Journal of Orthopaedic Research®最新文献

{"title":"Photobiomodulation Controls the Expression of Lipoxin Receptors, Promoting the Resolution of the Inflammatory Process in an Experimental Tendinitis Model","authors":"Rodrigo Labat Marcos,&nbsp;Mateus Moura Evaristo,&nbsp;Patrícia de Almeida-Mattos,&nbsp;Cristina Nunes Capeloa,&nbsp;José Maria Miguel Aguilera Cantero,&nbsp;Renato Araújo Prates,&nbsp;José Antônio Silva Junior,&nbsp;Andrey Jorge Serra,&nbsp;Leonardo Longo,&nbsp;Nivaldo Antonio Parizotto,&nbsp;Rodrigo Álvaro Brandão Lopes Martins","doi":"10.1002/jor.26063","DOIUrl":"10.1002/jor.26063","url":null,"abstract":"<div>\u0000 \u0000 <p>Tendinopathies are a significant global health issue due to their detrimental effects on mobility and quality of life. Pharmacological treatments, although widely used for pain management, often demonstrate limited efficacy. Photobiomodulation therapy (PBM) has emerged as a potential adjunctive treatment due to its capacity to modulate inflammation and alleviate pain. Nevertheless, further research is required to elucidate its mechanisms of action, particularly concerning the resolution of the inflammatory process. This study aimed to evaluate the effects of PBM on inflammation control in an experimental tendinitis model by analyzing inflammatory infiltrate, myeloperoxidase (MPO) activity, the expression of inflammatory and resolution markers (TNF-α, TGF-β, COX-2, and ALX), and protein levels of PGE2 and COX-2 in rat Achilles tendons with type I collagen-induced tendinitis. Male Wistar rats were randomized into five groups: healthy control (CTL), untreated tendinitis (NT), PBM-treated tendinitis (830 nm; 3 J; 30 mW; 64 J/cm²), or tendinitis treated with sodium diclofenac (DIC; 1 mg/kg IM). After 2 or 12 h, tissues and blood were collected for biochemical and histological analysis. The NT group exhibited increased inflammatory infiltrate, MPO activity (<i>p</i> &lt; 0.001), COX-2, TNF-α (<i>p</i> &lt; 0.001), and PGE2 expression (<i>p</i> &lt; 0.01) but lacked ALX receptor upregulation. PBM and DIC treatments significantly reduced inflammatory infiltrate and MPO activity (PBM: <i>p</i> &lt; 0.001; DIC: <i>p</i> &lt; 0.01). PBM enhanced ALX and TGF-β expression (<i>p</i> &lt; 0.001) and maintenance of COX-2 similar to the NT group, suggesting lipoxin involvement in inflammation resolution. These findings highlight PBM as a promising therapy for tendinopathies by targeting both inflammatory and resolution pathways.</p>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 5","pages":"1035-1044"},"PeriodicalIF":2.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AMPK Signaling Pathway Regulates Tendon Regeneration via Fatty Acid Metabolism","authors":"Tianhao Wu,&nbsp;Lisha Zhu,&nbsp;Min Yu,&nbsp;Xinjia Cai,&nbsp;Liyuan Chen,&nbsp;He Zhang,&nbsp;Xiaolan Wu,&nbsp;Chengye Ding,&nbsp;Hangbo Liu,&nbsp;Shiying Zhang,&nbsp;Chang Li,&nbsp;Xinmeng Shi,&nbsp;Yu Wang,&nbsp;Yan Liu","doi":"10.1002/jor.26061","DOIUrl":"10.1002/jor.26061","url":null,"abstract":"<div>\u0000 \u0000 <p>Tendon and ligament injuries are the most common musculoskeletal injuries, and their regeneration is a complex process due to the poor natural healing ability of these tissues. The current therapies for tendon repair are limited in efficacy and their cellular and molecular mechanisms remain unclear. In this study, we identified AMP-activated protein kinase (AMPK) as a markedly upregulated factor in newborn tendons with high regenerative capacity. Both in vivo and in vitro experiments demonstrated that treatment with dorsomorphin, an AMPK inhibitor, significantly decreased the tendon healing potential. Further analyses revealed that carnitine palmitoyltransferase 1A, a key enzyme, is a putative downstream target of AMPK and is closely associated with the proliferation and tenogenic differentiation of tendon stem/progenitor cells. Collectively, we highlight the essential role of AMPK in tendon repair and propose a potential therapeutic intervention for tendon injuries.