Journal of Orthopaedic Research®最新文献_第3页

Impact of Femoral and Tibial Torsion on Patellofemoral Loading in Individuals With Patellofemoral Instability.

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2025-02-24 DOI: 10.1002/jor.26058

Bernhard Guggenberger, Willi Koller, Andreas Habersack, Tanja Kraus, Matthias Sperl, Martin Svehlik, Hans Kainz

{"title":"Impact of Femoral and Tibial Torsion on Patellofemoral Loading in Individuals With Patellofemoral Instability.","authors":"Bernhard Guggenberger, Willi Koller, Andreas Habersack, Tanja Kraus, Matthias Sperl, Martin Svehlik, Hans Kainz","doi":"10.1002/jor.26058","DOIUrl":"https://doi.org/10.1002/jor.26058","url":null,"abstract":"Patellofemoral stability is affected by several morphological factors including torsional alignment. To elucidate the impact of factors responsible for the stability of the patellofemoral joint, biomechanical research utilizes the analysis of joint contact forces. At present, there is a paucity of modeling-based research examining the influence of lower limb torsion on patellofemoral joint loading in individuals with patellofemoral instability. The objective of this study was to investigate the impact of the femoral version and tibial torsion on the patellofemoral joint loading. Musculoskeletal simulations were conducted based on 3D motion capture data of 40 individuals with patellofemoral instability using OpenSim. We created three models with different lower limb torsions for each participant: (i) generic torsion, (ii) personalized lower limb (femur and tibia) torsion, and (iii) isolated personalized femoral version model. We correlated femoral version and tibial torsion to differences in patellofemoral joint loading, muscle forces, and lever arms between models. Tibial torsion correlated to differences in mediolateral patellofemoral force (ρ = 0.39), whereas the femoral version showed no significant correlation to the differences in mediolateral patellofemoral force (ρ = 0.01). Notably, when neglecting individual tibial torsion, the femoral version correlated to differences in mediolateral patellofemoral force (ρ = 0.65). The femoral version can increase the lateralizing force on the patella, but this effect diminishes when addressing whole lower limb torsion in musculoskeletal simulations. Studies investigating solely the femoral version should, therefore, be interpreted with caution. Our findings underscore the necessity of evaluating whole lower limb torsion for a comprehensive assessment of its impact on patellofemoral stability and planning treatments. Level of Evidence: Retrospective cohort study, Level III.","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of Low-Intensity Exercise in Mitigating Active Arthritis Exacerbation in a Mouse Rheumatoid-Arthritis Model.

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2025-02-22 DOI: 10.1002/jor.26056

Kaichi Ozone, Tatsunori Kumagai, Kohei Arakawa, Takehito Sugasawa, Wenchao Gu, Sora Kawabata, Naoki Shimada, Haruna Takahashi, Moe Yoneno, Yuki Minegishi, Kei Takahata, Michiaki Sato, Yuichiro Oka, Naohiko Kanemura

