Journal of Parkinson's disease最新文献

{"title":"Cerebral metabolic trajectories alterations in multiple system atrophy: A longitudinal FDG-PET study.","authors":"Yixin Zhao, Huamei Lin, Xinyi Li, Qi Shen, Jing Wang, Chuantao Zuo, Jian Wang, Jingjie Ge, Feng-Tao Liu","doi":"10.1177/1877718X261455593","DOIUrl":"10.1177/1877718X261455593","url":null,"abstract":"<p><p>Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disorder with different metabolic patterns in parkinsonian (MSA-P) and cerebellar (MSA-C) subtypes, but their longitudinal changes are not well understood. To characterize longitudinal changes of glucose metabolism and network connectivity in MSA using ¹⁸F-FDG-PET for early diagnosis and disease progression tracking, we retrospectively analyzed 29 MSA patients (17 MSA-P, 12 MSA-C) and 28 healthy controls. Regional glucose uptake was assessed as standardized uptake value ratios (SUVR). We examined inter-regional connectivity via correlation analysis and modeled metabolic decline using nonlinear mixed-effects models. Clinical progression was measured using the Unified Multiple System Atrophy Rating Scale (UMSARS). MSA-P displayed progressive hypometabolism in the putamen, cerebellum, and frontal cortex, while MSA-C showed declines primarily in the cerebellum and frontal regions. Longitudinal modeling indicated a faster putaminal decline in MSA-P (<i>β</i> = -0.015 ± 0.006) than in MSA-C (<i>β</i> = 0 ± 0.011), whereas cerebellar metabolism declined over time in both groups with overlapping slopes in MSA-P (<i>β</i> = -0.022 ± 0.006) and MSA-C (<i>β</i> = -0.022 ± 0.011). Regional metabolic reductions correlated with UMSARS progression (putamen in MSA-P: <i>r</i> = -0.59, <i>p</i> < 0.001; cerebellum in MSA-C: <i>r</i> = -0.62, <i>p</i> < 0.001). Significant connectivity disruptions were noted in frontal, basal ganglia, and cerebellar-parietal circuits. Longitudinal FDG-PET reveals distinct metabolic decline patterns in MSA subtypes-putamen in MSA-P and cerebellum in MSA-C-linked to clinical severity. These findings may inform clinical practice and trial design, supporting the use of FDG-PET for biological staging, monitoring disease progression, and potentially evaluating treatment responses.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"992-1001"},"PeriodicalIF":5.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13435192/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148042719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Celebrating the legacy of two decades of Parkinson's disease research in South Africa.","authors":"Khaleila Flisher, Amy Claire Buck, Jessica Burns, Lusanda Madula, Kathryn Step, Katherine Atkinson, Debbie Acker, Riaan van Coller, Jonathan A Carr, Soraya Bardien","doi":"10.1177/1877718X261457797","DOIUrl":"10.1177/1877718X261457797","url":null,"abstract":"<p><p>Plain language summary<b>Celebrating the legacy of two decades of Parkinson's disease research in South Africa</b>Parkinson's disease (PD) has been well-studied in Western Countries, but there are far fewer studies in other parts of the world, especially in Africa. This lack of research is partly because there are insufficient neurologists in many African countries, leading to missed or incorrect diagnoses. Stigma around PD and the absence of national disease registries also make research more difficult. To help fill this gap, our team has spent the past 20 years studying PD in South Africa. We have built a collection of almost 2,000 South African participants and report our main findings here. Overall, we found only 20 PD-causing variants in our collection of 689 unrelated PD cases. Interestingly, some of these genetic findings appear to be unique to South Africans, likely due to the unique genetic composition of the country's population. Our functional studies showed how variants in genes, such as <i>PRKN</i> and <i>LRRK2</i>, disrupt the function of mitochondria. Mitochondria are tiny structures in cells that supply the energy required for the cells to function. Cells die when they do not have the necessary energy, potentially explaining why brain cells die in PD. A third part of our research focuses on curcumin, a natural compound found in turmeric known for its antioxidant and anti-inflammatory effects. Using cell models, including cells from individuals with PD, we found that curcumin can protect cells from damage caused by paraquat, a harmful chemical which has been linked to the development of PD. However, this rescue is only seen when curcumin is given before the damage occurs. This suggests that curcumin may help prevent neuronal loss in PD. In summary, our work adds to global knowledge about the genetics, disease processes, and possible treatments for PD. It also shows what a small African laboratory can achieve, despite limited personnel and resources.