Journal of Pain & Palliative Care Pharmacotherapy最新文献

Pharmacological Challenges in Short Gut Syndrome and Pain Management: A Case Series and Review of Literature. 短肠综合征和疼痛管理的药理学挑战：病例系列和文献综述。

IF 1

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-07-27 DOI: 10.1080/15360288.2025.2538516

Cindy T Nguyen, Kathryn Barrett, Piyush Gupta, Ryan Winstead

{"title":"Pharmacological Challenges in Short Gut Syndrome and Pain Management: A Case Series and Review of Literature.","authors":"Cindy T Nguyen, Kathryn Barrett, Piyush Gupta, Ryan Winstead","doi":"10.1080/15360288.2025.2538516","DOIUrl":"https://doi.org/10.1080/15360288.2025.2538516","url":null,"abstract":"Short gut syndrome presents multiple unique challenges in pain management and orally delivered medications. The removal or reduction of gastrointestinal sites of absorption, high-output states, and inability to absorb oral medications often limit pain management strategies. We report our experiences caring for individuals with short gut syndrome and share the challenges and strategies we have utilized to optimize pain control for our patients. Case 1 describes a 49-year-old male with an extensive history of abdominal surgery leading to chronic abdominal pain requiring alternative routes of administration and utilization of unique pharmacology considerations to optimize oral absorption and pain control. Case 2 describes a 68-year-old female with cancer-related pain, which required high opioid requirements and utilization of opioids with unique mechanisms of action for complex pain syndromes. We will include potential management strategies described in the cases and conclude with pharmacokinetic considerations for various drug therapy options in pain management.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"1-8"},"PeriodicalIF":1.0,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Technique for Indwelling Pigtail Catheter Placement in the Management of Ascites in Ovarian Carcinoma: A Case Report. 一种新型留置尾纤管治疗卵巢癌腹水的方法：1例报告。

IF 0.9

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-07-23 DOI: 10.1080/15360288.2025.2534905

Himanshu Varshney, Prashant Sirohiya

引用次数: 0

Emerging Use of Low-Dose Ketamine for Pain Management Beyond the ICU. 低剂量氯胺酮在ICU外疼痛管理中的新应用。

IF 0.9

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-07-20 DOI: 10.1080/15360288.2025.2532657

Eesha Oza, Yashvi Rateshwar, Aneesha Santhosh, Vinnidhy Dave

{"title":"Emerging Use of Low-Dose Ketamine for Pain Management Beyond the ICU.","authors":"Eesha Oza, Yashvi Rateshwar, Aneesha Santhosh, Vinnidhy Dave","doi":"10.1080/15360288.2025.2532657","DOIUrl":"https://doi.org/10.1080/15360288.2025.2532657","url":null,"abstract":"Pain management is a critical challenge in healthcare as acute and chronic pain affect millions of individuals globally. Opioid-based therapies that were once considered the traditional treatment methods are facing scrutiny due to their limitations and risks, due to which it is evident that an equally effective alternative pain management approach is necessary. Ketamine is a promising solution. Ketamine acts as an NMDA (N-methyl-D-aspartate) receptor antagonist, and modulates pain pathways at central and peripheral levels, which enables it to address complex pain mechanisms that opioids cannot adequately target. It is a valuable option for patients who are opioid refractory, intolerant, or have insufficient pain relief from standard therapies. While traditionally used in intensive care units (ICUs), ketamine use has been expanded to general inpatient floors at our institution. This article will present a model for implementing a low-dose ketamine protocol for pain management in a community hospital setting, using our experience as a prototype. It will highlight ketamine's pharmacological advantages, safety considerations, and the staff education, logistics, and collaboration necessary for implementation. By pioneering this model in our county, our goal is to provide a model for other community hospitals to adopt.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"1-8"},"PeriodicalIF":0.9,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sublingual Ketamine as Breakthrough Analgesia in Patients with Advanced Cancer-A Feasibility Randomised Controlled Repeated Cross-over Trial. 舌下氯胺酮作为晚期癌症患者突破性镇痛的可行性随机对照重复交叉试验。

IF 0.9

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-07-12 DOI: 10.1080/15360288.2025.2531008

Yi-Ching Lee, Emma Zhao, Kenny Kwon Ho Lee, Wei Lee, Alix Dumitrescu, John Loadsman, Robert Sanders, Timothy Brake, Andy Yi-Yang Wang

