Journal of Parkinson's disease最新文献_第3页

Pathophysiology and pharmacological management for sleep problems in Parkinson's disease. 帕金森病睡眠问题的病理生理学和药理学管理。

IF 5 3区医学

Journal of Parkinson's disease Pub Date : 2025-09-02 DOI: 10.1177/1877718X251371945

Cristian Falup-Pecurariu, Larisa Ungureanu, Iulia Murasan, Stefania Diaconu

{"title":"Pathophysiology and pharmacological management for sleep problems in Parkinson's disease.","authors":"Cristian Falup-Pecurariu, Larisa Ungureanu, Iulia Murasan, Stefania Diaconu","doi":"10.1177/1877718X251371945","DOIUrl":"https://doi.org/10.1177/1877718X251371945","url":null,"abstract":"Sleep problems are among the most frequently reported non-motor symptoms of Parkinson's disease (PD), with a broad range of disorders: insomnia, REM sleep behavior disorder, restless legs syndrome, excessive daytime sleepiness, and sleep-related breathing disorders. These disturbances evolve in complexity across PD severity stages, significantly impact the patients' quality of life and may exacerbate motor and other non-motor symptoms. Neurodegenerative processes, impaired function of neurotransmitters, medication side effects, circadian rhythm dysfunction are among the most proposed mechanisms that may explain the frequent occurrence of sleep disorders in PD. However, there are still many unanswered questions related to the pathophysiological mechanisms of sleep disorders in PD that may offer the clue to better therapeutical options. Although the prevalence of sleep disturbances is very high, the treatment options are still limited. The current review focuses on main sleep disturbances encountered in PD, pathophysiological insights, current therapeutical options and future perspectives for a better and more personalized management of these disorders in PD.","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"1877718X251371945"},"PeriodicalIF":5.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144958060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patients with small fiber neuropathy exhibit more pronounced non-motor symptoms in Parkinson's disease. 患有小纤维神经病的患者在帕金森病中表现出更明显的非运动症状。

IF 5 3区医学

Journal of Parkinson's disease Pub Date : 2025-09-02 DOI: 10.1177/1877718X251371538

Chunge Xie, Jieling Chen, Rong Gan, Yuyuan Gao, Limin Wang, Guixian Ma, Yuhu Zhang, Kun Nie, Lijuan Wang

{"title":"Patients with small fiber neuropathy exhibit more pronounced non-motor symptoms in Parkinson's disease.","authors":"Chunge Xie, Jieling Chen, Rong Gan, Yuyuan Gao, Limin Wang, Guixian Ma, Yuhu Zhang, Kun Nie, Lijuan Wang","doi":"10.1177/1877718X251371538","DOIUrl":"https://doi.org/10.1177/1877718X251371538","url":null,"abstract":"BackgroundPeripheral neuropathy in Parkinson's disease (PD) may not be an isolated pathological phenomenon but may interact with other non-motor symptoms.ObjectiveTo conduct a comprehensive investigation of the non-motor symptoms observed in PD patients, with a comparative analysis between patients with and without peripheral neuropathy, to explore the relationships between peripheral neuropathy and non-motor symptoms.Methods100 PD patients were recruited from the Neurology Department of Guangdong Provincial People's Hospital. Extensive clinical data were collected, and assessments were performed to evaluate both motor and non-motor symptoms in patients with and without peripheral neuropathy. Spearman's rank correlation analysis was employed to evaluate the association between peripheral neuropathy and non-motor symptoms. Multiple linear regression analysis was conducted to adjust for confounding variables to clarify the impact of peripheral neuropathy on non-motor symptoms.Results57 individuals (57%) were identified as having peripheral neuropathy. Of these, 38 individuals were diagnosed with small fiber neuropathy. After adjusting for confounding variables, higher scores on the 13-item Small Fiber Neuropathy Symptom Inventory Questionnaire were significantly correlated with heightened symptoms of depression (B = 0.498, 95% CI = 0.080-0.917, p = 0.020), anxiety (B = 0.504, 95% CI = 0.099-0.908, p = 0.015), autonomic dysfunction (B = 1.118, 95% CI = 0.828-1.409, p < 0.001), and sleep disturbances (B = 0.694, 95% CI = 0.309-1.080, p = 0.001).ConclusionsPD patients with neuropathy, particularly those with small fiber neuropathy, demonstrate more pronounced non-motor symptoms. The severity of small fiber neuropathy is correlated with the extent of depression, anxiety, autonomic dysfunction, and sleep disturbances. These findings underscore the necessity for routine screening and early detection of peripheral neuropathy in PD patients.","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"1877718X251371538"},"PeriodicalIF":5.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144958023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trained dogs can detect the odor of Parkinson's disease. 经过训练的狗能嗅出帕金森氏症的气味。

