Journal of NeuroVirology最新文献_第4页

The OLR1/NF-κB feedback loop exacerbates HIV-1 Tat-induced microglial inflammatory response and neuronal apoptosis. OLR1/NF-κB反馈回路加剧了HIV-1 tat诱导的小胶质细胞炎症反应和神经元凋亡。

IF 2.3 4区医学

Journal of NeuroVirology Pub Date : 2025-04-01 Epub Date: 2025-03-26 DOI: 10.1007/s13365-025-01249-8

Qifei Zhang, Wenhua Tao, Jing Wang, Meijuan Qian, Mingming Zhou, Lin Gao

{"title":"The OLR1/NF-κB feedback loop exacerbates HIV-1 Tat-induced microglial inflammatory response and neuronal apoptosis.","authors":"Qifei Zhang, Wenhua Tao, Jing Wang, Meijuan Qian, Mingming Zhou, Lin Gao","doi":"10.1007/s13365-025-01249-8","DOIUrl":"10.1007/s13365-025-01249-8","url":null,"abstract":"Oxidized low density lipoprotein receptor 1 (OLR1), a type II integral membrane glycoprotein, is involved in multiple neurological diseases. However, the roles and mechanisms of OLR1 in HIV-associated neurocognitive disorder (HAND) remain unclear. In the central nervous system, Transactivator of transcription (Tat) induces inflammatory response in microglia, thereby leading to neuronal apoptosis. In the present study, we demonstrated that OLR1 expression was upregulated during ectopic expression of Tat or soluble Tat stimulus in BV-2 microglial cells. Moreover, OLR1 signaling was proved to facilitate Tat-triggered inflammatory response and alleviated the microglia-derived conditioned media-mediated HT-22 neural cells apoptosis in a NF-κB-dependent manner. Conversely, Tat augmented OLR1 expression via NF-κB signaling pathway. Finally, in mouse models, we determined that silencing of OLR1 significantly ameliorated Tat‑induced neuroinflammation and hippocampal neuronal death. Taken together, our study clarifies the potential role of the OLR1/NF-κB feedback loop in Tat-induced microglial inflammatory response and neuronal apoptosis, which could be a novel therapeutic target for relief of HAND.","PeriodicalId":16665,"journal":{"name":"Journal of NeuroVirology","volume":" ","pages":"170-186"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maintaining the battle against vaccine-preventable neurological diseases in the United States. 在美国继续与疫苗可预防的神经系统疾病作斗争。

IF 1.9 4区医学

Journal of NeuroVirology Pub Date : 2025-04-01 Epub Date: 2025-04-22 DOI: 10.1007/s13365-025-01256-9

Farrah J Mateen

引用次数: 0

In vitro characterization of the antiviral activity of Bat Interferon-Induced protein with tetratricopeptide repeats 5 (bat IFIT5) against bat-associated rabies virus. 蝙蝠干扰素诱导蛋白与四肽重复5 （Bat IFIT5）对蝙蝠相关狂犬病毒抗病毒活性的体外鉴定

IF 2.3 4区医学

Journal of NeuroVirology Pub Date : 2025-04-01 Epub Date: 2025-02-28 DOI: 10.1007/s13365-025-01245-y

Camila Mosca Barboza, Raphaela Mello Zamudio, Ana Claudia Franco, Helena Beatriz de Carvalho Ruthner Batista

