Journal of Pain & Palliative Care Pharmacotherapy最新文献_第3页

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2024-08-28 DOI: 10.1080/15360288.2024.2393843

Dalmacito Cordero

引用次数: 0

Outcomes of Psychotherapy for Co-Morbid Pain and Substance Use Disorders: A Review of the Literature. 疼痛与药物使用障碍并存时的心理治疗效果：文献综述

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2024-08-26 DOI: 10.1080/15360288.2024.2393842

Samuel J Mendez Araque, Lynn T Nguyen, Celeste N Nadal

{"title":"Outcomes of Psychotherapy for Co-Morbid Pain and Substance Use Disorders: A Review of the Literature.","authors":"Samuel J Mendez Araque, Lynn T Nguyen, Celeste N Nadal","doi":"10.1080/15360288.2024.2393842","DOIUrl":"https://doi.org/10.1080/15360288.2024.2393842","url":null,"abstract":"Chronic pain is often treated with opioids, placing patients at risk for misuse. An estimated 11.5% of these patients engage in opioid misuse behaviors such as self-medication. Non-pharmacological interventions have efficacy in managing chronic pain and substance use disorders separately; comorbid management may benefit from psychotherapy. This review provides perspective on novel and existing therapies and their efficacy. The literature search was conducted using PubMed. Boolean search terms were selected from DSM and ICD diagnoses. Studies were included if patients had comorbid substance use disorder and chronic pain diagnoses, participants were age 18 or older, and psychotherapeutic interventions were implemented. The PubMed search yielded 1937 references; 25 references were obtained through other means. 30 sources met inclusion criteria. Reported trials included: Acceptance and Commitment Therapy (ACT, 2 trials); Cognitive Behavioral Therapy (CBT, 11 trials); Mindfulness-Oriented Recovery Enhancement (MORE, 5 trials); and novel psychotherapies (12 trials). Unique features included primary care (4 trials), technology such as phone or Internet (6 trials), and group settings (9 trials). Several psychotherapies effectively treat co-occurring substance use disorders and chronic pain; novel treatments continue to be developed. Further investigation may lead to a wider variety of treatments for clinical use.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"1-17"},"PeriodicalIF":0.9,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antidepressant Efficacy in Managing Nonspecific Chronic Lower Back Pain Among Older Adults: A Review. 抗抑郁药在治疗老年人非特异性慢性腰背痛中的疗效：综述。

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2024-08-12 DOI: 10.1080/15360288.2024.2384961

Krzysztof Wilczyński, Adam Mazurski, Kornela Kotucha

{"title":"Antidepressant Efficacy in Managing Nonspecific Chronic Lower Back Pain Among Older Adults: A Review.","authors":"Krzysztof Wilczyński, Adam Mazurski, Kornela Kotucha","doi":"10.1080/15360288.2024.2384961","DOIUrl":"https://doi.org/10.1080/15360288.2024.2384961","url":null,"abstract":"This review evaluates the use of antidepressants in older patients for the treatment of nonspecific chronic lower back pain (LBP), emphasizing age-related physiological changes and common degenerative conditions in this age group. We conducted a comprehensive search targeting studies on antidepressant use in older patients with LBP. Selective serotonin reuptake inhibitors, while effective for mood regulation, show limited benefits for LBP. Serotonin-norepinephrine reuptake inhibitors, particularly duloxetine, demonstrate potential in managing LBP, though further research is needed to confirm these findings. Tricyclic antidepressants have shown potential for pain relief, with limited evidence for LBP, but have a substantial side effect profile, including cardiotoxicity, weight gain, and severe anticholinergic effects. The evidence for trazodone in the treatment of LBP is limited. When prescribing new medications for older adults, it is crucial to carefully consider the patient's overall health, potential drug interactions, and sensitivity to side effects, ensuring that the benefits of treatment outweigh the risks. This review underscores the need for further research to understand the long-term effects and benefits of antidepressants in older patients with LBP, aiming to balance pain relief, mood stabilization, and minimized side effects.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"1-15"},"PeriodicalIF":0.9,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141971317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Effectiveness and Safety of Sublingual Fentanyl in the Treatment of Breakthrough Cancer Pain in Older Patients with Cancer: Results from a Retrospective Observational Study. 舌下含服芬太尼治疗老年癌症患者突破性癌痛的有效性和安全性：一项回顾性观察研究的结果。

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2024-08-08 DOI: 10.1080/15360288.2024.2385680