IF 5 3区医学

Journal of Parkinson's disease Pub Date : 2025-09-01 Epub Date: 2025-07-14 DOI: 10.1177/1877718X251342485

Nicola Rooney, Drupad K Trivedi, Eleanor Sinclair, Caitlin Walton-Doyle, Monty Silverdale, Perdita Barran, Tilo Kunath, Steve Morant, Mark Somerville, Jayde Smith, Julie Jones-Diette, Jenny Corish, Joy Milne, Claire Guest

引用次数: 0

Psychosis in early onset Parkinson's disease: A retrospective cohort study in southeast Minnesota. 早发性帕金森病的精神病：明尼苏达州东南部的一项回顾性队列研究

IF 5 3区医学

Journal of Parkinson's disease Pub Date : 2025-09-01 Epub Date: 2025-06-30 DOI: 10.1177/1877718X251354978

Mohamed Derhab, Aidan F Mullan, Pierpaolo Turcano, Emanuele Camerucci, Capucine Piat, Khaled Ghoniem, Ali Zare Dehnavi, James H Bower, Rodolfo Savica

{"title":"Psychosis in early onset Parkinson's disease: A retrospective cohort study in southeast Minnesota.","authors":"Mohamed Derhab, Aidan F Mullan, Pierpaolo Turcano, Emanuele Camerucci, Capucine Piat, Khaled Ghoniem, Ali Zare Dehnavi, James H Bower, Rodolfo Savica","doi":"10.1177/1877718X251354978","DOIUrl":"10.1177/1877718X251354978","url":null,"abstract":"BackgroundEarly onset Parkinson's disease (EOPD), defined as Parkinson's disease (PD) diagnosed before age 50, often presents unique challenges compared to late-onset PD, particularly with regard to non-motor symptoms. Psychosis in EOPD is associated with increased functional impairment and may lead to a higher mortality risk.ObjectiveOur study is aimed to determine the prevalence of psychosis in EOPD patients and its impact on all-cause mortality, along with examining the effects of antipsychotic medications and Selective Serotonin Reuptake Inhibitors (SSRIs) on mortality in EOPD patients.MethodsOur retrospective cohort included EOPD patients diagnosed between 1990 and 2022 at Mayo Clinic, Rochester, Minnesota. Psychosis was defined using the National Institute of Neurological Disorders and Stroke/the National Institute of Mental Health (NINDS/NIMH) Work Group criteria. Cox proportional hazards models were used to analyze the association of psychosis and medications with mortality.ResultsOf 829 patients with EOPD, 158 (19.1%) developed psychosis at a median of 12.1 years after PD motor symptom onset. Psychosis was significantly associated with increased mortality in unadjusted (HR = 4.31, 95% CI: 2.59-7.18, p < 0.001) and adjusted (HR = 3.55, 95% CI: 2.10-6.01, p < 0.001) models. No significant difference in mortality risk was observed between patients treated with antipsychotics or SSRIs versus those who were not.ConclusionsPsychosis is a possible complication in EOPD and is associated with a significant increase in all-cause mortality. The use of antipsychotics and SSRIs did not significantly alter the mortality risk in these patients. Further research is needed to understand the mechanisms driving this association and to develop tailored interventions.","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"1078-1085"},"PeriodicalIF":5.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early detection of Parkinson's disease: Machine learning-based prediction of UPDRS Part III scores in de novo patients using smartphone assessments. 帕金森病的早期检测：使用智能手机评估新发患者UPDRS第三部分评分的基于机器学习的预测

