Journal of Orthopaedic Research®最新文献

{"title":"The Journal of Orthopaedic Research extends gratitude and recognition to the many scientists who contributed as peer reviewers between October 1, 2023 and September 30, 2024. Their efforts greatly improved not only individual manuscripts but the quality of the journal and overall research in the field of orthopaedics. They include:","authors":"","doi":"10.1002/jor.25997","DOIUrl":"10.1002/jor.25997","url":null,"abstract":"<p>Aaron, Roy</p><p>Abe, Shingo</p><p>Abraham, Adam</p><p>Ackland, David</p><p>Adam, Emma</p><p>Ahn, Jaimo</p><p>Ai Yuan, Wang</p><p>Aitken, Holly</p><p>Akgün, Doruk</p><p>Akkouch, Adil</p><p>Akkus, Ozan</p><p>Alenchery, Rahul</p><p>Alford, Andrea</p><p>Alford, Andrea</p><p>Alkalay, Ron</p><p>Almarza, Alejandro</p><p>Alsiri, Najla</p><p>Al-Zube, Loay</p><p>Amadio, Peter</p><p>Amanatullah, Derek</p><p>Amanatullah, Derek</p><p>Amrami, Kimberly</p><p>Anderson, Andrew E.</p><p>Anderson, Donald</p><p>Anderst, William</p><p>Andrysek, Jan</p><p>Angelelli, Lucia</p><p>Arena, Sara</p><p>Arnold, William</p><p>Arnold, William</p><p>Aro, Hannu</p><p>Asahara, Hiroshi</p><p>Astephen Wilson, Janie</p><p>Atasoy-Zeybek, Aysegul</p><p>Ateshian, Gerard</p><p>Atkins, Gerald</p><p>Attur, Mukundan</p><p>Audenaert, Emmanuel</p><p>Augat, Peter</p><p>Awad, Hani</p><p>Bacon, Kathy</p><p>Bafor, Anirejuoritse</p><p>Bahney, Chelsea</p><p>Bal, Zeynep</p><p>Barber, Lauren</p><p>Barcik, Jan</p><p>Barry, Frank</p><p>Bates, Nathaniel</p><p>Baxter, Josh</p><p>Beaulé, Paul</p><p>Beaulé, Paul</p><p>Beckers, Gautier</p><p>Bernstein, David</p><p>Bernthal, Nicholas</p><p>Bertolini, Gladson</p><p>Besier, Thor</p><p>Bey, Michael</p><p>Bian, Liming</p><p>Binder, Benjamin</p><p>Bischoff, Jeffrey</p><p>Bixby, Sarah D.</p><p>Blokhuis, Taco</p><p>Boden, Scott</p><p>Bonassar, Lawrence</p><p>Bonnheim, Noah</p><p>Bontempi, Marco</p><p>Bottlang, Michael</p><p>Boughton, Oliver</p><p>Boyd, Steven</p><p>Braun, John</p><p>Brophy, Robert</p><p>Bruce Leicht, Amelia</p><p>Buck, Ashley</p><p>Buckley, Mark</p><p>Bumgardner, Joel</p><p>Burkhart, Timothy</p><p>Burssens, Arne</p><p>Byrd, J. W. Thomas</p><p>Cai, Aijia</p><p>Cain, Jarrett D.</p><p>Calafiore, Dario</p><p>Callary, Stuart</p><p>Cao, Chike</p><p>Cardozo, Christopher P.</p><p>Carli, Alberto V.</p><p>Carlson, Cathy</p><p>Carpenter, Dana</p><p>Carroll, Chad</p><p>Catelas, Isabelle</p><p>Chang, Joan</p><p>Chao, Grace</p><p>Chappard, Christine</p><p>Chen, Antonia</p><p>Chen, Antonia</p><p>Chen, Bin</p><p>Chen, Tony</p><p>Chen, Zhihao</p><p>Chen, Weiheng</p><p>Chen, Chung-Hwan</p><p>Chen, Szu-Fu</p><p>Chen, Zhenxian</p><p>Cheng, Boyle</p><p>Chisari, Emanuele</p><p>Chiu, Yung-Cheng</p><p>Cho, Woojin</p><p>Choe, Hyonmin</p><p>Choe, Hyonmin</p><p>Chougule, Amit</p><p>Chow, Simon</p><p>Christ, Alexander</p><p>Christiansen, Blaine</p><p>Citters, Douglas Van</p><p>Ciufo, David</p><p>Clark, J. David</p><p>Clouthier, Allison</p><p>Cnudde, Peter</p><p>Cobian, Daniel</p><p>Colbath, Aimee</p><p>Cole, C.</p><p>Coleman, Mitchell</p><p>Coleman, Rhima</p><p>Collier, Christopher</p><p>Collins, Kelsey</p><p>Connizzo, Brianne</p><p>Cook, James L.</p><p>Cook, James</p><p>Cooper, David</p><p>Corino, Valentina</p><p>Corr, David</p><p>Couppe, Christian</p><p>Creemers, Laura</p><p>Crisco, Joseph</p><p>Cui, Quanjun (Trey)</p><p>Curreli, Cristina</p><p>Dai, Boyi</p><p>Dailey, Hannah</p><p>Daiss, John</p><p>Dakin, Stephanie</p><p>Dar, Ayelet</p><p>De Marco, Giacomo</p><p>DeFrate","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"42 12","pages":"2863-2866"},"PeriodicalIF":2.1,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.25997","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Information - Cover","authors":"","doi":"10.1002/jor.25623","DOIUrl":"https://doi.org/10.1002/jor.25623","url":null,"abstract":"","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"42 12","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.25623","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142664716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of effects of intra-articular diclofenac etalhyaluronate and hyaluronic acid in a