Journal of Parkinson's disease最新文献_第10页

Predictive potential of circular walking in prodromal Parkinson's disease. 绕圈行走对前驱帕金森病的预测潜力。

IF 4 3区医学

Journal of Parkinson's disease Pub Date : 2025-02-01 Epub Date: 2025-01-14 DOI: 10.1177/1877718X241306141

M Encarna Micó-Amigo, Idsart Kingma, Sebastian Heinzel, Susanne Solbrig, Markus A Hobert, Morad Elshehabi, Kathrin Brockmann, Florian G Metzger, Rob C van Lummel, Daniela Berg, Walter Maetzler, Jaap H van Dieën

{"title":"Predictive potential of circular walking in prodromal Parkinson's disease.","authors":"M Encarna Micó-Amigo, Idsart Kingma, Sebastian Heinzel, Susanne Solbrig, Markus A Hobert, Morad Elshehabi, Kathrin Brockmann, Florian G Metzger, Rob C van Lummel, Daniela Berg, Walter Maetzler, Jaap H van Dieën","doi":"10.1177/1877718X241306141","DOIUrl":"10.1177/1877718X241306141","url":null,"abstract":"BackgroundDevelopment of objective, reliable and easy-to-use methods to detect the onset of motor changes in Parkinson's disease (PD) is required to identify the temporal window in which neuromodulatory therapies could be implemented. Turning impairments are present at early stages of PD. However, it is unclear, to date, whether circular walking is also altered in prodromal PD.ObjectiveExplore the predictive potential of circular walking in prodromal PD.MethodsWe included 102 subjects from a nine-year prospective cohort study (with 712 participants) in the current nested case-control analysis: 16 diagnosed with PD during follow-up (incident PD) and 96 healthy controls, matched in gender, age, and education with a 1:6 ratio. Forty-one gait features were extracted from baseline assessments with accelerometers under single and dual-tasking conditions. A Cox proportional hazards regression analysis was used to test the temporal association of non-correlated gait features to the probability of being diagnosed with PD.ResultsWe identified associations between time from baseline measurement to PD diagnosis for eleven gait features, mostly based on harmonic ratios, step and stride variability, and index of harmonicity, partially in combination with gait speed. Most significant associations indicated that low gait symmetry and low rhythmicity were associated with larger hazard of being diagnosed with PD. Area under the curve ranged 0.63-0.69.ConclusionsDespite low sensitivity and specificity, the findings potentially reflect prodromal motor impairments of PD manifested during circular walking, assessed quantitatively with a low-cost and wearable instrument. This will contribute to the characterization of pre-diagnostic PD motor symptoms.","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"140-153"},"PeriodicalIF":4.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Opicapone for Parkinson's disease-related sleep disturbances: The OASIS clinical trial. Opicapone治疗帕金森病相关睡眠障碍：OASIS临床试验

IF 4 3区医学

Journal of Parkinson's disease Pub Date : 2025-02-01 Epub Date: 2025-01-17 DOI: 10.1177/1877718X241306711

Joaquim J Ferreira, Miguel F Gago, Raquel Costa, Miguel M Fonseca, Joana Almeida, José Francisco Rocha, Joerg Holenz, Claudia Trenkwalder

