Journal of paediatrics and child health最新文献

{"title":"Efficacy of short-course antibiotics for culture-positive neonatal sepsis: A systematic review and meta-analysis","authors":"Poonam Singh,&nbsp;Mayank Priyadarshi,&nbsp;Suman Chaurasia,&nbsp;Sriparna Basu","doi":"10.1111/jpc.16647","DOIUrl":"10.1111/jpc.16647","url":null,"abstract":"<p>Sepsis is a common cause of neonatal mortality and morbidity. Though antibiotics are the mainstay of treatment in culture-positive neonatal sepsis, the dilemma persists for the optimum duration of antimicrobial therapy. The present study aimed to evaluate the efficacy of short-course antibiotics for uncomplicated culture-positive neonatal sepsis. This systematic review and meta-analysis (PROSPERO: CRD42023444899) identified, appraised, and synthesised the available evidence from randomised and quasi-randomised controlled trials related to the efficacy of short-course (7–10 days) versus standard-course (14 days) antibiotics for uncomplicated culture-positive neonatal sepsis on the rate of treatment failure, mortality, duration of hospitalisation, morbidities including antibiotics-related adverse events, long-term neurodevelopmental outcomes and cost analysis. Data were pooled using RevMan 5.4 software. Certainty of evidence (COE) for predefined outcomes was analysed by GRADE. Available evidence showed no significant difference in the rate of treatment failure between 7- to 10-day versus 14-day antibiotics courses [risk ratio (95% confidence interval, CI), 2.45 (0.93–6.47), <i>I</i>² = 0%, six studies, <i>n</i> = 573, very low COE]. No incidence of death was reported in either treatment arm in the two included studies. Duration of hospitalisation was significantly shorter with the short-course antibiotics arm compared to standard-course [mean difference (95% CI), −3.88 (−4.22 to −3.54) days, <i>I</i>² = 0%, five studies, <i>n</i> = 507, low COE]. Morbidities reported in the three studies were similar. Other outcomes were not reported. To conclude the evidence is very uncertain about the effect of short-course antibiotic regimen, compared to a standard-course, on the treatment failure rate in uncomplicated culture-positive neonatal sepsis. Adequately powered trials with outcomes including death and long-term neurodevelopmental impairment are needed.</p>","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":"60 11","pages":"630-639"},"PeriodicalIF":1.6,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of telehealth in delivering diagnostic developmental assessments for children in South Western Sydney during the COVID-19 pandemic: Clinician and family perspectives","authors":"Sinthu Vivekanandarajah,&nbsp;David Carr,&nbsp;Romy Hurwitz,&nbsp;Lydia So,&nbsp;Shanti Raman","doi":"10.1111/jpc.16637","DOIUrl":"10.1111/jpc.16637","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>Children with neuro-developmental disorders faced significant challenges in accessing services during the COVID-19 pandemic. Telehealth has been adopted by health services globally to facilitate access to clinical services. Our aims were to evaluate the utility of the telehealth modality for providing developmental assessment services and explore enablers and barriers to using telehealth, in a culturally diverse and socioeconomically disadvantaged population in Sydney.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We reviewed telehealth developmental assessments in South Western Sydney conducted between 1 April and 30 June 2020. Data were collated on demographics; telehealth modality; diagnostic formulation; recommendations; and requested follow up. We conducted retrospective semi-structured telephone interviews with 79 families and 11 clinicians about their telehealth experience. Thematic analysis was carried out on the open text responses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 205 children assessed across six sites, median age was 48 months; 45% were assessed with video and 55% with telephone only. Diagnostic formulation and therapeutic recommendations were provided for 203 (99%) children and 138 (67%) were asked to come for face-to-face follow-up. The majority of families (76%) were satisfied or extremely satisfied with telehealth. Median clinician satisfaction was 3.5 out of 5, whilst clinician confidence with diagnostic formulation was 4 out of 5. Qualitative data revealed a range of barriers and enablers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Telehealth was a successful modality for contributing to the assessment journey for children with neuro-developmental disorders in our culturally, linguistically and socioeconomically diverse clinical population in the context of a pandemic lockdown. We discuss the potential for telehealth modalities in child developmental assessments beyond the pandemic.