monoiodoacetate rat osteoarthritis model.","authors":"Soichiro Tokeshi, Miyako Suzuki-Narita, Ikuko Tajiri, Kazuhide Inage, Jun Takeuchi, Takahito Arai, Yuya Kawarai, Hiroakira Terakawa, Seiji Ohtori, Sumihisa Orita","doi":"10.1002/jor.26012","DOIUrl":"https://doi.org/10.1002/jor.26012","url":null,"abstract":"<p><p>Diclofenac etalhyaluronate (DF-HA) sustained diclofenac release with the effects of hyaluronic acid (HA), offering long-term analgesia in osteoarthritis. In this study, the effects of DF-HA on pain improvement and osteoarthritis were evaluated in a rat knee monoiodoacetate-induced osteoarthritis model compared to HA. Eight rats per group had been injected with monoiodoacetate (2.0 mg) or saline in the right knee for 4 weeks and were injected with either DF-HA (1.25 mg/kg; 0.5 mg), HA (0.5 mg), vehicle which was a substrate without DF-HA (50 μL), or saline and followed for 4 weeks. Mechanical plantar skin sensitivity was assessed weekly using the von Frey assay. Osteoarthritis changes were monitored with Larsen scores via CT imaging at every 2 weeks. The articular cartilage was analyzed using OARSI scores through H&E, Safranin-O staining at 8 weeks. The percentage of Iba-1 positive microglia in the spinal dorsal horn and of FG + CGRP-labeled cells among FG-positive cells in the dorsal root ganglion were evaluated by immunohistochemical staining. TNF-α and IL-6 mRNA expression levels in the knee synovium were evaluated by PCR. The DF-HA showed significantly improved pain hypersensitivity compared with the HA at 6-8 weeks. The percentage of Iba-1-positive microglia was significantly lower than that in the vehicle and the percentage of FG + CGRP/FG was significantly lower than that in the HA. OARSI scores did not differ among treatment groups, Larsen scores indicated lower in the DF-HA than in the vehicle. DF-HA was as effective as HA in joint protection and significantly improved inflammatory pain compared to HA.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic bone fracture healing simulations in an ovine tibia model validated with in vivo sensors.","authors":"Peter Schwarzenberg, Jérôme Schlatter, Manuela Ernst, Markus Windolf, Hannah L Dailey, Peter Varga","doi":"10.1002/jor.26007","DOIUrl":"https://doi.org/10.1002/jor.26007","url":null,"abstract":"<p><p>Bone fracture healing is a complex physiological process influenced by biomechanical and biomolecular factors. Mechanical stability is crucial for successful healing, and disruptions can lead to delayed healing or nonunion. Bone commonly heals itself through secondary fracture healing, which is governed by the mechanical strain at the fracture site. To investigate these phenomena, a validated methodology for capturing the mechanoregulatory process in specimen-specific models of fracture healing could provide insight into the healing process. This study implemented a prognostic healing simulation framework to predict healing trajectories based on mechanical stimuli. Sixteen sheep were subjected to a 3 mm transverse tibial mid-shaft osteotomy, stabilized with a custom plate, and equipped with displacement transducer sensors to measure interfragmentary motion over 8 weeks. Computed tomography scans were used to create specimen-specific bone geometries for finite element analysis. Virtual mechanical testing was performed iteratively to calculate strains in the callus region, which guided tissue differentiation and consequently, healing. The predicted healing outcomes were compared to continuous in vivo sensor data, providing a unique validation data set. Healing times derived from the in vivo sensor and in silico sensor showed no significant differences, suggesting the potential for these predictive models to inform clinical assessments and improve nonunion risk evaluations. This study represents a crucial step towards establishing trustworthy computational models of bone healing and translating these to the preclinical and clinical setting, enhancing our understanding of fracture healing mechanisms. Clinical significance: Prognostic bone fracture healing simulation could assist in non-union diagnosis and prediction.