Journal of Parkinson's disease最新文献

{"title":"Relating movement behaviours and non-motor characteristics in people with Parkinson's disease: A compositional data analysis approach.","authors":"Kristina Larsson, Hanna Johansson, Daniel Peterson, Jenny Sedhed, Breiffni Leavy","doi":"10.1177/1877718X251384816","DOIUrl":"https://doi.org/10.1177/1877718X251384816","url":null,"abstract":"<p><p>BackgroundPeople with Parkinson's disease (PwPD) have unhealthier movement behaviours (less moderate-to-vigorous physical activity (MVPA) and more sedentary behaviour (SB)), than healthy older adults. Associations across movement patterns and non-motor characteristics are poorly understood.ObjectivesTo investigate associations between relative time spent in MVPA, light-intensity physical activities (LIPA) and SB, and non-motor characteristics among PwPD, and to investigate theoretical changes in non-motor characteristics when time in different movement behaviours is reallocated.MethodsBaseline data from 119 participants in the STEPS randomised controlled trial was used. Movement behaviours were measured by ActiGraph GT3X accelerometers. Compositional data analysis assessed relative time in MVPA, LIPA and SB. Linear regression assessed associations between MVPA, LIPA and SB and self-reported anxiety and depression (HADS), executive function (TMT IV), self-efficacy for exercise (S-ESES) and activities-specific balance confidence (ABC). Isotemporal substitution modelling investigated theoretical changes in outcomes when time in MVPA, LIPA and SB were reallocated.ResultsBetter executive function was associated with more relative time in MVPA and less in LIPA. Higher exercise-self-efficacy was associated with more relative time in MVPA and less in SB. Better balance confidence related to more relative time in MVPA. Reallocating time showed that losing 20 min MVPA had a worse theoretical impact for these outcomes than the benefit of gaining 20 min.ConclusionsThe observed relationships between MVPA and executive function, balance confidence, and exercise-self-efficacy suggests particular importance of maintaining MVPA in PwPD. These findings can be utilized clinically by communicating the importance of maintaining time in MVPA among PwPD.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"1877718X251384816"},"PeriodicalIF":5.0,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Buspirone regulates cortico-striatal gamma oscillations to ameliorate dyskinesia.","authors":"Han Liu, Ruizuo Wang, Yuming Xu, Weina Dai, Pengfei Wang","doi":"10.1177/1877718X251380196","DOIUrl":"https://doi.org/10.1177/1877718X251380196","url":null,"abstract":"<p><p>BackgroundLevodopa-induced dyskinesia (LID) in Parkinson's disease (PD) is linked to exaggerated gamma oscillations. Buspirone, a 5-HT1A receptor agonist, is a potent medication for psychiatric conditions, predominantly prescribed for anxiety treatment.ObjectiveThis study aims to investigate whether buspirone alleviates dyskinesia in LID rat and its effects on pathological oscillatory activity and cortico-striatal functional connectivity.MethodsWe collected motor behavior and electrophysiological data of cortico-striatal from Sham rats, unilateral 6-hydroxydopamine (6-OHDA)-lesioned PD model rats, and rats with LID. We further examined the behavioral and electrophysiological changes in LID rats following buspirone intervention.ResultsPD rats showed increased beta activity and aperiodic components at 10-50 Hz, while LID rats exhibited excessive gamma oscillations and aperiodic activity at 50-150 Hz. Additionally, gamma-band functional connectivity within the cortico-striatal circuit was significantly enhanced during on-state dyskinesia, when rats exhibited abnormal involuntary movements. Administration of buspirone effectively reduced dyskinesia severity, suppressed gamma activity, decreased aperiodic components (50-150 Hz), and disrupted gamma-band functional connectivity without compromising the antiparkinsonian effects of levodopa.ConclusionsExcessive gamma oscillations represent a key electrophysiological marker of dyskinesia. Altered gamma-band connectivity within the cortico-striatal network may contribute to its pathophysiology. Buspirone appears to be a promising candidate for the treatment of LID, potentially offering a novel therapeutic strategy.