Journal of Parasitic Diseases最新文献_第2页

Molecular identification of Fasciola and Dicrocoelium species isolates in ruminants livestock from Kashan and Arak in center of Iran. 伊朗中部卡尚和阿拉克地区反刍家畜片形虫和双骨吸虫分离株的分子鉴定。

Journal of Parasitic Diseases Pub Date : 2025-06-01 Epub Date: 2024-12-26 DOI: 10.1007/s12639-024-01771-2

Mohsen Arbabi, Hossein Hooshyar, Mahdi Delavari

{"title":"Molecular identification of Fasciola and Dicrocoelium species isolates in ruminants livestock from Kashan and Arak in center of Iran.","authors":"Mohsen Arbabi, Hossein Hooshyar, Mahdi Delavari","doi":"10.1007/s12639-024-01771-2","DOIUrl":"10.1007/s12639-024-01771-2","url":null,"abstract":"Fascioliasis and Dicrocoeliasis are important trematode infections that affect humans and ruminants worldwide. Molecular techniques have a conclusive role in detection of liver flukes. The purpose of the current study was to find outthe genotypic diversity of Fasciola and Dicrocoelium spp. isolated from different hosts in Iran. Totally, 160 and 200 adult Fasciola and Dicrocoelium spp. isolates were collected from infected cattle, sheep, and goatsfrom two abattoirs in the center of Iran.PCR-RFLP, and DNA sequences nuclear markers (18 S, 28 S, ITS) and the mitochondrial marker (ND1, CO1) were applied. PCR products of Dicrocoelium and Fasciola samples were subjected to digestion by BfaI, Tru1I, BsrBI, ECO881, and Hind III enzymes. DNA from 60 isolates of Fasciola and Dicrocoelium of different hosts were sequenced and evaluated. The PCR reaction showed the length of 18 S, 28 S, ND1, CO1 of Fasciola at 260 bp, 618 bp, 700 bp, and 500 bp, and the length of the ITS2 and 28 S of Dicrocoelium was 236 bp and 963 bp respectively. D. dendriticum has an RFLP pattern of 110, and 126 bp (ITS2), and 116, 293, 409 bp (28 S) using, BfaI and Tru1I restriction enzymes. F. gigantica has a profile of 333, and 285 bp (28 S) using BsrBI enzyme. The RFLP pattern of genotype F. hepatica was 73, 120, and 507 bp (ND1) and 119 and 381 bp (CO1) in size using Hind III and ECO881 enzymes. Using the PCR-RFLP, two species of Fasciola (F. hepatica and F. gigantica), and one species of Dicrocoelium (D. dendriticum) were identified. To uncover the genetic population structure of liver flukes across the country, future studies are still required.","PeriodicalId":16664,"journal":{"name":"Journal of Parasitic Diseases","volume":"49 2","pages":"453-464"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parasitological and molecular detection of Hepatozoon canis in Rhipicephalus sanguineus and Rhipicephalus turanicus in Khorasan Razavi province, Iran. 伊朗呼罗珊拉扎维省多血根头和图兰根头犬肝虫病的病原学和分子检测。

Journal of Parasitic Diseases Pub Date : 2025-06-01 Epub Date: 2024-11-06 DOI: 10.1007/s12639-024-01760-5

