Journal of Pain & Palliative Care Pharmacotherapy最新文献_第2页

An Older Man with Clonus, Rigidity, Hyperreflexia, and Hand Tremors. 一位老年男性伴有阵挛、僵直、反射亢进和手部震颤。

IF 0.9

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2024-12-28 DOI: 10.1080/15360288.2024.2443013

Olga Abel, Yan Press

{"title":"An Older Man with Clonus, Rigidity, Hyperreflexia, and Hand Tremors.","authors":"Olga Abel, Yan Press","doi":"10.1080/15360288.2024.2443013","DOIUrl":"https://doi.org/10.1080/15360288.2024.2443013","url":null,"abstract":"Serotonin toxicity (ST) is a preventable, life-threatening condition caused by serotonergic agents. It typically arises from combined drug use that affects serotonin's release and metabolism. While often presenting with mild symptoms that may be overlooked or misdiagnosed, severe toxicity is associated with significant mortality. The older population is particularly at risk due to altered drug pharmacokinetics, a tendency for multiple drug use, and symptom overlap with common neurodegenerative conditions. The case study discusses an older patient with prolonged ST developed with the use of several serotonergic drugs for postherpetic neuralgia. It emphasizes the challenges of polypharmacy in older patients, offering insights into the serotoninergic potential of multiple medicines commonly used in older adults, the pathophysiology, proper diagnosis and differential diagnoses, and management strategies of ST. Accurate diagnosis requires heightened vigilance from healthcare professionals regarding potential drug interactions and familiarity with the specific clinical criteria. Regular revision and adjustment of medications in older patients and preference for the non-pharmacological treatment of chronic pain are essential for preventing ST. This case report is a convenient way for many healthcare professionals to update their knowledge about ST, its diagnosis and management.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"1-7"},"PeriodicalIF":0.9,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety of Naldemedine for Opioid-Induced Constipation - A Systematic Review and Meta-Analysis. 纳德美定治疗阿片类药物引起的便秘的安全性：一项系统综述和荟萃分析。

IF 0.9

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2024-12-19 DOI: 10.1080/15360288.2024.2427324

Bastian Wobbe, Maximilian Gerner, Claus-Henning Köhne

{"title":"Safety of Naldemedine for Opioid-Induced Constipation - A Systematic Review and Meta-Analysis.","authors":"Bastian Wobbe, Maximilian Gerner, Claus-Henning Köhne","doi":"10.1080/15360288.2024.2427324","DOIUrl":"https://doi.org/10.1080/15360288.2024.2427324","url":null,"abstract":"Naldemedine is a peripheral acting µ-opioid receptor antagonist approved by the Food and Drug Administration to treat opioid-induced constipation. Concerns about side effects like opioid withdrawal prevent its widespread use, especially for cancer patients. We performed this systematic review and meta-analysis to evaluate existing safety data of naldemedine treating opioid-induced constipation following the PRISMA guidelines. We searched PubMed and the Cochrane Library on April 16th 2024 to identify studies evaluating naldemedine treatment among patients with opioid-induced constipation. Our analysis found no differences between groups comparing naldemedine therapy with placebo-control for treatment-emergent adverse events (OR = 1.06; 95%-CI: 0.91-1.24), serious adverse events (OR = 1.02; 95%-CI: 0.76-1.38). We found no increased risk for opioid withdrawal, while an increased risk for gastrointestinal disorders (OR = 2.08; 95%-CI: 1.72-2.51), particularly higher incidences of diarrhea (OR = 2.44; 95%-CI: 1.81-3.29) and abdominal pain (OR = 3.31; 95%-CI: 2.16-5.06) were found. In the cancer subgroup, treatment-emergent and serious adverse events were more frequent. However, no increased risk for opioid withdrawal was observed. This analysis confirms naldemedine's overall safety in treating opioid-induced constipation, with manageable gastrointestinal side effects. However, the higher adverse events in cancer patients require further investigation to ensure safe use in this population.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"1-18"},"PeriodicalIF":0.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intravenous Magnesium Sulfate as an Adjunct to Intravenous Ketamine for Acute Pain: A Case Series. 静脉注射硫酸镁辅助静脉注射氯胺酮治疗急性疼痛：一个病例系列。

IF 0.9

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2024-12-13 DOI: 10.1080/15360288.2024.2441794

Nathan Smith, Sanny Juresic, Kia Lor, Carrie Schmidt, Annie Bell Howrigon, Oludare Olatoye

引用次数: 0

Deafferentation in Pain Medicine: A Narrative Review of Mechanisms and Management. 疼痛医学中的神经传入障碍：机制和管理的叙述性回顾。

IF 0.9

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2024-12-12 DOI: 10.1080/15360288.2024.2432640

