Therapeutic challenges of schistosomiasis: mechanisms of action and current limitations.

Q3 Immunology and Microbiology
Journal of Parasitic Diseases Pub Date : 2025-09-01 Epub Date: 2025-02-03 DOI:10.1007/s12639-025-01785-4
Abdelaali Balahbib, Nasreddine El Omari, Hajar Lghazi, Kenza Hatoufi, Yassin El Atki, Abdelhakim Bouyahya, Fatima Amarir
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引用次数: 0

Abstract

Schistosomiasis, a parasitic disease caused by Schistosoma species, affects millions of people worldwide. This review explores the therapeutic challenges of schistosomiasis, focusing on the mechanisms of action of current treatments and their limitations. Praziquantel, the standard therapy, induces lesions and muscle contractions in the parasites, thereby facilitating their clearance by the host immune system. However, the biological complexity of schistosomes and their ability to modulate the immune response present hurdles to sustained treatment efficacy. Challenges include the emergence of resistance, adverse side effects, and inconsistent cure rates. Additionally, the remarkable longevity of schistosomes-spanning years to decades-complicates the evaluation of treatment outcomes. Addressing these issues, requires ongoing surveillance, research into novel therapeutic agents, and an integrated approach that combines medical interventions with preventive measures. This paper underscores the importance of understanding schistosome biology and advocates for comprehensive strategies to improve the management and control of this debilitating parasitic infection.

血吸虫病的治疗挑战:作用机制和目前的局限性。
血吸虫病是一种由血吸虫引起的寄生虫病,影响着全世界数百万人。这篇综述探讨了血吸虫病的治疗挑战,重点是目前治疗的作用机制及其局限性。吡喹酮,标准疗法,诱导寄生虫病变和肌肉收缩,从而促进它们被宿主免疫系统清除。然而,血吸虫的生物学复杂性及其调节免疫反应的能力为持续的治疗效果带来了障碍。挑战包括耐药性的出现、不良副作用和治愈率不一致。此外,血吸虫的显著寿命(从数年到数十年)使治疗结果的评估复杂化。要解决这些问题,需要持续的监测、对新型治疗剂的研究以及将医疗干预与预防措施相结合的综合方法。本文强调了了解血吸虫生物学的重要性,并提倡采取综合策略来改善这种使人衰弱的寄生虫感染的管理和控制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Parasitic Diseases
Journal of Parasitic Diseases Immunology and Microbiology-Parasitology
CiteScore
2.60
自引率
0.00%
发文量
86
期刊介绍: The primary constituency of the Journal of Parasitic Diseases is parasitology. It publishes original research papers (pure, applied and clinical), which contribute significantly to any area of parasitology. Research papers on various aspects of cellular and molecular parasitology are welcome.
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