Gholamreza Razmi, Saeed Yaghfoori, Amin Bakhshani, Ali Barati

{"title":"Parasitological and molecular detection of Hepatozoon canis in Rhipicephalus sanguineus and Rhipicephalus turanicus in Khorasan Razavi province, Iran.","authors":"Gholamreza Razmi, Saeed Yaghfoori, Amin Bakhshani, Ali Barati","doi":"10.1007/s12639-024-01760-5","DOIUrl":"10.1007/s12639-024-01760-5","url":null,"abstract":"Hepatozoon canis infects the haemolymphatic tissues of both domestic and wild dogs, resulting in symptoms such as anemia and lethargy. The transmission of this parasite occurs primarily through Rhipicephalus sanguineus and various other ixodid tick species. A study was conducted to determine the tick vector of H. canis in dogs in the Mashhad region, Khorasan Razavi province, from 2018 to 2021. A total of 976 ixodid ticks were collected from 39 sheepdogs and 76 shelterdogs during activating seasons of ticks. Adult ticks were identified according to general identification keys. The collected female ticks were separated into 81 tick pools according to their species. The hemolymph smear was prepared from engorged and semi-engorged female ticks and stained with the Giemsa method, Then, the DNA of each tick pool was extracted using a commercial kit and analyzed by PCR. Two ixodid species, R. sanguineus and R. turanicus were identified in infested dogs. The frequency of R. sanguineus and R. turanicus infestation in sheepdogs was 80.25% and 19.75% and in shelterdogs 76.5% and 23.5%, respectively. H. canis DNA has only been detected in 15 (18.5%) tick pool samples of R. sanguineus. Immature oocysts of Hepatozoon were detected in two hemolymph smears obtained from engorged female R. sanguineus that tested positive via PCR and were collected from shelter dogs. It is concluded that R. sanguineus was the dominant tick in sheepdogs and shelter dogs in the Mashhad area. Moreover, the results of the molecular and parasitological examination indicated that R. sanguineus ticks could be a vector of H. canis in dogs in Iran for the first time.","PeriodicalId":16664,"journal":{"name":"Journal of Parasitic Diseases","volume":"49 2","pages":"313-319"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repurposing of Amiodarone for treatment of muscle phase of experimental trichinellosis spiralis. 胺碘酮在实验性旋毛虫病肌肉期治疗中的应用。

Journal of Parasitic Diseases Pub Date : 2025-06-01 Epub Date: 2024-12-06 DOI: 10.1007/s12639-024-01763-2

Gehad A Abdelhamid, Amany A Abdel-Aal, Manal Badawi, Mennat-Elrahman A Fahmy, Asmaa R Abd-Alghany

{"title":"Repurposing of Amiodarone for treatment of muscle phase of experimental trichinellosis spiralis.","authors":"Gehad A Abdelhamid, Amany A Abdel-Aal, Manal Badawi, Mennat-Elrahman A Fahmy, Asmaa R Abd-Alghany","doi":"10.1007/s12639-024-01763-2","DOIUrl":"10.1007/s12639-024-01763-2","url":null,"abstract":"Recently, testing existing drugs for new therapeutic purposes has been highly recommended. Trichinellosis is a parasitic infection caused by roundworms from the genus Trichinella. Treating trichinellosis is facing many challenges and offering new pharmacological therapeutics is needed. In this study, Amiodarone, the antiarrhythmic medication was repurposed for the first time for treating the muscle phase of trichinellosis in experimental mice. Thirty-five mice were used and divided as follows; normal, infected, infected, and treated with Albendazole (ALB), and the infected and treated with Amiodarone (AMD). Thirty-five days post inoculation of infection and after euthanasia; the diaphragms of all mice were subjected to histopathological examination while the whole muscle masses of the infected and infected-treated mice were subjected to digestion and examination for assessing the number of larvae per gram. Compared to ALB, AMD showed the best results in this study. A significant reduction of muscle larval burden (71.43%, versus ALB 62.36%; P <.001) and improvement of the diaphragmatic histopathological changes with a significant reduction of inflammatory infiltrates (P <.001). According to our results, AMD showed an anti-inflammatory plus antiparasitic action against the muscular phase of experimental trichinellosis. In addition, ALB, the drug of choice till now should be tested in combination with other treatments to improve its intestinal absorption and subsequently its anti-larval efficacy, plus reducing its consequential severe inflammatory reaction.","PeriodicalId":16664,"journal":{"name":"Journal of Parasitic Diseases","volume":"49 2","pages":"419-425"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Helminthic intestinal perforations in children: our experience. 儿童蠕虫肠道穿孔：我们的经验。

Journal of Parasitic Diseases Pub Date : 2025-06-01 Epub Date: 2024-11-13 DOI: 10.1007/s12639-024-01764-1

