Journal of Pain & Palliative Care Pharmacotherapy最新文献

Comparing Maintenance Therapy Achievement for Opioid-Experienced Patients Converted to Buprenorphine for Chronic Pain Management. 有阿片类药物经验的患者改用丁丙诺啡治疗慢性疼痛的维持治疗效果比较。

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-06-01 Epub Date: 2025-02-20 DOI: 10.1080/15360288.2025.2464686

Caylee Sams, Serena Cheng

{"title":"Comparing Maintenance Therapy Achievement for Opioid-Experienced Patients Converted to Buprenorphine for Chronic Pain Management.","authors":"Caylee Sams, Serena Cheng","doi":"10.1080/15360288.2025.2464686","DOIUrl":"10.1080/15360288.2025.2464686","url":null,"abstract":"Treatment of chronic, non-cancer pain can be challenging in the presence of long-term opioid therapy (LTOT). Buprenorphine products can provide a unique option for chronic pain treatment due to the improved safety profile with a ceiling effect on respiratory depression. Drug manufacturers provide recommendations for conversion from full mu agonist to buprenorphine which typically includes tapering to lower morphine equivalent doses (MEDD). This study will attempt to compare if there is a difference in the ability of achieving buprenorphine maintenance therapy for chronic pain based on the starting opioid MEDD. This study's primary endpoint is the difference in ability to achieve buprenorphine maintenance therapy for chronic, non-cancer pain based on baseline MEDD (i.e., ≤30 MEDD vs >30 MEDD). Secondary endpoints will describe method of conversion to buprenorphine, difference in frequency of follow up and average time to achieve maintenance doses. There was no difference in ability to achieve buprenorphine maintenance doses between either group. Approximately 40% of patients in each group achieved maintenance doses regardless of baseline MEDD. Patients on higher MEDDs had the same likelihood of achieving buprenorphine maintenance therapy for chronic pain as those were at 30 MEDD and can be considered for buprenorphine therapy without tapering first.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"195-201"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post-Operative Pain Control Following LVAD Placement in a Patient with Prior History of Opioid Use Disorder: A Case Report. 有阿片类药物使用障碍史的患者放置LVAD后的术后疼痛控制：一例报告。

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-06-01 Epub Date: 2025-04-10 DOI: 10.1080/15360288.2025.2482110

Maithri Kondapaka, Richa Gupta, Maximillian H Stevenson, Keki Balsara, Maria E Rodrigo, Farooq H Sheikh, Anirudh Rao

引用次数: 0

Perioperative Use of Melatonin in Joint Arthroplasty: A Critical Systematic Review of Randomized Clinical Studies. 褪黑素在关节置换术中的围手术期应用：一项随机临床研究的关键系统综述。

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-06-01 Epub Date: 2025-04-12 DOI: 10.1080/15360288.2025.2490654

Ayman K Saleh, Hany Said Ismail Ramadan, Saeed Mostafa Abdelhameed, Mohammed Ezzelarab, Ahmed Gamal Salah Elsawy, Samia S Ahmed, Marwa M Abdel-Aziz, Naglaa A Elshehawy, Gehan Eissa Zahran, Nashwa Mohammed Ibrahiem, Naif N Alshahrani

{"title":"Perioperative Use of Melatonin in Joint Arthroplasty: A Critical Systematic Review of Randomized Clinical Studies.","authors":"Ayman K Saleh, Hany Said Ismail Ramadan, Saeed Mostafa Abdelhameed, Mohammed Ezzelarab, Ahmed Gamal Salah Elsawy, Samia S Ahmed, Marwa M Abdel-Aziz, Naglaa A Elshehawy, Gehan Eissa Zahran, Nashwa Mohammed Ibrahiem, Naif N Alshahrani","doi":"10.1080/15360288.2025.2490654","DOIUrl":"10.1080/15360288.2025.2490654","url":null,"abstract":"Joint arthroplasty for shoulder, hip and knee joints is a widely performed surgical intervention in orthopedics practice. Early postoperative complications include pain, delirium and cognitive dysfunction, urinary retention, sleep disturbance, anxiety and others. Melatonin is a sleep-inducing hormone successfully tried for management of many painful conditions, postoperative sleep disturbance, and postoperative delirium. This systematic review aimed to critically analyze the randomized clinical studies on the therapeutic effects of perioperative melatonin administration in patients submitted to joint arthroplasty. It was conducted according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Eight articles were progressed to final analysis. The effect of melatonin administration on postoperative pain and sleep quality was assessed by six studies while its effect on delirium was assessed by two studies. In conclusion, the present review found variable degrees of success of melatonin administration for management of postoperative pain, sleep disturbance and delirium. However, based on published studies, use of melatonin for management of these conditions lacks robust clinical evidence.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"276-285"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 更正。