{"title":"In vitro characterization of the antiviral activity of Bat Interferon-Induced protein with tetratricopeptide repeats 5 (bat IFIT5) against bat-associated rabies virus.","authors":"Camila Mosca Barboza, Raphaela Mello Zamudio, Ana Claudia Franco, Helena Beatriz de Carvalho Ruthner Batista","doi":"10.1007/s13365-025-01245-y","DOIUrl":"10.1007/s13365-025-01245-y","url":null,"abstract":"Bats are important reservoirs of zoonotic viruses, including the rabies virus (RABV), which causes rabies, a significant and fatal disease. In Brazil, RABV has been detected in several bat species. Interferon-induced protein with tetratricopeptide repeats 5 (IFIT5) is part of a group of interferon-stimulated genes (ISGs) known for their antiviral activity. This study investigated the interaction between batIFIT5 and different genetic lineages of RABV. The batIFIT5 was expressed in HEK-293T cells, which were infected with RABV genetic lineages isolated from Eptesicus furinalis (IP 964/06) and Tadarida brasiliensis (IP 3214/19), at varying infectious doses (pure, 100, 10, and 1). Direct immunofluorescence was performed to assess the effect of batIFIT5 on virus replication through the counting of fluorescent foci. Subsequently, after the expression of batIFIT5, 1 MOI was selected and used to evaluate the potential antiviral effect. Immunofluorescence was performed 24 and 48 h after infection. As a result, the viral concentration remained similar in the presence of batIFIT5 across distinct infectious doses. After infection with 1 MOI, a 30% reduction in infection rates was observed, particularly for the IP 3214/19 isolate after 24 h. These results highlight the potential antiviral role of IFIT5 against RABV infection.","PeriodicalId":16665,"journal":{"name":"Journal of NeuroVirology","volume":" ","pages":"163-169"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Progressive multifocal leukoencephalopathy during 4 years of Palbociclib for advanced breast cancer with a history of follicular lymphoma patient. 更正：有滤泡性淋巴瘤病史的晚期乳腺癌患者在帕博西尼治疗4年期间出现进行性多灶性脑白质病变。

IF 2.3 4区医学

Journal of NeuroVirology Pub Date : 2025-04-01 DOI: 10.1007/s13365-025-01259-6

Mariko Nishihara, Ryosuke Koyamada, Tetsuhiro Masaki, Tomohito Shimada, Kazuhiro Ishikawa, Jun Hashimoto, Nobuyoshi Mori, Asami Namai, Hideaki Yokoo, Kenta Takahashi, Tadaki Suzuki, Kazuo Nakamichi, Shinichiro Mori

引用次数: 0

Assessing cognitive impairment in HIV-infected: a comparative study of international HIV Dementia Scale, HIV Dementia Scale Italian version and Montreal cognitive assessment in clinical practice. 评估HIV感染者的认知障碍：国际HIV痴呆量表、意大利版HIV痴呆量表和蒙特利尔认知评估在临床实践中的比较研究

IF 2.3 4区医学

Journal of NeuroVirology Pub Date : 2025-04-01 Epub Date: 2025-02-28 DOI: 10.1007/s13365-025-01248-9

Maristella Belfiori, Francesco Salis, Camilla Podda, Lorenzo Stanisci, Benedetta Puxeddu, Francesco Ortu, Paola Piano, Stefano Del Giacco, Antonella Mandas

{"title":"Assessing cognitive impairment in HIV-infected: a comparative study of international HIV Dementia Scale, HIV Dementia Scale Italian version and Montreal cognitive assessment in clinical practice.","authors":"Maristella Belfiori, Francesco Salis, Camilla Podda, Lorenzo Stanisci, Benedetta Puxeddu, Francesco Ortu, Paola Piano, Stefano Del Giacco, Antonella Mandas","doi":"10.1007/s13365-025-01248-9","DOIUrl":"10.1007/s13365-025-01248-9","url":null,"abstract":"The combination of antiretroviral therapy (cART) and preventive measures has significantly enhanced the management of Human Immunodeficiency Virus (HIV) infection. However, HIV-associated neurocognitive disorders (HAND) remain a challenge. This study aims to compare cognitive impairment (CI) assessments in people living with HIV/AIDS (PLWHA) using the International HIV Dementia Scale (IHDS), HIV Dementia Scale-Italian Version (HDS-IT) and MoCA (Montreal Cognitive Assessment), while also identifying significant associations. The cross-sectional study encompassed 294 outpatient PLWHA (median age: 57) on cART. Participants underwent cognitive, functional, and depression assessments, laboratory testing and CNS Penetration-Effectiveness (CPE) index assessment. IHDS, HDS-IT and MoCA identified CI in different proportions of PLWHA. Factors such as age, education level, infection duration, and substance use were associated with CI. The IHDS score (OR 0.79) and Level CD4 + T-lymphocytes nadir (OR 0.99) demonstrated independent and negative associations with the CPE-index. IHDS and MoCA tests appear to be useful for detecting CI in outpatient settings, enabling healthcare providers to conduct initial evaluations of PLWHA. IHDS assessment may be used for detecting CI related to high CPE regimens, while the MoCA provides a comprehensive assessment, also in domains not studied by IHDS. However, further research is needed to confirm these findings and refine their clinical applicability.","PeriodicalId":16665,"journal":{"name":"Journal of NeuroVirology","volume":" ","pages":"131-144"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12137510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the impact of simulated microgravity on HSV-1 infection, neuroinflammation, and endogenous retroviral activation in SH-SY5Y cells. 揭示模拟微重力对HSV-1感染、神经炎症和SH-SY5Y细胞内源性逆转录病毒激活的影响。