{"title":"Effectiveness of Low-Intensity Exercise in Mitigating Active Arthritis Exacerbation in a Mouse Rheumatoid-Arthritis Model.","authors":"Kaichi Ozone, Tatsunori Kumagai, Kohei Arakawa, Takehito Sugasawa, Wenchao Gu, Sora Kawabata, Naoki Shimada, Haruna Takahashi, Moe Yoneno, Yuki Minegishi, Kei Takahata, Michiaki Sato, Yuichiro Oka, Naohiko Kanemura","doi":"10.1002/jor.26056","DOIUrl":"https://doi.org/10.1002/jor.26056","url":null,"abstract":"Rheumatoid arthritis is an autoimmune disease characterized by synovitis, reducing the quality of life of affected individuals through joint swelling and inflammation. Recently, the efficacy of exercise therapy has been proposed for rheumatoid arthritis, but its detailed mechanism is still unclear. Herein, we used a mouse model of human rheumatoid-arthritis pathology to investigate the effects of low-intensity exercise on active arthritis. Twenty-four SKG mice were divided into three groups: \"sedentary,\" \"AR\" (induced arthritis), and \"AREx\" (induced arthritis plus low-intensity exercise), with only the AREx group performing treadmill exercise for 4 weeks. During the rearing period, macroscopic arthritis scores were assessed weekly, and histological and bone morphometric analysis of the ankle joints was performed after all interventions. In addition, bulk mRNA sequencing was performed for the synovial-fat pad complex. Consequently, the histological synovitis score showed no change; however, the arthritis score was significantly lower in the AREx group than in the AR group (p < 0.05). The calcaneal and talar bone volumes decreased in the AR group, whereas the AREx group showed no significant change. In the synovial-fat pad complex tissue, the gene expression of inflammatory cytokines decreased in the AREx group compared with the AR group, particularly the suppression of IL6/Jak/Stat3. IHC analysis revealed significantly decreased expression of pro-inflammatory cytokines and increased expression of anti-inflammatory cytokines in the synovium of the AREx group compared with the AR group (p < 0.05). In summary, low-intensity exercise therapy for active rheumatoid arthritis was suggested to have anti-inflammatory effects and to mitigate arthritis exacerbation.","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validity of the Uninjured Limb as a Control for Preoperative Assessment in Anterior Cruciate Ligament Reconstruction. 将未受伤肢体作为前交叉韧带重建术术前评估的对照的有效性。

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2025-02-21 DOI: 10.1002/jor.26057

Ronan Grimandi, Florine Tissier, Marc Garetier, Julien Labban, Romain Gérard, Emmanuelle Courtois-Communier, Christophe Andro, Hélène Bisseriex, François-Xavier Gunepin, Fabrice Rannou, Marie-Agnès Giroux-Metges

{"title":"Validity of the Uninjured Limb as a Control for Preoperative Assessment in Anterior Cruciate Ligament Reconstruction.","authors":"Ronan Grimandi, Florine Tissier, Marc Garetier, Julien Labban, Romain Gérard, Emmanuelle Courtois-Communier, Christophe Andro, Hélène Bisseriex, François-Xavier Gunepin, Fabrice Rannou, Marie-Agnès Giroux-Metges","doi":"10.1002/jor.26057","DOIUrl":"https://doi.org/10.1002/jor.26057","url":null,"abstract":"Monitoring muscle atrophy in patients undergoing anterolateral cruciate ligament reconstruction is pivotal for optimizing postoperative recovery. Conventionally, the uninjured contralateral limb serves as the control. However, its relevance in patients with prolonged physical activity hiatus due to knee instability remains uncertain. Our objectives were to compare limbs within a control group by assessing combined force measurements, cross-sectional areas (CSAs), and neuromuscular activation. In addition, we compared the contralateral limb of the surgery group preoperatively to the control group. This prospective controlled study (evidence level 2) included 40 healthy subjects (HG) and 30 patients scheduled for ACL surgery (SG). Both groups underwent identical assessments. The two HG limbs were compared to establish the standard difference for all assessed variables, whereas SG contralateral limb was compared with the mean of the control limbs. For HG, the comparisons between limbs showed no significant differences in muscle strength, CSA area, or electromyographic parameters. Similarly, comparisons between the SG contralateral limb and the mean of HG limbs revealed no significant differences in isometric and dynamic strength for the quadriceps and hamstrings (2.5 ± 0.5 and 2.6 ± 0.9 N.m/kg, and 1.7 ± 0.3 and 1.7 ± 0.4 N.m/kg, respectively). Neuromuscular activation and fatigue patterns were also comparable between groups. CSAs discrepancies were attributed to differences in body mass index between groups. These findings indicate that the contralateral limb in ACL_injured patients is functionally similar to that of healthy controls, supporting its use as a valid reference for monitoring postoperative recovery. Trial Registration: NCT03200678.","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of Reliable and High-Throughput Human Biomimetic Cartilage and Bone Models to Explore Senescence and Personalized Osteoarthritis Treatment Options.