{"title":"Opicapone for Parkinson's disease-related sleep disturbances: The OASIS clinical trial.","authors":"Joaquim J Ferreira, Miguel F Gago, Raquel Costa, Miguel M Fonseca, Joana Almeida, José Francisco Rocha, Joerg Holenz, Claudia Trenkwalder","doi":"10.1177/1877718X241306711","DOIUrl":"10.1177/1877718X241306711","url":null,"abstract":"BackgroundWhile sleep disturbances are among the most frequent non-motor symptoms of Parkinson's disease (PD), there is a lack of evidence to support its treatment.ObjectiveTo evaluate the efficacy of opicapone 50 mg in treating sleep disturbances in patients with PD and end-of-dose motor fluctuations.MethodsOASIS was an exploratory, open-label, single-arm clinical trial in PD patients with end-of-dose motor fluctuations and associated sleep disturbances. The primary endpoint was change from baseline to week 6 in Parkinson's Disease Sleep Scale 2 (PDSS-2). Secondary endpoints included functional motor and non-motor assessments (Movement Disorder Society [MDS]-Unified Parkinson's Disease Rating Scale [UPDRS], MDS-Non-motor Scale [NMS], 8-item PD Questionnaire [PDQ-8], 16-item PD Fatigue Scale [PFS-16], ON/OFF home diary), Clinical and Patient Global Impression of Change (CGI-C; PGI-C) and adverse events.ResultsAt week 6, there was a significant reduction of -7.9 points (95%CI -13.6, -2.2; p = 0.0099) in PDSS-2 total score, with a significant mean change of -4.7 in the PDSS-2 domain of disturbed sleep (95%CI: -7.2, -2.3; p = 0.0009). Significant reductions were also observed in PFS-16 (-9.6; p = 0.0211), MDS-NMS total score (-28.9; p = 0.0015), MDS-UPDRS-III (-6.3; p = 0.0253), MDS-UPDRS-IV (-1.2; p = 0.0044) and PDQ-8 (-14.2; p = 0.0051). Absolute OFF-time was reduced (-142.1 min). Most patients (93.3%) and most clinicians (80.0%) reported improvements on PGI-C and CGI-C, respectively. Opicapone was well tolerated.ConclusionsAdding opicapone 50 mg to levodopa/DDCI therapy in patients with PD and motor fluctuations and sleep disturbances improved both sleep disturbances and OFF time in these patients.","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"87-96"},"PeriodicalIF":4.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estimation of and clinical consensus on the meaningful motor progression threshold on MDS-UPDRS Part III. MDS-UPDRS中有意义运动进展阈值的估计和临床共识（第三部分）。

IF 4 3区医学

Journal of Parkinson's disease Pub Date : 2025-02-01 Epub Date: 2025-01-14 DOI: 10.1177/1877718X241302337

Dylan Trundell, Evan W Davies, Louise Barrett, Stefano Zanigni, Nima Shariati, Rebecca Rogers, Annabelle Monnet, Emma Moore, Nathalie Pross, Gennaro Pagano, Stefan Cano, Tania Nikolcheva

{"title":"Estimation of and clinical consensus on the meaningful motor progression threshold on MDS-UPDRS Part III.","authors":"Dylan Trundell, Evan W Davies, Louise Barrett, Stefano Zanigni, Nima Shariati, Rebecca Rogers, Annabelle Monnet, Emma Moore, Nathalie Pross, Gennaro Pagano, Stefan Cano, Tania Nikolcheva","doi":"10.1177/1877718X241302337","DOIUrl":"10.1177/1877718X241302337","url":null,"abstract":"BackgroundTo understand changes in the underlying progression of early Parkinson's disease, it is important to derive estimates of the threshold for meaningful motor progression on the MDS-UPDRS Part III in OFF medication state.ObjectiveTo estimate this threshold using two approaches: anchor-based analyses, and clinical consensus via a modified Delphi panel.MethodsFor the anchor-based analyses, data from a Phase II clinical trial were used. Mean and median MDS-UPDRS Part III change scores were calculated for those participants rated as 'Minimally worse' on the Clinical Global Impression of Improvement (using the first visit rated as 'Minimally worse' or worse, and at Weeks 24 and 52). Cumulative data up to Week 104 were used to assess the difference between motor progressors' and non-progressors' change scores on motor-related outcomes. For the modified Delphi panel, a panel of 13 expert clinicians received an online survey in two rounds and provided responses anonymously.ResultsFor the anchor-based analyses, estimates of meaningful change ranged from 4-6 points. Numerically worse change scores were identified on motor-related outcomes for participants who had experienced motor progression compared with those who had not. For the modified Delphi panel, consensus was reached in Round 2, with 92% agreeing that 5 points is suitable to define a clinically meaningful motor progression threshold.ConclusionsResults of the anchor-based analyses and modified Delphi panel were consistent, supporting a meaningful motor progression threshold of a worsening of 5 points on the MDS-UPDRS Part III (OFF medication state) in an early Parkinson's disease population.","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"97-110"},"PeriodicalIF":4.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New insights from a Malaysian real-world deep brain stimulation cohort. 来自马来西亚现实世界深部脑刺激队列的新见解。