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-06-01 Epub Date: 2024-10-21 DOI: 10.1080/15360288.2024.2419784

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Evaluation of Low-Dose Naltrexone for Chronic Pain Management. 低剂量纳曲酮治疗慢性疼痛的评价。

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-06-01 Epub Date: 2025-02-03 DOI: 10.1080/15360288.2025.2456279

Alexa Spargo, Lauren Gonser, Brittany Faley

{"title":"Evaluation of Low-Dose Naltrexone for Chronic Pain Management.","authors":"Alexa Spargo, Lauren Gonser, Brittany Faley","doi":"10.1080/15360288.2025.2456279","DOIUrl":"10.1080/15360288.2025.2456279","url":null,"abstract":"Naltrexone is an opioid antagonist approved by the Food and Drug Administration (FDA) for alcohol use disorder and opioid use disorder. More recently, naltrexone has been used off-label at low doses of 4.5 mg daily for chronic pain due to fibromyalgia, neuropathy, complex regional pain syndrome, and multiple sclerosis. While several studies show the promise of low-dose naltrexone in treating chronic pain, most had small sample sizes and short-term follow up, which warrants additional investigation into the effectiveness of low-dose naltrexone. This medication use evaluation aimed to evaluate the effectiveness of low-dose naltrexone for chronic pain in Veterans through retrospective chart review. The average duration of low-dose naltrexone therapy was 123 days with approximately half of Veterans still taking it at the time of chart review. The average change in pain score from initiation to most recent visit was -0.83. Low-dose naltrexone was generally well-tolerated with 32% (13 of 41) of Veterans reporting adverse effects including vivid dreams, drowsiness, dizziness, and nausea. Low-dose naltrexone resulted in a small decrease in pain, although may be considered after a patient has failed multiple lines of therapy for additional pain control after a risk versus benefits discussion.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"319-322"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of Topical Agents in Management of Pain Associated with Myofascial Pain Dysfunction Syndrome-A Systematic Review. 局部药物治疗肌筋膜疼痛功能障碍综合征相关疼痛的有效性：系统综述。

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-06-01 Epub Date: 2025-04-09 DOI: 10.1080/15360288.2025.2480236

Harshini Manoharan, Veena K M, Prashanth Shenoy

{"title":"Effectiveness of Topical Agents in Management of Pain Associated with Myofascial Pain Dysfunction Syndrome-A Systematic Review.","authors":"Harshini Manoharan, Veena K M, Prashanth Shenoy","doi":"10.1080/15360288.2025.2480236","DOIUrl":"10.1080/15360288.2025.2480236","url":null,"abstract":"Various invasive and non-invasive treatment modalities have been performed for the treatment of Myofascial pain dysfunction syndrome (MPDS). Topical agents may be effective with minimal disadvantages, and can be the first line of non-invasive treatment option in the management of MPDS. This systematic review was done to evaluate the safety and effectiveness of topical agents and patches in the management of pain associated with MPDS as a non-invasive management option. According to PRISMA guidelines, the PubMed, Embase, Web of science and Cochrane engine databases were searched for clinical trials which were published till July 2023. A total of 5 articles met the study inclusion criteria. Data were extracted from these studies and a qualitative analysis was performed. Topical agents in forms of ointment, gels and patches was found to improve the pain symptoms along with better quality of life and range of motion in patients with MPDS. This systematic review showed that topical interventions provide a non-invasive option for pain management in MPDS, demonstrating efficacy compared to placebo with a favorable safety profile. However, direct comparisons with invasive methods are limited and further studies directly comparing topical and invasive interventions are needed before establishing them as a first-line treatment.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"266-275"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 更正。

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-06-01 Epub Date: 2024-09-20 DOI: 10.1080/15360288.2024.2406708

引用次数: 0

A Comparative Study Between Hydrodilatation and Intra-Articular Corticosteroid Injection in Patients with Shoulder Adhesive Capsulitis: A Single-Blinded Randomized Clinical Trial. 单盲随机临床试验：肩关节粘连性囊炎患者肩关节内皮质类固醇注射与水合扩张的比较研究。

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-06-01 Epub Date: 2025-01-17 DOI: 10.1080/15360288.2024.2446284