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"1877718X251380196"},"PeriodicalIF":5.0,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parkinson's disease participant-led research: Towards neuroimaging-assisted deep brain stimulation programming.","authors":"Mark D McAuley, Alena A Ionova, Andreas Horn, Ethan Heming, Celestina A Onabajo, Madison M Solie, Sara A Stephenson, Susan E Boehnke","doi":"10.1177/1877718X251381454","DOIUrl":"https://doi.org/10.1177/1877718X251381454","url":null,"abstract":"<p><p>Deep brain stimulation (DBS) can improve Parkinson's disease symptoms; however, its effectiveness depends on selecting optimal settings. DBS parameter selection can be challenging, as objective metrics to guide the process are lacking. This n-of-1 study explored using functional near-infrared spectroscopy (fNIRS) to guide DBS programming. Led by the participant, the study embedded a patient perspective at the center of the project. Multiple DBS settings were tested, and their effects on gait and cortical functional connectivity were measured. The DBS program that best supported gait had the lowest functional connectivity with the left dorsolateral prefrontal cortex as seed. This suggests fNIRS may be used to guide individual optimization of DBS treatment.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"1877718X251381454"},"PeriodicalIF":5.0,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PARKinSOUND: Impact of participation in an orchestra in patients with Parkinson's disease.","authors":"Sofia Lopes, Sofia Marques, Andreia Ferreira, Ana Rita Silva, Octavia Costa, Sara Varanda, Gisela Carneiro, Pedro Santos, Ana Goios, Margarida Rodrigues","doi":"10.1177/1877718X251381089","DOIUrl":"https://doi.org/10.1177/1877718X251381089","url":null,"abstract":"<p><p>Music therapy has emerged as a promising complementary intervention for Parkinson's disease (PD). PARKinSOUND, a non-randomized clinical trial, evaluated the feasibility of a community orchestra intervention for individuals with PD (n = 22), compared to a control group (n = 21). After the intervention, the orchestra group showed a modest improvement in depressive symptoms compared to baseline (Beck Depression Inventory: -0.5, p = 0.049) and controls (-5.5, p = 0.011), while motor scores (MDS-UPDRS III) remained stable. Self-reported overall improvements (PGI-C) were also higher in the orchestra group (p = 0.003). Although placebo effects may partly explain the benefits, these findings suggest emotional benefits and perceived overall improvement, providing insights for future research.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"1877718X251381089"},"PeriodicalIF":5.0,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A longitudinal study on physical activity in early Parkinson's disease.","authors":"Samuel Yong-Ern Ng, Darakhshan Naheed, Ehsan Seyed Saffari, Nicole Shuang-Yu Chia, Xinyi Choi, Dede Liana Heng, Shermyn Xiu-Min Neo, Zheyu Xu, Kay-Yaw Tay, Wing-Lok Au, Eng-King Tan, Louis Chew-Seng Tan","doi":"10.1177/1877718X251380487","DOIUrl":"https://doi.org/10.1177/1877718X251380487","url":null,"abstract":"<p><p>Physical activity (PA) remains critical in the slowing of disease progression in early Parkinson's disease (PD), although the longitudinal follow-up of such studies remain scarce. Using data from an early PD Cohort, we longitudinally examined the impact of unprescribed PA on symptoms of early PD, controlling for demographics and medications. Over five years, the reported PA in early PD declined significantly annually. When maintained, the overall PA had significant association with improved motor symptoms, cognition, and quality of life<b>.</b> Higher PA maintained longitudinally is associated with a slower progression of motor and non-motor symptoms, and predict better quality of life in patients with early PD.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"1877718X251380487"},"PeriodicalIF":5.0,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative measurements of α-synuclein seeds in CSF inform diagnosis of synucleinopathies.","authors":"Ilham Y Abdi, Indulekha P Sudhakaran, Simona S Ghanem, Nishant N Vaikath, Nour Majbour, Yee Y Goh, Nirosen Vijiaratnam, Christine Girges, Vasilios C Constantinides, Elisabeth Kapaki, George P Paraskevas, Sandrina Weber, Gholam Adeli, Kostas Vekrellis, Daniel Erskine, Michele Hu, Thomas Foltynie, Henry Houlden, Laura Parkkinen, Wilma Dj van de Berg, Brit Mollenhauer, Michael G Schlossmacher, Omar Ma El-Agnaf","doi":"10.1177/1877718X251379292","DOIUrl":"https://doi.org/10.1177/1877718X251379292","url":null,"abstract":"<p><p>Diagnosing α-synucleinopathies and assessing target engagement in trials is hindered by the lack