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2025-02-17 DOI: 10.1002/jor.26052

Ilja Boone, Evelyn Houtman, Margo Tuerlings, Jim J van den Berg, Johannes Lehmann, Peter L J de Keizer, Rob G H H Nelissen, Ingrid Meulenbelt

{"title":"Development of Reliable and High-Throughput Human Biomimetic Cartilage and Bone Models to Explore Senescence and Personalized Osteoarthritis Treatment Options.","authors":"Ilja Boone, Evelyn Houtman, Margo Tuerlings, Jim J van den Berg, Johannes Lehmann, Peter L J de Keizer, Rob G H H Nelissen, Ingrid Meulenbelt","doi":"10.1002/jor.26052","DOIUrl":"https://doi.org/10.1002/jor.26052","url":null,"abstract":"To facilitate effective preclinical testing of senescence treatments for osteoarthritis (OA), we have created reliable biomimetic and high-throughput models using aged human joint tissues. Moreover, concerns regarding scalability led to the concurrent development of a high-throughput human in vitro senescence cartilage organoid model. Osteochondral explants and cells for the cartilage organoid model were isolated from patients undergoing joint replacement surgery due to OA. To induce senescence, explants and organoids were subjected to radiation and/or mechanical loading. Samples were harvested; gene expression of relevant senescent and cartilage genes was measured using RT-qPCR, and protein expression was evaluated using histology. A general senescence phenotype was induced by the perturbations, as shown by senescence-associated β-galactosidase staining. In-depth gene expression analysis revealed that hyperphysiological mechanical loading upregulated gene expression of IL8 and SERPINE1, representing aspects of a senescence-associated secretory phenotype (SASP) profile. Irradiation upregulated CDKN1A, encoding p21, and downregulated LMNB1, representing a cell cycle arrest profile with the absence of a SASP response. Combining the two perturbations showed upregulation of CDKN1A, IL8, and SERPINE and downregulation of LMNB1, representing a complementary senescence model. The high-throughput human in vitro cartilage organoid senescence model showed similar effects to the irradiation explant model. In this study, we present a variety of senescence models of human aged chondrocytes that allows for rapid initial screening of anti-senescence compounds in high-throughput, as well as in-depth, characterization of post-mitotic aged chondrocytes prone to OA pathophysiology. This research advances the development of essential therapeutics for OA.","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Involvement of Nerve Growth Factor in the Reparative Reaction to Osteonecrotic Lesions.

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2025-02-10 DOI: 10.1002/jor.26055

Yusuke Ayabe, Goro Motomura, Ryosuke Yamaguchi, Takeshi Utsunomiya, Hidenao Tanaka, Kosei Sakamoto, Yasuharu Nakashima

{"title":"Involvement of Nerve Growth Factor in the Reparative Reaction to Osteonecrotic Lesions.","authors":"Yusuke Ayabe, Goro Motomura, Ryosuke Yamaguchi, Takeshi Utsunomiya, Hidenao Tanaka, Kosei Sakamoto, Yasuharu Nakashima","doi":"10.1002/jor.26055","DOIUrl":"https://doi.org/10.1002/jor.26055","url":null,"abstract":"The reparative zone in femoral head osteonecrosis is pivotal for repair; however, the repair response mechanism remains poorly understood. Although neurotrophic nerve growth factor significantly contributes to bone formation in fatigue fractures and ectopic ossification, the relationship between nerve growth factor and the repair response to osteonecrosis remains unexplored. We aimed to elucidate the role of nerve growth factor in osteonecrosis repair. Twenty-seven wholly resected femoral heads diagnosed with Japanese Investigation Committee Stage 3 femoral head osteonecrosis, excluding those with severe collapse, were analyzed. Histopathological diagnosis confirmed the presence of necrotic, reparative, and viable zones in all examined femoral heads. Quantitative evaluation of immunohistological staining, including nerve growth factor, vascular endothelial growth factor, osteocalcin, CD31, and TUBB3, was conducted in each zone. Additionally, micro-computed tomography was used to measure the trabecular bone microstructure in the reparative zone. Nerve growth factor expression was detected in all 27 femoral heads with osteonecrosis, exhibiting a significantly higher prevalence in the reparative zone than in other regions (p < 0.0001). Nerve growth factor was predominantly distributed on the necrotic side within the reparative zone, rather than the viable side. In the reparative zone, nerve growth factor expression was positively correlated with bone formation parameters derived from micro-computed tomography images. Vascular endothelial growth factor, osteocalcin, CD31(+) vascular endothelial cells, and TUBB3(+) nerve cells also significantly increased in the reparative zone. In conclusion, nerve growth factor expression was consistent across all femoral heads with osteonecrosis and may play a role in reparative reaction to osteonecrotic lesions.","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Issue Information - Editorial Board and TOC