IF 5 3区医学

Journal of Parkinson's disease Pub Date : 2025-09-01 Epub Date: 2025-07-28 DOI: 10.1177/1877718X251359494

Wei-Hang Guo, Xiao-Dong Yang, Zheng Ruan, Xu Wang, Dan-Zuo Zhang, Shu-Chao Song, Yi-Qiang Chen, Piu Chan

{"title":"Early detection of Parkinson's disease: Machine learning-based prediction of UPDRS Part III scores in de novo patients using smartphone assessments.","authors":"Wei-Hang Guo, Xiao-Dong Yang, Zheng Ruan, Xu Wang, Dan-Zuo Zhang, Shu-Chao Song, Yi-Qiang Chen, Piu Chan","doi":"10.1177/1877718X251359494","DOIUrl":"10.1177/1877718X251359494","url":null,"abstract":"BackgroundDetecting motor symptoms in Parkinson's disease (PD) at home, especially in the prodromal, is crucial for disease-modifying therapies.ObjectiveTo evaluate the effectiveness of machine learning models using smartphone-based assessments in predicting motor symptoms in untreated de novo PD.MethodsUsing a clinical trial in early de novo patients with PD, the PDAssist smartphone application and machine learning models were investigated for eight motor tasks: resting tremor, postural tremor, finger tapping, facial expressions, rigidity, speech, walking, and pronation/supination to predict motor symptoms of PD as comparing with UPDRS Part III scores.ResultsOur prediction model demonstrated acceptable performance in detecting PD mild symptoms, with accuracy ranging from 0.87 to 0.93 for resting tremor, postural tremor, finger tapping, facial expressions and postural stability, while the rigidity model achieved 0.81 accuracy with a Kappa of 0.74, and the speech model showed 0.79 accuracy and 0.61 Kappa, emphasizing its potential for detecting subtle motor deficits and remote monitoring. External validation confirmed the model's robustness, with significantly higher predicted scores (all tasks) for PD patients (9.45 ± 3.08) compared to healthy controls (3.79 ± 1.99, t = -14.27, p < 0.001), validating its ability to differentiate between the two groups.ConclusionsSmartphone-based assessments effectively discriminate de novo PD patients from controls and monitor motor symptoms in prodromal and early PD patients. Future work will involve expanding patient cohorts and refining algorithms for better generalizability and reliability of self-collected data in home settings.","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"1099-1110"},"PeriodicalIF":5.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Motor features that distinguish isolated REM sleep behavior disorder patients from healthy controls: A systematic review. 区分孤立的快速眼动睡眠行为障碍患者和健康对照者的运动特征：一项系统综述。

IF 5 3区医学

Journal of Parkinson's disease Pub Date : 2025-09-01 DOI: 10.1177/1877718X251359225

Salma Elasfar, Hajr Hameed, Kaylena Ehgoetz Martens

{"title":"Motor features that distinguish isolated REM sleep behavior disorder patients from healthy controls: A systematic review.","authors":"Salma Elasfar, Hajr Hameed, Kaylena Ehgoetz Martens","doi":"10.1177/1877718X251359225","DOIUrl":"https://doi.org/10.1177/1877718X251359225","url":null,"abstract":"Individuals with isolated REM sleep behavior disorder (iRBD) are at high risk of developing α-synucleinopathies, particularly Parkinson's disease (PD) and dementia with Lewy bodies (DLB). With the development of potential neuroprotective treatments for synucleinopathies, including PD, identifying clinical features that can allow for tracking subtle changes in prodromal disease and thereby monitoring risk of phenoconversion in iRBD is paramount. Subtle motor deficits have been suggested to be present in iRBD, making them potentially important clinical markers for predicting future phenoconversion. This review aims to summarize existing literature that has investigated differences in motor function between iRBD and healthy individuals, as well as progression of motor decline in iRBD. 39 eligible studies were included in this review. The results suggest that quantitative motor assessments may be more sensitive to motor impairments in this population than clinical scales. Moreover, dual-tasking tended to unmask subtle motor deficits in individuals with iRBD, particularly in gait, balance, and tapping assessments. Longitudinal studies demonstrate that motor function worsens over time in iRBD, with earliest signs of motor deficits and clear progression in tapping assessments in particular. Larger longitudinal studies that use quantitative methods of motor assessments are needed to better characterize motor progression in iRBD, and confirm the reliability of different motor markers for predicting phenoconversion of iRBD into PD and other synucleinopathies.","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"1877718X251359225"},"PeriodicalIF":5.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discontinuation or acute unplanned cessation of oral dopaminergic medications in persons with Parkinson's disease: A practice review. 帕金森病患者口服多巴胺能药物的停药或急性计划外停药：实践回顾