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":"60 10","pages":"579-585"},"PeriodicalIF":1.6,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jpc.16637","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nirsevimab: Alleviating the burden of RSV morbidity in young children","authors":"Marcus Wing Choy Loe,&nbsp;Helen Soenong,&nbsp;Evelyn Lee,&nbsp;Jean Li-Kim-Moy,&nbsp;Phoebe CM Williams,&nbsp;Kee Thai Yeo","doi":"10.1111/jpc.16643","DOIUrl":"10.1111/jpc.16643","url":null,"abstract":"<p>Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infections (LRTIs) and hospital admissions in early childhood. Recent advancements in novel preventive therapies, including extended half-life monoclonal antibodies and antenatal vaccination, have afforded new opportunities to significantly reduce the burden of this infection. Nirsevimab is a novel monoclonal antibody that provides sustained protection against RSV for at least 5 months among newborns and young children. It has received regulatory approval in numerous countries and is being implemented across various settings. Two pivotal Phase 3 trials (MELODY, HARMONIE) demonstrated significant reductions in RSV-associated LRTI hospitalisations following nirsevimab administration, with treatment efficacy of 62.1% and 83.2%. Emerging real-world data from early adopters of nirsevimab corroborates these findings. Studies from Spain, Luxembourg, France and the USA report effectiveness rates between 82% and 90% in preventing RSV-associated hospitalisations among infants entering their first RSV season. Current implementation strategies for nirsevimab have primarily focused on seasonal administration for all infants, aligned to local RSV seasons, and often include catch-up doses for those born before the season begins. Available cost-effectiveness analyses indicate that while nirsevimab offers significant potential public health benefits, its adoption must carefully consider economic factors such as treatment costs, implementation strategies tailored to local viral epidemiology, and logistics for vaccine delivery. Overall, nirsevimab presents a promising opportunity to alleviate the burden of severe RSV infections in young children. However, ongoing surveillance and refinements in implementation strategies are crucial to optimise its impact and ensure sustainability across diverse health-care settings.</p>","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":"60 10","pages":"489-498"},"PeriodicalIF":1.6,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jpc.16643","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of therapeutic touch on colic symptoms in infantile colic infants: A randomised controlled study","authors":"Selda Ateş Beşirik,&nbsp;Emine Geçkil","doi":"10.1111/jpc.16646","DOIUrl":"10.1111/jpc.16646","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aimed to examine the effects of therapeutic touch (TT) on infantile colic symptoms (Infant Colic Scale (ICS) score, crying time and sleep time).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This randomised controlled trial included infants aged 4–12 weeks diagnosed with infantile colic in a pediatric unit of a hospital. Infants were assigned to intervention or control groups using a stratified randomisation method. The intervention group received TT sessions six times, 3 days a week, in addition to usual care for 2 weeks. The control group received the usual care. Data were collected using Mother–Infant Information Form, ICS, Crying and Sleep Time Follow-Up Forms. The infants were followed up for two weeks.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 64 infants who met the criteria were included in the study, including intervention (<i>n</i> = 32) and control (<i>n</i> = 32) groups. There was a statistically significant difference between the groups (intervention and control) in terms of ICS scores (<i>U</i> = 4.5; <i>P</i> &lt; 0.001; <i>d</i> = 3.252; 95% confidence interval (CI) = 2.505–3.999), crying time (<i>F</i> = 57.097; <i>ŋ</i>_<i>p</i>² = 0.461; <i>P</i> &lt; 0.001) and sleep time (<i>F</i> = 17.884; <i>ŋ</i>_<i>p</i>² = 0.211; <i>P</i> &lt; 0.001). When the intervention group was compared with the control group at all time points, the size of the effect (group × time interaction) was found to be high.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>TT effectively relieved symptoms, decreased crying time and increased sleep time in infants with infantile colic. TT is recommended to relieve colic in infants.