</p></div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 5","pages":"1012-1023"},"PeriodicalIF":2.1,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural Variations of Tendons: A Systematic Search and Narrative Review of Histological Differences Between Tendons, Tendon Regions, Sex, and Age","authors":"Samantha A. Hefferan,&nbsp;Carina L. Blaker,&nbsp;Dylan M. Ashton,&nbsp;Christopher B. Little,&nbsp;Elizabeth C. Clarke","doi":"10.1002/jor.26060","DOIUrl":"10.1002/jor.26060","url":null,"abstract":"<p>Tendons are force-transmitting structures which facilitate musculoskeletal functioning. Characterizing variations between different anatomical tendons, regions within tendons, as well as between the sexes and with age can improve understanding of tendon physiology and pathology. A systematic search of the literature was conducted to identify and summarize microscopic structural (histological) variations in normal/healthy tendons in relation to these variables (Tendon, Region, Age, Sex, and Other). Regional differences within individual tendons have been investigated in numerous studies, however investigations comparing histological variations between a range of different tendons are sparse, with most focusing on a few select tendons. When injured, ageing tendons typically have a greater degree of pathological changes than younger tendons, but few studies have documented variations in tendon histology throughout typical (uninjured) ageing or across large age spans. Similarly, sex-related observations of tendon structure are underreported. This narrative review summarizes studies on these topics and explores interactions between these variables, as well as the implications of these in the context of selecting control samples for studies of tendon pathology. Future studies should endeavour to improve knowledge of tendon structural variations—specifically focusing on normal tendons—to facilitate understanding of tendon structure-function relationships, physiological mechanisms involved in tendon damage/healing, and to aid clinical research and practice.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 5","pages":"994-1011"},"PeriodicalIF":2.1,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.26060","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Cardiopulmonary Safety of Intramedullary Bone Graft Harvesting: A Comparative Study of the RIA 2 System and the ARA Concept","authors":"Markus Laubach,&nbsp;Agathe Bessot,&nbsp;Siamak Saifzadeh,&nbsp;Craig Simon,&nbsp;Wolfgang Böcker,&nbsp;Nathalie Bock,&nbsp;Dietmar W. Hutmacher,&nbsp;Jacqui McGovern","doi":"10.1002/jor.26059","DOIUrl":"10.1002/jor.26059","url":null,"abstract":"<p>The management of large osseous defects requires innovative intramedullary bone graft harvesting techniques to optimize healing while minimizing complications. Intramedullary bone graft harvesting is, however, associated with potential cardiopulmonary adverse events due to embolic phenomena and systemic inflammation. This study compares the newly introduced aspirator + reaming-aspiration (ARA) concept with the established second-generation Reamer-Irrigator-Aspirator (RIA 2) system, focusing on cardiopulmonary safety in a non-fracture sheep femur model. Sixteen female Merino sheep underwent intramedullary bone grafting using either the RIA 2 system or the ARA concept. The primary outcomes measured were blood loss, hemodynamic parameters, pulmonary function via the Horovitz index, and systemic inflammatory responses postprocedure. Findings revealed minimal and comparable blood loss between the two groups (<i>p</i> = 0.55). Additionally, no significant differences were found in hemodynamic stability (all <i>p</i> ≥ 0.05), pulmonary function (<i>p</i> = 0.96), or systemic inflammation (all <i>p</i> ≥ 0.10) between the RIA 2 system and ARA concept groups, demonstrating the comparable safety profile of the ARA concept to the RIA 2 system. In conclusion, the ARA concept emerges as a viable and effective alternative to the RIA 2 system for intramedullary bone graft harvesting, with similar safety profiles. These promising results advocate for further clinical trials to validate the utility of the ARA concept in human patients.