IF 5 3区医学

Journal of Parkinson's disease Pub Date : 2025-09-01 Epub Date: 2025-07-06 DOI: 10.1177/1877718X251356896

Milan Beckers, Danny Hommel, Herma Lennaerts, Clementine Stuijt, Paul Smit, Bastiaan R Bloem

{"title":"Discontinuation or acute unplanned cessation of oral dopaminergic medications in persons with Parkinson's disease: A practice review.","authors":"Milan Beckers, Danny Hommel, Herma Lennaerts, Clementine Stuijt, Paul Smit, Bastiaan R Bloem","doi":"10.1177/1877718X251356896","DOIUrl":"10.1177/1877718X251356896","url":null,"abstract":"Planned discontinuation or acute unplanned cessation of oral dopaminergic medications might result in a severe relapse of Parkinson's symptoms or, sporadically, in life-limiting withdrawal syndromes. Unplanned cessation may occur due to dysphagia or decreased alertness, amongst other reasons. Planned acute discontinuation occurs during surgery or a medical necessity for a 'nil per os' policy (such as hospitalizations for gastrointestinal diseases). Non-oral alternatives are available, such as transdermal rotigotine, subcutaneous apomorphine, and levodopa delivered subcutaneously or via an enteral tube. Selecting the best treatment can be difficult and should be based upon clinical considerations, patient preference and be tailored to the care setting. These considerations will differ during the course of disease. For example, more invasive treatment options can be considered in hospitalized persons with early to moderate-stage disease, whereas symptomatic palliative treatments are more appropriate towards the end of life. Here, we discuss several practical considerations for three, partially overlapping, but conceptually distinct moments at which acute discontinuation or cessation events occur: during hospitalization (including surgery), late-stage disease and end of life. We stress the need for prevention and early advance care planning and present a stepwise pharmacological approach to address unplanned acute cessation or planned discontinuation.","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"1062-1077"},"PeriodicalIF":5.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parkinson's disease and routine traffic stops: An exploration of patient experiences and perceptions. 帕金森氏症和日常交通停车：探索患者的经验和看法。

IF 5 3区医学

Journal of Parkinson's disease Pub Date : 2025-09-01 Epub Date: 2025-07-15 DOI: 10.1177/1877718X251356514

Rebecca Eilish Irvine, Alexis P Kruger, Alfred Quaicoe, Roshni Kotwani, Anna DePold Hohler, Okeanis Vaou

引用次数: 0

Utility of a newly created questionnaire on subtle motor symptoms in high-risk subjects with Parkinson's disease. 帕金森病高危人群细微运动症状调查问卷的应用

IF 5 3区医学

Journal of Parkinson's disease Pub Date : 2025-09-01 Epub Date: 2025-07-27 DOI: 10.1177/1877718X251361506

Daigo Tamakoshi, Keita Hiraga, Taiki Fukushima, Takashi Uematsu, Takashi Tsuboi, Maki Sato, Makoto Hattori, Yuki Satake, Atsushi Hashizume, Masayuki Yamamoto, Hideaki Shimizu, Masakazu Wakai, Masahisa Katsuno

