Journal of Orthopaedic Research®最新文献_第3页

Analgesic effects of co-administration of mirogabalin and diclofenac sodium on neuropathic pain in rats. 米罗加巴林和双氯芬酸钠联合给药对大鼠神经性疼痛的镇痛作用

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-09-22 DOI: 10.1002/jor.25977

Hiroto Chikubu, Kazuhide Inage, Sumihisa Orita, Yasuhiro Shiga, Masahiro Inoue, Keisuke Shimizu, Miyako Suzuki-Narita, Ikuko Tajiri, Michiaki Mukai, Natsuko Nozaki-Taguchi, Seiji Ohtori

{"title":"Analgesic effects of co-administration of mirogabalin and diclofenac sodium on neuropathic pain in rats.","authors":"Hiroto Chikubu, Kazuhide Inage, Sumihisa Orita, Yasuhiro Shiga, Masahiro Inoue, Keisuke Shimizu, Miyako Suzuki-Narita, Ikuko Tajiri, Michiaki Mukai, Natsuko Nozaki-Taguchi, Seiji Ohtori","doi":"10.1002/jor.25977","DOIUrl":"https://doi.org/10.1002/jor.25977","url":null,"abstract":"Co-administration of mirogabalin besylate and nonsteroidal anti-inflammatory drugs is effective for neuropathic pain; however, mechanism of its action remains unknown. We aimed to evaluate the mechanism of this synergistic effect of the concomitant administration for neuropathic pain using chronic constriction injury model rats. Fifty male Wister rats of 7-week-old were used. Right sciatic nerve ligation was performed in 40 rats and they were sub-divided into four groups: vehicle, mirogabalin, diclofenac sodium and co-administration of them. Ten rats underwent sham surgery. Fluorogold was attached to sciatic nerve during surgery. Von Frey filament and weight bearing tests were performed on postoperative Day 6 as behavioral assessments and drug was administrated intraperitoneally. Half rats in each group underwent behavioral assessment and perfusion fixation using 4% paraformaldehyde on postoperative Day 7 and remaining on postoperative Day 14. Subsequently, dorsal root ganglion at L4 to L6 was collected and examined immunohistochemistry for calcitonin gene-related peptide, and their immunoreactivity in fluorogold-labeled neurons was measured. Spinal cord at lumbar swelling was resected, immunostained for ionized-calcium-binding adapter molecule-1 and glial fibrillary acidic protein, and immunoreactive neurons in dorsal horn of spinal cords were calculated as the occupancy of them. Mirogabalin suppresses the neuropeptide-release from presynaptic afferent neuron directly and it resulted in suppressing glia cells activation. Diclofenac sodium inhibits cyclooxygenase-2 and prostaglandin production, related to allodynia. These effects of mirogabalin and diclofenac sodium, respectively, inhibited glia cells strongly, which is presumed to be one of the mechanisms for the effectiveness of their co-administration for neuropathic pain.","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of biocompatibility and osseointegration of multi-component TiAl6V4 titanium alloy implants. 评估多组分 TiAl6V4 钛合金植入体的生物相容性和骨整合性。

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-09-16 DOI: 10.1002/jor.25974

Zaina Jacobs, Rossana Schipani, Maria Pastrama, Seyed Mohammad Ahmadi, Banafsheh Sajadi

{"title":"Evaluation of biocompatibility and osseointegration of multi-component TiAl6V4 titanium alloy implants.","authors":"Zaina Jacobs, Rossana Schipani, Maria Pastrama, Seyed Mohammad Ahmadi, Banafsheh Sajadi","doi":"10.1002/jor.25974","DOIUrl":"https://doi.org/10.1002/jor.25974","url":null,"abstract":"This study aimed to investigate the biocompatibility and osseointegration of novel titanium (Ti) implants with a perforated part with high surface roughness (Ra >4 μm) and a smooth solid part (test group), as compared to smooth solid Ti implants (control group; Ra < 0.8 μm). Test and control implants were implanted in rabbit femurs. After 4 and 15 weeks, host tissue reaction and quality of tissue formed were evaluated with histopathology, while micro-CT scans were used to quantitatively assess bone-implant contact (BIC), surrounding bone formation, and bone ingrowth. After 4 and 15 weeks, minimal host reaction was found in the test group. Histopathological analysis showed new bone formation around the implants in both the test and control groups after 4 weeks. Furthermore, additional bone growth was often observed within the holes of the test implants. After 15 weeks, the test implants showed high bone ingrowth and the presence of mature bone in direct contact with the implant surface, whereas, bone ingrowth was poorer for the control group with 30% of the control implants, showing larger gaps at the bone-implant interface. Quantitative micro-CT analysis revealed comparable BIC and bone formation in both groups at 4 weeks, but higher BIC and more bone formation in the test group than in the control group after 15 weeks. No significant differences were observed in any of the analyses. In conclusion, partially perforated, high-roughness Ti implants showed excellent osseointegration and minimal host reaction, indicating their potential for orthopedic applications in bone repair and regeneration.","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Capsule release surgery temporarily reduces contracture in a rat elbow model of arthrofibrosis. 胶囊松解手术可暂时减轻大鼠肘关节纤维化模型的挛缩。