IF 2.3 4区医学

Journal of NeuroVirology Pub Date : 2025-04-01 Epub Date: 2025-03-20 DOI: 10.1007/s13365-025-01251-0

Seyedesomaye Jasemi, Elena Rita Simula, Kawaguchi Yasushi, Leonardo Antonio Sechi

{"title":"Unveiling the impact of simulated microgravity on HSV-1 infection, neuroinflammation, and endogenous retroviral activation in SH-SY5Y cells.","authors":"Seyedesomaye Jasemi, Elena Rita Simula, Kawaguchi Yasushi, Leonardo Antonio Sechi","doi":"10.1007/s13365-025-01251-0","DOIUrl":"10.1007/s13365-025-01251-0","url":null,"abstract":"Microgravity (µg) during spaceflight affects cellular and molecular functions of both human cells and microbial pathogens, influencing viral replication and the host immune system. This study aimed to investigate the effects of simulated µg on Herpes Simplex Virus-1 (HSV-1) replication, host pro-inflammatory cytokine, and human endogenous retrovirus (HERV) activation in human neuroblastoma SH-SY5Y cells. Our results show that µg has a negative impact on HSV-1 replication, leading to significantly reduced viral titers and lower expression levels of HSV-1 early genes (ICP0, ICP4, and ICP27) compared to 1 gravity (1 g) conditions. Interestingly, despite lower viral titers and HSV-1 gene expressions under µg condition, we observed higher levels of HERVs and pro-inflammatory cytokine gene expression. In addition, there was a significant correlation between HSV-1 immediate-early genes with HERVs and pro-inflammatory cytokine gene expression, with stronger correlations observed under µg conditions. Taken together, µg reduces HSV-1 replication and increases host pro-inflammatory and HERVs gene expression, which demands further investigation for human health protection in space.","PeriodicalId":16665,"journal":{"name":"Journal of NeuroVirology","volume":" ","pages":"154-162"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12137466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progressive multifocal leukoencephalopathy during 4 years of Palbociclib for advanced breast cancer with a history of follicular lymphoma patient. 4年帕博西尼治疗晚期乳腺癌伴滤泡性淋巴瘤患者进展性多灶性脑白质病

IF 2.3 4区医学

Journal of NeuroVirology Pub Date : 2025-04-01 Epub Date: 2025-04-21 DOI: 10.1007/s13365-025-01255-w

Ryosuke Koyamada, Mariko Nishihara, Tetsuhiro Masaki, Tomohito Shimada, Kazuhiro Ishikawa, Jun Hashimoto, Nobuyoshi Mori, Asami Namai, Hideaki Yokoo, Kenta Takahashi, Tadaki Suzuki, Kazuo Nakamichi, Shinichiro Mori

引用次数: 0

SARS-CoV-2: A synergy to the Alzheimer's disease. SARS-CoV-2：与阿尔茨海默病的协同作用

IF 2.3 4区医学

Journal of NeuroVirology Pub Date : 2025-02-01 Epub Date: 2025-02-25 DOI: 10.1007/s13365-025-01247-w

