Journal of Pain & Palliative Care Pharmacotherapy最新文献

A Comparative Study Between Hydrodilatation and Intra-Articular Corticosteroid Injection in Patients with Shoulder Adhesive Capsulitis: A Single-Blinded Randomized Clinical Trial. 单盲随机临床试验：肩关节粘连性囊炎患者肩关节内皮质类固醇注射与水合扩张的比较研究。

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-01-17 DOI: 10.1080/15360288.2024.2446284

Aref Nasiri, Maryam Mirhadi, Vahideh Nadgaran, Amirsalar Motamedi, Maryamsadat Fakheri

{"title":"A Comparative Study Between Hydrodilatation and Intra-Articular Corticosteroid Injection in Patients with Shoulder Adhesive Capsulitis: A Single-Blinded Randomized Clinical Trial.","authors":"Aref Nasiri, Maryam Mirhadi, Vahideh Nadgaran, Amirsalar Motamedi, Maryamsadat Fakheri","doi":"10.1080/15360288.2024.2446284","DOIUrl":"https://doi.org/10.1080/15360288.2024.2446284","url":null,"abstract":"This study compares the efficacy of hydrodilatation (HD) alone with intra-articular corticosteroid injection (ICI) in treating frozen shoulder (FS). A total of 48 patients with FS were randomly assigned to two groups: 24 patients received HD treatment, while the other 24 patients received ICI treatment. HD involved 20 mL 0.9% normal saline solution with 3 mL 2% lidocaine, and ICI included 1 mL of 40 mg/mL methylprednisolone acetate with 1 mL 2% lidocaine and 3 mL normal saline. Outcome measures included Visual Analog Scale (VAS), Shoulder Pain and Disability Index (SPADI), and passive range of motion (ROM) at baseline, two-, four-, and eight-week follow-ups. Both treatments demonstrated significant improvement in the VAS, SPADI, and passive ROM, when between-times comparison was conducted in each group at all follow-up points over the eight-week study period (p < 0.001). However, no significant differences were found in between groups comparison at study end (p > 0.05), with no significant interaction between groups and times (p > 0.05). Absolute changes from baseline to eight-week follow-up were not significantly different between HD and ICI (p > 0.05). In the short term, HD alone demonstrates strong efficacy in managing FS, matching the effectiveness of ICI.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"1-11"},"PeriodicalIF":0.9,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Opioid Allergy Cross-Reactivity: A Retrospective Study Across Three Opioid Classes. 阿片类药物过敏交叉反应：三类阿片类药物的回顾性研究。

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-01-02 DOI: 10.1080/15360288.2024.2448531

Ali Khalaf, Matthew Lane, Jennifer Meyer Reid

{"title":"Opioid Allergy Cross-Reactivity: A Retrospective Study Across Three Opioid Classes.","authors":"Ali Khalaf, Matthew Lane, Jennifer Meyer Reid","doi":"10.1080/15360288.2024.2448531","DOIUrl":"https://doi.org/10.1080/15360288.2024.2448531","url":null,"abstract":"IgE-mediated opioid hypersensitivities, or true allergies, are rare and most adverse reactions to opioids can be attributed to side effects or to pseudo-allergies. Given that immune-mediated allergies to opioids are uncommon, literature regarding cross-reactivity among opioid classes are limited. This retrospective study aimed to determine the rates of cross-reactivity and tolerance among patients with previously documented opioid allergy or adverse drug reaction (ADR) across three opioid drug classes (natural, semisynthetic, and synthetic opioids). Patients with documented allergy(s) and/or ADR(s) to opioids were assessed for outcomes of subsequent opioid exposure during any hospital admission at a Veterans Affairs hospital over a 10-year time-period. Veterans were sorted into three cohorts based on the opioid class of the previously documented allergy or ADR. Each cohort had three study arms, one for each class of subsequent opioid exposure. A total of 1507 patients were identified with previously documented allergy or ADR to at least one opioid and at least one subsequent opioid drug exposure. No cross-reactivity among any of the opioid drug classes were found resulting in 100% re-exposure tolerance rates with all study arms. These findings could increase confidence in utilizing opioids in patients with historically documented opioid allergies or ADRs.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"1-7"},"PeriodicalIF":0.9,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142920570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peripheral Edema as an Adverse Drug Reaction to Mirtazapine in an Oral Cavity Cancer Patient Receiving Palliative Care at Tertiary Care Centre: A Case Report. 外周水肿是在三级医疗中心接受姑息治疗的口腔癌患者米氮平的不良反应：一个病例报告。