Usama Ahmed, Mohjir Baloch

{"title":"Deafferentation in Pain Medicine: A Narrative Review of Mechanisms and Management.","authors":"Usama Ahmed, Mohjir Baloch","doi":"10.1080/15360288.2024.2432640","DOIUrl":"https://doi.org/10.1080/15360288.2024.2432640","url":null,"abstract":"Deafferentation is an umbrella term that includes several clinical conditions. The exact mechanism is not yet known, and the different clinical conditions do not necessarily share common pathophysiology. It includes both non-painful and painful conditions, including cancer pain conditions. Clinical presentation can be immediate or delayed, sometimes years after the causative lesion. Patients experience neuropathic pain symptoms in an area of abnormal or absent sensation. Laboratory tests show denervation and loss of function. Pain management strategies can be directed toward alleviating symptoms rather than eradication. The site of origin of the pain can help decide the treatment modalities to be tried. Gabapentinoids, antidepressants, and sodium channel blockers can be used. This type of pain is typically opioid-nonresponsive, but some patients may benefit. Neuronal destructive procedures are indicated for brachial plexus avulsion injuries. Spinal cord stimulation, dorsal root entry zone rhizotomy, deep brain thalamic stimulation, and motor cortex stimulation have been suggested for the management of the complex clinical conditions under the umbrella of deafferentation.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"1-10"},"PeriodicalIF":0.9,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Teaching People About Pain: A Path to Healing Beyond Medication. 教导人们关于疼痛：一条超越药物治疗的道路。

IF 0.9

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2024-12-11 DOI: 10.1080/15360288.2024.2436979

Jeff Clyde G Corpuz

引用次数: 0

Medicinal Cannabis: A Potential Tool for Managing Chronic Pain and Mental Health in Asia. 药用大麻：在亚洲管理慢性疼痛和心理健康的潜在工具。

IF 0.9

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2024-12-11 DOI: 10.1080/15360288.2024.2436975

John Patrick C Toledo

引用次数: 0

Case Report: Buprenorphine for Palliation in a Patient with End Stage Renal Disease. 病例报告：丁丙诺啡对终末期肾病患者的缓解作用。

IF 0.9

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2024-12-05 DOI: 10.1080/15360288.2024.2435425

Sing Ping Chow, Scott Donelenko, Chris Coppock

引用次数: 0

Intrathecal Baclofen Pump Refill-Related Cardiac Arrest: A Case Report. 鞘内巴氯芬泵再充相关心脏骤停1例报告。

IF 0.9

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2024-11-28 DOI: 10.1080/15360288.2024.2433639

Mohammad Aldalahmeh, Elie Bou Sanayeh, Waleed Sadiq, Chapman Wei, Michel Chalhoub

引用次数: 0

Pain-Induced Delirium in Patient with Dementia: A Case Report and Narrative Review. 痴呆患者的疼痛性谵妄：1例报告及叙述回顾。

IF 0.9

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2024-11-28 DOI: 10.1080/15360288.2024.2433198

Julia Dian Christiani Adi Santoso, Erikavitri Yulianti

{"title":"Pain-Induced Delirium in Patient with Dementia: A Case Report and Narrative Review.","authors":"Julia Dian Christiani Adi Santoso, Erikavitri Yulianti","doi":"10.1080/15360288.2024.2433198","DOIUrl":"https://doi.org/10.1080/15360288.2024.2433198","url":null,"abstract":"Pain management is the hallmark of palliative care; however, pain is commonly underassessed in cases of advanced dementia and delirium (acute confusional state). We present a case of a 66-year-old female patient with severe dementia who was hospitalized because of behavioral changes and sleep disturbance. Symptoms of confusion, disorientation, inattention, and agitation were most severe at night. The patient never complained of any pain. Thorough examination revealed delirium superimposed on dementia with behavioral and psychological symptoms of dementia, frozen shoulder, osteoarthritis, tooth pain, and geriatric syndrome. Treatment with tablets memantine 5 mg q.12 h, donepezil 10 mg q.day, haloperidol 1 mg q.12 h, lorazepam 1 mg q.day (if necessary), acetaminophen 500 mg q.8 h, and methylprednisolone 4 mg q.8 h, along with psychosocial support, improved her symptoms. Pain often manifests as neuropsychiatric symptoms, resulting in inappropriate use of antipsychotics. Precise pain assessment and effective treatment are imperative, particularly in advanced dementia. Underassessed and undertreated pain in dementia may lead to delirium and progression of dementia. It is paramount for future studies to emphasize comprehensive multidimensional pain assessment and total pain to better manage pain in advanced dementia, which will further enhance psychological well-being and quality of life in palliative care.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"1-12"},"PeriodicalIF":0.9,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Family Caregivers in Palliative Care Therapeutic Management: An Integrative Review. 姑息治疗管理中的家庭照顾者：一项综合综述。

IF 0.9

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2024-11-28 DOI: 10.1080/15360288.2024.2433204

Dora Margarida Fragoso Santos, Patrícia Silva-Pereira

引用次数: 0