Aniruddha D Bhagwat, Rashmi Patil, Apoorva Makan, Dhananjay Vaze, Pranav Jadhav

{"title":"Helminthic intestinal perforations in children: our experience.","authors":"Aniruddha D Bhagwat, Rashmi Patil, Apoorva Makan, Dhananjay Vaze, Pranav Jadhav","doi":"10.1007/s12639-024-01764-1","DOIUrl":"10.1007/s12639-024-01764-1","url":null,"abstract":"Intestinal perforations by worms are rare. Ascariasis is the commonest helminthic infestation in the world. Ascariasis must be considered as a differential diagnosis in intestinal obstruction and perforation especially in endemic regions. The clinical presentation can vary from an asymptomatic patient to severe complicated disease. Symptoms depend on the intestinal worm load and intestinal obstruction is a common complication. Because of the rarity of helminthic intestinal perforations and more so given the large-scale migration from developing countries, we wish to emphasize the need to inculcate awareness among treating clinicians, even from the developed world, about this potentially dangerous yet treatable condition. Early diagnosis and treatment is crucial to prevent significant mortality and morbidity from disease complications. Conservative treatment is advised for uncomplicated intestinal Ascariasis. Surgery is life saving in Ascaris complications. There is no effective vaccine available till date. Prevention is better than cure. We present a case series analysis of five children with worm infestation and intestinal perforation, and report clinical presentations, imaging modalities used, treatment and outcomes for each of the case.","PeriodicalId":16664,"journal":{"name":"Journal of Parasitic Diseases","volume":"49 2","pages":"368-377"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An antecedental approach in prevalence analysis of CBD parasites from rural population of eastern part of Meghalaya, India. 印度梅加拉亚邦东部农村人群CBD寄生虫流行分析的前期方法。

Journal of Parasitic Diseases Pub Date : 2025-06-01 Epub Date: 2024-11-04 DOI: 10.1007/s12639-024-01752-5

Damanbha Lyngdoh, Abhijeet Purkayastha, Rangksan Singh Thangkhiew, Mario Danny Hek, Calvin Donkupar Warjri, Philayung Zas

{"title":"An antecedental approach in prevalence analysis of CBD parasites from rural population of eastern part of Meghalaya, India.","authors":"Damanbha Lyngdoh, Abhijeet Purkayastha, Rangksan Singh Thangkhiew, Mario Danny Hek, Calvin Donkupar Warjri, Philayung Zas","doi":"10.1007/s12639-024-01752-5","DOIUrl":"10.1007/s12639-024-01752-5","url":null,"abstract":"The invasion of endoparasites into the human organ system causes a significant number of health issues and other clinical problems. In developing countries like India, such health predicaments are a well-established fact due to individuals' lifestyles as well as environmental factors to some extent. A very common case of parasitic infestation is seen with Ascaris sp., which is often overlooked in rural areas. Therefore, this study primarily focuses on determining the parasitic roundworms extracted from the common bile duct (CBD) of patients who came forward after experiencing severe conditions. The general trend of children being more affected than adults was observed in the study, with a maximum of 20 worms extracted from a 4-year-old child. All the patients who reported the same symptoms were thoroughly diagnosed and observed to exhibit normal health conditions. The rate of infection was higher in the case of female patients, indicating that females are more susceptible to the effects. The results provide valuable information about CBD parasites from cases in rural parts of eastern Meghalaya.","PeriodicalId":16664,"journal":{"name":"Journal of Parasitic Diseases","volume":"49 2","pages":"306-312"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of nitazoxanide, ivermectin and albendazole in treatment of cryptosporidiosis in immunosuppressed mice. 硝唑尼特、伊维菌素和阿苯达唑治疗免疫抑制小鼠隐孢子虫病的疗效观察。

Journal of Parasitic Diseases Pub Date : 2025-06-01 Epub Date: 2024-11-07 DOI: 10.1007/s12639-024-01751-6