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 5","pages":"984-993"},"PeriodicalIF":2.1,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.26059","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143501688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Femoral and Tibial Torsion on Patellofemoral Loading in Individuals With Patellofemoral Instability","authors":"Bernhard Guggenberger,&nbsp;Willi Koller,&nbsp;Andreas Habersack,&nbsp;Tanja Kraus,&nbsp;Matthias Sperl,&nbsp;Martin Svehlik,&nbsp;Hans Kainz","doi":"10.1002/jor.26058","DOIUrl":"10.1002/jor.26058","url":null,"abstract":"<p>Patellofemoral stability is affected by several morphological factors including torsional alignment. To elucidate the impact of factors responsible for the stability of the patellofemoral joint, biomechanical research utilizes the analysis of joint contact forces. At present, there is a paucity of modeling-based research examining the influence of lower limb torsion on patellofemoral joint loading in individuals with patellofemoral instability. The objective of this study was to investigate the impact of the femoral version and tibial torsion on the patellofemoral joint loading. Musculoskeletal simulations were conducted based on 3D motion capture data of 40 individuals with patellofemoral instability using OpenSim. We created three models with different lower limb torsions for each participant: (i) generic torsion, (ii) personalized lower limb (femur and tibia) torsion, and (iii) isolated personalized femoral version model. We correlated femoral version and tibial torsion to differences in patellofemoral joint loading, muscle forces, and lever arms between models. Tibial torsion correlated to differences in mediolateral patellofemoral force (<i>ρ </i>= 0.39), whereas the femoral version showed no significant correlation to the differences in mediolateral patellofemoral force (<i>ρ </i>= 0.01). Notably, when neglecting individual tibial torsion, the femoral version correlated to differences in mediolateral patellofemoral force (<i>ρ </i>= 0.65). The femoral version can increase the lateralizing force on the patella, but this effect diminishes when addressing whole lower limb torsion in musculoskeletal simulations. Studies investigating solely the femoral version should, therefore, be interpreted with caution. Our findings underscore the necessity of evaluating whole lower limb torsion for a comprehensive assessment of its impact on patellofemoral stability and planning treatments.</p><p>Level of Evidence: Retrospective cohort study, Level III.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 5","pages":"973-983"},"PeriodicalIF":2.1,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.26058","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Low-Intensity Exercise in Mitigating Active Arthritis Exacerbation in a Mouse Rheumatoid-Arthritis Model","authors":"Kaichi Ozone,&nbsp;Tatsunori Kumagai,&nbsp;Kohei Arakawa,&nbsp;Takehito Sugasawa,&nbsp;Wenchao Gu,&nbsp;Sora Kawabata,&nbsp;Naoki Shimada,&nbsp;Haruna Takahashi,&nbsp;Moe Yoneno,&nbsp;Yuki Minegishi,&nbsp;Kei Takahata,&nbsp;Michiaki Sato,&nbsp;Yuichiro Oka,&nbsp;Naohiko Kanemura","doi":"10.1002/jor.26056","DOIUrl":"10.1002/jor.26056","url":null,"abstract":"<div>\u0000 \u0000 <p>Rheumatoid arthritis is an autoimmune disease characterized by synovitis, reducing the quality of life of affected individuals through joint swelling and inflammation. Recently, the efficacy of exercise therapy has been proposed for rheumatoid arthritis, but its detailed mechanism is still unclear. Herein, we used a mouse model of human rheumatoid-arthritis pathology to investigate the effects of low-intensity exercise on active arthritis. Twenty-four SKG mice were divided into three groups: “sedentary,” “AR” (induced arthritis), and “AREx” (induced arthritis plus low-intensity exercise), with only the AREx group performing treadmill exercise for 4 weeks. During the rearing period, macroscopic arthritis scores were assessed weekly, and histological and bone morphometric analysis of the ankle joints was performed after all interventions. In addition, bulk mRNA sequencing was performed for the synovial-fat pad complex. Consequently, the histological synovitis score showed no change; however, the arthritis score was significantly lower in the AREx group than in the AR group (<i>p </i>&lt; 0.05). The calcaneal and talar bone volumes decreased in the AR group, whereas the AREx group showed no significant change. In the synovial-fat pad complex tissue, the gene expression of inflammatory cytokines decreased in the AREx group compared with the AR group, particularly the suppression of IL6/Jak/Stat3. IHC analysis revealed significantly decreased expression of pro-inflammatory cytokines and increased expression of anti-inflammatory cytokines in the synovium of the AREx group compared with the AR group (<i>p </i>&lt; 0.05). In summary, low-intensity exercise therapy for active rheumatoid arthritis was suggested to have anti-inflammatory effects and to mitigate arthritis exacerbation.