Journal of paediatrics and child health最新文献

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The Determinants of Bone Health in Children With Autism Spectrum Disorder: A Systematic Narrative Review 自闭症谱系障碍儿童骨骼健康的决定因素:一项系统的叙述综述。
IF 1.6 4区 医学
Journal of paediatrics and child health Pub Date : 2025-04-22 DOI: 10.1111/jpc.70063
Romy Tamara Lipszyc, Christine P. Rodda, Martin Wright, Rachel L. Duckham
{"title":"The Determinants of Bone Health in Children With Autism Spectrum Disorder: A Systematic Narrative Review","authors":"Romy Tamara Lipszyc,&nbsp;Christine P. Rodda,&nbsp;Martin Wright,&nbsp;Rachel L. Duckham","doi":"10.1111/jpc.70063","DOIUrl":"10.1111/jpc.70063","url":null,"abstract":"<p>Autism spectrum disorder (ASD) is a complex disorder associated with social and communication impairments and repetitive and restrictive behavioural patterns. Children with ASD often present with concurrent conditions, including poor bone health, which affect long-term health. Although there is compelling evidence to suggest that children with ASD have poorer bone traits than typically developing children, the primary factors associated with these differences are unclear. This review will explore the potential role that factors such as physical activity, nutrition (calcium, protein, vitamin C, vitamin D) and lifestyle (sleep, medication) play on bone health in children with ASD. Having a greater understanding of the influencing factors of low BMD and how these might interact in a synergistic manner in ASD children will provide an opportunity to develop targeted interventions to improve bone health aiming to avert attainment of suboptimal peak bone mass which may lead to early onset osteoporosis, fracture and muscle deconditioning in this paediatric population.</p>","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":"61 6","pages":"852-864"},"PeriodicalIF":1.6,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jpc.70063","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Vitamin B12 Deficiency on Hemogram Parameters and Its Relationship With Thyroid Hormones in Infancy 维生素B12缺乏对婴儿血象参数的影响及其与甲状腺激素的关系。
IF 1.6 4区 医学
Journal of paediatrics and child health Pub Date : 2025-04-22 DOI: 10.1111/jpc.70065
Büşra Demirci, Dilek Konuksever, Gülşah Efeoğlu Gülsoy, Sevinç Püren Yücel
{"title":"Effects of Vitamin B12 Deficiency on Hemogram Parameters and Its Relationship With Thyroid Hormones in Infancy","authors":"Büşra Demirci,&nbsp;Dilek Konuksever,&nbsp;Gülşah Efeoğlu Gülsoy,&nbsp;Sevinç Püren Yücel","doi":"10.1111/jpc.70065","DOIUrl":"10.1111/jpc.70065","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Vitamin B12 is a vital vitamin essential for DNA synthesis, central nervous system myelination and erythropoiesis. Its deficiency, particularly during the rapid growth phase of infancy, can lead to neurological and haematological complications. This study aimed to investigate the relationship between vitamin B12 deficiency, hemogram parameters, and thyroid hormones in children under 36 months of age.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials &amp; Methods</h3>\u0000 \u0000 <p>Conducted at Bilkent Children's Hospital between 2020 and 2024, the study evaluated 10 268 children, grouped based on their B12 levels (≤ 200 pg/mL: deficient, 200–800 pg/mL: normal).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Vitamin B12 deficiency was identified in 7.8% of the participants, with the highest prevalence (12.3%) in the 0–12 months age group. In the deficiency group, WBC, NEU, NEU/LYM ratio, HGB and TSH levels were found to be lower, while PLT levels were higher. Neutropenia was found to be significantly more frequent in the low B12 group (<i>p</i> &lt; 0.001). No significant difference was found in the prevalence of lymphopenia and leukopenia between the groups. Regarding thyroid hormone levels, fT4 levels were similar across groups, but TSH levels were lower in the B12-deficient group. A positive correlation was observed between TSH and HGB levels, while a negative correlation was noted with the NEU/LYM ratio.