Journal of Parkinson's disease最新文献_第9页

The fixel GI Parkinson's research and integrated support model (PRISM). fixel GI帕金森病研究及综合支持模型（PRISM）。

IF 4 3区医学

Journal of Parkinson's disease Pub Date : 2025-05-01 Epub Date: 2025-04-17 DOI: 10.1177/1877718X251335047

Grace Hey, Manuel Amaris, Matthew Beke, Nur Walker-Pizarro, Candice Rogers, Vinata Vedam-Mai, Rachael Dorsey, Nicole Herndon, Michael S Okun, Adolfo Ramirez-Zamora

{"title":"The fixel GI Parkinson's research and integrated support model (PRISM).","authors":"Grace Hey, Manuel Amaris, Matthew Beke, Nur Walker-Pizarro, Candice Rogers, Vinata Vedam-Mai, Rachael Dorsey, Nicole Herndon, Michael S Okun, Adolfo Ramirez-Zamora","doi":"10.1177/1877718X251335047","DOIUrl":"10.1177/1877718X251335047","url":null,"abstract":"BackgroundThe complexity of gastrointestinal (GI) disorders associated with Parkinson's disease (PD) and the significant interactions between GI medications and the dopaminergic axis necessitates expert management. The integrated care model for disorders of the brain-gut interaction (DBGI) has advantages, however, has not been applied in concurrent DBGI and PD.ObjectiveTo test the hypothesis that our Parkinson's Research and Integrated Support Model (PRISM) will reduce symptom severity and improve the quality of life (QOL) in patients with GI symptoms associated with PD.MethodsPatients with refractory GI symptoms referred to the PRISM clinic were evaluated and treated by the integrated efforts of movement disorder specialists, neurogastroenterologists, dietitians, occupational therapists, speech-swallow therapists, and neuroscientists. Patients underwent a battery of GI symptoms and QOL questionnaires and personalized actionable biomarkers (motility testing and swallowing studies). Inflammatory markers and stool tests were collected. An individualized standard of care treatment was established based on the specific DBGI diagnosis uncovered during the PRISM evaluation.Results44 adult PD patients with GI complaints were evaluated. The most common symptoms included constipation (97%), dysphagia (61%), and gastroesophageal reflux (34%). Actionable biomarkers were highly positive revealing esophageal dysmotility (20/21, 95%), slow-transit constipation (40/42, 90%), intestinal methanogen overgrowth (7/8, 87%), gastroparesis (17/20, 85%), oropharyngeal dysphagia (28/44, 63%), and dyssynergic defecation (27/42, 61%). GI symptom severity and QOL significantly improved (p < 0.05) as measured by all questionnaires.ConclusionsMore severely affected patients with Parkinson's treated with the Fixel PRISM approach showed significant improvements in GI symptom frequency, severity, and QOL.","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"573-584"},"PeriodicalIF":4.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum to "Decline of olfactory function in Parkinson's disease: A ten-year longitudinal study". “帕金森病嗅觉功能衰退：一项十年纵向研究”的勘误。

IF 4 3区医学

Journal of Parkinson's disease Pub Date : 2025-05-01 Epub Date: 2025-04-02 DOI: 10.1177/1877718X251333920

引用次数: 0

Integrating virtual reality into multidisciplinary care for Parkinson's disease: A narrative review. 将虚拟现实整合到帕金森病的多学科治疗中：叙述性回顾。

IF 4 3区医学

Journal of Parkinson's disease Pub Date : 2025-05-01 Epub Date: 2025-03-16 DOI: 10.1177/1877718X251323916

Daniela Pimenta Silva, Filipa Pona-Ferreira, Ricardo Cacho, Beatriz Santos, Teresa Lobo, Raquel Bouça-Machado, Joaquim J Ferreira