Jordi Guitart-Vela, Ángela Magrone, Gloria González, Jordi Folch

{"title":"Effectiveness and Safety of Sublingual Fentanyl in the Treatment of Breakthrough Cancer Pain in Older Patients with Cancer: Results from a Retrospective Observational Study.","authors":"Jordi Guitart-Vela, Ángela Magrone, Gloria González, Jordi Folch","doi":"10.1080/15360288.2024.2385680","DOIUrl":"10.1080/15360288.2024.2385680","url":null,"abstract":"The study assessed sublingual fentanyl citrate (SFC) effectiveness and safety for breakthrough cancer pain (BtCP) in older patients. A multicenter, retrospective, observational study was conducted in three subgroups of cancer patients aged over 65 years with BtCP. The reports were collected by 20 oncologists across 12 hospitals. The primary goal was to measure changes in BtCP intensity with SFC treatment over 30 days; secondary objectives included pain relief onset and adverse events. A total of 127 patients with long-term cancer (mean: 3.3 years) were recruited. All of them had BtCP, mostly of mixed origin (62.5%). A significantly lower dose was needed in the high-age group at the final visit compared to baseline (212.90 ± 200.45 mcg vs. 206 ± 167.08 mcg; p = 0.000). Pain intensities at the beginning of the flare and at 30 min after SFC administration were significantly lower when the last and first visits were compared (1.9 vs. 2.3, p = 0.000; and 6.2 vs. 6.8 p = 0.006, respectively). The onset of analgesia was significantly more rapid for half of the patients ≥75 years, compared with 65-69 and 70-74 age groups. SFC appears then to be effective, well-tolerated, and safe to treat BtCP in older cancer patients.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"1-12"},"PeriodicalIF":0.9,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141902091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outpatient Patient Controlled Analgesia (PCA) for the Palliative Care Patient. 姑息治疗病人的门诊病人控制镇痛（PCA）。

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2024-08-05 DOI: 10.1080/15360288.2024.2383415

Jacob T Painter, Kennede McLeroy-Charles, Heather Moore, Sarah Harrington, Lindsey E Dayer

{"title":"Outpatient Patient Controlled Analgesia (PCA) for the Palliative Care Patient.","authors":"Jacob T Painter, Kennede McLeroy-Charles, Heather Moore, Sarah Harrington, Lindsey E Dayer","doi":"10.1080/15360288.2024.2383415","DOIUrl":"https://doi.org/10.1080/15360288.2024.2383415","url":null,"abstract":"This study explores the under-researched domain of patient-controlled analgesia (PCA) for cancer pain management in adult outpatients, focusing on the transition from patient-controlled analgesia pumps (PCA pump) to oral medications. While existing literature primarily addresses the use of PCA in inpatient settings, this descriptive study investigates the initiation of outpatient PCA in palliative care patients. The retrospective chart review includes data from all admissions between July 1, 2014, and December 31, 2020. Among the 49 identified patients, 41 were admitted for cancer-related pain, with an indication for PCA such as insufficient pain relief, highly fluctuating pain, or inadequate response to other routes. Of these patients, 13 were successfully transitioned from outpatient PCA to oral opioids. The study underscores the effective use of PCA as a transitional tool following a pain crisis that necessitates inpatient admission. Future research avenues could explore healthcare utilization, length of stay, and required outpatient resources, such as home visits or telehealth, for optimal PCA use in outpatient settings.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"1-6"},"PeriodicalIF":0.9,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Methadone for Pain Management in Chemotherapy-Induced Peripheral Neuropathy: A Retrospective Review. 美沙酮用于化疗引起的周围神经病变的疼痛治疗：回顾性综述。

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2024-07-30 DOI: 10.1080/15360288.2024.2383423

Christiane Boen, Julia Ridley, Philippa Hawley

{"title":"Methadone for Pain Management in Chemotherapy-Induced Peripheral Neuropathy: A Retrospective Review.","authors":"Christiane Boen, Julia Ridley, Philippa Hawley","doi":"10.1080/15360288.2024.2383423","DOIUrl":"https://doi.org/10.1080/15360288.2024.2383423","url":null,"abstract":"Chemotherapy-Induced Peripheral Neuropathy (CIPN) refers to damage of peripheral nerve fibers due to the use of neurotoxic chemotherapy to treat various cancers. It occurs in more than 30% of patients and only duloxetine has currently been identified to show limited efficacy in symptomatic treatment of CIPN. Opioids have traditionally been used to treat cancer pain, and there is evidence for their use in treatment of peripheral neuropathic pain from other causes. With a similar mechanism of action to duloxetine, methadone has rationale for treating neuropathic pain. This study is a retrospective chart review to evaluate the outcomes of using methadone for CIPN pain. Out of 31 patients, 65% felt that methadone was an effective treatment, 19% felt that it was ineffective, and 16% felt that it was partially or temporarily effective. These results suggest that analgesic response to methadone varies between patients, but that it has a potential role in painful CIPN. Its advantages for long-term use include low cost and lack of metabolites. Potential risks include a long half-life, drug interactions, and potential for QT prolongation at high doses. Prospective studies should be conducted to evaluate the role of methadone in CIPN pain management more comprehensively.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"1-10"},"PeriodicalIF":0.9,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141855804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The Foreigner. 外国人