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In conclusion, B12 deficiency during infancy can cause significant changes in hemogram parameters. During this period, when physiological anaemia is common, MCV may remain normal. Neutropenia and a lower Neu/Lym ratio appear to be the most striking hemogram parameters associated with vitamin B12 deficiency in infants undergoing routine check-ups. Decreased TSH levels may be related to B12 deficiency, and the NEU/LYM ratio could serve as a predictor of thyroid dysfunction. This study stands out as a large-scale study demonstrating the effects of B12 deficiency on haematological and thyroid parameters.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":"61 7","pages":"1030-1038"},"PeriodicalIF":1.6,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeted Cerebral Oxygenation Using Dedicated Treatment Versus Usual Care in Extremely Preterm Infants: Protocol for a Multicentre International Phase II Randomised Controlled Trial 在极早产儿中使用专门治疗与常规护理的靶向脑氧合:一项多中心国际II期随机对照试验方案
IF 1.6 4区 医学
Journal of paediatrics and child health Pub Date : 2025-04-21 DOI: 10.1111/jpc.70066
Pranav R. Jani, Traci-Anne Goyen, Kiran Kumar Balegar Virupakshappa, Rajesh Maheshwari, Dharmesh Shah, Maria Saito-Benz, Tim Schindler, James Moore, James Elhindi, Himanshu Popat, NIRTURE Trial Group
{"title":"Targeted Cerebral Oxygenation Using Dedicated Treatment Versus Usual Care in Extremely Preterm Infants: Protocol for a Multicentre International Phase II Randomised Controlled Trial","authors":"Pranav R. Jani,&nbsp;Traci-Anne Goyen,&nbsp;Kiran Kumar Balegar Virupakshappa,&nbsp;Rajesh Maheshwari,&nbsp;Dharmesh Shah,&nbsp;Maria Saito-Benz,&nbsp;Tim Schindler,&nbsp;James Moore,&nbsp;James Elhindi,&nbsp;Himanshu Popat,&nbsp;NIRTURE Trial Group","doi":"10.1111/jpc.70066","DOIUrl":"10.1111/jpc.70066","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Near infrared spectroscopy (NIRS) allows continuous monitoring of cerebral oxygenation and therefore has the potential to be neuroprotective. Recurrent episodes of cerebral hypo-and/or hyperoxia may result in brain injury. The Safe-BoosC-II study reported stable cerebral oxygenation in extremely preterm infants by combining a dedicated treatment guideline with NIRS monitoring using several devices and adult sensors. The ability to maintain stable cerebral oxygenation with a dedicated treatment algorithm using one type of NIRS device with neonatal sensors has not been previously investigated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this multicentre, 2-arm, parallel, single-blinded, phase II RCT, stratified by gestation and hospital site, 100 participants born &lt; 29 weeks' gestation (inborn and outborns, singleton and twins) will be randomised to targeted cerebral oxygenation using dedicated treatment or usual care with blinded cerebral NIRS monitoring for the first 5 days of life. We will exclude infants &gt; 6 h of age, those with congenital anomaly requiring major surgery or a genetic disorder, and triples or higher multiple births. The primary outcome is the burden of cerebral hypoxia and hyperoxia for the first 5 days after birth expressed as percent hours.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>The findings of this trial will provide essential information on (i) validating results from the Safe-BoosC-II study, considering the differences in the study methodology between the two trials (ii) strengthening support for routine use of cerebral NIRS monitoring in this population and (iii) informing the design of future RCTs on the effects of targeted cerebral oxygenation on neurodevelopment in early childhood as the primary outcome.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>Australian New Zealand Clinical Trials Registry registration number ACTRN12621000778886</p>\u0000 </section>\u0000 </div>","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":"61 7","pages":"1020-1029"},"PeriodicalIF":1.6,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jpc.70066","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrosive Substance Ingestion: When to Perform Endoscopy? 腐蚀性物质摄入:何时进行内窥镜检查?