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-09-15 DOI: 10.1002/jor.25967

Austin J Scholp, Jordan A Jensen, Timothy P Fowler, Emily Petersen, Douglas Fredericks, Aliasger K Salem, Dongrim Seol, Mitchell Coleman, Spencer P Lake, James A Martin, Edward A Sander

{"title":"Capsule release surgery temporarily reduces contracture in a rat elbow model of arthrofibrosis.","authors":"Austin J Scholp, Jordan A Jensen, Timothy P Fowler, Emily Petersen, Douglas Fredericks, Aliasger K Salem, Dongrim Seol, Mitchell Coleman, Spencer P Lake, James A Martin, Edward A Sander","doi":"10.1002/jor.25967","DOIUrl":"https://doi.org/10.1002/jor.25967","url":null,"abstract":"Elbow trauma can lead to joint contracture and reduced range of motion (ROM). Nonsurgical interventions can improve ROM, but in some cases capsule release surgery is required. Although surgery can improve ROM, it often does not restore full ROM. Thus, alternatives are needed. One approach is to target activated myofibroblasts, which are commonly associated with fibrotic tissue. Mechanical and biochemical cues drive a feedback loop that can result in normal or pathological healing. We hypothesize that this feedback loop exists in joint contracture and can be manipulated so that myofibroblast activity is reduced, normal healing is achieved, and ROM is improved. We previously demonstrated that blebbistatin can inhibit myofibroblast contractile forces and reduce collagen synthesis in vitro. Thus, the purpose of this study was to assess the use of blebbistatin in an animal model of elbow contracture, which was induced in 7 groups of 4 rats each (n = 28). All elbows were mechanically and histologically tested. The uninjured contralateral elbows of each rat were used as a control group. Capsule release surgery significantly improved (p < 0.01) outcomes 1 week after surgery compared to injury alone and was not significantly different from uninjured elbows. Three weeks after surgery, outcomes worsened, indicating joint stiffening consistent with what is observed clinically. The addition of blebbistatin did not significantly improve outcomes. Future work will investigate relationships among treatment, fibrotic tissue deposition, myofibroblast activity, and biomechanics to determine if blebbistatin is a useful adjunctive therapy for treating joint contracture.","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanically compliant locking plates for diaphyseal fracture fixation: A biomechanical study. 用于骺端骨折固定的机械顺应性锁定钢板：生物力学研究

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-09-15 DOI: 10.1002/jor.25968

Connor Huxman, Gregory Lewis, April Armstrong, Gary Updegrove, Zachary Koroneos, Jared Butler

{"title":"Mechanically compliant locking plates for diaphyseal fracture fixation: A biomechanical study.","authors":"Connor Huxman, Gregory Lewis, April Armstrong, Gary Updegrove, Zachary Koroneos, Jared Butler","doi":"10.1002/jor.25968","DOIUrl":"https://doi.org/10.1002/jor.25968","url":null,"abstract":"Axial micromotion between bone fragments can stimulate callus formation and fracture healing. In this study, we propose a novel mechanically compliant locking plate which achieves up to 0.6 mm of interfragmentary motion as flexures machined into the plate elastically deflect under physiological load. We investigated the biomechanical performance of three compliant plate variations in comparison to rigid control plates with small and large working lengths in a comminuted bridge plating scenario using humeral diaphysis surrogates. Under static axial loading, average interfragmentary motion was 6 times larger at 100 N (0.38 vs. 0.05 mm) and nearly three times larger at 350 N (0.58 vs. 0.2 mm) for compliant plates than rigid plates, respectively. Compliant plates delivered between 2.5 and 3.4 times more symmetric interfragmentary motion than rigid plates (p < 0.01). The bi-phasic stiffness of compliant pates provided 74%-96% lower initial axial stiffness up to approximately 100 N (p < 0.01), after which compliant plate stiffness was similar to rigid plates with increased working length (p > 0.3). The strength to failure of compliant plates under dynamic loading was on average 48%-55% lower than rigid plate groups (p < 0.01); however, all plates survived cyclic fatigue loading of 100,000 cycles at 350 N. This work characterizes the improvement in interfragmentary motion and the reduction in strength to failure of compliant plates compared to control rigid plates. Compliant plates may offer potential in comminuted fracture healing due to their ability to deliver symmetric interfragmentary motion into the range known to stimulate callus formation while surviving moderate fatigue loading with no signs of failure.","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Issue Information - Editorial Board and TOC 期刊信息 - 编辑委员会和目录

