Journal of Pain & Palliative Care Pharmacotherapy最新文献_第3页

Efficacy of Low-Dose Naltrexone in Treating Patients with Fibromyalgia: systematic Review and Meta-Analysis. 低剂量纳曲酮治疗纤维肌痛的疗效：系统评价和荟萃分析。

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-09-01 Epub Date: 2025-04-24 DOI: 10.1080/15360288.2025.2496526

Abiodun Ologunowa, Marianne N Otoo, Aisling R Caffrey, Ashley Buchanan, Uche J Eze, Ami Vyas

{"title":"Efficacy of Low-Dose Naltrexone in Treating Patients with Fibromyalgia: systematic Review and Meta-Analysis.","authors":"Abiodun Ologunowa, Marianne N Otoo, Aisling R Caffrey, Ashley Buchanan, Uche J Eze, Ami Vyas","doi":"10.1080/15360288.2025.2496526","DOIUrl":"10.1080/15360288.2025.2496526","url":null,"abstract":"Low-dose naltrexone (LDN) has demonstrated mixed efficacy in treating fibromyalgia. This systematic review and meta-analysis aimed to evaluate the efficacy of LDN for fibromyalgia. We systematically searched electronic databases and gray literature from inception to May 2024. Included studies were clinical trials in humans published in English, reporting mean changes in pain scores and fibromyalgia symptom severity, comparing baseline to endpoint and LDN to placebo. Of 575 identified articles, eight met the eligibility criteria. In the LDN group, the Standardized Mean Difference (SMD) for pain decreased by 1.03 (95% confidence interval (CI): -1.25, -0.80; I2 = 25%), and fibromyalgia symptom severity decreased by 1.02 (95% CI: -1.35, -0.69; I2 = 52%) post-LDN treatment compared to the baseline. However, no significant differences in mean change in pain (SMD -0.50, 95% CI: -1.19, 0.19; I2 = 91%) and fibromyalgia symptoms severity scores (SMD -0.67, 95% CI: -1.67, 0.34; I2 = 95%) were observed between the LDN and placebo groups. Although LDN marginally reduced pain and symptom severity from baseline, these effects were not superior to placebo. This suggests that LDN may not provide significant clinical benefit over placebo in fibromyalgia management, warranting further research.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"363-373"},"PeriodicalIF":1.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TRPV1 in Dorsal Root Ganglion Contributed to Chronic Pancreatitis Pain. 背根神经节TRPV1与慢性胰腺炎疼痛有关。

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-09-01 Epub Date: 2025-05-15 DOI: 10.1080/15360288.2025.2500984

Yali Li, Chenshuai Li, Haiyun Zhu, Yuru Chu

{"title":"TRPV1 in Dorsal Root Ganglion Contributed to Chronic Pancreatitis Pain.","authors":"Yali Li, Chenshuai Li, Haiyun Zhu, Yuru Chu","doi":"10.1080/15360288.2025.2500984","DOIUrl":"10.1080/15360288.2025.2500984","url":null,"abstract":"Chronic pancreatitis presents a formidable challenge in pain management, often leading to significant suffering and reduced quality of life for affected individuals. The intricate interplay of factors contributing to this pain, including inflammation and neural sensitization, has garnered increasing attention in recent research. Among the key players in this scenario are the transient receptor potential vanilloid 1(TRPV1) channels located in dorsal root ganglion (DRG) neurons. These channels, known for their role in pain perception, exhibit heightened sensitivity and altered expression patterns in the context of chronic pancreatitis. Sensitization of TRPV1 channels amplifies their response to various pain triggers, exacerbating the perception of discomfort. Furthermore, dysregulated expression of TRPV1 within DRG neurons contributes to the chronic pain phenotype associated with pancreatitis. Understanding the nuanced mechanisms governing TRPV1 modulation in DRG neurons promises to unlock novel therapeutic avenues for managing chronic pancreatitis pain. By targeting TRPV1 channels specifically in DRG neurons, researchers aim to develop treatments that alleviate pain while minimizing adverse effects, ultimately offering hope for improved outcomes and enhanced well-being for individuals grappling with this debilitating condition.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"384-392"},"PeriodicalIF":1.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determinants of Effective Pain Management in Pediatric Patients: An Assessment of Attitudes and Barriers. 儿童患者有效疼痛管理的决定因素：态度和障碍的评估。

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-09-01 Epub Date: 2025-04-14 DOI: 10.1080/15360288.2025.2491699

Basma Salameh, Inad Nawajah, Ismael Ahmad Al-Nawaja'a, Sameer A Alkubati, Haitham Khatatbeh, Mohammed ALBashtawy, Mohammad Rababa, MainNaser Alolayyan

引用次数: 0

Pain and Palliative Care. 疼痛和姑息治疗。

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-09-01 Epub Date: 2025-05-14 DOI: 10.1080/15360288.2025.2504464

Awu Isaac Oben

引用次数: 0

Can Generative Artificial Intelligence Reduce Pain? 生成式人工智能能减轻疼痛吗？

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-09-01 Epub Date: 2025-05-12 DOI: 10.1080/15360288.2025.2504461