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioengineered lubricin alters the lubrication modes of cartilage in a dose-dependent manner.","authors":"Karan Vishwanath, Jin Su, Marshall J Colville, Matthew Paszek, Heidi L Reesink, Lawrence J Bonassar","doi":"10.1002/jor.26009","DOIUrl":"https://doi.org/10.1002/jor.26009","url":null,"abstract":"<p><p>The low friction nature of articular cartilage has been attributed to the synergistic interaction between lubricin and hyaluronic acid in the synovial fluid (SF). Lubricin is a mucinous glycoprotein that lowers the boundary mode coefficient of friction of articular cartilage in a dose-dependent manner. While there have been multiple attempts to produce recombinant lubricin and lubricin mimetic cartilage lubricants over the last two decades, these materials have not found clinical use due to challenges associated with large scale production, manufacturing, and purification. Recently, a novel method using codon scrambling was developed to produce a stable, full-length bioengineered equine lubricin (eLub) in large reproducible quantities. While preliminary frictional analysis of eLub and other recombinantly produced forms revealed they can lubricate cartilage, a complete tribological characterization is lacking, with previous studies evaluating the friction coefficient only at a single dose or a single speed. The objective of this study was to analyze the dose-dependent tribological properties of eLub using the Stribeck framework of tribological analysis. Recombinantly produced eLub at doses greater than 1.5 mg/mL exhibits friction coefficients on par with healthy bovine SF, and a maximal 5 mg/mL dose exhibits a nearly 50% lower friction coefficient than healthy SF. eLub also modulates the shift in lubrication mode of the cartilage from the high friction boundary mode to the low friction minimum mode at high concentrations.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CD1530, selective RARγ agonist, facilitates Achilles tendon healing by modulating the healing environment including less chondrification in a mouse model.","authors":"Dilimulati Yimiti, Kenta Uchibe, Minoru Toriyama, Yuta Hayashi, Yasunari Ikuta, Tomoyuki Nakasa, Haruhiko Akiyama, Hitomi Watanabe, Gen Kondoh, Aki Takimoto, Chisa Shukunami, Nobuo Adachi, Shigeru Miyaki","doi":"10.1002/jor.26006","DOIUrl":"https://doi.org/10.1002/jor.26006","url":null,"abstract":"<p><p>Heterotopic ossification (HO) in Achilles tendon often arises due to endochondral ossification during the healing process following trauma. Retinoic acid receptor γ (RARγ) plays a critical role in this phenomenon. This study aims to elucidate the therapeutic effects of CD1530, an RARγ selective agonist, along with the contributing cells, in Achilles tendon healing, utilizing a cell lineage tracing system. Local injection of CD1530 facilitated histological tendon healing by inhibiting chondrification in a mouse Achilles rupture model. Resident Scleraxis (Scx)⁺ cells in Achilles tendon were not found to be actively involved in HO or　tendon healing following injury. Instead, these processes were primarily driven by tendon stem/progenitor cells (TSPC)-like cells. Furthermore, an in vitro assay revealed that CD1530 attenuated inflammation in injured Achilles tendon-derived tendon fibroblasts (iATF) and inhibited the chondrogenesis of iATF. This dual effect suggests the potential of CD1530 in effectively modulating the healing environment during tendon healing. Together, the present study demonstrated that the local administration of CD1530 accelerated tendon healing by modulating the healing environment, including reducing chondrification via targeting TSPC-like cells in a mouse Achilles tendon rupture model. These results suggest that CD1530 may have the potential to be a novel tendon therapy that offers benefits via the inhibition of chondrogenesis.