―アンケート結果を中心に― 作为早期体验实习(early exposure)的养老机构体验实习的现状和课题——以问卷调查结果为主——
Yamaguchi Medical Journal Pub Date : 2014-11-01 DOI: 10.2342/YMJ.63.263
文吾 白澤, 龍也 藤宮, 誠司 瀬川, 上田 真寿美, 邦彦 松井
{"title":"早期体験実習（early exposure）としての高齢者施設体験実習の現状と課題―アンケート結果を中心に―","authors":"文吾 白澤, 龍也 藤宮, 誠司 瀬川, 上田 真寿美, 邦彦 松井","doi":"10.2342/YMJ.63.263","DOIUrl":"https://doi.org/10.2342/YMJ.63.263","url":null,"abstract":"","PeriodicalId":166832,"journal":{"name":"Yamaguchi Medical Journal","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126386758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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