IF 1.6 4区 医学
Journal of paediatrics and child health Pub Date : 2025-04-21 DOI: 10.1111/jpc.70064
Ufuk Ateş, Gülnur Göllü, Ergun Ergün, Fırat Serttürk, Anar Jafarov, Merve Bülbül, Ege Evin, Sümeyye Sözduyar, Meltem Bingöl Koloğlu, Ahmet Murat Çakmak
{"title":"Corrosive Substance Ingestion: When to Perform Endoscopy?","authors":"Ufuk Ateş,&nbsp;Gülnur Göllü,&nbsp;Ergun Ergün,&nbsp;Fırat Serttürk,&nbsp;Anar Jafarov,&nbsp;Merve Bülbül,&nbsp;Ege Evin,&nbsp;Sümeyye Sözduyar,&nbsp;Meltem Bingöl Koloğlu,&nbsp;Ahmet Murat Çakmak","doi":"10.1111/jpc.70064","DOIUrl":"10.1111/jpc.70064","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Ingestion of corrosive substances is a difficult and important medical problem to manage. The aim of this study is to present an algorithm that will regulate the treatment and follow-up of paediatric patients with corrosive ingestion.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Children who were admitted to the paediatric emergency department with corrosive substance ingestions between July 2015 and December 2021 were included. Between July 2015 and January 2020, endoscopy was performed on all patients. After January 2020, endoscopy was performed only for patients presenting with hypersalivation and dysphagia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>172 patients were followed up and treated in our clinic due to corrosive substance ingestion. Endoscopic evaluation of 19 patients with hypersalivation revealed oesophageal corrosion stages as follows: grade I in 5 patients, grade II-A in 1 patient, grade II-B in 3 patients, and normal findings in the remaining patients. Of the 14 patients with dysphagia, 1 had grade I, 2 had grade II-A, and 4 had grade II-B corrosion, and the remaining patients had normal endoscopic findings. In the long-term follow-up of the patients without hypersalivation and dysphagia, no complications developed and no additional treatment was required.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In patients presenting with suspicion of ingestion of high risk corrosive substances, there is no need for endoscopy unless hypersalivation and dysphagia are present simultaneously.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":"61 6","pages":"967-973"},"PeriodicalIF":1.6,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jpc.70064","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multiple Fractures and Hypercalcaemia Secondary to Parathyroid Hormone-Related Peptide (PTHrP): An Uncommon Presentation of Hepatoblastoma 多发骨折和继发于甲状旁腺激素相关肽(PTHrP)的高钙血症:肝母细胞瘤的一种罕见表现。
IF 1.6 4区 医学
Journal of paediatrics and child health Pub Date : 2025-04-21 DOI: 10.1111/jpc.70050
J. Hawkins, M. Lambeth, M. Sullivan, J. A. Heath
{"title":"Multiple Fractures and Hypercalcaemia Secondary to Parathyroid Hormone-Related Peptide (PTHrP): An Uncommon Presentation of Hepatoblastoma","authors":"J. Hawkins,&nbsp;M. Lambeth,&nbsp;M. Sullivan,&nbsp;J. A. Heath","doi":"10.1111/jpc.70050","DOIUrl":"10.1111/jpc.70050","url":null,"abstract":"","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":"61 7","pages":"1134-1137"},"PeriodicalIF":1.6,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paediatric Endocrinology: Before and Beyond ‘Ringing the Bell’ 儿科内分泌学:在“敲钟”之前和之后。
IF 1.6 4区 医学
Journal of paediatrics and child health Pub Date : 2025-04-15 DOI: 10.1111/jpc.70055
Louise S. Conwell