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2025-02-08 DOI: 10.1002/jor.25882

引用次数: 0

Paracrine Influence of Masquelet's Induced Membrane on Marrow Derived Mesenchymal Stem Cells.

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2025-02-08 DOI: 10.1002/jor.26053

Meredyth Bowman, Gracie Sclamberg, Emma Wessels, Kyle Cragg, Alexis Donneys, Kurt D Hankenson, Mark E Hake, Andrea I Alford

{"title":"Paracrine Influence of Masquelet's Induced Membrane on Marrow Derived Mesenchymal Stem Cells.","authors":"Meredyth Bowman, Gracie Sclamberg, Emma Wessels, Kyle Cragg, Alexis Donneys, Kurt D Hankenson, Mark E Hake, Andrea I Alford","doi":"10.1002/jor.26053","DOIUrl":"https://doi.org/10.1002/jor.26053","url":null,"abstract":"Masquelet's induced membrane technique (MIMT) is a staged surgical procedure that leverages the foreign body induced membrane (IM) that forms around a cement spacer placed into a segmental bone defect to support subsequent bone grafting. The mechanisms by which the IM supports bone consolidation are not fully understood. We present an indirect coculture system for studying IM-MSC interactions using a rat model of MIMT. Compared to control cells, MSC Tnap (alkaline phosphatase) was induced by 4- but not 8-week IM. MSC Spp1 (Osteopontin) was attenuated by both 4- and 8-week IM. Although Tnfrsf11b (osteoprotegrin) in MSC exposed to IM was not different from control cells, it was induced by 8-week IM compared to 4-week IM. MSC Tnfsf11 (RANKL) was reduced by 4-week and 8-week IM. MSC Thbs2 (Tsp2) was induced by 8-week but not 4-week IM. Ablation of macrophages in IM blocked the induction of Thbs2 by 8-week IM. MSC Col1a1 expression was not affected under any condition tested. TMT proteomics analysis of IM-conditioned medium revealed 150 unique secreted proteins, 7 of which were differentially abundant (fold change ≥ 2 and FDR corrected p ≤ 0.05) in 8-week versus 4-week IM secretomes. All differentially abundant proteins were elevated in medium conditioned by 8-week IM. Our data suggest that factor(s) secreted by IM resident cells affect MSC gene expression, and that duration of IM development influences the potency and nature of this paracrine effect. Patient-specific factors including age and interval between MIMT surgeries may affect IM biological potency and graft to bone consolidation.","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Issue Information - Cover

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2025-02-08 DOI: 10.1002/jor.25883

引用次数: 0

The Anti-Inflammatory Effects of Liraglutide in Equine Inflammatory Joint Models.

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2025-02-04 DOI: 10.1002/jor.26050

Ann-Sofie Scheike, Saskia Plomp, Maria Carlotta Fugazzola, Coralie Meurot, Francis Berenbaum, Paul René van Weeren, Marianna Andriana Tryfonidou, Johannes Hendrick von Hegedus