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"1041-1045"},"PeriodicalIF":5.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13579119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Planning for prevention of Parkinson's and related synucleinopathies: A trial design forum (conference abstracts).","authors":"","doi":"10.1177/1877718X261441451","DOIUrl":"10.1177/1877718X261441451","url":null,"abstract":"","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"1046-1067"},"PeriodicalIF":5.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13435158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147982000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Declining verbal fluency after DBS in Parkinson's disease: Mental speed or executive dysfunction?","authors":"Vivianne H M Pennings, Esmée Verwijk, Rob M A de Bie, Rick Schuurman, Gert J Geurtsen","doi":"10.1177/1877718X261455458","DOIUrl":"10.1177/1877718X261455458","url":null,"abstract":"<p><p>BackgroundDespite the frequent decline in verbal fluency after STN-DBS surgery, the cause of decline remains unclear.ObjectiveThis study investigates whether mental speed and executive dysfunctions are underlying mechanisms of the phonemic verbal fluency decline after STN-DBS in Parkinson's patients.MethodsNeuropsychological assessments consisting of phonemic verbal fluency, Trail Making Test (TMT), and Stroop test were conducted before and 6 months after STN-DBS in 94 Parkinson's patients in the Galaxy Trial. A Reliable Change Index (RCI) pre- versus postoperative of verbal fluency was calculated, representing the magnitude of change. Content assessment of phonemic verbal fluency resulted in content profiles (clusters and switches).ResultsA statistically significant decline in postoperative phonemic verbal fluency was found, with statistically significant declined switching, while cluster size remained stable. Postoperative, statistically significant increases in time to perform TMT-B and all Stroop subtests was found. However, phonemic verbal fluency decline was correlated to change scores of Stroop I and II only. Comparisons of declined (<i>N</i> = 23) and improved (<i>N</i> = 11) patients, according to RCI's, revealed that decliners had higher preoperative phonemic verbal fluency scores.ConclusionsPostoperative phonemic verbal fluency decline could not be explained by the proposed underlying mechanisms of mental speed and executive dysfunction. However, the significant correlation of phonemic verbal fluency decline to Stroop I and II change scores suggests other possible underlying mechanisms, like slower speech.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"1012-1021"},"PeriodicalIF":5.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13435166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148101473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deficits in episodic memory and executive functions in relation to CB1 receptor availability in Parkinson's disease.","authors":"Riikka M Ajalin, Haidar Al-Abdulrasul, Jouni M Tuisku, Mira Karrasch, Jussi Hirvonen, Anna K Kirjavainen, Henrik Zetterberg, Juha O Rinne, Anna E Brück","doi":"10.1177/1877718X261457830","DOIUrl":"10.1177/1877718X261457830","url":null,"abstract":"<p><p>BackgroundThe endocannabinoid system (ECS) is important for several neurophysiological functions, including the regulation of emotions and cognitive processes. The most abundant brain cannabinoid receptor is cannabinoid receptor type 1 (CB1R). Several preclinical studies in Parkinson's disease (PD) models suggest that modulating CB1R may impact cognitive processing. However, there are very limited studies of the relation between CB1R and cognitive processing in PD patients.ObjectiveTo explore the relationship between CB1R availability and cognitive dysfunction in PD with [18F]FMPEP-d2 positron emission tomography (PET).MethodsA total of 23 individuals with PD underwent [18F]FMPEP-d2 PET to measure cerebral CB1R availability. Cognitive symptoms were evaluated using a standardized neuropsychological test battery covering various cognitive domains, such as episodic and working memory, executive functioning, language function, visuospatial function and attention, and were correlated with CB1R availability using voxel-wise regression analysis corrected for multiple comparisons using false discovery rate (FDR) at p < 0.01.ResultsPD patients with poorer performance in episodic memory tests showed lower CB1R availability, particularly in the cingulate, temporal, and visual cortices, and thalami. Also, PD patients with poorer executive functioning showed lower CB1R availability predominantly in the insulae, caudate nuclei, thalami, brainstem, and temporal cortices. No relationship was found between CB1R availability and language function, visuospatial function, or working memory capacity.ConclusionsDecreased CB1R availability in PD patients is correlated with episodic memory impairment and executive dysfunction, suggesting that the ECS has a role in the pathophysiology of cognitive symptoms in PD.Plain language summary titleProblems with Episodic Memory or Executive Functions are Related to Disturbances in Endocannabinoid System Functioning in Parkinson's Disease.