{"title":"Paediatric Endocrinology: Before and Beyond ‘Ringing the Bell’","authors":"Louise S. Conwell","doi":"10.1111/jpc.70055","DOIUrl":"10.1111/jpc.70055","url":null,"abstract":"&lt;p&gt;\u0000 &lt;i&gt;Ringing the bell…&lt;/i&gt;\u0000 &lt;/p&gt;&lt;p&gt;Many cancer centres have adopted a naval tradition of bell ringing to signify ‘when the job is done’ at the completion of treatment. Despite global disparities [&lt;span&gt;1, 2&lt;/span&gt;], the childhood cancer cure rates have improved, and the population of ageing survivors is increasing [&lt;span&gt;3&lt;/span&gt;]. However, the majority experience cancer- and treatment-related effects requiring life-long care [&lt;span&gt;3&lt;/span&gt;]. The most prevalent severe chronic health conditions include endocrine disorders, subsequent neoplasms, and cardiovascular disease [&lt;span&gt;4&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;In 2006, an expert panel met in Italy to produce the Erice Statement, updated a decade later: ‘the long-term goal of the cure and care of a child with cancer is that they become a resilient and autonomous adult with optimal health-related quality of life, accepted in society at the same level as their age peers’ [&lt;span&gt;5, 6&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;I had the opportunity to reflect on two decades of Australian and Canadian ‘Paediatric Endocrine Oncology’ experience with an enthusiastic group of Australian and New Zealand paediatric endocrinology trainees. The themes were (i) acute endocrinology (ii) chronic endocrinology (‘within care’ and ‘after care’), (iii) late effects surveillance, more aptly and positively described as ‘Aftercare’ or ‘Survivorship’ and (iv) endocrinology within childhood cancer genetic predisposition syndromes. I shared reflections relevant to before and beyond ‘ringing the bell’, with a selection included below.&lt;/p&gt;&lt;p&gt;\u0000 &lt;i&gt;Know their story…&lt;/i&gt;\u0000 &lt;/p&gt;&lt;p&gt;A child approaching pubertal age with a history of acute lymphoblastic leukaemia (ALL) is referred. The child's story: an early infantile diagnosis, a poor short-term prognosis and an uncertain journey ahead. The parents' stories convey their differing approaches: a 10-year division of cognitive load, one cure and one care.&lt;/p&gt;&lt;p&gt;\u0000 &lt;i&gt;Know their story before…&lt;/i&gt;\u0000 &lt;/p&gt;&lt;p&gt;An adolescent girl with a craniopharyngioma is experiencing the challenging sequelae of hypothalamic obesity and learning difficulties [&lt;span&gt;7, 8&lt;/span&gt;]. A short duration before: high levels of academic and sporting achievement. Familial expectations of these outcomes persist.&lt;/p&gt;&lt;p&gt;\u0000 &lt;i&gt;Sticky notes…&lt;/i&gt;\u0000 &lt;/p&gt;&lt;p&gt;These colourful, small pieces of paper with a re-adherable strip of glue are found peppered across workplaces and homes. Covering text- and notebooks, they were the clue to another adolescent's short-term memory struggles.&lt;/p&gt;&lt;p&gt;My first ‘aftercare’ experience in the early 1990s was a preschool-age boy with microcephaly and cognitive impairment after treatment for high-risk ALL [&lt;span&gt;9&lt;/span&gt;]. Modern treatments differ, but deficits in neurocognitive functioning persist [&lt;span&gt;10&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;\u0000 &lt;i&gt;Shifting goals…&lt;/i&gt;\u0000 &lt;/p&gt;&lt;p&gt;The safety of growth hormone is continually monitored [&lt;span&gt;11&lt;/span&gt;]. The par","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":"61 6","pages":"993-995"},"PeriodicalIF":1.6,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jpc.70055","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Paediatric Case of Granulomatosis With Polyangiitis Presenting With Kawasaki Disease-Like Symptoms 小儿肉芽肿病合并多血管炎表现为川崎病样症状1例。
IF 1.6 4区 医学
Journal of paediatrics and child health Pub Date : 2025-04-15 DOI: 10.1111/jpc.70061
Shinnosuke Haruta, Yukari Aida, Kazuya Yatani, Kengo Nakashima, Hiroko Sano, Yusuke Ishida, Shogo Minamikawa, Mao Mizuta, Yosuke Inaguma, Hiroshi Kaito, Yasuo Nakagishi