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 4D time-lapse morphometry method to quantify bone formation and resorption during distraction osteogenesis.","authors":"Sishun Pu, Ruisen Fu, David Bertrand, Bettina M Willie, Haisheng Yang","doi":"10.1002/jor.26008","DOIUrl":"https://doi.org/10.1002/jor.26008","url":null,"abstract":"<p><p>Distraction osteogenesis (DO) is widely utilized for treating limb length discrepancy, nonunion, bone deformities and defects. This study sought to develop a 4D time-lapse morphometry method to quantify bone formation and resorption in mouse femur during DO based on image registration of longitudinal in vivo micro-CT scans. Female C57BL/6 mice (n = 7) underwent osteotomy, followed by 5 days of latency, 10 days of distraction and 35 days of consolidation. The mice were scanned with micro-CT at Days 5, 15, 25, 35, 45, and 50. Histological sectioning and Movat Pentachrome straining were performed at Day 50. After registration of two consecutive micro-CT images of the same bone (day x and day y), the spatially- and temporally-linked sequences of formation, resorption and quiescent bones at the distraction gap were identified and bone formation and resorption rates (BFR_dayx-y and BRR_dayx-y) were calculated. The overall percentage error of the registration method was 2.98% ± 0.89% and there was a strong correlation between histologically-measured bone area fraction and micro-CT-determined bone volume fraction at Day 50 (r = 0.89, p < 0.05). The 4D time-lapse morphometry indicated a rapid bone formation during the first 10 days of the consolidation phase (BFR_day15-25 = 0.14 ± 0.05 mm³/day), followed by callus reshaping via equivalent bone formation and resorption rates. The 4D time-lapse morphometry method developed in this study allows for a continuous quantitative monitoring of the dynamic process of bone formation and resorption following distraction, which may offer a better understanding of the mechanism for mechano-regulated bone regeneration and aid for development of new treatment strategies of DO.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Learning on a Limb: An outreach module to engage high school students in orthopaedics.","authors":"Christopher J Panebianco, Tala F Azar, Michael P Duffy, Madhura P Nijsure, Emily Sharp, Margaret K Tamburro, Michael Hast, Eileen M Shore, Robert L Mauck, Louis J Soslowsky, Jamie R Shuda, Sarah E Gullbrand","doi":"10.1002/jor.26010","DOIUrl":"10.1002/jor.26010","url":null,"abstract":"<p><p>Orthopaedic researchers need new strategies for engaging underrepresented minority (URM) students. Our field has demonstrated noticeable gaps in racial, ethnic, and gender diversity, which inhibit our ability to innovate and combat the severe socioeconomic burden of musculoskeletal disorders. Towards this goal, we designed, implemented, and evaluated Learning on a Limb (LoaL), an orthopaedic research outreach module to teach URM high school students about orthopaedic research. During the 4-h module, students completed hands-on activities to learn how biomechanical testing, microcomputed tomography, cell culture, and histology are used in orthopaedic research. Over 3 years, we recruited 32 high school students from the Greater Philadelphia Area to participate in LoaL. Most participants identified as racial/ethnic or gender minorities in orthopaedic research. Using pre/post-tests, we found that students experienced significant learning gains of 51 percentage points from completing LoaL. In addition to teaching students about orthopaedic research, post-survey data demonstrated that participating in LoaL strongly influenced students' interest in orthopaedic research and scientific confidence. Several students acted on this interest by completing summer research experiences in the McKay Orthopaedic Research Laboratory at the University of Pennsylvania. LoaL instructors also benefited by having the opportunity to \"pay it forward\" to the next generation of students and build community within their department. Empowering institutions to host modules like LoaL would synergistically inspire URM high school students and strengthen community within orthopaedic departments to ultimately enhance orthopaedic research innovations.