A Stepwise Approach to Transitioning from Methadone to Buprenorphine for Cancer-Related Pain in an Outpatient Setting: A Novel Opioid Rotation Without Clinically Evident Withdrawal Symptoms.

This case report details a successful transition of a patient with cancer-related pain from long-term methadone therapy to sublingual buprenorphine using a micro-induction protocol in an outpatient setting. The transition involved initiating low-dose transdermal buprenorphine while gradually tapering methadone, followed by the introduction of sublingual buprenorphine. This approach resulted in a smooth conversion without clinically evident withdrawal symptoms and led to improved pain control, reduced adverse effects, and enhanced functional status. A gradual transition from methadone to buprenorphine represents a safe and effective outpatient strategy for managing cancer-related pain. Future research should focus on refining micro-induction protocols and exploring precision medicine in opioid transitions.