IF 4 3区医学

Journal of Parkinson's disease Pub Date : 2025-02-01 Epub Date: 2024-12-08 DOI: 10.1177/1877718X241297715

Alfand Marl F Dy Closas, Ai Huey Tan, Yi Wen Tay, Jia Wei Hor, Tzi Shin Toh, Jia Lun Lim, Choey Yee Lew, Chun Yoong Cham, Carolyn Chue Wai Yim, Kok Yoon Chee, Chong Guan Ng, Lei Cheng Lit, Anis Nadhirah Khairul Anuar, Lara M Lange, Zih-Hua Fang, Sara Bandres Ciga, Katja Lohmann, Christine Klein, Azlina Ahmad-Annuar, Kalai Arasu Muthusamy, Shen-Yang Lim

{"title":"New insights from a Malaysian real-world deep brain stimulation cohort.","authors":"Alfand Marl F Dy Closas, Ai Huey Tan, Yi Wen Tay, Jia Wei Hor, Tzi Shin Toh, Jia Lun Lim, Choey Yee Lew, Chun Yoong Cham, Carolyn Chue Wai Yim, Kok Yoon Chee, Chong Guan Ng, Lei Cheng Lit, Anis Nadhirah Khairul Anuar, Lara M Lange, Zih-Hua Fang, Sara Bandres Ciga, Katja Lohmann, Christine Klein, Azlina Ahmad-Annuar, Kalai Arasu Muthusamy, Shen-Yang Lim","doi":"10.1177/1877718X241297715","DOIUrl":"10.1177/1877718X241297715","url":null,"abstract":"BackgroundThe availability of deep brain stimulation (DBS), a highly efficacious treatment for several movement disorders, remains low in developing countries, with scarce data available on utilization and outcomes.ObjectiveWe characterized the DBS cohort and outcomes at a Malaysian quaternary medical center.MethodsA retrospective chart review was done on DBS-related surgery at the University of Malaya, including clinico-demographic, genetics, and outcomes data focusing on post-operative medication reduction and complications.Results149 Parkinson's disease (PD) patients underwent DBS targeting the subthalamic nucleus. Six had globus pallidus internus DBS (primarily for dystonia). Only 16.1% of patients were government-funded. Of the 133 PD patients operated in the past decade (2013-2022), 25 (18.8%) had disease duration <5 years. At 6-12 months post-DBS, median levodopa-equivalent daily dose (LEDD) reduction was 440.5 [418.9] mg/day, corresponding to a reduction of ≥50% and ≥30% in 42.2% and 69.8% of patients, respectively. LEDD reductions were larger in the early-onset and short-duration subgroups. Three patients (1.9% of 155) had symptomatic intracranial hemorrhage, resulting in stroke in two. Pathogenic monogenic or GBA1 variants were detected in 12/76 (16%) of patients tested, mostly comprising the \"severe\" GBA1 variant p.L483P (12%).ConclusionsThis is the largest report on DBS from Southeast Asia. The procedures were effective, and complication rates on par with international norms. Our study found a high frequency of GBA1-PD; and included a substantial number of patients with short-duration PD, who had good outcomes. It also highlights regional inequities in access to device-aided therapy.","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"189-201"},"PeriodicalIF":4.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic connectivity of freezing in Parkinson's disease. 帕金森病中冷冻的代谢联系。

IF 4 3区医学

Journal of Parkinson's disease Pub Date : 2025-02-01 Epub Date: 2024-12-27 DOI: 10.1177/1877718X241305713