</p></div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 5","pages":"949-961"},"PeriodicalIF":2.1,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity of the Uninjured Limb as a Control for Preoperative Assessment in Anterior Cruciate Ligament Reconstruction","authors":"Ronan Grimandi,&nbsp;Florine Tissier,&nbsp;Marc Garetier,&nbsp;Julien Labban,&nbsp;Romain Gérard,&nbsp;Emmanuelle Courtois-Communier,&nbsp;Christophe Andro,&nbsp;Hélène Bisseriex,&nbsp;François-Xavier Gunepin,&nbsp;Fabrice Rannou,&nbsp;Marie-Agnès Giroux-Metges","doi":"10.1002/jor.26057","DOIUrl":"10.1002/jor.26057","url":null,"abstract":"<p>Monitoring muscle atrophy in patients undergoing anterolateral cruciate ligament reconstruction is pivotal for optimizing postoperative recovery. Conventionally, the uninjured contralateral limb serves as the control. However, its relevance in patients with prolonged physical activity hiatus due to knee instability remains uncertain. Our objectives were to compare limbs within a control group by assessing combined force measurements, cross-sectional areas (CSAs), and neuromuscular activation. In addition, we compared the contralateral limb of the surgery group preoperatively to the control group. This prospective controlled study (evidence level 2) included 40 healthy subjects (HG) and 30 patients scheduled for ACL surgery (SG). Both groups underwent identical assessments. The two HG limbs were compared to establish the standard difference for all assessed variables, whereas SG contralateral limb was compared with the mean of the control limbs. For HG, the comparisons between limbs showed no significant differences in muscle strength, CSA area, or electromyographic parameters. Similarly, comparisons between the SG contralateral limb and the mean of HG limbs revealed no significant differences in isometric and dynamic strength for the quadriceps and hamstrings (2.5 ± 0.5 and 2.6 ± 0.9 N.m/kg, and 1.7 ± 0.3 and 1.7 ± 0.4 N.m/kg, respectively). Neuromuscular activation and fatigue patterns were also comparable between groups. CSAs discrepancies were attributed to differences in body mass index between groups. These findings indicate that the contralateral limb in ACL_injured patients is functionally similar to that of healthy controls, supporting its use as a valid reference for monitoring postoperative recovery. <b>Trial Registration:</b> NCT03200678</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 5","pages":"962-972"},"PeriodicalIF":2.1,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.26057","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of Reliable and High-Throughput Human Biomimetic Cartilage and Bone Models to Explore Senescence and Personalized Osteoarthritis Treatment Options","authors":"Ilja Boone,&nbsp;Evelyn Houtman,&nbsp;Margo Tuerlings,&nbsp;Jim J. van den Berg,&nbsp;Johannes Lehmann,&nbsp;Peter L. J. de Keizer,&nbsp;Rob G. H. H. Nelissen,&nbsp;Ingrid Meulenbelt","doi":"10.1002/jor.26052","DOIUrl":"10.1002/jor.26052","url":null,"abstract":"<p>To facilitate effective preclinical testing of senescence treatments for osteoarthritis (OA), we have created reliable biomimetic and high-throughput models using aged human joint tissues. Moreover, concerns regarding scalability led to the concurrent development of a high-throughput human in vitro senescence cartilage organoid model. Osteochondral explants and cells for the cartilage organoid model were isolated from patients undergoing joint replacement surgery due to OA. To induce senescence, explants and organoids were subjected to radiation and/or mechanical loading. Samples were harvested; gene expression of relevant senescent and cartilage genes was