在利比亚人群中调查帕金森病G2019S突变的患病率。

IF 4 3区医学 Q2 NEUROSCIENCES

Journal of Parkinson's disease Pub Date : 2025-05-01 Epub Date: 2025-03-17 DOI:10.1177/1877718X251324407

Nuri H Awayn, Sara A Hashish, Sultan A Salem, Sulieman Abod, Sana M Elgahmasi, Khalid Ouararhni, Houari Abdesselem, Ilham Y Abdi, Omar A El-Agnaf

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引用次数: 0

摘要

帕金森病（PD）是一种受环境和遗传危险因素影响的进行性神经退行性疾病。本研究调查了利比亚140名PD患者和58名对照人群中LRRK2 G2019S突变的患病率。血液样本的遗传分析显示，19.5%的PD患者携带G2019S突变，表明与该疾病存在遗传关联。该研究强调了G2019S突变是利比亚PD的潜在遗传风险因素，并强调了基因筛查对于更好地了解和管理该疾病的重要性。

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Investigating the prevalence of the G2019S mutation in Parkinson's disease among a Libyan population.

Parkinson's disease (PD) is a progressive neurodegenerative disorder influenced by both environmental and genetic risk factors. This study investigates the prevalence of the LRRK2 G2019S mutation in a Libyan population of 140 PD patients and 58 controls. Genetic analysis of blood samples revealed that 19.5% of PD patients carry the G2019S mutation, indicating a genetic association with the disease. The study highlights the G2019S mutation as a potential genetic risk factor for PD in Libya and emphasizes the importance of genetic screening for better understanding and management of the disease.

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来源期刊

Journal of Parkinson's disease NEUROSCIENCES-

CiteScore

8.40

自引率

5.80%

发文量

338

审稿时长

>12 weeks

期刊介绍： The Journal of Parkinson''s Disease (JPD) publishes original research in basic science, translational research and clinical medicine in Parkinson’s disease in cooperation with the Journal of Alzheimer''s Disease. It features a first class Editorial Board and provides rigorous peer review and rapid online publication.