Céline Tard, Arnaud Delval, Luc Defebvre, Pierre Lenfant, David Devos, Caroline Moreau, Nacim Betrouni

{"title":"Metabolic connectivity of freezing in Parkinson's disease.","authors":"Céline Tard, Arnaud Delval, Luc Defebvre, Pierre Lenfant, David Devos, Caroline Moreau, Nacim Betrouni","doi":"10.1177/1877718X241305713","DOIUrl":"10.1177/1877718X241305713","url":null,"abstract":"BackgroundFreezing of gait (FoG) is among the most disabling gait disorders of Parkinson's disease. The full understanding of its mechanisms requires a network study approach. So far, FoG was mainly studied using magnetic resonance imaging, and especially using the resting state functional sequence, which does not completely reflect the brain actual modifications.ObjectiveThis study aims to investigate metabolic networks using position emission tomography (PET) imaging. Exploration after a rest or gait session combined with a delayed tracer's uptake are assumed to reflect the actual metabolism modifications.MethodsTwenty-six patients in the off-drug state underwent two PET imaging sessions using [18F]- fluorodeoxyglucose, the first after 30 min of rest (rest condition) and the second after 30 min of real gait (gait condition). Twelve patients presented real FoG during cerebral glucose uptake. Brain connectivity matrices were measured for each group and condition, and then compared.ResultsIn the rest condition, the freezing group showed globally reduced metabolic connectivity between brain regions compared to the non-freezing group. During gait, enhanced connectivity was observed in the cerebellum, cerebello-cortical loops and parieto-frontal regions, with high recruitment of the visual cortex in the freezing group. However, connectivity inside cerebellar networks remained lower in the freezing group than in the non-freezing group, while occipito-frontal connectivity was higher in the freezing group.ConclusionsStudying real freezing of gait in a vertical position emphasized the role of the visual cortex and cerebellum in gait problems.","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"154-162"},"PeriodicalIF":4.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Freezing of gait detection: The effect of sensor type, position, activities, datasets, and machine learning model. 步态检测的冻结：传感器类型、位置、活动、数据集和机器学习模型的影响。

IF 4 3区医学

Journal of Parkinson's disease Pub Date : 2025-02-01 Epub Date: 2025-03-16 DOI: 10.1177/1877718X241302766

Luigi Borzì, Florenc Demrozi, Ruggero Angelo Bacchin, Cristian Turetta, Luis Sigcha, Domiziana Rinaldi, Giuliana Fazzina, Giulio Balestro, Alessandro Picelli, Graziano Pravadelli, Gabriella Olmo, Stefano Tamburin, Leonardo Lopiano, Carlo Alberto Artusi

{"title":"Freezing of gait detection: The effect of sensor type, position, activities, datasets, and machine learning model.","authors":"Luigi Borzì, Florenc Demrozi, Ruggero Angelo Bacchin, Cristian Turetta, Luis Sigcha, Domiziana Rinaldi, Giuliana Fazzina, Giulio Balestro, Alessandro Picelli, Graziano Pravadelli, Gabriella Olmo, Stefano Tamburin, Leonardo Lopiano, Carlo Alberto Artusi","doi":"10.1177/1877718X241302766","DOIUrl":"10.1177/1877718X241302766","url":null,"abstract":"BackgroundFreezing of gait (FoG) is a complex, frequent, and disabling motor symptom of Parkinson's disease (PD). Wearable technology has the potential to improve FoG assessment by providing objective, quantitative, and continuous monitoring.ObjectiveThis study aims to develop a robust FoG detection algorithm that can be embedded in a simple and unobtrusive wearable sensor system and can lead to a reliable unsupervised home assessment.MethodsTwenty-two subjects with PD and FoG were enrolled, equipped with four inertial modules on the ankles, back, and wrist, and asked to perform different tasks. Feature-driven and data-driven machine learning approaches were implemented, optimized, and evaluated. Further testing was conducted on two external datasets including a total of 545 FoG episodes.ResultsSixteen subjects experienced FoG, providing a total number of 101 FoG events. Results demonstrated that a single sensor on the ankle, with an adequate algorithm of data analysis based on machine learning, can provide a non-invasive approach for accurate FoG detection. The model proved robust on the independent datasets, with 88-95% FoG episodes correctly detected. Interestingly, while FoG can be easily discriminated from walking, static positions, and postural transitions, turning represents a significant challenge. The high number of false alarms still represents the main limitation of the FoG recognition algorithms.ConclusionsThe collected dataset includes data from different sensors at different body positions. This, together with detailed labeling of tasks, activities, FoG episodes and their severity, can be a significant contribution to research on automatic FoG detection and characterization.","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"163-181"},"PeriodicalIF":4.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurotrophic factors for Parkinson's disease: Current status, progress, and remaining questions. Conclusions from a 2023 workshop. 帕金森病的神经营养因子：现状、进展和遗留问题来自2023年研讨会的结论。