Awu Isaac Oben

引用次数: 0

Oral Ketamine as an Analgesic Therapy: Systematic Review of Randomised Clinical Trials. 口服氯胺酮作为一种镇痛疗法：随机临床试验的系统评价。

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-09-01 Epub Date: 2025-04-30 DOI: 10.1080/15360288.2025.2496520

María Alejandra Umbacia, Agnès Calsina-Berna, Angie Nathalia Hernández-Rico, Fernan Alejandro Mendoza-Montenegro, Juan Sebastián Gallo-Hincapié, Lina Marcela Ruiz Cadena, María Fernanda Martínez-Díaz, Sebastian Del Castillo Visbal, Juan Esteban Correa-Morales

{"title":"Oral Ketamine as an Analgesic Therapy: Systematic Review of Randomised Clinical Trials.","authors":"María Alejandra Umbacia, Agnès Calsina-Berna, Angie Nathalia Hernández-Rico, Fernan Alejandro Mendoza-Montenegro, Juan Sebastián Gallo-Hincapié, Lina Marcela Ruiz Cadena, María Fernanda Martínez-Díaz, Sebastian Del Castillo Visbal, Juan Esteban Correa-Morales","doi":"10.1080/15360288.2025.2496520","DOIUrl":"10.1080/15360288.2025.2496520","url":null,"abstract":"Ketamine is an analgesic used to manage neuropathic pain, but its use is limited by side effects and intravenous administration. Recently, the use of oral and nasal administration has expanded. However, no systematic review of randomized studies on its efficacy and safety. A search was conducted in PubMed, CINHAL, and Web of Science up to December 19, 2023. Randomized studies evaluating oral ketamine for managing any type of pain were included. Articles were assessed for quality using the ROB2 tool, and results were reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The search yielded 1439 results. Six randomized studies were selected. The oral ketamine dose ranged from 0.5 to 10 mg/kg, up to a maximum of 400 mg/day. Three studies comparing oral ketamine with other analgesics found no differences between groups. Two studies compared oral ketamine to placebo; one showed a reduction in local anesthetic use and intraoperative pain, while the other found no difference. Adverse reactions were common, but their severity was not reported. Preliminary evidence suggests that oral ketamine may be considered in select patients with refractory chronic neuropathic pain. The potential use in outpatient settings warrants further high-quality studies.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"353-362"},"PeriodicalIF":1.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Pharmacist's Guide to Managing Difficult Conversations in Pain Management and Opioid Use Settings. 在疼痛管理和阿片类药物使用设置中管理困难对话的药剂师指南。

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-08-23 DOI: 10.1080/15360288.2025.2547831

Denise Courtney, Sudheer Potru, Sing Ping Chow, Paige Mathew, Ariana M Nelson

{"title":"A Pharmacist's Guide to Managing Difficult Conversations in Pain Management and Opioid Use Settings.","authors":"Denise Courtney, Sudheer Potru, Sing Ping Chow, Paige Mathew, Ariana M Nelson","doi":"10.1080/15360288.2025.2547831","DOIUrl":"https://doi.org/10.1080/15360288.2025.2547831","url":null,"abstract":"Pain remains one of the most common reasons that individuals seek healthcare. Despite advances in pain care and an improved understanding of the harms associated with opioid use, there is still considerable reliance on opioid medications for treating both acute and chronic pain. With the implementation of guidelines emphasizing opioid risk mitigation strategies and non-pharmacologic treatments, healthcare providers increasingly engage in conversations with patients about opioid safety and alternative therapies. Pharmacists are highly accessible healthcare professionals who practice in a variety of settings and, therefore, often face conversations related to pain management and opioid use. Healthcare professionals in general receive limited training in pain care and empathetic communication, which can create barriers to effective patient-provider interactions. This publication aims to equip pharmacists with practical tools and strategies for managing difficult conversations related to pain management and opioid use. With the appropriate tools, pharmacists can work toward improving patient-provider relationships, enhancing patient outcomes, and creating a more supportive environment.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"1-9"},"PeriodicalIF":1.0,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144958075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post-Operative Bleed Risks Associated with Perioperative Nonsteroidal Anti-Inflammatory Drugs: A Narrative Review. 围手术期非甾体类抗炎药物与术后出血风险相关的综述。

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-08-19 DOI: 10.1080/15360288.2025.2547839