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular vesicles from cartilage progenitors stimulate type II collagen expression and wound healing in meniscal cells.","authors":"Daniel J Betensky, Maxwell D Chen, Jay Trivedi, Salomi Desai, John Twomey-Kozak, Sicheng Wen, Chathuraka T Jayasuriya","doi":"10.1002/jor.26013","DOIUrl":"https://doi.org/10.1002/jor.26013","url":null,"abstract":"<p><p>Knee meniscus tearing is a common orthopaedic injury that can heal poorly if left untreated, increasing the risk of post-traumatic Osteoarthritis. Intraarticular injection of human cartilage-derived progenitor cells (CPCs) has been shown to promote meniscus healing after injury. However, the mechanism by which CPCs stimulated this effect was unclear. The purpose of this study was to determine the paracrine effects that CPC-derived extracellular vesicles (EVs) have on native meniscal cells during healing. EVs from human CPCs and marrow-derived stromal cells were isolated via ultracentrifugation. EVs produced by each cell type were quantified, and their sizes were determined via NanoSight. EV protein expression was characterized via western blot. Meniscal fibrochondrocyte cellular metabolic activity (as an indicator of cell viability and proliferation) following treatment with EVs, was quantified using MTT and ATP assays. A 2D wound healing assay was used to determine the effects of treating inner meniscal fibrochondrocytes with EVs in a dose-dependent manner. Gene expression analysis for chondrogenesis genes was performed via RT-qPCR on inner meniscal fibrochondrocytes following treatment with EVs. Our results showed that CPCs produced a wide size range of EVs expressing CD9, CD81, and HSP70. Treatment of inner meniscal fibrochondrocytes with CPC-EVs improved 2D wound healing, in comparison to EVs isolated from marrow-derived stromal cell controls. CPC-EV treatment increased Type II Collagen mRNA expression in inner meniscal fibrochondrocytes. These findings demonstrate that CPC-EVs stimulate chondrogenic matrix production and wound healing in meniscal cells at the optimal dose of 1.0 × 10⁷ particles/mL, significantly outperforming the effects of marrow stromal cell-derived EVs.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and validation of finite element models for the assessment of post-fixation distal femur fracture motion.","authors":"Scott Telfer, William R Ledoux, Aerie Grantham, William D Lack","doi":"10.1002/jor.26011","DOIUrl":"10.1002/jor.26011","url":null,"abstract":"<p><p>Fracture site motion is thought to play an important role in the healing of complex fractures of the distal femur via mechanotransduction. Measuring this motion in vivo is challenging, and this has led researchers to turn to finite element modeling approaches to gain insights into the mechanical environment at the fracture site. Developing a systematic understanding of the effect of different model choices for distal femur fractures may allow more accurate prediction of fracture site motion from these types of simulations. In this study, we aim to assess the effect of four different modeling choices and parameters. We looked at the effect of using bone specific density distributions vs generic values, employing landmark-based geometry generation, varying fracture alignment within clinically relevant ranges, and determining whether direct apposition of the fracture to the plate was achieved. For validation, five cadaveric femurs had fractures created and repaired with plated constructs, and these were then loaded and fracture site motion was directly measured. We found that using landmark based bone geometry and patient-specific bone density distributions had a minimal effect on the overall model predictions. Changing the alignment, particularly into varus and procurvatum could have a large (>50%) effect on predicted shear motion, as could direct apposition of the bone to the plate. These findings demonstrate that modeling choices can play an important role in simulating distal femur fracture mechanics, and it is particularly critical that patient customized models attempt to accurately represent alignment of the bone fragments and lateral plate apposition.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}