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2024-07-25 DOI: 10.1080/15360288.2024.2383463

Tarek Zieneldien

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All Palliative Care Should Be Integrative Palliative Care. 所有姑息关怀都应是整合性姑息关怀。

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2024-07-24 DOI: 10.1080/15360288.2024.2377998

Delia Chiaramonte

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Intravenous Ketamine for Cancer Pain: A Single-Center Retrospective Analysis Comparing Fixed-Rate Versus Weight-Based Dosing. 静脉注射氯胺酮治疗癌症疼痛：固定剂量与按体重给药的单中心回顾性分析比较。

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2024-07-11 DOI: 10.1080/15360288.2024.2374297

Leslie Siegel, Kyle Quirk, Gary Houchard, Sarah Ehrman, Eric McLaughlin, Omar Hajmousa, Maureen Saphire

{"title":"Intravenous Ketamine for Cancer Pain: A Single-Center Retrospective Analysis Comparing Fixed-Rate Versus Weight-Based Dosing.","authors":"Leslie Siegel, Kyle Quirk, Gary Houchard, Sarah Ehrman, Eric McLaughlin, Omar Hajmousa, Maureen Saphire","doi":"10.1080/15360288.2024.2374297","DOIUrl":"10.1080/15360288.2024.2374297","url":null,"abstract":"Although weak evidence exists to support subanesthetic ketamine for cancer pain treatment, successful use may be hindered in the absence of standardized dosing guidance. We aimed to compare the success rates of intravenous ketamine fixed-rate versus weight-based dosing strategies for cancer pain treatment, and to assess patient characteristics that correlate with treatment success. We conducted a single-center retrospective review including non-critically ill adults with cancer pain who received subanesthetic ketamine for at least 24-h. All patients received fixed-rate ketamine; weight-based doses were retrospectively determined using total body weight. Treatment was considered successful if after reaching the maximum prescribed ketamine dose the patient had a 30% reduction in: baseline pain score, as-needed opioid use, or total morphine equivalent daily dose over a standardized 24-h. Of 105 included patients, 51 (48.6%) successfully responded to ketamine. Responders had lower fixed-rate ketamine doses compared to non-responders (median[IQR] 15 mg/hr[10-15] vs. 15 mg/hr[15-20], p = 0.043), but no difference in retrospectively calculated weight-based doses (0.201 ± 0.09 mg/kg/hr vs. 0.209 ± 0.08 mg/kg/hr, p = 0.59). Responders had higher daily opioid requirements at baseline compared to non-responders (p = 0.04). Though underpowered, our findings suggest that weight-based ketamine dosing may not convey additional benefit over fixed-rate dosing.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"1-9"},"PeriodicalIF":0.9,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141590573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Opioid Medication Errors in Patients Followed by Home Palliative Care Support Teams in the Community of Madrid. 马德里社区居家姑息关怀支持团队随访患者的阿片类药物用药错误。

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Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2024-07-05 DOI: 10.1080/15360288.2024.2369542

María Consuelo Fernández Gómez, Genoveva Díaz Sierra, María Del Carmen Peinado Cañaveras, María Antonia Berrocal Higuero, Cristina de Miguel Sánchez

{"title":"Opioid Medication Errors in Patients Followed by Home Palliative Care Support Teams in the Community of Madrid.","authors":"María Consuelo Fernández Gómez, Genoveva Díaz Sierra, María Del Carmen Peinado Cañaveras, María Antonia Berrocal Higuero, Cristina de Miguel Sánchez","doi":"10.1080/15360288.2024.2369542","DOIUrl":"10.1080/15360288.2024.2369542","url":null,"abstract":"The presence of comorbidities and complex drug regimens makes palliative care patients more susceptible to opioid medication errors. Most of the studies conducted so far have mainly focused on patients admitted to hospitals or hospice facilities. During this study, we examined the frequency of medication errors with opioids and the causes and consequences for patients, followed by home palliative care teams. Errors occurred in 39% of patients (n = 378) and 27% of all prescribed opioids (n = 708). Of the 148 (39%) patients with error/s in the opioid/s prescribed, in 55% the patient and/or the caregiver were involved in the error; in 26% the health care providers were involved. An association was found between the presence of error in the prescribed opioid and the level of patient education, p = .038, and with the number of days of follow-up, p < .001. Considering their formulation, the prescribed opioids were associated with medication error, type of error, and cause of the error. The study demonstrated an association between the route of administration and error p < .004, and type of error p < .001.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"1-11"},"PeriodicalIF":0.9,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141534620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0