{"title":"Sublingual Ketamine as Breakthrough Analgesia in Patients with Advanced Cancer-A Feasibility Randomised Controlled Repeated Cross-over Trial.","authors":"Yi-Ching Lee, Emma Zhao, Kenny Kwon Ho Lee, Wei Lee, Alix Dumitrescu, John Loadsman, Robert Sanders, Timothy Brake, Andy Yi-Yang Wang","doi":"10.1080/15360288.2025.2531008","DOIUrl":"https://doi.org/10.1080/15360288.2025.2531008","url":null,"abstract":"This pilot study aimed to determine feasibility of a larger definitive study evaluating sublingual ketamine efficacy as first-line breakthrough analgesia for moderate-to-severe pain in advanced cancer. This prospective, double-blind, randomized, placebo-controlled, repeated cross-over trial included patients (≥18 years) with moderate-to-severe pain from advanced cancer requiring opioid analgesia, randomized to weekly-alternating treatment sequences (APAPAP, APAPPA, APPAAP, APPAPA, PAAPAP, PAAPPA, PAPAAP, PAPAPA; A = sublingual ketamine, P = placebo). The primary outcome was attrition rate, measured by completion of two treatment cycles over 12-months. Of 64 patients referred, 29 were randomized, 11 received intervention. The pre-determined criterion of 24 patients completing 2-cycles over 12-months was not met. Most patients perceived receiving active drugs in placebo (0.71) and active (0.67) periods. Ketamine scored higher than placebo for pain reduction, perceived to be more efficacious than usual breakthrough analgesia, and increased quality-of-life scores. This study design will be infeasible for a larger trial due to a high attrition rate. The patients' inability to discriminate between the placebo versus active medication and the minimal adverse effects suggested that the chosen dose was possibly too low. The potential issue of disease progression over the study period suggests that further target population refinement should be considered.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"1-14"},"PeriodicalIF":0.9,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144618674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Establishing Buprenorphine for Acute Postoperative Pain Management. 丁丙诺啡在急性术后疼痛治疗中的应用。

IF 0.9

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-07-07 DOI: 10.1080/15360288.2025.2524688

Audrey Abelleira, Thomas R Hickey

{"title":"Establishing Buprenorphine for Acute Postoperative Pain Management.","authors":"Audrey Abelleira, Thomas R Hickey","doi":"10.1080/15360288.2025.2524688","DOIUrl":"https://doi.org/10.1080/15360288.2025.2524688","url":null,"abstract":"Opioids continue to be relied on to treat postoperative pain and continue to result in harms ranging from pruritis to overdose. The partial agonist opioid buprenorphine was synthesized in the 1960s as result of a search for a safe and effective opioid analgesic. While formulations of buprenorphine are approved for the treatment of pain, it is more commonly known as a medication for opioid use disorder. However, there is increasing interest in employing buprenorphine as a front-line perioperative opioid analgesic. We review the continued reliance on full agonist opioids and associated harms, highlight key efficacy and safety advantages of buprenorphine compared to usual care opioids, and describe the evolution of our consideration of buprenorphine for acute perioperative pain management. We then describe the process by which we worked within our institution to arrive at a twice daily buccal film and describe the clinical pathway ultimately implemented, providing details on training of staff, order set development, and surgical populations included. Buprenorphine presents a promising opportunity to reduce opioid harms while potentially improving pain outcomes after surgery. Our experience suggests that the buccal formulation possesses unique advantages for perioperative administration. Future directions will inform buprenorphine's impact on key pain and opioid-related outcomes.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"1-12"},"PeriodicalIF":0.9,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Nebulized Lidocaine in Managing Cough in Lung Cancer in an Inpatient Setting - A Case Series. 雾化利多卡因在治疗住院肺癌咳嗽中的作用-一个病例系列。

IF 0.9

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-06-19 DOI: 10.1080/15360288.2025.2519657

Jing Ru Lee, Zi Xin Peh, Mo Yee Chau, Mervyn Yong Hwang Koh

引用次数: 0

Effectiveness of Full Spectrum Cannabis Extracts in the Treatment of Chronic Pain: An Open Label Study. 全谱大麻提取物治疗慢性疼痛的有效性：一项开放标签研究。

IF 0.9

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-06-17 DOI: 10.1080/15360288.2025.2517778

Aragon F, Lozada M, Bigatti G, González-José R, Kochen S, McCarthy I

{"title":"Effectiveness of Full Spectrum Cannabis Extracts in the Treatment of Chronic Pain: An Open Label Study.","authors":"Aragon F, Lozada M, Bigatti G, González-José R, Kochen S, McCarthy I","doi":"10.1080/15360288.2025.2517778","DOIUrl":"https://doi.org/10.1080/15360288.2025.2517778","url":null,"abstract":"The aim of this work was to assess the effectiveness of full-spectrum cannabis (THC and CBD) extracts as adjuvants in the treatment of chronic pain. This is a prospective, open label, longitudinal study. Major cannabinoids were analyzed in herbal preparations using high performance liquid chromatography (HPLC). Subjects were included when chronic pain diagnosis criteria was met according to physicians' diagnosis. A patient stratification protocol was developed using a visual analogue scale to measure pain, a numerical scale for life quality parameters and a self-administered health survey. Eighty-eight patients aged between 35 and 88 years were included. A significant decrease in both pain and other life quality parameters was observed between time zero and subsequent time intervals, excepting the \"appetite\" variable. Overall, 51 individuals reported a decrease in pain, 38 a decrease in anxiety and 48 in insomnia, with \"decrease\" defined as symptom reduction of 50% or more between the first and last consultation. In addition, 23 subjects reduced or discontinued other analgesics and/or anti-inflammatory drugs during the trial. Adverse effects were mild and reversible. These results are consistent with previous studies, supporting effectiveness and safety of cannabis extracts as adjuvants in the treatment of chronic pain.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"1-7"},"PeriodicalIF":0.9,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subcutaneously Administered Anesthetics and Analgesics for Pain Management: An Integrative Review. 皮下注射麻醉药和镇痛药治疗疼痛：综合综述。