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-01-02 DOI: 10.1080/15360288.2024.2447820

Surendra Kumar Pingoliya, Yogendra Singhal

{"title":"Peripheral Edema as an Adverse Drug Reaction to Mirtazapine in an Oral Cavity Cancer Patient Receiving Palliative Care at Tertiary Care Centre: A Case Report.","authors":"Surendra Kumar Pingoliya, Yogendra Singhal","doi":"10.1080/15360288.2024.2447820","DOIUrl":"https://doi.org/10.1080/15360288.2024.2447820","url":null,"abstract":"Mirtazapine is a selective serotonergic antidepressant that functions by blocking adrenergic alpha2-autoreceptors and heteroreceptors and inhibiting 5-HT2 and 5-HT3 receptors. It is a noradrenergic drug. Mirtazapine has anxiolytic or sleep-quality-improving effects, aggravates appetite-stimulation, and has stomach emptying functions. When treating poly-symptoms such as appetite loss, anxiety, depression, nausea, and sleeplessness off-label, mirtazapine is being used more and more. A not so common side effect of mirtazapine medication is peripheral edema. The ensuing case study will demonstrate how peripheral edema is an uncommon mirtazapine adverse effect. Peripheral edema was observed in a patient with advanced oral cavity cancer three days after starting a daily dose of 15 mg of mirtazapine for polysymptomatology. The peripheral edema completely resolved after stopping mirtazapine. To the best of our knowledge, this is the first instance of a patient with advanced oral cavity cancer experiencing peripheral edema as a result of receiving mirtazapine medication. Our study will assist medical professionals in identifying the potential use of mirtazapine in situations where peripheral edema develops quickly, facilitating its quick clearance.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"1-3"},"PeriodicalIF":0.9,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The End of the Palliative Journey. 缓和之旅的终结。

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2024-12-29 DOI: 10.1080/15360288.2024.2446276

Tarek Zieneldien

引用次数: 0

An Older Man with Clonus, Rigidity, Hyperreflexia, and Hand Tremors. 一位老年男性伴有阵挛、僵直、反射亢进和手部震颤。

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2024-12-28 DOI: 10.1080/15360288.2024.2443013

Olga Abel, Yan Press

{"title":"An Older Man with Clonus, Rigidity, Hyperreflexia, and Hand Tremors.","authors":"Olga Abel, Yan Press","doi":"10.1080/15360288.2024.2443013","DOIUrl":"https://doi.org/10.1080/15360288.2024.2443013","url":null,"abstract":"Serotonin toxicity (ST) is a preventable, life-threatening condition caused by serotonergic agents. It typically arises from combined drug use that affects serotonin's release and metabolism. While often presenting with mild symptoms that may be overlooked or misdiagnosed, severe toxicity is associated with significant mortality. The older population is particularly at risk due to altered drug pharmacokinetics, a tendency for multiple drug use, and symptom overlap with common neurodegenerative conditions. The case study discusses an older patient with prolonged ST developed with the use of several serotonergic drugs for postherpetic neuralgia. It emphasizes the challenges of polypharmacy in older patients, offering insights into the serotoninergic potential of multiple medicines commonly used in older adults, the pathophysiology, proper diagnosis and differential diagnoses, and management strategies of ST. Accurate diagnosis requires heightened vigilance from healthcare professionals regarding potential drug interactions and familiarity with the specific clinical criteria. Regular revision and adjustment of medications in older patients and preference for the non-pharmacological treatment of chronic pain are essential for preventing ST. This case report is a convenient way for many healthcare professionals to update their knowledge about ST, its diagnosis and management.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"1-7"},"PeriodicalIF":0.9,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety of Naldemedine for Opioid-Induced Constipation - A Systematic Review and Meta-Analysis. 纳德美定治疗阿片类药物引起的便秘的安全性：一项系统综述和荟萃分析。

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2024-12-19 DOI: 10.1080/15360288.2024.2427324