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-09-09 DOI: 10.1002/jor.25618

引用次数: 0

Issue Information - Cover 发行信息 - 封面

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-09-09 DOI: 10.1002/jor.25619

引用次数: 0

Locking plate augmentation of polymethylmethacrylate-filled distal femoral defects: A biomechanical study. 聚甲基丙烯酸甲酯填充股骨远端缺损的锁定钢板增量术：生物力学研究

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-09-01 DOI: 10.1002/jor.25965

Harrison R Ferlauto, Bruno Belanger, Alexander L Lazarides, Julia D Visgauss, Brian E Brigman, William C Eward

{"title":"Locking plate augmentation of polymethylmethacrylate-filled distal femoral defects: A biomechanical study.","authors":"Harrison R Ferlauto, Bruno Belanger, Alexander L Lazarides, Julia D Visgauss, Brian E Brigman, William C Eward","doi":"10.1002/jor.25965","DOIUrl":"https://doi.org/10.1002/jor.25965","url":null,"abstract":"Benign, locally aggressive tumors of the distal femur are typically treated with intralesional curettage and polymethylmethacrylate (PMMA) cementation. However, it is not known whether plate fixation should be added to biomechanically augment these PMMA-filled defects. The purpose of this study was to evaluate the performance of two competing techniques for reconstruction of a distal femoral defect. For this biomechanical study, we used 12 composite femurs with properties comparable to bone. In nine femurs, identical contained medial distal femoral defects were created using a robotic arm. Group A contained three intact femurs, Group B three femurs with an unfilled defect, Group C three femurs reconstructed with PMMA alone, and Group D three femurs reconstructed with PMMA plus a medial locking plate. Locations of greatest stress concentration were determined by PhotoStress analysis, then three strain gauges were applied to each specimen at these high-stress locations. Specimens were loaded within a physiologic range followed by loading to failure. Outcome measures included construct stiffness, strain along the distal femur, and load at failure. Results showed that stiffness and strain were not significantly different between reconstructive techniques; however, both techniques reduced tensile strain along the popliteal surface by approximately 40% compared to non-reconstructed specimens. All specimens failed at the femoral neck before failing at the distal femur. These findings suggest that plate augmentation of PMMA-filled distal femoral defects like the one in this study offers insignificant biomechanical benefit within physiologic loads and therefore may be unnecessary.","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Individual joint contributions to forward propulsion during treadmill walking in women with hip osteoarthritis. 患有髋关节骨关节炎的女性在跑步机上行走时，各关节对向前推进力的贡献。

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-08-31 DOI: 10.1002/jor.25964

Francesca Wade, Chun-Hao Huang, Kharma C Foucher

{"title":"Individual joint contributions to forward propulsion during treadmill walking in women with hip osteoarthritis.","authors":"Francesca Wade, Chun-Hao Huang, Kharma C Foucher","doi":"10.1002/jor.25964","DOIUrl":"https://doi.org/10.1002/jor.25964","url":null,"abstract":"As we age, reliance on the ankle musculature for push-off during walking reduces and increased reliance on the hip musculature is observed. It is unclear how joint pathology like osteoarthritis may affect this distal-to-proximal redistribution of propulsion. Here, we revisited a proof-of-concept study to study the effect of split-belt treadmill training, designed to reduce step length asymmetry, on forward propulsion during walking. Eleven women with hip osteoarthritis and five age-matched control participants walked on an instrumented split-belt treadmill at their preferred speed (hip osteoarthritis: 0.73 ± 0.11 m/s; controls: 0.59 ± 0.26 m/s). Women with hip osteoarthritis had less ankle power and propulsive force than controls, and greater hip contributions to forward propulsion on their involved limb. Following split-belt treadmill training, propulsive force increased on the involved limb. Five of 11 participants experienced a change in redistribution ratio that was greater than the minimal clinically meaningful difference. These \"responders\" had greater variability in pre-training redistribution ratio compared to non-responders. Women with hip osteoarthritis had poorer propulsive gait mechanics than controls yet split-belt treadmill training improved propulsive force. Redistribution ratio also changed in participants with high baseline variability. Our results suggest that split-belt treadmill training may be beneficial to people with hip osteoarthritis who have high variability in walking parameters. Further, the age-related shift to increased hip contributions to propulsion across populations of older adults may be due to increased variability during walking.","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual and opposing role of retinoic acid receptor signaling in mesenchymal stem cells for tendon ossification in mice. 视黄酸受体信号在间充质干细胞中对小鼠肌腱骨化的双重和对立作用。