{"title":"Utility of a newly created questionnaire on subtle motor symptoms in high-risk subjects with Parkinson's disease.","authors":"Daigo Tamakoshi, Keita Hiraga, Taiki Fukushima, Takashi Uematsu, Takashi Tsuboi, Maki Sato, Makoto Hattori, Yuki Satake, Atsushi Hashizume, Masayuki Yamamoto, Hideaki Shimizu, Masakazu Wakai, Masahisa Katsuno","doi":"10.1177/1877718X251361506","DOIUrl":"10.1177/1877718X251361506","url":null,"abstract":"BackgroundProdromes of Parkinson's disease (PD) include both motor and non-motor symptoms. Although questionnaires have been established for non-motor symptoms, no quantitative self-assessment tool has been developed to assess subtle motor symptoms during the prodromal stage.ObjectiveTo develop a self-administered questionnaire to assess subtle motor symptoms during the prodromal stage.MethodsWe created the Screening Questionnaire for Subtle Parkinsonism (SQSP). The SQSP and questionnaires on non-motor symptoms were collected from health checkup examinees. Individuals with ≥ 2 non-motor symptoms, including autonomic dysfunction, hyposmia, and REM sleep behavior disorder, were classified as high-risk, while those without these symptoms were low-risk. We also conducted comprehensive evaluations, including neurological examinations and imaging tests, on 30 patients with PD, 71 high-risk, and 24 low-risk subjects.ResultsAmong 1183 health checkup examinees, high-risk subjects had higher SQSP scores than low-risk (9 [4-15] vs. 3 [1-6]). Patients with PD had the highest SQSP scores, followed by high-risk subjects and then low-risk. SQSP scores correlated with MDS-UPDRS II and III scores and specific binding ratios of DaT-SPECT. High-risk subjects with abnormal DaT-SPECT had higher SQSP scores than those with normal imaging (9 [7-19] vs. 5.5 [2-10]). Although 26 of the 71 high-risk and 23 of the 24 low-risk subjects scored zero on the MDS-UPDRS II, most high-risk and half low-risk subjects had SQSP scores above zero.ConclusionsThe SQSP was deemed effective for assessing subtle motor symptoms during the prodromal stage of PD and identifying prodromal PD cases within the general population.","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"1086-1098"},"PeriodicalIF":5.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Care partner needs in Parkinson's disease: A systematic review of qualitative and quantitative data. 帕金森病患者的护理伙伴需求：对定性和定量数据的系统回顾。

IF 5 3区医学

Journal of Parkinson's disease Pub Date : 2025-09-01 Epub Date: 2025-05-30 DOI: 10.1177/1877718X251344066

Max Hulshoff, Christine Sun, Elaine Book, Caroline Tanner, Nabila Dahodwala, Brenda Reynolds, Heather Boon, Connie Marras

{"title":"Care partner needs in Parkinson's disease: A systematic review of qualitative and quantitative data.","authors":"Max Hulshoff, Christine Sun, Elaine Book, Caroline Tanner, Nabila Dahodwala, Brenda Reynolds, Heather Boon, Connie Marras","doi":"10.1177/1877718X251344066","DOIUrl":"10.1177/1877718X251344066","url":null,"abstract":"BackgroundCare for persons with Parkinson's disease (PD) is to a great extent carried out by care partners. It is important to understand their needs to ease their burden and help with their important role.ObjectiveTo present (1) what is known about needs in caregiving for someone with PD from both qualitative and quantitative papers; and (2) to identify research gaps in the existing literature to guide future research.MethodsA systematic search was conducted, searching PubMed, CINAHL, PsychINFO, and MEDLINE for both qualitative and quantitative studies examining care partner needs in Parkinson's disease published from the start of the databases up to 13 November 2024. The best-fit framework synthesis method was employed for qualitative data extraction and analysis. The Critical Appraisal Skills Programme (CASP) and the Newcastle-Ottawa Scale (NOS) were used for quality assessment of studies.ResultsForty-eight qualitative studies, ten quantitative studies, and three mixed methods studies met the eligibility criteria. All studies were of observational, cross-sectional design. A total of nine themes (the need for information, the need to be heard, PD healthcare, emotional support, daily living, financial support, skills, care partner physical well-being, and respite care) were identified from qualitative data and all quantitative data could fit this framework. Quantitative data on the frequency of needs and when they arise over the course of PD were scarce. Only one quantitative study made use of a validated measurement instrument to measure care partner needs, the Family Needs Questionnaire.ConclusionsCare partner needs in PD are wide-ranging. A significant gap identified is the absence of quantitative data to determine the prevalence, timing, and factor contributing to the needs revealed by the qualitative research.","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"1043-1061"},"PeriodicalIF":5.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0