Journal of Occupational Health最新文献_第5页

Application of machine learning for detecting high fall risk in middle-aged workers using video-based analysis of the first 3 steps. 机器学习应用于检测中年工人的高跌倒风险，使用基于视频的前三个步骤分析。

IF 2.6 4区医学

Journal of Occupational Health Pub Date : 2025-01-07 DOI: 10.1093/joccuh/uiae075

Naoki Sakane, Ken Yamauchi, Ippei Kutsuna, Akiko Suganuma, Masayuki Domichi, Kei Hirano, Kengo Wada, Masashi Ishimaru, Mitsuharu Hosokawa, Yosuke Izawa, Yoshihiro Matsumura, Junichi Hozumi

{"title":"Application of machine learning for detecting high fall risk in middle-aged workers using video-based analysis of the first 3 steps.","authors":"Naoki Sakane, Ken Yamauchi, Ippei Kutsuna, Akiko Suganuma, Masayuki Domichi, Kei Hirano, Kengo Wada, Masashi Ishimaru, Mitsuharu Hosokawa, Yosuke Izawa, Yoshihiro Matsumura, Junichi Hozumi","doi":"10.1093/joccuh/uiae075","DOIUrl":"10.1093/joccuh/uiae075","url":null,"abstract":"Objectives: Falls are among the most prevalent workplace accidents, necessitating thorough screening for susceptibility to falls and customization of individualized fall prevention programs. The aim of this study was to develop and validate a high fall risk prediction model using machine learning (ML) and video-based first 3 steps in middle-aged workers.Methods: Participants to provide training data (n = 190, mean [SD] age = 54.5 [7.7] years, 48.9% male) and validation data (n = 28, age = 52.3 [6.0] years, 53.6% male) were enrolled in this study. Pose estimation was performed using a marker-free deep pose estimation method called MediaPipe Pose. The first 3 steps, including the movements of the arms, legs, trunk, and pelvis, were recorded using an RGB camera, and the gait features were identified. Using these gait features and fall histories, a stratified k-fold cross-validation method was used to ensure balanced training and test data, and the area under the curve (AUC) and 95% CI were calculated.Results: Of 77 gait features in the first 3 steps, we found 3 gait features in men with an AUC of 0.909 (95% CI, 0.879-0.939) for fall risk, indicating an \"excellent\" (0.9-1.0) classification, whereas we determined 5 gait features in women with an AUC of 0.670 (95% CI, 0.621-0.719), indicating a \"sufficient\" (0.6-0.7) classification.Conclusions: These findings suggest that fall risk prediction can be developed based on ML and the first 3 steps in men; however, the accuracy was only \"sufficient\" in women. Further development of the formula for women is required to improve its accuracy in the middle-aged working population.","PeriodicalId":16632,"journal":{"name":"Journal of Occupational Health","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11848130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health effects of indium compounds in animal experiments. 动物实验中铟化合物对健康的影响。

IF 2.6 4区医学

Journal of Occupational Health Pub Date : 2025-01-07 DOI: 10.1093/joccuh/uiaf007

Akiyo Tanaka

{"title":"Health effects of indium compounds in animal experiments.","authors":"Akiyo Tanaka","doi":"10.1093/joccuh/uiaf007","DOIUrl":"10.1093/joccuh/uiaf007","url":null,"abstract":"Before 2000, very little attention had been paid to the health effects of indium, a rare metal, because there was very little information in the literature on its toxicity. A fatal case of indium-tin oxide (ITO) inhalation occurred in 2001, followed by concerns regarding occupational exposure to indium compounds and their health effects. Epidemiological studies and case reports have established a causal relationship between the inhalation of insoluble indium compounds, mainly ITO, and the development of lung damage. This review focuses on the results of animal studies of ITO and other insoluble indium compounds. Available data indicate that insoluble indium compounds such as ITO, indium arsenide (InAs), indium phosphide (InP), and copper indium gallium diselenide (CIGS) solar cell materials are toxic to the lungs of animals. In addition to lung damage, ITO nanoparticles have been found to cause kidney damage, whereas InAs, InP, and ITO cause testicular damage. Furthermore, there is compelling evidence for the carcinogenic potential of InP in long-term inhalation studies using rats and mice, which was evident in rats exposed to ITO. Based on the results of these animal experiments, the International Agency for Research on Cancer evaluated InP as probably carcinogenic to humans (Group 2A) and ITO as possibly carcinogenic to humans (Group 2 B). Based on the results of animal studies, it should be noted that occupational exposure of humans to insoluble indium compounds not only may cause lung damage, but also lung carcinogenesis and kidney or testicular damage in the future. Greater attention should be directed towards human occupational exposure to insoluble indium compounds.","PeriodicalId":16632,"journal":{"name":"Journal of Occupational Health","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Demographic and work-related correlates of general and workplace loneliness among employees in Japan: a large-scale descriptive cross-sectional study. 日本员工一般孤独感和工作孤独感的人口统计学和工作相关关系：一项大规模描述性横断面研究。

IF 2.6 4区医学

Journal of Occupational Health Pub Date : 2025-01-07 DOI: 10.1093/joccuh/uiaf015

Norito Kawakami, Akihito Shimazu, Hisashi Eguchi, Kazuhiro Watanabe, Keiichi Matsuzaki, Reiko Inoue, Naoki Kikuchi, Yasuhiro Sekine, Akizumi Tsutsumi