of reliable biomarkers. Here, we introduce a first-in-kind quantitative, highly sensitive, and disease-specific diagnostic assay, named Seeding Amplification ImmunoAssay (SAIA), developed and validated to detect synucleinopathy-linked disorders. To this end, we used wide range of specimens, including 38 brain homogenates (BH) and 559 cerebrospinal fluid (CSF) samples from subjects with diverse synucleinopathy disorders, non-synucleinopathy diseases, idiopathic REM sleep behavior disorder (iRBD), and controls. SAIA generated robust results detecting disease-related α-synuclein seeds in BH samples at attogram levels, as referenced to preformed fibrils of α-synuclein. Furthermore, we conducted side-by-side comparisons between SAIA and a traditional Seeding Amplification Assay (SAA), which revealed high concordance. Further, SAIA distinguished synucleinopathies from non-synucleinopathies and controls with sensitivities and specificities ranging between 80-100% and area under the curve values exceeding 0.9. SAIA also accurately identified 24/24 (100%) iRBD cases, considered a prodromal state of PD, with 100% sensitivity and 80% specificity. Further optimization of SAIA through timepoint analyses revealed that shorter incubation times enhanced the assay's specificity for distinguishing MSA from PD highlighting the potential for improved differentiation between specific synucleinopathies. In conclusion, SAIA represents a novel, high-throughput method to screen, diagnose, and monitor synucleinopathy disorders in living subjects, offering significant improvements over existing methods through its quantitative output, shorter incubation time, and simplified workflow, features that enhance its suitability for clinical trial applications.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"1877718X251379292"},"PeriodicalIF":5.0,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevention of cognitive impairment and dementia in people with Parkinson's disease: A call-to-action.","authors":"Elke Kalbe, Tobias Warnecke, Carsten Eggers, Anja Ophey, Ann-Kristin Folkerts","doi":"10.1177/1877718X251365769","DOIUrl":"https://doi.org/10.1177/1877718X251365769","url":null,"abstract":"<p><p>Mild cognitive impairment and dementia are common symptoms in people with Parkinson's disease (PwPD) that impair the quality of life of those affected. However, PD-specific concepts for the prevention of cognitive decline are rarely incorporated into routine care. Here, we provide key data on cognitive impairment in PwPD and a framework for primary, secondary, and tertiary prevention in this context. The importance of cognitive reserve as a protective buffer for cognitive decline in PwPD is highlighted. Relevant lifestyle and health-related factors, including cognitive aspects, physical and social activity, diet, hearing loss, and cardiovascular factors, are discussed. Evidence on the efficacy of possible cognition-enhancing interventions in PwPD-pharmacological, cognitive, physical, nutritional, and multidomain interventions-is summarized. On this basis, and the recommendations of the European Task Force for Brain Health Services, a proposal is developed outlining options for preventing cognitive impairment in PwPD that could be implemented in routine care, as well as further developments needed to achieve a best-case scenario. The main pillars of a strategic agenda for this purpose include: (i) regular assessment of cognitive state, overall risk, and risk factors for cognitive decline; (ii) risk communication and education concerning modifiable risk factors with standardized procedures; (iii) risk reduction with multi-domain interventions for secondary prevention; and (iv) cognitive enhancement with cognitive and physical training for tertiary prevention. As the proposal makes clear, the prevention of cognitive impairment in PwPD requires interdisciplinary collaboration organized throughout PD care networks.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"1877718X251365769"},"PeriodicalIF":5.