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":"60 10","pages":"569-578"},"PeriodicalIF":1.6,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jpc.16646","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141982499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seven-year-old boy with severe dyspnoea and influenza virus infection","authors":"Shintaro Fujiwara,&nbsp;Yousuke Higuchi,&nbsp;Mahoko Furujo,&nbsp;Mayu Goda,&nbsp;Yuki Takigawa,&nbsp;Ken Sato,&nbsp;Kohsuke Hitomi,&nbsp;Wataru Mukai,&nbsp;Masahiko Oiwa","doi":"10.1111/jpc.16644","DOIUrl":"10.1111/jpc.16644","url":null,"abstract":"","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":"60 10","pages":"619-620"},"PeriodicalIF":1.6,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EEG and equity in health care","authors":"Gabriel Dabscheck","doi":"10.1111/jpc.16642","DOIUrl":"10.1111/jpc.16642","url":null,"abstract":"&lt;p&gt;On the 4 hours drive to Albury, to do a paediatric neurology outreach clinic, I recently had a phone call with a colleague. ‘How many patients did you refer for tests in Melbourne?’ she asked. ‘How many of your patients will you see on the Hume driving back to Melbourne with you?’.&lt;/p&gt;&lt;p&gt;Like many of my colleagues I do outreach clinics to regional and remote areas. I feel welcomed by the clinicians, the clinic, and the community. I like to think that every patient I see in a clinic regionally is a patient who does not have to commute to a capital city, with all the visible and invisible costs incurred.&lt;/p&gt;&lt;p&gt;The rapid adoption of telehealth, during the pandemic, has gone a long way in addressing some of the equity and access issues that our regional and remote patients have experienced. After 4 years, it is clear that some things can be done well over a video call, but most things can be done better face to face, which is why I still do the outreach clinics. For all the gaps that telehealth has addressed, our patients still have to attend medical investigations and interventions in person.&lt;/p&gt;&lt;p&gt;So I send my patients 4 hours down the road to Melbourne to have neurological investigations, primarily EEG.&lt;/p&gt;&lt;p&gt;As a paediatric specialist I am mostly blind to the economic forces that dictate where my patients have investigations. Health-care economics is a jumble of federal and state funding, private health insurance gaps, and patient co-pays.&lt;/p&gt;&lt;p&gt;There is an EEG service in Albury, but it needs to charge a gap to remain viable. The EEG Medicare rebate is $119.25. Each paediatric EEG takes an hour for an experienced scientist to set up, record and disconnect. The Medicare rebate is expected to cover the cost of the rent, the staff, the consumables, the hardware, the software, the scientist's time, and the neurologist's time. To cover these costs the Medicare rebate would, at least, have to double. This is why many of my patients cannot afford the gap, and instead choose the cost of travel to Melbourne, where there is no charge to them at the public hospital.&lt;/p&gt;&lt;p&gt;As paediatricians, we lobby for our patients all the time. We work with our departments to create specialty and subspecialty clinics, to provide state-of-the-art care. We work with patient advocacy groups to promote funding. Some of us work with industry to promote the adoption of life-saving medications and procedures.&lt;/p&gt;&lt;p&gt;While there are multiple regional services in Victoria offering paediatric EEG services, none offer EEG services for children under 2 years of age. Some centres, such as Bendigo, Ballarat and Shepparton, offer EEG for older children through the state-funded public hospitals. For patients who live near the Murray, no state government-funded EEG services are available.&lt;/p&gt;&lt;p&gt;Four hours is a long time to sit in a car. On my next trip to Albury in August, I am going to call my colleague back and tell her that I know what the solution is to save my patients the 8-h retu","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":"60 10","pages":"616"},"PeriodicalIF":1.6,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jpc.16642","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parental views on prospective consent: Experience from a pilot randomised trial recruiting extremely preterm infants during the perinatal period","authors":"Hannah Skelton,&nbsp;Traci-Anne Goyen,&nbsp;Patricia Viola,&nbsp;James Marceau,&nbsp;Daphne D'Cruz,&nbsp;Rajesh Maheshwari,&nbsp;Dharmesh Shah,&nbsp;Bronwyn Edney,&nbsp;Melissa Luig,&nbsp;Pranav R Jani","doi":"10.1111/jpc.16645","DOIUrl":"10.1111/jpc.16645","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To explore parental perceptions of the consenting process and understanding of the study in a pilot randomised controlled trial wherein extremely premature infants (&lt;29 weeks' gestation) were recruited either antenatally or by 4 h of life.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We prospectively surveyed parents who had consented, declined consent or were eligible infants in the Positioning Preterm Infants for Neuroprotection study, a low-risk intervention study in the first 72 h of life. Structured interview questions explored the process and acceptability of the consenting approach by the parents and their knowledge of the study. Additional comments made by the parents were transcribed verbatim.