Basma M Elmansory, Rabab Sayed Zalat, Eman Khaled, Noha Madbouly Taha

{"title":"Efficacy of nitazoxanide, ivermectin and albendazole in treatment of cryptosporidiosis in immunosuppressed mice.","authors":"Basma M Elmansory, Rabab Sayed Zalat, Eman Khaled, Noha Madbouly Taha","doi":"10.1007/s12639-024-01751-6","DOIUrl":"10.1007/s12639-024-01751-6","url":null,"abstract":"Cryptosporidiosis is one of the main causes of fatal watery diarrhea, especially in immunocompromised patients worldwide. Although nitazoxanide (NTZ) is the only effective FDA approved drug for cryptosporidiosis, it is partially effective in immunocompromised patients. So, there is an urgent need for new alternatives for treating cryptosporidiosis in those patients. The present study aims to assess the efficacy of ivermectin (IVM) and albendazole (ALB) as compared to NTZ and their combinations in treatment of cryptosporidiosis in immunosuppressed infected mice. Mice were divided into 7 groups (G) with 10 mice each; GI: treated with NTZ. GII: treated with IVM. GIII: treated with ALB. GIV: treated with combined NTZ and IVM. GV: treated with combined NTZ and ALB. GVI: non-infected non-treated (negative control). GVII: infected non-treated (positive control). Parasitological, histopathological, and immunological studies were done for all studied groups. The combined therapy of NTZ and IVM showed the best results in reducing the oocysts shedding (reduction rate of 91.9%), healing the histopathological inflammatory changes of ileum, in addition to enhancing the cellular immune response by marked elevation of serum INF-γ levels as compared to the other treatment regimens. Therefore, we concluded that this synergistic combination is promising in controlling cryptosporidiosis in immunocompromised patients.","PeriodicalId":16664,"journal":{"name":"Journal of Parasitic Diseases","volume":"49 2","pages":"343-350"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Socio-environmental maps as tools to characterize the risk of parasitosis in the horticultural peri-urban area of La Plata, Argentina. 社会环境地图作为表征阿根廷拉普拉塔园艺城市周边地区寄生虫病风险的工具。

Journal of Parasitic Diseases Pub Date : 2025-06-01 Epub Date: 2024-11-22 DOI: 10.1007/s12639-024-01761-4

Andrea Celina Falcone, Gabriel Atilio Rivas, Daniela Patricia Nieto, Juan Manuel Unzaga

{"title":"Socio-environmental maps as tools to characterize the risk of parasitosis in the horticultural peri-urban area of La Plata, Argentina.","authors":"Andrea Celina Falcone, Gabriel Atilio Rivas, Daniela Patricia Nieto, Juan Manuel Unzaga","doi":"10.1007/s12639-024-01761-4","DOIUrl":"10.1007/s12639-024-01761-4","url":null,"abstract":"Characterize the socio-environmental risk associated with parasitic infection based on the analysis of geographic distribution patterns and the population, household, and housing conditions of the productive peri-urban area of La Plata. A \"Kernel\" density map was used and a Socio-environmental Risk Analysis (SRA) criterion was developed to evaluate the tendency shown by the risk factors of parasitic contamination. The construction of the SRA was based on the variables of the concept of Unsatisfied Basic Needs and Territorial Vulnerability Index. In the \"Kernel\" density map a similar distribution trend was observed in the points analyzed that determine the presence of parasites, plots with intensive crops and the areas of highest altitude and watersheds of the basins. In the SRA, the majority of the surface area (71%) was important in the characterization of high risk. The houses built with sheet metal and wood, high critical overcrowding, limited access to waste collection, frequent flooding, distances to educational and limited access to health coverage are the variables that contributed most to the risk, confirming that access to drinking water and sewage systems are not the only limiting factors for parasitic infections. Consequently, non-farming families living in the region in conditions of similar materiality and without access to public services present a high risk of contamination by parasitic species. The information analyzed shows that the construction of distributive social policies and preventive health management to mitigate the presence of parasitic species in the region is priority.","PeriodicalId":16664,"journal":{"name":"Journal of Parasitic Diseases","volume":"49 2","pages":"389-406"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abnormal forms of Myxobolus sp. (Myxosporea: Bivalvulida) spores with caudal appendages in Pellona castelnaeana (Teleostei: Clupeiformes) from Marajó island, Brazil. 巴西Marajó岛粘孢子目：双valvulda)孢子尾端附肢的异常形态。

Journal of Parasitic Diseases Pub Date : 2025-06-01 Epub Date: 2024-12-26 DOI: 10.1007/s12639-024-01773-0

José Ledamir Sindeaux-Neto, Maylon Fernandes Amador, Jhonata Eduard, Michele Velasco