{"title":"Integrating virtual reality into multidisciplinary care for Parkinson's disease: A narrative review.","authors":"Daniela Pimenta Silva, Filipa Pona-Ferreira, Ricardo Cacho, Beatriz Santos, Teresa Lobo, Raquel Bouça-Machado, Joaquim J Ferreira","doi":"10.1177/1877718X251323916","DOIUrl":"10.1177/1877718X251323916","url":null,"abstract":"Parkinson's disease (PD) is a neurodegenerative disorder characterized by both motor and non-motor symptoms, significantly impacting patients' functionality and quality of life. Clinical exercise, as part of a multidisciplinary approach, is gaining a crucial role in PD management. Goal-based exercises, combining physical activity with cognitive tasks, external feedback and cues, motor sequencing strategies and dual-tasking may enhance motor learning processes and guide physiotherapy programs.Virtual reality (VR) and exergaming have also emerged as promising tools in PD rehabilitation, offering challenging activities in multisensory environments. They provide intensive and repetitive training, augmented feedback, and tailored exercises in highly interactive and enriched environments. Clinical studies have presented promising results in people with PD, supported by neuroimaging studies showing distinct brain activation patterns post-VR training. However, heterogeneity in study design and lack of standardized characterization of VR systems hinder further application in PD rehabilitation.In this review, we appraise the distinguishing features between different VR systems, highlight VR-related motor and cognitive training in PD and explore how VR interventions are aligned with principles of neuroplasticity and motor learning in PD.","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"459-479"},"PeriodicalIF":4.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is motor reserve associated with a rapid progression of Parkinson disease? 运动储备与帕金森病的快速进展有关吗？

IF 4 3区医学

Journal of Parkinson's disease Pub Date : 2025-05-01 Epub Date: 2025-03-24 DOI: 10.1177/1877718X251324413

Myung Jun Lee, Kyoungjune Pak, Jae-Hyeok Lee, Seok Jong Chung, Min Seok Baek

{"title":"Is motor reserve associated with a rapid progression of Parkinson disease?","authors":"Myung Jun Lee, Kyoungjune Pak, Jae-Hyeok Lee, Seok Jong Chung, Min Seok Baek","doi":"10.1177/1877718X251324413","DOIUrl":"10.1177/1877718X251324413","url":null,"abstract":"BackgroundThe motor reserve estimates (MRes) derived from a residual approach correlate with motor severity in Parkinson's disease (PD), leaving the independent effect of motor reserve on clinical outcomes unclear.ObjectiveInvestigate the independent influence of motor reserve on the long-term outcome.MethodsUsing the Parkinson's Progression Markers Initiative (PPMI) and Pusan National University Hospital (PNUH) datasets, we investigated the association of MRes with progression of motor severity as well as risk of phenoconversion to Hoehn & Yahr (H&Y) stage 3. Two MRes types were calculated: (1) original MRes, negative conversion of standardized residuals from a generalized linear model (GLM) between putaminal dopamine transporter (DAT) levels and motor severity, and (2) modified MRes, standardized residuals from the GLM between original MRes and motor scores.ResultsOriginal MRes correlated with baseline motor scores, while modified MRes did not. Modified MRes in both cohorts were associated with a rapid increase in motor severity (linear mixed effect model, interaction between MRes and disease duration; PPMI, Movement Disorder Society sponsored Unified Parkinson Disease Rating Scale part III [MDS-UPDRS III], estimate 2.248 × 10-3, p < 0.001; PNUH, UPDRS III, estimate 0.027, p = 0.014) In both cohorts, Kaplan-Meier plots showed high modified MRes indicated higher risk of progression to H&Y stage 3. Mediation models using original MRes agreed that high MRes were associated with an accelerated increase in motor scores.ConclusionsIndependent of baseline motor severity, MRes were associated with rapid motor deterioration and high risk of progression to H&Y stage 3.","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"552-560"},"PeriodicalIF":4.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk of Parkinson's disease in older people with tremor: A population-based prospective study. 老年震颤患者帕金森病的风险：一项基于人群的前瞻性研究

IF 4 3区医学

Journal of Parkinson's disease Pub Date : 2025-05-01 Epub Date: 2025-03-24 DOI: 10.1177/1877718X251327138