Laura L Seitz, Sanny Juresic, Leslie R Siegel, Nathan T Smith

{"title":"Post-Operative Bleed Risks Associated with Perioperative Nonsteroidal Anti-Inflammatory Drugs: A Narrative Review.","authors":"Laura L Seitz, Sanny Juresic, Leslie R Siegel, Nathan T Smith","doi":"10.1080/15360288.2025.2547839","DOIUrl":"10.1080/15360288.2025.2547839","url":null,"abstract":"Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used medications that function by inhibiting cyclooxygenase enzymes. Although they are highly effective in managing pain and inflammation, their potential for increasing bleeding risks continues to be a concern. Due to the increased risk for bleeding complications following surgical procedures, the safety of perioperative NSAIDs is debated. The primary objective of this article is to examine literature published in the past 10 years focused on post-operative bleeding risks associated with perioperative NSAID use. A systematic search was designed to include randomized controlled trials, systematic review meta-analyses, and retrospective or prospective reviews examining post-operative bleeding events associated with perioperative NSAID use in adults. Following the screening process and review, 11 articles were included. The reviewed literature primarily examines post-operative bleeding incidence, blood loss, hemoglobin decline, and the frequency of hematomas or hemorrhages. Overall, the evidence suggests that perioperative NSAIDs have minimal impact on post-operative bleeding risk. COX-2 selective NSAIDs may be a safer alternative to nonselective NSAIDs, with some studies indicating a lower risk of post-operative bleeding following their use. Ultimately, the decision to use NSAIDs in the perioperative period should be tailored to the specific surgical procedure and individual patient factors.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"1-7"},"PeriodicalIF":1.0,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medication Overuse Headache in the US: A National Cross-Sectional Survey. 美国药物过度使用头痛：一项全国性横断面调查。

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-08-19 DOI: 10.1080/15360288.2025.2538517

Naomi N Bailey, Christopher M Herndon, Timothy D Cruz

{"title":"Medication Overuse Headache in the US: A National Cross-Sectional Survey.","authors":"Naomi N Bailey, Christopher M Herndon, Timothy D Cruz","doi":"10.1080/15360288.2025.2538517","DOIUrl":"10.1080/15360288.2025.2538517","url":null,"abstract":"This study was conducted to assess participant understanding of medication-overuse headache (MOH) by adults in the US. It was conducted using an 18 item, descriptive questionnaire which addressed demographic information, frequency and severity of headaches, type of headaches experienced, medication use frequency, perceived risk for MOH of specific medications, and knowledge of the term \"medication-overuse or rebound headache.\" Descriptive statistics and Mann-Whitney U tests were used in analyzing data. The study included 329 (n = 329) participants. Almost half of respondents were between the ages 18 and 30 years old [155/329 (47.1%)]. The most common type of headache diagnosis reported was tension-type headache [144/329 (43.8%)]. About 10% (31/329) of survey respondents reported chronic daily headache, or headache that is present on at least 15 days per month. Of the survey respondents, 26.7% (88/329) had never heard of the term \"medication-overuse headache.\" A significant number of participants who reported overusing various medications also reported that they had never heard of the term \"medication-overuse headache.\" This study shows that many of the respondents, including some who use analgesics or abortive medications for headaches, were not familiar with MOH. Furthermore, it suggests that patients may benefit from further education on this condition.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"1-9"},"PeriodicalIF":1.0,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144883047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retrospective Study of Trigger Point Injections for Myofascial Pain Syndrome in Cancer Patients: Impact on Pain Relief and Opioid Tapering. 触发点注射治疗癌症患者肌筋膜疼痛综合征的回顾性研究：对疼痛缓解和阿片类药物逐渐减少的影响。

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-08-19 DOI: 10.1080/15360288.2025.2546572

Yohei Shimazaki, Yukiko Iwasaki, Ayaka Takasugi, Takuya Miyabe, Takayuki Yokota, Hiroki Kurihara, Yusuke Yajima, Hiroyuki Nagano, Tetsuo Kamiyama, Satoru Iwase

{"title":"Retrospective Study of Trigger Point Injections for Myofascial Pain Syndrome in Cancer Patients: Impact on Pain Relief and Opioid Tapering.","authors":"Yohei Shimazaki, Yukiko Iwasaki, Ayaka Takasugi, Takuya Miyabe, Takayuki Yokota, Hiroki Kurihara, Yusuke Yajima, Hiroyuki Nagano, Tetsuo Kamiyama, Satoru Iwase","doi":"10.1080/15360288.2025.2546572","DOIUrl":"10.1080/15360288.2025.2546572","url":null,"abstract":"Although the pathogenesis and management of Myofascial Pain Syndrome (MPS) have been discussed in the literature, only a few studies have examined the effects of trigger point injection (TPI) on MPS or opioid dosage in patients with cancer. We evaluated changes in numeric rating scale (NRS) scores and opioid dosage, along with the duration of opioid use, nutritional status, and the types of cancer and metastases in patients with cancer and MPS who received TPI, to evaluate its clinical significance. Data were collected retrospectively from 20 inpatients with cancer and MPS who received TPI for pain management from the palliative care team between April 2018 and January 2020. TPI improved NRS scores in several cases and reduced opioid dosage. Notably, long-term opioid users (up to 336 days) also experienced improvements in NRS scores and discontinued opioids. TPI is an effective intervention for managing MPS in patients with cancer and may help prevent unnecessary escalation of opioid therapy, reducing the associated risks of side effects and dependency.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"1-10"},"PeriodicalIF":1.0,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0