Subcortical tau burden correlates with regional brain atrophy and plasma markers in four-repeat tauopathy parkinsonism.

IF 4 3区 医学 Q2 NEUROSCIENCES
Journal of Parkinson's disease Pub Date : 2025-02-01 Epub Date: 2024-12-08 DOI:10.1177/1877718X241298192
Cheng-Hsuan Li, Sung-Pin Fan, Ming-Chieh Shih, Yi-Hsin Weng, Ta-Fu Chen, Hsun Li, Mei-Fang Cheng, Ming-Che Kuo, Pei-Ling Peng, Makoto Higuchi, Ing-Tsung Hsiao, Kun-Ju Lin, Chin-Hsien Lin
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引用次数: 0

Abstract

Background18F-florzolotau positron emission tomography (PET) assists in the in vivo diagnosis of progressive supranuclear palsy (PSP).ObjectiveWe aimed to investigate the relationship between 18F-florzolotau uptake and clinical severity, structural volume changes, and plasma markers in four-repeat tauopathies.MethodsA total of 80 participants were recruited: 35 with PSP (11 with PSP-Richardson syndrome and 24 with PSP non-Richardson syndrome), 9 with corticobasal syndrome (CBS), 10 with Alzheimer's disease (AD), 8 with Parkinson's disease, and 18 controls. All participants underwent 18F-florzolotau PET, brain magnetic resonance imaging (MRI), and plasma biomarker investigation (total and phosphorylated tau [pTau181], neurofilament light chain, and glial fibrillary acidic protein [GFAP]).Results18F-Florzolotau uptake was significantly higher in the subcortical regions of the pallidum, subthalamic nucleus (STN), midbrain, red nucleus, and raphe nucleus in PSP patients compared to the other groups (all p < 0.01). Subcortical tau tracer retention assisted in distinguishing PSP and CBS from controls (AUC = 0.836, p < 0.001). Tau tracer retention could differentiate PSP and CBS from AD in cortical (p < 0.001) and subcortical regions (p = 0.028). The motor severity of PSP positively correlated with tau burden in STN (p = 0.044) and substantia nigra (p = 0.035). Tau tracer uptake was associated with cortical volume changes in CBS (p = 0.031), PSP non-Richardson syndrome (p = 0.003), and AD (p = 0.044). Cortical tau retention correlated with plasma levels of GFAP (p = 0.001) and pTau181 (p = 0.036).ConclusionsSubcortical 18F-Florzolotau uptake assist the diagnosis of 4R tauopathy parkinsonism. Additionally, regional tau burden contributes to structural brain volume changes and correlates with plasma levels of GFAP and pTau181.

皮层下tau负荷与四重复tau病帕金森病的区域性脑萎缩和血浆标志物相关。
背景:18F-florzolotau正电子发射断层扫描(PET)有助于进行性核上性麻痹(PSP)的体内诊断。目的:探讨18F-florzolotau摄取与四重复tau病变的临床严重程度、结构体积变化和血浆标志物之间的关系。方法:共招募80名参与者:35名PSP患者(11名PSP- richardson综合征,24名PSP非richardson综合征),9名皮质基底综合征(CBS)患者,10名阿尔茨海默病(AD)患者,8名帕金森病患者,18名对照组。所有参与者均接受了18F-florzolotau PET、脑磁共振成像(MRI)和血浆生物标志物(总tau蛋白和磷酸化tau蛋白[pTau181]、神经丝轻链和胶质纤维酸性蛋白[GFAP])的检测。结果:PSP患者皮层下皮层区、丘脑下核(STN)、中脑、红核和中脑核的18F-Florzolotau摄取明显高于其他组(p p p p = 0.028)。PSP的运动严重程度与STN (p = 0.044)和黑质(p = 0.035) tau负荷呈正相关。Tau示踪剂摄取与CBS (p = 0.031)、PSP非理查德森综合征(p = 0.003)和AD (p = 0.044)的皮质体积变化有关。皮层tau保留与血浆GFAP (p = 0.001)和pTau181 (p = 0.036)水平相关。结论:皮质下18F-Florzolotau摄取有助于4R tau病帕金森病的诊断。此外,区域tau负担有助于结构性脑容量变化,并与血浆GFAP和pTau181水平相关。
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来源期刊
CiteScore
8.40
自引率
5.80%
发文量
338
审稿时长
>12 weeks
期刊介绍: The Journal of Parkinson''s Disease (JPD) publishes original research in basic science, translational research and clinical medicine in Parkinson’s disease in cooperation with the Journal of Alzheimer''s Disease. It features a first class Editorial Board and provides rigorous peer review and rapid online publication.
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