IF 4 3区医学

Journal of Parkinson's disease Pub Date : 2024-11-01 Epub Date: 2024-12-27 DOI: 10.1177/1877718X241301041

Roger A Barker, Mart Saarma, Clive N Svendsen, Catherine Morgan, Alan Whone, Massimo S Fiandaca, Matthias Luz, Krystof S Bankiewicz, Brian Fiske, Lyndsey Isaacs, Arthur Roach, Thomas Phipps, Jeffrey H Kordower, Emma L Lane, Henri J Huttunen, Aideen Sullivan, Gerard O'Keeffe, Valeria Yartseva, Howard Federoff

{"title":"Neurotrophic factors for Parkinson's disease: Current status, progress, and remaining questions. Conclusions from a 2023 workshop.","authors":"Roger A Barker, Mart Saarma, Clive N Svendsen, Catherine Morgan, Alan Whone, Massimo S Fiandaca, Matthias Luz, Krystof S Bankiewicz, Brian Fiske, Lyndsey Isaacs, Arthur Roach, Thomas Phipps, Jeffrey H Kordower, Emma L Lane, Henri J Huttunen, Aideen Sullivan, Gerard O'Keeffe, Valeria Yartseva, Howard Federoff","doi":"10.1177/1877718X241301041","DOIUrl":"10.1177/1877718X241301041","url":null,"abstract":"In 2023, a workshop was organized by the UK charity Cure Parkinson's with The Michael J Fox Foundation for Parkinson's Research and Parkinson's UK to review the field of growth factors (GFs) for Parkinson's disease (PD). This was a follow up to a previous meeting held in 2019.1 This 2023 workshop reviewed new relevant data that has emerged in the intervening 4 years around the development of new GFs and better models for studying them including the merit of combining treatments as well as therapies that can be modulated. We also discussed new insights into GF delivery and trial design that have emerged from the analyses of completed GDNF trials, including the patient voice, as well as the recently completed CDNF trial.2 We then concluded with our recommendations on how GF studies in PD should develop going forward.","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":"14 8","pages":"1659-1676"},"PeriodicalIF":4.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acknowledgment to reviewers 2024. 感谢审稿人2024年。

IF 4 3区医学

Journal of Parkinson's disease Pub Date : 2024-11-01 Epub Date: 2025-01-14 DOI: 10.1177/1877718X241305891

引用次数: 0

IF 4 3区医学

Journal of Parkinson's disease Pub Date : 2024-11-01 Epub Date: 2024-11-04 DOI: 10.3233/JPD-240267

Roy Dayan, Atira S Bick, Caroline Weill, Max Bauer, Halen Baker Erdman, Zvi Israel, Hagai Bergman, Netta Levin, David Arkadir