Xitong Xu, Jie Chen, Shaozhen Ji, MeiJie Chen, Shuying Liu, Piu Chan

{"title":"Risk of Parkinson's disease in older people with tremor: A population-based prospective study.","authors":"Xitong Xu, Jie Chen, Shaozhen Ji, MeiJie Chen, Shuying Liu, Piu Chan","doi":"10.1177/1877718X251327138","DOIUrl":"10.1177/1877718X251327138","url":null,"abstract":"BackgroundTremor is prevalent among older adults and is suggested to be associated with the subsequent development of Parkinson's disease (PD). However, prospective evidence for the association is scarce.ObjectiveThis population-based prospective study aimed to estimate PD risk and to explore predictive factors for PD conversion in community-dwelling older people with tremor.MethodsThe study was based on the Beijing Longitudinal Study on Aging (BLSA) II. Tremor was assessed using a validated self-administered method. Participants without parkinsonism and with any tremor were followed for an average of 7.7 years. The standardized incidence ratio (SIR) was used to estimate the risk of developing PD in older people with tremor, with age- and sex-specific incidence rates of PD in the general Chinese population as a reference. Risk factors, prodromal symptoms, and tremor features were assessed to identify predictors for incident PD.ResultsSeventeen (8.4%) of 202 participants with tremor developed parkinsonism, including 9 (4.4%) diagnosed with PD. The presence of any tremor was associated with an increased risk of developing PD (SIR: 3.12, 95% confidence interval [CI]: 1.52-5.73). Sensitivity analyses yielded similar results. Probable REM sleep behavior disorder (RBD), identified using the RBD Questionnaire-Hong Kong, and self-report of new-onset rest tremor predicted PD conversion.ConclusionsTremor is associated with an elevated risk of PD in the general older population. Screening for RBD and monitoring the evolution of tremor characteristics using simple questionnaires may help identify individuals at high risk for PD among community-dwelling older adults with tremor.","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"531-540"},"PeriodicalIF":4.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parkinson's disease participant-led research on the impact of deep brain stimulation frequency. 帕金森病参与者主导的深部脑刺激频率影响研究。

IF 5 3区医学

Journal of Parkinson's disease Pub Date : 2025-05-01 Epub Date: 2025-04-11 DOI: 10.1177/1877718X251331904

Mark D McAuley, John M Dean, Ethan Heming, Alena A Ionova, Celestina A Onabajo, Madison Solie, Sara A Stephenson, Susan E Boehnke

引用次数: 0

Fears and uncertainties of people with Parkinson's disease. 帕金森氏症患者的恐惧和不确定性。

IF 4 3区医学

Journal of Parkinson's disease Pub Date : 2025-05-01 Epub Date: 2025-04-03 DOI: 10.1177/1877718X251328565

Esme D Trahair, Darby Steiger, Nashay Lowe, Robyn Rapoport, Caitlin Kelliher, Stephanie Benvengo, Catherine Kopil, Lana M Chahine, Connie Marras, Sneha Mantri

{"title":"Fears and uncertainties of people with Parkinson's disease.","authors":"Esme D Trahair, Darby Steiger, Nashay Lowe, Robyn Rapoport, Caitlin Kelliher, Stephanie Benvengo, Catherine Kopil, Lana M Chahine, Connie Marras, Sneha Mantri","doi":"10.1177/1877718X251328565","DOIUrl":"10.1177/1877718X251328565","url":null,"abstract":"BackgroundThe patient experience of Parkinson's disease (PD) is heterogeneous, with limited prognostic tools to predict individual outcomes, leading to significant uncertainty for people with PD. Under-recognition of both psychosocial and biological drivers of fear and uncertainty in Parkinson's disease (PD) by clinicians may further contribute to patient distress.ObjectiveThe objective of the present study is to investigate fear and uncertainty in people with PD.MethodsIn-depth interviews were conducted with twenty people with PD (11 semi-structured, 9 guided/prompted). Thematic analysis organized the fears/uncertainties by topic as well as by contextual factors such as the timing of the fear (e.g., active or anticipatory; at the time of diagnosis or developed subsequent to diagnosis) and the lexicon used to describe it.ResultsParticipants expressed a wide range of fears and uncertainties about their future and quality of life with PD, which shifted with disease progression. Most fears were anticipatory rather than in response to current concerns. Participants reported substantial psychosocial influence from media personalities or family/friends with PD. Most participants reported that they had not disclosed their fears to their healthcare providers.ConclusionsClinicians caring for people with PD should be aware of a range of often-unspoken fears and uncertainties, which may carry a substantial psychosocial burden. Open acknowledgement and normalization by clinicians may help patients feel less isolated in their disease.","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"595-602"},"PeriodicalIF":4.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advice to people with Parkinson's in my clinic: Get a cardiopulmonary exercise test. 给我诊所帕金森患者的建议是：做一个心肺运动测试。

IF 4 3区医学

Journal of Parkinson's disease Pub Date : 2025-05-01 Epub Date: 2025-04-13 DOI: 10.1177/1877718X251330814