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface electromyographic profiles during gait initiation in people with Parkinson's disease: The effects of external sensory cueing.","authors":"Lesley A Perg, Chiahao Lu, Matthew N Petrucci, Jae Woo Chung, Paul J Tuite, Colum D MacKinnon, Sommer L Amundsen-Huffmaster","doi":"10.1177/1877718X251382575","DOIUrl":"https://doi.org/10.1177/1877718X251382575","url":null,"abstract":"<p><p>BackgroundImpaired gait initiation is a debilitating motor symptom in people with Parkinson's disease (PD). During self-paced (uncued) gait initiation, anticipatory postural adjustments (APAs) are often absent or attenuated, and the first steps are abnormally short. External sensory cues can significantly improve APAs.ObjectiveThe effect of external cueing on lower limb muscle activation during gait initiation, compared to self-initiated steps, was examined in people with PD and healthy older adults (HOA).MethodsGround reaction forces, center of pressure excursions, and lower-limb surface electromyographic profiles (in seven bilateral muscles) were examined in 32 individuals with PD (off-medication) and 10 age-matched HOA during the APA and first step of self-paced or acoustically cued gait initiation.ResultsAnterior (tibialis anterior, vastus lateralis, rectus femoris) and gluteus medius muscles were primarily activated during the early phases of gait initiation, while later phases predominantly involved posterior (soleus, gastrocnemius, biceps femoris) and gluteus medius activations. Cueing facilitated anterior muscles and suppressed posterior muscle activity in both groups, however, activation patterns in PD were not restored to HOA levels. Instead, the PD group had lower early activity during the APA (compared to HOA) and higher late activity.ConclusionsCueing increased anterior muscle activation during gait initiation, rather than evoking a global gain across muscles and timings, demonstrating that cueing predominantly facilitates neural circuitry critical for early APA phases. People with PD showed enhanced late phase activity, probably to compensate for ineffective APAs, and thus have a stronger need to facilitate cue-evoked improvements.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"1877718X251382575"},"PeriodicalIF":5.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advice to people with Parkinson's in my clinic: How to manage running-induced dystonia.","authors":"Michele L Callisaya, Jane Alty, Dave de Groot, Guillaume Lamotte, Nijee Luthra, Kathleen E McKee, Emily J Su, Daniel M Corcos","doi":"10.1177/1877718X251372786","DOIUrl":"https://doi.org/10.1177/1877718X251372786","url":null,"abstract":"<p><p>Exercise is an essential part of the treatment of Parkinson's disease. However, certain symptoms can make exercise difficult. In this viewpoint, we describe an under recognized symptom called running-induced dystonia (RID), which can prevent people with Parkinson's from exercising in their preferred way. We summarize the existing literature and use three case studies to outline potential mechanisms, aggravating and relieving factors and both pharmacological and non-pharmacological therapies to get rid of RID.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"1877718X251372786"},"PeriodicalIF":5.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145176135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the brain: The colorectal impact of Parkinson's disease.","authors":"Sidra Khan, Aparna Gupta, Aman Agarwal, Mohammad Ajaz Alam, Sai Gautham Kanagala, Rohit Jain","doi":"10.1177/1877718X251380261","DOIUrl":"https://doi.org/10.1177/1877718X251380261","url":null,"abstract":"<p><p>Parkinson's disease (PD) is a rapidly developing neurodegenerative disorder characterized by degeneration of dopaminergic neurons in the basal ganglia of the brain. Its prevalence is estimated to exceed 1.2 million cases in the United States by 2030. Emerging evidence suggests that PD may originate in the gut and hence is linked to gastrointestinal (GI) dysfunctions such as inflammatory bowel disease and GI cancers. Colorectal cancer (CRC) is one of the most common cancers seen worldwide. It shares several risk factors with PD, including advancing age, male gender, genetic predispositions, and environmental exposures. Although these shared factors indicate a possible correlation, the studies evaluating this relationship have suggested inconsistent results. Some research proposes an increased risk of CRC in PD patients, potentially due to overlapping genetic and inflammatory pathways. Alternatively, others argue an inverse relationship due to opposing underlying mechanisms of neuro degeneration in PD and cellular proliferation in CRC. This narrative review explores the intricate relationship between PD and CRC and seeks to understand how neurodegenerative and malignant diseases may overlap.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"1877718X251380261"},"PeriodicalIF":5.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}