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Sixty-two parents participated in the surveys; of those, 41 had provided their consent, 8 declined consent and 13 were parents of missed eligible infants. Overall, most parents reported they understood the study well before providing their consent and approaching them for consenting did not create a burden for them. A verbal explanation of the study by the study team, especially by the medical practitioners, was viewed as beneficial. Where consent was obtained in the birthing unit (imminent births and within 4 h of birthing), it was suggested that the 4-h period for obtaining post-natal consent may be too short. A deferred consent with a follow-up opportunity for obtaining informed consent could be a suitable alternative.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Parents found the consenting process acceptable and indicated they had sufficient understanding of the study to provide an informed consent. Deferred consent should be explored for future, low-risk intervention studies as an alternative to prospective consent where extremely preterm infants need to be recruited in the immediate neonatal period.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":"60 10","pages":"561-568"},"PeriodicalIF":1.6,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jpc.16645","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of social media in child sexual abuse","authors":"Monica Hong","doi":"10.1111/jpc.16638","DOIUrl":"10.1111/jpc.16638","url":null,"abstract":"<p>With the rise of technology, social media consumption by young children has become part of normal life. The ease of fabricating an online persona also means children become accessible by predators, placing them at risk of exploitation including the production of child abuse material, online grooming and child sexual abuse. The content uploaded on social media is difficult to monitor enabling children to be exposed to potentially harmful material. Online safety for children needs to be prioritised and parents made aware of the resources available to them.</p>","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":"60 10","pages":"476-478"},"PeriodicalIF":1.6,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jpc.16638","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attitudes and responses of Victorian paediatric intensive care doctors to the detection and reporting of child maltreatment","authors":"Anna K Butlinski,&nbsp;Warwick W Butt","doi":"10.1111/jpc.16631","DOIUrl":"10.1111/jpc.16631","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To determine the attitudes and responses of Victorian paediatric intensive care doctors to the detection and reporting of child maltreatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A prospective study conducted in a 30-bed paediatric intensive care unit of a university teaching hospital using data collected from a questionnaire completed by paediatric intensive care consultants and registrars. The questionnaire covered the following domains – doctors' knowledge of Victorian mandatory reporting legislation, doctors' history of reporting and doctors' current role in the detection and reporting of child maltreatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The questionnaire was completed by 37 doctors. All but one doctor considered their role in the detection and reporting of all six forms of maltreatment (physical abuse, sexual abuse, emotional abuse, neglect, exposure to domestic violence and grooming to facilitate later sexual activity with a child) very important or somewhat important. Thirty-two percent of doctors did not feel adequately trained to detect child maltreatment while 51% did not feel adequately trained to report maltreatment. If a doctor wanted to make a report to Child Protection about the physical or sexual abuse of a child, only one would likely make Child Protection their first point of contact.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Paediatric intensive care doctors show a strong intent to detect and report child maltreatment across a broad range of maltreatment types. Doctors are likely to contact one or more members of a child's care team and/or one or more relevant hospital/community services before making a report to Child Protection about the physical or sexual abuse of a child. Opportunities exist for the further education of doctors in regards to the detection and reporting of child maltreatment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":"60 10","pages":"555-560"},"PeriodicalIF":1.6,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pemphigus vulgaris: A rare diagnosis in a paediatric ward","authors":"","doi":"10.1111/jpc.1_16616","DOIUrl":"10.1111/jpc.1_16616","url":null,"abstract":"","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":"60 8","pages":"390"},"PeriodicalIF":1.6,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}