SARS-CoV-2: A synergy to the Alzheimer's disease.

IF 1.9 4区 医学 Q3 NEUROSCIENCES
Journal of NeuroVirology Pub Date : 2025-02-01 Epub Date: 2025-02-25 DOI:10.1007/s13365-025-01247-w
Khaja Moinuddin Shaik, Deepak Kumar, Pirangi Srikanth, Sukhendu Nandi
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引用次数: 0

Abstract

COVID-19 was a nightmare in humankind's history that challenged our advanced medical technology. All credit goes to the researchers who played a crucial role in curbing COVID-19 and proved our medical technology supremacy. However, COVID-19 has left some mysterious scars on human well-being. It is believed that COVID-19 has a significant negative impact on various cardiovascular (CVS) and central nervous system (CNS) diseases, especially in the case of CNS diseases like Alzheimer's. Surprisingly, COVID-19 affects the respiratory system, whereas Alzheimer's disease (AD) alters brain function. To explain this phenomenon, several hypotheses were proposed, but the mechanism needs to be clearly understood. Another critical thing to be concerned about is that COVID-19 will worsen pre-existing conditions and lead to the onset of AD. In the race to curb COVID-19, the invention of vaccines was speeded up, and it is necessary to fight against COVID-19. However, postvaccination follow-up is mandatory when an individual is a victim of AD. In this review article, we compiled the various dreadful effects of the COVID-19 virus on AD, the Post effects of the virus on AD, and the effect of the COVID-19 vaccination on AD. This article provides a new direction for research concerning COVID-19 and AD.

SARS-CoV-2:与阿尔茨海默病的协同作用
新冠肺炎疫情是人类历史上的一场噩梦,对我们先进的医疗技术提出了挑战。这一切都归功于为遏制新冠肺炎疫情发挥关键作用、证明我国医疗技术优势的研究人员。然而,新冠肺炎给人类福祉留下了一些神秘的伤疤。人们认为,COVID-19对各种心血管(CVS)和中枢神经系统(CNS)疾病,特别是像阿尔茨海默病这样的中枢神经系统疾病,具有显著的负面影响。令人惊讶的是,COVID-19会影响呼吸系统,而阿尔茨海默病(AD)会改变大脑功能。为了解释这一现象,提出了几种假设,但其机制需要清楚地了解。另一个需要关注的关键问题是,COVID-19会恶化已有的疾病,并导致阿尔茨海默病的发作。在遏制新冠病毒的竞赛中,疫苗的发明加快了,抗击新冠病毒是必要的。然而,当一个人是阿尔茨海默病的受害者时,接种疫苗后的随访是强制性的。在这篇综述文章中,我们综述了COVID-19病毒对AD的各种可怕影响、病毒对AD的后影响以及COVID-19疫苗对AD的影响。本文为COVID-19与AD的研究提供了新的方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of NeuroVirology
Journal of NeuroVirology 医学-病毒学
CiteScore
6.60
自引率
3.10%
发文量
77
审稿时长
6-12 weeks
期刊介绍: The Journal of NeuroVirology (JNV) provides a unique platform for the publication of high-quality basic science and clinical studies on the molecular biology and pathogenesis of viral infections of the nervous system, and for reporting on the development of novel therapeutic strategies using neurotropic viral vectors. The Journal also emphasizes publication of non-viral infections that affect the central nervous system. The Journal publishes original research articles, reviews, case reports, coverage of various scientific meetings, along with supplements and special issues on selected subjects. The Journal is currently accepting submissions of original work from the following basic and clinical research areas: Aging & Neurodegeneration, Apoptosis, CNS Signal Transduction, Emerging CNS Infections, Molecular Virology, Neural-Immune Interaction, Novel Diagnostics, Novel Therapeutics, Stem Cell Biology, Transmissable Encephalopathies/Prion, Vaccine Development, Viral Genomics, Viral Neurooncology, Viral Neurochemistry, Viral Neuroimmunology, Viral Neuropharmacology.
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