Khaja Moinuddin Shaik, Deepak Kumar, Pirangi Srikanth, Sukhendu Nandi

{"title":"SARS-CoV-2: A synergy to the Alzheimer's disease.","authors":"Khaja Moinuddin Shaik, Deepak Kumar, Pirangi Srikanth, Sukhendu Nandi","doi":"10.1007/s13365-025-01247-w","DOIUrl":"10.1007/s13365-025-01247-w","url":null,"abstract":"COVID-19 was a nightmare in humankind's history that challenged our advanced medical technology. All credit goes to the researchers who played a crucial role in curbing COVID-19 and proved our medical technology supremacy. However, COVID-19 has left some mysterious scars on human well-being. It is believed that COVID-19 has a significant negative impact on various cardiovascular (CVS) and central nervous system (CNS) diseases, especially in the case of CNS diseases like Alzheimer's. Surprisingly, COVID-19 affects the respiratory system, whereas Alzheimer's disease (AD) alters brain function. To explain this phenomenon, several hypotheses were proposed, but the mechanism needs to be clearly understood. Another critical thing to be concerned about is that COVID-19 will worsen pre-existing conditions and lead to the onset of AD. In the race to curb COVID-19, the invention of vaccines was speeded up, and it is necessary to fight against COVID-19. However, postvaccination follow-up is mandatory when an individual is a victim of AD. In this review article, we compiled the various dreadful effects of the COVID-19 virus on AD, the Post effects of the virus on AD, and the effect of the COVID-19 vaccination on AD. This article provides a new direction for research concerning COVID-19 and AD.","PeriodicalId":16665,"journal":{"name":"Journal of NeuroVirology","volume":" ","pages":"16-23"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Momordica charantia phytoconstituents can inhibit human T-lymphotropic virus type-1 (HTLV-1) infectivity in vitro and in vivo. 苦瓜植物成分在体外和体内均能抑制人t淋巴细胞嗜型病毒（HTLV-1）的感染性。

IF 2.3 4区医学

Journal of NeuroVirology Pub Date : 2025-02-01 Epub Date: 2023-08-02 DOI: 10.1007/s13365-023-01160-0

Sanaz Ahmadi Ghezeldasht, Hamid Reza Bidkhori, Raheleh Miri, Arezoo Baghban, Arman Mosavat, Seyed Abdolrahim Rezaee

{"title":"Momordica charantia phytoconstituents can inhibit human T-lymphotropic virus type-1 (HTLV-1) infectivity in vitro and in vivo.","authors":"Sanaz Ahmadi Ghezeldasht, Hamid Reza Bidkhori, Raheleh Miri, Arezoo Baghban, Arman Mosavat, Seyed Abdolrahim Rezaee","doi":"10.1007/s13365-023-01160-0","DOIUrl":"10.1007/s13365-023-01160-0","url":null,"abstract":"There is an urgent need to find an effective therapy for life-threatening HTLV-1-associated diseases. Bitter melon (Momordica charantia) is considered a traditional herb with antiviral and anticancer properties and was tested in this study on HTLV-1 infectivity. GC-MS analyzed the alcoholic extract. In vitro assay was carried out using transfection of HUVEC cells by HTLV-1-MT2 cell line. The cells were exposed to alcoholic and aqueous extracts at 5,10, and 20 µg/mL concentrations. In vivo, mice were divided into four groups. Three groups were treated with HTLV-1-MT-2 cells as test groups and positive control, and PBS as the negative control group in the presence and absence of M. charantia extracts. Peripheral blood mononuclear cells (PBMCs), mesenteric lymph nodes (MLNs), and splenocytes were collected for HTLV-1-proviral load (PVL) assessment, TaqMan-qPCR. The GC-MS analysis revealed 36 components in M. charantia. The studies showed significant reductions in HTLV-1-PVL in the presence of extract in the HUVEC-treated groups (P = 0.001). Furthermore, the inhibitory effects of extracts on HTLV-1 infected mice showed significant differences in HTLV-1-PVL among M. charantia treated groups with untreated (P = 0.001). The T-cells in MLNs were significantly more susceptible to HTLV-1 than others (P = 0.001). There were significant differences among HTLV-1-infected cells in MLNs and splenocytes (P = 0.001 and 0.046, respectively). Also, aqueous and alcoholic extract-treated groups significantly affected HTLV-1-infected PBMCs (P = 0.002 and 0.009, respectively). M. charantia may have effective antiviral properties. The substantial compound of M. charantia could have inhibitory effects on the proliferation and transmission of HTLV-1 oncovirus.","PeriodicalId":16665,"journal":{"name":"Journal of NeuroVirology","volume":" ","pages":"24-34"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9917734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High glucose potentiates Zika virus induced-astroglial dysfunctions. 高葡萄糖增强寨卡病毒诱导的星形胶质细胞功能障碍。