{"title":"A Paediatric Case of Granulomatosis With Polyangiitis Presenting With Kawasaki Disease-Like Symptoms","authors":"Shinnosuke Haruta,&nbsp;Yukari Aida,&nbsp;Kazuya Yatani,&nbsp;Kengo Nakashima,&nbsp;Hiroko Sano,&nbsp;Yusuke Ishida,&nbsp;Shogo Minamikawa,&nbsp;Mao Mizuta,&nbsp;Yosuke Inaguma,&nbsp;Hiroshi Kaito,&nbsp;Yasuo Nakagishi","doi":"10.1111/jpc.70061","DOIUrl":"10.1111/jpc.70061","url":null,"abstract":"","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":"61 6","pages":"985-988"},"PeriodicalIF":1.6,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Alarming Widespread Vesicular Rash in a Neonate 新生儿出现广泛的水疱性皮疹
IF 1.6 4区 医学
Journal of paediatrics and child health Pub Date : 2025-04-15 DOI: 10.1111/jpc.70062
Geethanjali Sahadevan, Malathi Munisamy
{"title":"An Alarming Widespread Vesicular Rash in a Neonate","authors":"Geethanjali Sahadevan,&nbsp;Malathi Munisamy","doi":"10.1111/jpc.70062","DOIUrl":"https://doi.org/10.1111/jpc.70062","url":null,"abstract":"","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":"61 5","pages":"822-824"},"PeriodicalIF":1.6,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143908904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global, Regional, and National Incidence and Prevalence of Children With Peptic Ulcer Disease: A Temporal Trend and Bayesian Age-Period-Cohort Analysis Based on the 2021 Global Burden of Disease Study 全球、地区和国家儿童消化性溃疡疾病的发病率和患病率:基于2021年全球疾病负担研究的时间趋势和贝叶斯年龄-时期-队列分析
IF 1.6 4区 医学
Journal of paediatrics and child health Pub Date : 2025-04-15 DOI: 10.1111/jpc.70058
Haosen Cui, Congfeng Xu, Yue Fan, Zhanyu Wang
{"title":"Global, Regional, and National Incidence and Prevalence of Children With Peptic Ulcer Disease: A Temporal Trend and Bayesian Age-Period-Cohort Analysis Based on the 2021 Global Burden of Disease Study","authors":"Haosen Cui,&nbsp;Congfeng Xu,&nbsp;Yue Fan,&nbsp;Zhanyu Wang","doi":"10.1111/jpc.70058","DOIUrl":"10.1111/jpc.70058","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Identifying temporal trends in children with peptic ulcer disease (PUD) could enhance public awareness and inform future policy development.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Utilising data from GBD 2021, we analysed the incidence, prevalence and age-specific rates (ASR) of children with PUD from 1990 to 2021, conducting stratified analyses based on regional temporal variations. A Bayesian age-period-cohort (BAPC) model was employed to project the global burden of children with PUD over the next 15 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Globally, both the incidence and prevalence of children with PUD exhibited a marked decline, with incidence and prevalence cases decreasing by 0.93% and 3.67%, respectively. Regions with lower sociodemographic index (SDI) bore a heavier burden, with the highest incidence and prevalence observed in Oceania, Western sub-Saharan Africa and the Caribbean in 2021. By 2035, the global incidence and prevalence of children with PUD are projected to further decline.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>While the global burden of children with PUD had significantly decreased, regional disparities persist. Low-SDI countries continue to face disproportionately high incidence and prevalence rates, warranting sustained attention and intervention.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":"61 6","pages":"957-966"},"PeriodicalIF":1.6,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Historic First Global Status Report on Drowning Prevention Highlights Challenges and Opportunities for Preventing Drowning Among Children and Adolescents 首份具有历史意义的《全球预防溺水现状报告》强调了预防儿童和青少年溺水的挑战和机遇
IF 1.6 4区 医学
Journal of paediatrics and child health Pub Date : 2025-04-11 DOI: 10.1111/jpc.70057
Sanghamitra Pati, Arohi Chauhan, Puspa Raj Pant, Bhagabati Sedain, Amy E. Peden
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