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"980-991"},"PeriodicalIF":5.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13435193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148330523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Off-State dyspnea induced by diaphragmatic-chest wall asynchrony in Parkinson's disease: A novel observation and review of the literature.","authors":"Wen-Che Li, Li-Ta Keng, Kai-Hsiang Stanley Chen","doi":"10.1177/1877718X261455572","DOIUrl":"10.1177/1877718X261455572","url":null,"abstract":"<p><p></p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"1037-1040"},"PeriodicalIF":5.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13435168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148205229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Content and quality analysis of YouTube videos on therapeutic exercises for Parkinson's disease.","authors":"Anıl Tosun, Duygu Aktar Reyhanioglu","doi":"10.1177/1877718X261438620","DOIUrl":"10.1177/1877718X261438620","url":null,"abstract":"<p><p>BackgroundParkinson's disease (PD) is the most common movement disorder, and patients increasingly use YouTube to obtain health-related information.ObjectiveThis study aimed to assess the content quality and informational reliability of YouTube videos on PD exercises.MethodsA total of 150 English-language YouTube videos were screened using the search terms \"Parkinson exercises\", \"Parkinson physiotherapy exercises\", and \"Parkinson home exercise program\". For each video, the source, upload date, number of views, likes, dislikes, and comments were recorded. The Video Power Index (VPI) was assessed using the view ratio (views/day) and like ratio (likes × 100 / [likes + dislikes]). The clinical quality, reliability, and educational value of PD-specific exercise videos were assessed using the Global Quality Scale (GQS), modified DISCERN (mDISCERN), and guideline-based criteria derived from the European Physiotherapy Guideline for Parkinson's Disease (PD-GEC).ResultsA total of 29 videos met the inclusion criteria and were analyzed. Videos explaining how and why exercises were performed demonstrated higher mDiscern and GQS scores, while providing repetition, duration, and intensity information was associated with higher GQS scores but not mDiscern (p = 0.080); no differences were observed for disease specificity, functional linkage, or safety warnings (all p > 0.05). PD-GEC scores were not significantly related to video engagement metrics.ConclusionHigher-quality videos tended to provide clear explanations of exercise rationale and dosage, while guideline-based clinical features, including PD-GEC criteria, were not associated with viewer engagement.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"956-964"},"PeriodicalIF":5.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13435159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential effects of levodopa on social cognition in people with Parkinson's disease.","authors":"Teodor Danaila, Élise Métereau, Hélène Klinger, Adélaide Jaulent, Océane Porte, Léon Tremblay, Paul Jaulent, Chloé Laurencin, Stéphane Prange, Stéphane Thobois","doi":"10.1177/1877718X261435304","DOIUrl":"10.1177/1877718X261435304","url":null,"abstract":"<p><p>Social cognition impairment is a frequent non-motor feature of Parkinson's disease. While dopaminergic therapy modulates motor symptoms, its effects on social cognition remain incompletely understood. We investigated the effects of acute levodopa administration on cognitive and affective Theory of Mind, as well as on emotional resonance to dynamic whole-body social interactions, in 36 people with Parkinson's disease with motor fluctuations and 14 matched healthy controls. Social cognition was assessed using the Mini-Social Cognition and Emotional Assessment (Mini-SEA) and a point-light display task indexing emotional resonance through emotional valence ratings. Patients were evaluated in OFF and ON states during an acute dopaminergic challenge performed according to the CAPSIT-PD protocol, with responsiveness defined as an improvement greater than 50% on the MDS-UPDRS part III. Compared with healthy controls, patients showed impaired cognitive Theory of Mind performance, particularly on the faux pas subtest (p = 0.0001), while affective Theory of Mind based on facial emotion recognition was preserved. Acute levodopa did not improve cognitive or affective Theory of Mind (faux pas OFF vs ON, p = 0.7049). In contrast, emotional resonance was impaired in the OFF state and selectively improved in the ON state, with increased ratings of positive (p = 0.0035) and negative (p = 0.0387) emotional valence. These findings demonstrate a dissociation between Theory of Mind and emotional resonance in Parkinson's disease and show that acute levodopa selectively modulates emotional resonance without restoring Theory of Mind abilities.