IF 0.9

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-06-12 DOI: 10.1080/15360288.2025.2516521

Bruno D'Paula Andrade, William Caracas Moreira, Roger Rodrigues da Silva, Ticiane Santana Gomes Santiago, Emilio Carlos Del Massa

{"title":"Subcutaneously Administered Anesthetics and Analgesics for Pain Management: An Integrative Review.","authors":"Bruno D'Paula Andrade, William Caracas Moreira, Roger Rodrigues da Silva, Ticiane Santana Gomes Santiago, Emilio Carlos Del Massa","doi":"10.1080/15360288.2025.2516521","DOIUrl":"https://doi.org/10.1080/15360288.2025.2516521","url":null,"abstract":"This article aims to summarize evidence regarding subcutaneously administered anesthetics and analgesics and their effects on pain management. Searches were conducted in September 2023 by a paired review in the MEDLINE database via the Virtual Health Library (BVS) and SCOPUS via Elsevier. Study selection was independently performed by two researchers according to inclusion criteria: primary studies, published in any language, and without temporal restriction. Duplicates, irrelevant studies, and those outside the research scope were excluded, with discrepancies resolved by a third reviewer. The final sample for the review comprised 45 articles, predominantly clinical trials with eligible patients, published between 1982 and 2022. Key drug classes identified in the evaluation of subcutaneous administration for pain management included amide and amino-amide anesthetics, opioids, and adjuvant agents (such as anti-inflammatory drugs, antihypertensives, and catecholamines). Primary advantages noted were reduced postoperative opioid use, effective analgesic control in postoperative settings, adjuvant efficacy in intraoperative settings and invasive exams, fewer cognitive side effects compared to other anesthesia types, decreased coughing, and shorter hospitalization and ambulation times. Disadvantages included subcutaneous bupivacaine's poor adjuvant performance when combined with general anesthesia, tissue necrosis associated with tumescent anesthesia technique, and ambiguity regarding postoperative respiratory function.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"1-10"},"PeriodicalIF":0.9,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Use of Intravenous Infliximab to Treat Cancer Related Fistulae: A Case Report in Home-Based Palliative Care Improving Quality of Life and Closure. 静脉注射英夫利昔单抗治疗癌症相关瘘管：家庭姑息治疗改善生活质量和闭合的病例报告

IF 0.9

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-06-11 DOI: 10.1080/15360288.2025.2517770

Carolina Simões, Miguel Julião, Paula Câmara, Maria João Gomes, Maria Paula Custódio, Inês Goulão

引用次数: 0

The Complementary Role of Supportive and Palliative Care in Enhancing Bone Marrow Transplant Outcomes. 支持和姑息治疗在提高骨髓移植结果中的互补作用。

IF 0.9

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-06-08 DOI: 10.1080/15360288.2025.2512465

Suzanne Hojjat-Assari, Zahra Ebrahimzadeh, Asma Mehrjoo, Haanieh Nasiraei Mir, Shayesteh Kokabi Hamidpour, Mohammad Jahangiri, Seyed Mohammadamin Nejati Niaki, Babak Arjmand

{"title":"The Complementary Role of Supportive and Palliative Care in Enhancing Bone Marrow Transplant Outcomes.","authors":"Suzanne Hojjat-Assari, Zahra Ebrahimzadeh, Asma Mehrjoo, Haanieh Nasiraei Mir, Shayesteh Kokabi Hamidpour, Mohammad Jahangiri, Seyed Mohammadamin Nejati Niaki, Babak Arjmand","doi":"10.1080/15360288.2025.2512465","DOIUrl":"10.1080/15360288.2025.2512465","url":null,"abstract":"Hematopoietic stem cell transplantation is one of the important treatment modalities for a wide range of malignant and nonmalignant hematological disorders, as well as congenital and acquired disorders of the immune system. Through bone marrow transplantation, candidates face unique challenges throughout the treatment process, which can be accompanied by high physical and psychological burdens. To address the challenges, emerging interventions, such as supportive and palliative care, have shown significant potential for improving quality of life, enhancing overall well-being, alleviating pain, and reducing patient symptoms. The integration of supportive and palliative care in all types of bone marrow transplantation has become increasingly crucial throughout all phases of transplantation, including pre-, during, and post. Therefore, there has to be a specialized team available that can provide complete care, from diagnosis to post-transplantation. Supportive and palliative care requires collaboration for their shared efforts in meeting the special needs of the patients, increasing their quality of life, hope, mood, and well-being. Accordingly, supportive and palliative care, as an integral part of the transplant process, provides patients comprehensive care that addresses their physical, emotional, and psychological well-being.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"1-19"},"PeriodicalIF":0.9,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0