{"title":"Atrophy-related corticospinal changes in advanced Parkinson's disease are associated with the genetic etiology of the disease.","authors":"Roy Dayan, Atira S Bick, Caroline Weill, Max Bauer, Halen Baker Erdman, Zvi Israel, Hagai Bergman, Netta Levin, David Arkadir","doi":"10.3233/JPD-240267","DOIUrl":"10.3233/JPD-240267","url":null,"abstract":"Background: Compensatory mechanisms in Parkinson's disease (PD) are thought to explain the temporal delay between the beginning of the neurodegenerative process and the appearance of clinical signs. The enhanced structural integrity of the corticospinal tract was previously suggested as one of these mechanisms.Objective: To understand the relations between corticospinal tract integrity and the anatomical, clinical, electrophysiological, and genetic PD characteristics.Methods: We analyzed diffusion tensor imaging (DTI) fractional anisotropy (FA) data from 40 genotyped patients with PD (18 without known genetic cause, 11 with LRRK2-PD and 11 with GBA-PD) who were candidates for subthalamic deep brain stimulation (STN-DBS) and from 25 healthy, age-matched, controls.Results: PD is associated with higher corticospinal FA values (p < 0.001) that are negatively correlated with the disease duration (p = 0.032), confirming previous results. Higher FA values are negatively correlated with cerebral grey matter volumes (p < 0.001) but not with the motor or cognitive PD characteristics, or with the subthalamic beta-oscillatory activity measured intra-operatively. Increased corticospinal FA values are strongly affected by the genetic etiology of PD, with higher values in the monogenic forms of the disease (p < 0.001). The compensatory index, calculated by dividing the corticostriatal FA value by the cerebral grey matter volume, is highest in GBA-PD (p < 0.001) at the time of evaluation for STN-DBS.Conclusions: The genetic etiology of PD strongly shapes corticospinal tract changes along with disease-duration and cerebral grey matter atrophy. The changes may serve as compensatory mechanism.","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":"14 8","pages":"1584-1593"},"PeriodicalIF":4.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical prognostic factors in progressive supranuclear palsy: Implications for clinical trials. 进行性核上性麻痹的临床预后因素：对临床试验的影响。

IF 4 3区医学

Journal of Parkinson's disease Pub Date : 2024-11-01 Epub Date: 2024-12-08 DOI: 10.1177/1877718X241291996

Félix Marchand, Anne-Sophie Blaise, Luc Defebvre, Emeline Cailliau, Stéphanie Bombois, David Devos, Caroline Moreau

{"title":"Clinical prognostic factors in progressive supranuclear palsy: Implications for clinical trials.","authors":"Félix Marchand, Anne-Sophie Blaise, Luc Defebvre, Emeline Cailliau, Stéphanie Bombois, David Devos, Caroline Moreau","doi":"10.1177/1877718X241291996","DOIUrl":"10.1177/1877718X241291996","url":null,"abstract":"Background: Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease with diverse clinical phenotypes, prompting the development of new diagnostic criteria known as the MDS-PSP classification. However, little is known about the prognostic value of this classification in order to better stratify patients for the clinical trials.Objective: To assess the impact of the different clinical phenotypes according to the MDS-PSP classification on prognosis using the clinical milestones of death, severe dysphagia, institutionalization, and need for walking aid.Methods: A prospective cohort of 205 PSP patients from Lille University Hospital was analyzed retrospectively. Patients were classified into different MSD-PSP phenotypes according to their clinical presentation after 3 years of follow-up. The milestones of death, severe dysphagia, institutionalization, and need for walking aid were recorded, and a survival analysis was performed to describe the prognosis of each disease presentation.Results: Median survival time was 6.4 (interquartile range (IQR): 4.8-8.6) years and mean diagnostic delay from symptom onset was 38.1 ± 22.5 months. PSP Richardson Syndrome (PSP-RS) had a poorer survival rate and a higher occurrence of severe dysphagia and need for walking aid compared to PSP variants such as PSP Parkinsonism (PSP-P), PSP postural instability without ocular motor dysfunction (PSP-PI), and other rare phenotypes.Conclusions: PSP-RS has a less favorable prognosis compared to PSP variants stratified according to the MDS-PSP classification. This classification could assist in selecting patients for clinical trials and help design outcomes that account for the disease heterogeneity.","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":"14 8","pages":"1652-1658"},"PeriodicalIF":4.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0