Garett J Griffith, Kathleen E McKee, Guillaume Lamotte, Nijee S Luthra, Daniel M Corcos

引用次数: 0

Seeding amplification assay: Limitations and insights for enhanced clinical and research applications. 种子扩增试验：增强临床和研究应用的局限性和见解。

IF 4 3区医学

Journal of Parkinson's disease Pub Date : 2025-05-01 Epub Date: 2025-03-02 DOI: 10.1177/1877718X251325124

Ilham Y Abdi, Sara A Hashish, Omar A El-Agnaf

{"title":"Seeding amplification assay: Limitations and insights for enhanced clinical and research applications.","authors":"Ilham Y Abdi, Sara A Hashish, Omar A El-Agnaf","doi":"10.1177/1877718X251325124","DOIUrl":"10.1177/1877718X251325124","url":null,"abstract":"The accurate diagnosis of synucleinopathies-neurodegenerative diseases marked by misfolded α-synuclein protein aggregates, such as Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy-remains a critical challenge. Conventional clinical criteria, frequently verified only through postmortem examination, results in diagnostic delays that impede timely intervention. Seeding amplification assay (SAA) has emerged as a promising diagnostic tool, offering high sensitivity for detecting α-synuclein aggregates even in early disease stages. While SAA enables early diagnosis by amplifying misfolded α-synuclein in biological samples, several barriers exist, including a lack of assay standardization, technical complexity, and difficulty differentiating among synucleinopathies. Additionally, the current SAA is primarily qualitative, limiting their ability to correlate with disease severity or progression. This review addresses these limitations by examining pre-analytical and analytical factors influencing SAA performance and exploring emerging quantitative approaches. Recent advancements include the integration of SAA with quantitative methodologies, which hold promise for enhanced diagnostic accuracy and clinical applicability. SAA's potential as a diagnostic and monitoring tool is significant and can be further improved by validation in longitudinal studies. The clinical implementation of SAA could revolutionize the early detection and management of synucleinopathies, ultimately improving patient outcomes through earlier diagnosis and tailored therapeutic strategies.","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"447-458"},"PeriodicalIF":4.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The potential of distributed diagnostics for the early detection of Parkinson's disease. 分布式诊断在帕金森病早期检测中的潜力。

IF 4 3区医学

Journal of Parkinson's disease Pub Date : 2025-05-01 Epub Date: 2025-04-17 DOI: 10.1177/1877718X251336118

Amit Khanna, James Beck, Kathleen Poston, Michael A Schwarzschild, Graham B Jones

{"title":"The potential of distributed diagnostics for the early detection of Parkinson's disease.","authors":"Amit Khanna, James Beck, Kathleen Poston, Michael A Schwarzschild, Graham B Jones","doi":"10.1177/1877718X251336118","DOIUrl":"10.1177/1877718X251336118","url":null,"abstract":"Parkinson's disease represents a major healthcare burden with over 1 million confirmed cases and economic costs of care exceeding $50 billion in the United States alone. A challenge in the evaluation of potentially disease delaying, preventing, or reversing agents is identification of patients in the very early, prodromal (asymptomatic, non-motor, or early motor) stages, which can span decades. Currently, diagnosis is based almost exclusively on clinical history and physical examination conducted by trained experts. Unfortunately for many patients, access to neurology and movement disorder specialists is geographically limited and coupled with the absence of coordinated disease awareness campaigns can contribute to substantial delays in diagnosis. As with any campaign, a key success factor is having multiple approaches which can appeal to a wide range of patient archetypes. Herein we elaborate on some emerging opportunities, which if fully developed could invigorate the approach to early detection and, critically, engage patients in this process. They include 1) Use of personal digital health technologies and community based point-of-care diagnostic instrumentation, 2) The potential to leverage annual testing services at non-traditional venues including optometry, dental and pharmacy, and 3) A consumer focused campaign to raise awareness of the importance of early detection, paralleling efforts in other diseases. There is every hope that combining traditional and non-traditional approaches to enhance early diagnosis rates can have an overall positive impact on patient outcomes and contribute substantively to efforts to develop new interventions. We urge the community to embrace these possibilities and begin active dialog on how to thoughtfully implement the approaches into routine care.","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"646-653"},"PeriodicalIF":4.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0