{"title":"Abnormal forms of Myxobolus sp. (Myxosporea: Bivalvulida) spores with caudal appendages in Pellona castelnaeana (Teleostei: Clupeiformes) from Marajó island, Brazil.","authors":"José Ledamir Sindeaux-Neto, Maylon Fernandes Amador, Jhonata Eduard, Michele Velasco","doi":"10.1007/s12639-024-01773-0","DOIUrl":"10.1007/s12639-024-01773-0","url":null,"abstract":"Myxobolus is one of the most speciose genera of myxozoans, most species are found infecting freshwater fish. Although the absence of caudal appendages is one of the main taxonomic criteria to differentiate this genus from other species, in some cases anomalous forms of Myxobolus are observed, with the presence of caudal appendages. The Brazilian Amazon contains a diverse fish population, which includes a large number of Myxobolus species, some of which are pathogenic. Pellona castelnaeana (Valenciennes, 1847) is a species with huge migratory flows that contributes for the population's diet food. This study reports the observation of Myxobolus, including aberrant forms, on the gills of P. castelnaeana, a freshwater fish. Gill arch cysts with myxospores were found in 90% of the specimens analyzed, with 5% having elongated caudal appendages ranging in size from 4 to 16 µm. This is the first report of Myxobolus Abnormal forms in Clupeiformes, adding to our understanding of the genus Myxobolus phenotypic plasticity in South American fish.","PeriodicalId":16664,"journal":{"name":"Journal of Parasitic Diseases","volume":"49 2","pages":"447-452"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular and serological assessment of the therapeutic efficacy of Ivermectin Loaded nanoparticles on Trichinella spiralis experimentally. 负载伊维菌素纳米颗粒对旋毛虫治疗效果的分子和血清学评价。

Journal of Parasitic Diseases Pub Date : 2025-06-01 Epub Date: 2024-11-07 DOI: 10.1007/s12639-024-01756-1

Howayda S F Moawad, Alaa M Elgendy, Sabah M A Mohamed, Esraa S Mousa, Raghda A Moustafa, Amira Abd El-Lateef Saleh

{"title":"Molecular and serological assessment of the therapeutic efficacy of Ivermectin Loaded nanoparticles on Trichinella spiralis experimentally.","authors":"Howayda S F Moawad, Alaa M Elgendy, Sabah M A Mohamed, Esraa S Mousa, Raghda A Moustafa, Amira Abd El-Lateef Saleh","doi":"10.1007/s12639-024-01756-1","DOIUrl":"10.1007/s12639-024-01756-1","url":null,"abstract":"Trichinosis is a real threat to public health that infects humans and animals. Current treatments have high resistance and limited bioavailability. Consequently, it is imperative to enhance the bioavailability of these drugs by developing new agents. So, the purpose of this study was to assess the efficacy of ivermectin-loaded chitosan nanoparticles (CS NPs) and their combination with albendazole (ABZ) on the muscular and intestinal phases of trichinosis. We had eight main groups of mice: non-infected control; infected control; infected and treated with ABZ; infected and treated with ivermectin (IVM); infected and treated with CS NPs; infected and treated with ABZ and IVM; infected and treated with IVM-loaded CS NPS; and infected and treated with ABZ combined with IVM-loaded CS NPS. Two subgroups were formed for each group: a and b for both phases, intestinal and muscular, respectively. Drug efficacy was parasitologically, histopathologically, serologically, and molecularly evaluated. The ABZ combined with IVM-loaded CS NPS-treated group showed the highest statistically significant reduction in adult and encysted larval counts and a noticeable reduction of both intestinal and muscular inflammation. In the treated groups, there was a significant decrease in TNF-α, iNOS, and IFN-γ gene expression when compared with the infected control. Although the level of IL10 was increased in all treated groups. In conclusion, IVM-loaded CS NPS enhanced the efficacy of ABZ against T. spiralis-infected mice.","PeriodicalId":16664,"journal":{"name":"Journal of Parasitic Diseases","volume":"49 2","pages":"322-333"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Parasitological and molecular detection of Hepatozoon canis in Rhipicephalus sanguineus and Rhipicephalus turanicus in Khorasan Razavi province, Iran. 更正：伊朗呼罗珊·拉扎维省血头和图兰头猪犬肝虫的寄生虫学和分子检测。

Journal of Parasitic Diseases Pub Date : 2025-06-01 Epub Date: 2025-02-19 DOI: 10.1007/s12639-024-01777-w

Gholamreza Razmi, Saeed Yaghfoori, Amin Bakhshani, Ali Barati

引用次数: 0