Bastian Wobbe, Maximilian Gerner, Claus-Henning Köhne

{"title":"Safety of Naldemedine for Opioid-Induced Constipation - A Systematic Review and Meta-Analysis.","authors":"Bastian Wobbe, Maximilian Gerner, Claus-Henning Köhne","doi":"10.1080/15360288.2024.2427324","DOIUrl":"https://doi.org/10.1080/15360288.2024.2427324","url":null,"abstract":"Naldemedine is a peripheral acting µ-opioid receptor antagonist approved by the Food and Drug Administration to treat opioid-induced constipation. Concerns about side effects like opioid withdrawal prevent its widespread use, especially for cancer patients. We performed this systematic review and meta-analysis to evaluate existing safety data of naldemedine treating opioid-induced constipation following the PRISMA guidelines. We searched PubMed and the Cochrane Library on April 16th 2024 to identify studies evaluating naldemedine treatment among patients with opioid-induced constipation. Our analysis found no differences between groups comparing naldemedine therapy with placebo-control for treatment-emergent adverse events (OR = 1.06; 95%-CI: 0.91-1.24), serious adverse events (OR = 1.02; 95%-CI: 0.76-1.38). We found no increased risk for opioid withdrawal, while an increased risk for gastrointestinal disorders (OR = 2.08; 95%-CI: 1.72-2.51), particularly higher incidences of diarrhea (OR = 2.44; 95%-CI: 1.81-3.29) and abdominal pain (OR = 3.31; 95%-CI: 2.16-5.06) were found. In the cancer subgroup, treatment-emergent and serious adverse events were more frequent. However, no increased risk for opioid withdrawal was observed. This analysis confirms naldemedine's overall safety in treating opioid-induced constipation, with manageable gastrointestinal side effects. However, the higher adverse events in cancer patients require further investigation to ensure safe use in this population.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"1-18"},"PeriodicalIF":0.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intravenous Magnesium Sulfate as an Adjunct to Intravenous Ketamine for Acute Pain: A Case Series. 静脉注射硫酸镁辅助静脉注射氯胺酮治疗急性疼痛：一个病例系列。

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2024-12-13 DOI: 10.1080/15360288.2024.2441794

Nathan Smith, Sanny Juresic, Kia Lor, Carrie Schmidt, Annie Bell Howrigon, Oludare Olatoye

引用次数: 0

Deafferentation in Pain Medicine: A Narrative Review of Mechanisms and Management. 疼痛医学中的神经传入障碍：机制和管理的叙述性回顾。

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2024-12-12 DOI: 10.1080/15360288.2024.2432640

Usama Ahmed, Mohjir Baloch

{"title":"Deafferentation in Pain Medicine: A Narrative Review of Mechanisms and Management.","authors":"Usama Ahmed, Mohjir Baloch","doi":"10.1080/15360288.2024.2432640","DOIUrl":"https://doi.org/10.1080/15360288.2024.2432640","url":null,"abstract":"Deafferentation is an umbrella term that includes several clinical conditions. The exact mechanism is not yet known, and the different clinical conditions do not necessarily share common pathophysiology. It includes both non-painful and painful conditions, including cancer pain conditions. Clinical presentation can be immediate or delayed, sometimes years after the causative lesion. Patients experience neuropathic pain symptoms in an area of abnormal or absent sensation. Laboratory tests show denervation and loss of function. Pain management strategies can be directed toward alleviating symptoms rather than eradication. The site of origin of the pain can help decide the treatment modalities to be tried. Gabapentinoids, antidepressants, and sodium channel blockers can be used. This type of pain is typically opioid-nonresponsive, but some patients may benefit. Neuronal destructive procedures are indicated for brachial plexus avulsion injuries. Spinal cord stimulation, dorsal root entry zone rhizotomy, deep brain thalamic stimulation, and motor cortex stimulation have been suggested for the management of the complex clinical conditions under the umbrella of deafferentation.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"1-10"},"PeriodicalIF":0.9,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Teaching People About Pain: A Path to Healing Beyond Medication. 教导人们关于疼痛：一条超越药物治疗的道路。

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2024-12-11 DOI: 10.1080/15360288.2024.2436979

Jeff Clyde G Corpuz

引用次数: 0

Medicinal Cannabis: A Potential Tool for Managing Chronic Pain and Mental Health in Asia. 药用大麻：在亚洲管理慢性疼痛和心理健康的潜在工具。

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2024-12-11 DOI: 10.1080/15360288.2024.2436975

John Patrick C Toledo

引用次数: 0