IF 2.3 4区医学

Journal of NeuroVirology Pub Date : 2025-02-01 Epub Date: 2024-12-03 DOI: 10.1007/s13365-024-01238-3

Natalie Katherine Thomaz, Larissa Daniele Bobermin, Patrícia Sesterheim, Ana Paula Muterle Varela, Thais Fumaco, Marina Seady, Belisa Parmeggiani, Marina Concli Leite, Guilhian Leipnitz, Lucélia Santi, Walter O Beys-da-Silva, Jorge Almeida Guimarães, Paulo M Roehe, Carlos-Alberto Gonçalves, Diogo Onofre Souza, André Quincozes-Santos

{"title":"High glucose potentiates Zika virus induced-astroglial dysfunctions.","authors":"Natalie Katherine Thomaz, Larissa Daniele Bobermin, Patrícia Sesterheim, Ana Paula Muterle Varela, Thais Fumaco, Marina Seady, Belisa Parmeggiani, Marina Concli Leite, Guilhian Leipnitz, Lucélia Santi, Walter O Beys-da-Silva, Jorge Almeida Guimarães, Paulo M Roehe, Carlos-Alberto Gonçalves, Diogo Onofre Souza, André Quincozes-Santos","doi":"10.1007/s13365-024-01238-3","DOIUrl":"10.1007/s13365-024-01238-3","url":null,"abstract":"Zika virus (ZIKV) is a neurotropic flavivirus that induces congenital Zika syndrome and neurodevelopmental disorders. Given that ZIKV can infect and replicate in neural cells, neurological complications in adult brain are also observed. Glial cells may emerge to delay and/or prevent the development of ZIKV-induced neurodegeneration. These cells actively participate in metabolic, inflammatory and redox processes, and consequently, in the pathophysiology of neurodegenerative diseases, including diabetic encephalopathy. In this sense, changes in glucose metabolism can support the inflammatory activity of astroglial cells; however, the effects of increased glucose concentration during ZIKV infection have not yet been explored in astroglial cells. Here, we evaluated functional parameters of astroglial cells exposed to ZIKV upon normal and high glucose concentrations, focusing on inflammatory profile, oxidative stress, and expression of critical genes for astroglial functions. High glucose potentiated the pro-inflammatory and oxidative effects of ZIKV, as well as potentiated the downregulation of signaling pathways, such as Nrf-2 (nuclear factor erythroid derived 2 like 2), sirtuin 1 (SIRT1), peroxisome proliferator activated receptor gamma coactivator 1-alpha (PGC-1α), and poly (ADP-ribose) polymerase (PARP). In summary, our results suggest that high glucose can favor the activation of inflammatory signaling while impairing cytoprotective pathways in astroglial cells exposed to ZIKV and reinforce the hypothesis that this virus is highly neurotrophic, with significant impact in glial cells.","PeriodicalId":16665,"journal":{"name":"Journal of NeuroVirology","volume":" ","pages":"84-94"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0