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-08-31 DOI: 10.1002/jor.25966

Masashi Isaji, Shinya Kondo, Takahiro Nakagawa, Takahiro Ishizaka, Masatoshi Amako, Kazuhiro Chiba, Keisuke Horiuchi

{"title":"Dual and opposing role of retinoic acid receptor signaling in mesenchymal stem cells for tendon ossification in mice.","authors":"Masashi Isaji, Shinya Kondo, Takahiro Nakagawa, Takahiro Ishizaka, Masatoshi Amako, Kazuhiro Chiba, Keisuke Horiuchi","doi":"10.1002/jor.25966","DOIUrl":"https://doi.org/10.1002/jor.25966","url":null,"abstract":"Heterotopic ossification is abnormal bone formation in soft tissues that occurs primarily after injury and major surgery. This condition often causes local pain and limits joint motion in the affected limb. Currently, there is no effective treatment or prophylaxis for this condition other than surgical removal of the lesion. Recent studies suggest that retinoic acid receptor (RAR) agonists are effective in suppressing heterotopic ossification in patients with Fibrodysplasia Ossificans Progressiva, a congenital disorder characterized by progressive ossification of soft tissue, by suppressing the aberrant differentiation of mesenchymal stem cells in muscle. In this study, we aimed to elucidate the potential use of RAR agonists in suppressing injury-induced ectopic tendon ossification using a mouse Achilles tenotomy model. Contrary to our initial hypothesis, administration of RAR agonists throughout the experimental period (5 weeks) accelerated ectopic tendon ossification in our model. Of note, in vitro differentiation experiments using tendon-derived mesenchymal stem cells revealed that RAR agonists play opposing roles in osteogenic and chondrogenic differentiation, promoting the former and suppressing the latter. Indeed, we found that RAR agonists suppressed tendon ossification when administered before cartilage nodule formation, but promoted it when administered after. These results suggest that RAR agonists have a dual and opposing effect on tendon ectopic ossification, depending on the duration and timing of their administration. Our data may provide a basis for further investigation of the potential use of RAR agonists in the treatment of injury-induced heterotopic ossification.","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nondestructive acoustic modal analysis for assessing bone screw stability: An ex vivo animal study. 用于评估骨螺钉稳定性的无损声学模态分析：体外动物研究

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-08-27 DOI: 10.1002/jor.25959

Mohammadjavad Matin Einafshar, Mohammad Najafidoust, Farshid Bastami, Elie Massaad, Ata Hashemi, Ali Kiapour

{"title":"Nondestructive acoustic modal analysis for assessing bone screw stability: An ex vivo animal study.","authors":"Mohammadjavad Matin Einafshar, Mohammad Najafidoust, Farshid Bastami, Elie Massaad, Ata Hashemi, Ali Kiapour","doi":"10.1002/jor.25959","DOIUrl":"https://doi.org/10.1002/jor.25959","url":null,"abstract":"Conventional insertion torque and pull-out tests are destructive and unsuitable for clinical bone screw fixation. This study evaluates screw stability using acoustic modal analysis (AMA) and Periotest compared to traditional methods in an ex vivo animal model. Titanium self-tapping screws (STS) and nonself-tapping screws (N-STS) were implanted in the proximal tibia of 12 rabbits. Four testing methods were used to assess screw stability: peak insertion torque (PIT) during implantation, AMA for natural frequency (NF), Periotest for Periotest value (PTV), and pull-out test for peak pullout force (PPF). Euthanization was performed at 0 (primary stability), 4, and 8 weeks (secondary stability). No significant difference in primary stability was found between STS and N-STS except for AMA (STS: NF 2434 ± 67 Hz, N-STS: NF 2572 ± 43 Hz; p = 0.62). Secondary stability increased significantly over time for both screw types (4-week: NF 3687 ± 36 vs. 3408 ± 45 Hz, PTV 1.4 ± 1.6 vs. -1.5 ± 1.8, PPF 236 ± 29 vs. 220 ± 34 N; 8-week: NF 3890 ± 39 vs. 3613 ± 31 Hz, PTV -3.2 ± 2.5 vs. -2 ± 4.3, PPF 248 ± 25 vs. 289 ± 28 N). Higher NF values for given PTV/PPF indicate potential clinical advantages. Significant differences between primary and secondary stabilities suggest osteointegration was mainly achieved in the 4-week group.","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142080690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0