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"947-955"},"PeriodicalIF":5.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13435218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early alcohol initiation is associated with higher lifetime Parkinson's disease risk after accounting for exposure latency.","authors":"Jung-Chen Chang, Amy Ming-Fang Yen, Sam Li-Sheng Chen, Horng-Huei Liou, Tony Hsiu-Hsi Chen","doi":"10.1177/1877718X261453796","DOIUrl":"10.1177/1877718X261453796","url":null,"abstract":"<p><p>BackgroundObservational evidence linking alcohol consumption to Parkinson's disease (PD) is inconsistent, potentially because conventional analyses do not account for the long latency between alcohol initiation and clinical onset or diagnosis.ObjectiveTo test whether latency-aware modeling changes alcohol-PD associations and whether earlier initiation increases lifetime risk.MethodsWe applied a latency-explicit semi-Markov framework in two longitudinal, community-based screening cohorts in Taiwan. The Keelung cohort (Community A; n = 23,475; aged ≥60 years; 2002-2005) was used for model development, and the Changhua cohort (Community B; n = 90,129; aged ≥50 years; 2005-2022) was used for external application. We compared conventional logistic regression with latency-adjusted relative rates, conducted smoking-stratified analyses, and benchmarked age-specific projections against an independent door-to-door PD survey.ResultsIn Community A, conventional regression suggested an inverse association (odds ratio 0.69; 95% confidence interval 0.53-0.91), whereas latency-adjusted modeling indicated higher PD risk among drinkers (relative rate 1.61; 95% confidence interval 1.32-1.95). Excess risk emerged ∼25, ∼35, and ∼45 years after initiation at ages 20, 30, and 40 years, respectively; alcohol-attributable risk by age 90 was 32.1%, 20.7%, and 4.9%. Smoking shortened estimated latency by 5 years. In Community B, PD incidence was higher among drinkers than non-drinkers, with wider separation at older ages (70-74 years: 58.6 vs 46.0 per 100,000).ConclusionAccounting for exposure timing and latency reversed the apparent protective signal and supported a higher modeled lifetime PD risk with alcohol use, particularly earlier initiation. Incorporating latency may strengthen etiologic inference and inform long-horizon prevention strategies.Plain language summary titleBecause Parkinson's disease develops slowly, early drinking may matter later in life.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"904-913"},"PeriodicalIF":5.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13435163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148015952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in sex-specific single-cell transcriptomic profiling in Parkinson's disease.","authors":"Vivien Hoof, Julia Schulze-Hentrich","doi":"10.1177/1877718X261436548","DOIUrl":"10.1177/1877718X261436548","url":null,"abstract":"<p><p>Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons and the accumulation of misfolded alpha-synuclein. While traditional bulk RNA-sequencing has provided valuable insights into PD pathology, it fails to capture the complex cellular heterogeneity of the human brain. Advances in single-cell transcriptomics have revolutionized our ability to dissect this complexity, enabling the identification of rare, disease-associated cell populations, or the inference of dysregulated intercellular communication networks. In this review, we discuss methodological and analytical frameworks of single-cell RNA-sequencing and summarize key findings from recent studies using single-cell RNA-sequencing that advance our understanding of PD. We highlight how single-cell transcriptomics has refined our understanding of neuronal vulnerability and revealed critical contributions of non-neuronal cells, particularly microglia and oligodendrocytes, to disease pathology in both human postmortem tissue and experimental model systems. Finally, we discuss emerging evidence for sex-specific molecular alterations in PD and emphasize the importance of sex-aware study design and analysis in future single-cell PD research.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"809-825"},"PeriodicalIF":5.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13435199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147839186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}