{"title":"The Anti-Inflammatory Effects of Liraglutide in Equine Inflammatory Joint Models.","authors":"Ann-Sofie Scheike, Saskia Plomp, Maria Carlotta Fugazzola, Coralie Meurot, Francis Berenbaum, Paul René van Weeren, Marianna Andriana Tryfonidou, Johannes Hendrick von Hegedus","doi":"10.1002/jor.26050","DOIUrl":"https://doi.org/10.1002/jor.26050","url":null,"abstract":"This study investigates the anti-inflammatory properties of liraglutide, a glucagon-like peptide 1 receptor agonists, in equine in vitro models and in an in vivo acute synovitis model in Shetland ponies. The anti-inflammatory effect of liraglutide was assessed by measuring concentrations of inflammatory biomarker C-C Motif Chemokine Ligand 2 (CCL2) in culture media of equine whole blood, peripheral blood mononuclear cells (PBMCs), chondrocytes, and synoviocytes, with or without lipopolysaccharide (LPS) or interleukin-1β. In the in vivo experiment, acute synovitis was bilaterally induced with 0.25 ng LPS in the intercarpal joints of seven healthy Shetland ponies. The ponies were subsequently treated with either 6 mg liraglutide or a placebo as a paired control in each joint. The impact of liraglutide on biomarkers associated with inflammation (including white blood cell count, total protein, CCL2, and bradykinin) and cartilage metabolism (such as glycosaminoglycans, general matrix metalloproteinase activity, carboxypropeptide type II collagen, and collagen-cleavage neoepitope of type II collagen) was assessed across serial synovial fluid samples. Liraglutide was found to have an anti-inflammatory effect by reducing CCL2 concentrations in culture media of whole blood, PBMCs, chondrocytes, and synoviocytes. In contrast, no significant differences in synovial fluid inflammatory nor cartilage metabolism biomarker levels were found between joints treated with LPS and 6 mg liraglutide, versus LPS and placebo. In conclusion, liraglutide demonstrates the potential to attenuate inflammatory processes in joint cells. Additional research is necessary to validate its efficacy within the complex milieu of an inflamed joint.","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Lumbar Degenerative Changes on Vertebral Bone Strength: A Finite Element Analysis.

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2025-02-04 DOI: 10.1002/jor.26054

Soji Tani, Koji Ishikawa, Erika Chiapparelli, Gaston Camino-Willhuber, Lukas Schönnagel, Thomas Caffard, Krizia Amoroso, Ali E Guven, Jennifer Shue, Benjamin A Alman, John A Carrino, Federico P Girardi, Andrew A Sama, Frank P Cammisa, Alexander P Hughes

{"title":"Impact of Lumbar Degenerative Changes on Vertebral Bone Strength: A Finite Element Analysis.","authors":"Soji Tani, Koji Ishikawa, Erika Chiapparelli, Gaston Camino-Willhuber, Lukas Schönnagel, Thomas Caffard, Krizia Amoroso, Ali E Guven, Jennifer Shue, Benjamin A Alman, John A Carrino, Federico P Girardi, Andrew A Sama, Frank P Cammisa, Alexander P Hughes","doi":"10.1002/jor.26054","DOIUrl":"https://doi.org/10.1002/jor.26054","url":null,"abstract":"Assessing the bone condition in patients with spinal disease is clinically valuable. However, evaluating bone strength in the presence of spine degenerative changes is challenging. Quantitative computed tomography (QCT) and finite element analysis (FEA) have been proposed as methods for more accurate bone quality assessment. This study investigates the relationship between bone strength predicted by FEA and other relevant biological parameters. This retrospective cross-sectional study included 127 patients with spinal disease who underwent preoperative CT scans between 2014 and 2020. Baseline patient characteristics, volumetric bone mineral density (vBMD) measured by QCT, and vertebral bone strength predicted by FEA were collected. The degree of degeneration was evaluated by classifying osteophyte formation, disc height narrowing, vertebral sclerosis, and spondylolisthesis into a grading scale ranging from 0 to 2. Multiple linear regression analysis was conducted to assess the effect of each factor on bone strength predicted by FEA. Of 127 patients, 120 patients (median age was 62 years) were included. The median vBMD and vertebral strength were 114.3 mg/cm3 and 7892.9 N, respectively. After adjusting for age, sex, body mass index, smoking status, diabetes mellitus, vBMD, and degenerative changes, multiple linear regression analysis revealed that sex, vBMD, and degree of degeneration independently increased the vertebral strength measured by FEA. This study suggests that in patients with spinal disease, vertebral bone strength is affected not only by sex and bone mineral density but also by degenerative changes. Thus, bone strength could be predicted more accurately in patients with spinal disease using FEA.","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0