measured using RT-qPCR, and protein expression was evaluated using histology. A general senescence phenotype was induced by the perturbations, as shown by senescence-associated β-galactosidase staining. In-depth gene expression analysis revealed that hyperphysiological mechanical loading upregulated gene expression of <i>IL8</i> and <i>SERPINE1</i>, representing aspects of a senescence-associated secretory phenotype (SASP) profile. Irradiation upregulated <i>CDKN1A</i>, encoding p21, and downregulated <i>LMNB1</i>, representing a cell cycle arrest profile with the absence of a SASP response. Combining the two perturbations showed upregulation of <i>CDKN1A, IL8,</i> and <i>SERPINE</i> and downregulation of <i>LMNB1</i>, representing a complementary senescence model. The high-throughput human in vitro cartilage organoid senescence model showed similar effects to the irradiation explant model. In this study, we present a variety of senescence models of human aged chondrocytes that allows for rapid initial screening of anti-senescence compounds in high-throughput, as well as in-depth, characterization of post-mitotic aged chondrocytes prone to OA pathophysiology. This research advances the development of essential therapeutics for OA.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 5","pages":"912-921"},"PeriodicalIF":2.1,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.26052","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Involvement of Nerve Growth Factor in the Reparative Reaction to Osteonecrotic Lesions","authors":"Yusuke Ayabe,&nbsp;Goro Motomura,&nbsp;Ryosuke Yamaguchi,&nbsp;Takeshi Utsunomiya,&nbsp;Hidenao Tanaka,&nbsp;Kosei Sakamoto,&nbsp;Yasuharu Nakashima","doi":"10.1002/jor.26055","DOIUrl":"10.1002/jor.26055","url":null,"abstract":"<div>\u0000 \u0000 <p>The reparative zone in femoral head osteonecrosis is pivotal for repair; however, the repair response mechanism remains poorly understood. Although neurotrophic nerve growth factor significantly contributes to bone formation in fatigue fractures and ectopic ossification, the relationship between nerve growth factor and the repair response to osteonecrosis remains unexplored. We aimed to elucidate the role of nerve growth factor in osteonecrosis repair. Twenty-seven wholly resected femoral heads diagnosed with Japanese Investigation Committee Stage 3 femoral head osteonecrosis, excluding those with severe collapse, were analyzed. Histopathological diagnosis confirmed the presence of necrotic, reparative, and viable zones in all examined femoral heads. Quantitative evaluation of immunohistological staining, including nerve growth factor, vascular endothelial growth factor, osteocalcin, CD31, and TUBB3, was conducted in each zone. Additionally, micro-computed tomography was used to measure the trabecular bone microstructure in the reparative zone. Nerve growth factor expression was detected in all 27 femoral heads with osteonecrosis, exhibiting a significantly higher prevalence in the reparative zone than in other regions (<i>p</i> &lt; 0.0001). Nerve growth factor was predominantly distributed on the necrotic side within the reparative zone, rather than the viable side. In the reparative zone, nerve growth factor expression was positively correlated with bone formation parameters derived from micro-computed tomography images. Vascular endothelial growth factor, osteocalcin, CD31(+) vascular endothelial cells, and TUBB3(+) nerve cells also significantly increased in the reparative zone. In conclusion, nerve growth factor expression was consistent across all femoral heads with osteonecrosis and may play a role in reparative reaction to osteonecrotic lesions.</p>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 5","pages":"939-948"},"PeriodicalIF":2.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Information - Editorial Board and TOC","authors":"","doi":"10.1002/jor.25882","DOIUrl":"https://doi.org/10.1002/jor.25882","url":null,"abstract":"","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 3","pages":"467-471"},"PeriodicalIF":2.1,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.25882","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143362797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}