Aref Nasiri, Maryam Mirhadi, Vahideh Nadgaran, Amirsalar Motamedi, Maryamsadat Fakheri

{"title":"A Comparative Study Between Hydrodilatation and Intra-Articular Corticosteroid Injection in Patients with Shoulder Adhesive Capsulitis: A Single-Blinded Randomized Clinical Trial.","authors":"Aref Nasiri, Maryam Mirhadi, Vahideh Nadgaran, Amirsalar Motamedi, Maryamsadat Fakheri","doi":"10.1080/15360288.2024.2446284","DOIUrl":"10.1080/15360288.2024.2446284","url":null,"abstract":"This study compares the efficacy of hydrodilatation (HD) alone with intra-articular corticosteroid injection (ICI) in treating frozen shoulder (FS). A total of 48 patients with FS were randomly assigned to two groups: 24 patients received HD treatment, while the other 24 patients received ICI treatment. HD involved 20 mL 0.9% normal saline solution with 3 mL 2% lidocaine, and ICI included 1 mL of 40 mg/mL methylprednisolone acetate with 1 mL 2% lidocaine and 3 mL normal saline. Outcome measures included Visual Analog Scale (VAS), Shoulder Pain and Disability Index (SPADI), and passive range of motion (ROM) at baseline, two-, four-, and eight-week follow-ups. Both treatments demonstrated significant improvement in the VAS, SPADI, and passive ROM, when between-times comparison was conducted in each group at all follow-up points over the eight-week study period (p < 0.001). However, no significant differences were found in between groups comparison at study end (p > 0.05), with no significant interaction between groups and times (p > 0.05). Absolute changes from baseline to eight-week follow-up were not significantly different between HD and ICI (p > 0.05). In the short term, HD alone demonstrates strong efficacy in managing FS, matching the effectiveness of ICI.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"286-296"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

UK Medical Cannabis Registry: An Analysis of Clinical Outcomes of Medicinal Cannabis Therapy for Cancer Pain. 英国医用大麻登记处：药用大麻治疗癌症疼痛的临床结果分析。

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-06-01 Epub Date: 2025-02-08 DOI: 10.1080/15360288.2025.2457101

Madhur Varadpande, Simon Erridge, Arushika Aggarwal, Isaac Cowley, Lilia Evans, Evonne Clarke, Katy McLachlan, Ross Coomber, James J Rucker, Michael W Platt, Shaheen Khan, Mikael Sodergren

{"title":"UK Medical Cannabis Registry: An Analysis of Clinical Outcomes of Medicinal Cannabis Therapy for Cancer Pain.","authors":"Madhur Varadpande, Simon Erridge, Arushika Aggarwal, Isaac Cowley, Lilia Evans, Evonne Clarke, Katy McLachlan, Ross Coomber, James J Rucker, Michael W Platt, Shaheen Khan, Mikael Sodergren","doi":"10.1080/15360288.2025.2457101","DOIUrl":"10.1080/15360288.2025.2457101","url":null,"abstract":"Cancer pain (CP) is a prevalent condition with limited pharmacotherapeutic options. Cannabis-based medicinal products (CBMPs) have shown analgesic effects, but their efficacy in CP remains contentious. This study aims to evaluate the change in patient-reported outcome measures (PROMs) and adverse events (AEs) in CP patients treated with CBMPs. A case series was conducted using prospectively collected clinical data from the UK Medical Cannabis Registry. Primary outcomes were the changes in the Brief Pain Inventory (BPI), pain visual analogue scale (Pain-VAS), EQ-5D-5L, Generalized Anxiety Disorder-7 (GAD-7), Patient Global Impression of Change (PGIC) and Single-Item Sleep Quality Scale (SQS) questionnaires from baseline to 1, 3, and 6 months. AEs were recorded and graded. p < 0.050 was considered statistically significant. One hundred and sixty-eight participants were included. CBMPs were associated with improvements in all pain-specific PROMs at all follow-up periods (p < 0.050). Improvements in GAD-7, SQS, and EQ-5D-5L index scores were also observed (p < 0.050). Twenty-nine AEs (17.26%) were reported by five patients (2.98%), mostly mild-to-moderate (72.41%). Although the observational design means causality cannot be established, the findings support the development of future randomized controlled trials into CP management with CBMPs.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"174-194"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Improving Support for Family Caregivers in Palliative Care: Insights and Policy Implications. 改善对姑息治疗家庭照顾者的支持：见解和政策意义。

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-06-01 Epub Date: 2025-03-21 DOI: 10.1080/15360288.2025.2480226

John Patrick C Toledo

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