{"title":"Demographic and work-related correlates of general and workplace loneliness among employees in Japan: a large-scale descriptive cross-sectional study.","authors":"Norito Kawakami, Akihito Shimazu, Hisashi Eguchi, Kazuhiro Watanabe, Keiichi Matsuzaki, Reiko Inoue, Naoki Kikuchi, Yasuhiro Sekine, Akizumi Tsutsumi","doi":"10.1093/joccuh/uiaf015","DOIUrl":"10.1093/joccuh/uiaf015","url":null,"abstract":"Objectives: There has been limited research on demographic and work-related characteristics of general and workplace loneliness. The present descriptive cross-sectional study aimed to determine the demographic and work-related correlates of general and workplace loneliness in a general working population of Japan.Methods: We recruited 25 000 persons aged 20 years or older and employed by a company, organization, or government agency. We limited the sample to only employees for this analysis. Demographic and work-related characteristics were assessed by a self-report questionnaire. General and workplace loneliness were measured by single-item questions and dichotomized.Results: A total of 24 021 respondents were subjected for the analysis. Prevalences of general and workplace loneliness were 9.0% and 8.3%, respectively. Those who responded \"others\" or refused to answer a gender question (possibly gender minority), were middle-aged, not married, with a low household income, working in the manufacturing sector (compared with some service sectors), and reporting long working hours were associated with both general and workplace loneliness. Middle-aged groups and work hours were significantly associated with workplace loneliness after adjusting for general loneliness.Conclusions: Common demographic and work-related correlates were found for both general and workplace loneliness. Middle age and working long hours may be factors for workplace loneliness, independent of general loneliness, in Japan.","PeriodicalId":16632,"journal":{"name":"Journal of Occupational Health","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A method for determining workers' exposure concentration to airborne nitrilotriacetic acid. 测定工人空气中硝基三乙酸暴露浓度的方法。

IF 2.6 4区医学

Journal of Occupational Health Pub Date : 2025-01-07 DOI: 10.1093/joccuh/uiaf025

Ai Yamada, Kenta Ishii, Akito Takeuchi, Tomiko Tashiro, Ginji Endo, Mariko Ono-Ogasawara

{"title":"A method for determining workers' exposure concentration to airborne nitrilotriacetic acid.","authors":"Ai Yamada, Kenta Ishii, Akito Takeuchi, Tomiko Tashiro, Ginji Endo, Mariko Ono-Ogasawara","doi":"10.1093/joccuh/uiaf025","DOIUrl":"10.1093/joccuh/uiaf025","url":null,"abstract":"Objectives: This study aimed to establish a method to determine workers' exposure concentrations to airborne nitrilotriacetic acid (NTA).Methods: The sampler used an air sampling cassette containing a glass-fiber filter (GFF). After sampling, NTA extracted from the GFF using ultrapure water was derivatized using a boron trifluoride-methanol complex methanol solution and analyzed using a gas chromatograph-mass spectrometer. The developed method was validated for the following parameters: retention efficiency, storage stability, method quantitation limit, and reproducibility.Results: The retention efficiency for NTA on the GFF was 94%-101%, with the relative SD indicating the overall reproducibility (range 0.9%-2.4%). NTA on the GFF was stable at 4°C for at least 7 days. The method quantitation limit was 4.8 μg per sample.Conclusions: The developed method will be useful for risk assessments because it can determine workers' exposure concentrations to NTA ranging from 0.02 to 4 mg/m3 in a 240 L sampling volume; the quantitation limit is 4.8 μg per sample.","PeriodicalId":16632,"journal":{"name":"Journal of Occupational Health","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adverse effects of nanoparticles on humans. 纳米粒子对人体的不良影响。

IF 2.6 4区医学

Journal of Occupational Health Pub Date : 2025-01-07 DOI: 10.1093/joccuh/uiaf002

Yasuo Morimoto, Hiroto Izumi, Taisuke Tomonaga, Chinatsu Nishida, Hidenori Higashi

引用次数: 0

Decoding the molecular enigma behind asbestos and fibrous nanomaterial-induced carcinogenesis. 解码石棉和纤维纳米材料致癌背后的分子谜团。

IF 2.6 4区医学

Journal of Occupational Health Pub Date : 2025-01-07 DOI: 10.1093/joccuh/uiae064

Shinya Toyokuni, Yingyi Kong

{"title":"Decoding the molecular enigma behind asbestos and fibrous nanomaterial-induced carcinogenesis.","authors":"Shinya Toyokuni, Yingyi Kong","doi":"10.1093/joccuh/uiae064","DOIUrl":"10.1093/joccuh/uiae064","url":null,"abstract":"Objectives: The natural fibrous mineral, asbestos, has been useful in industry for many centuries. In the 1960s, epidemiology recognized the association between asbestos exposure and mesothelioma, and in 1987 the International Agency for Research on Cancer designated all kinds of asbestos as Group 1 carcinogens. However, various scientific enigmas remained regarding the molecular mechanisms of asbestos-induced mesothelial carcinogenesis. This review article was undertaken to reveal and summarize recent discoveries to resolve those enigmas.Methods: We collected recent important findings from our own laboratory and others to explain why mesothelial cells are the target for asbestos-induced carcinogenesis and what are the key molecular mechanisms.Results: The long incubation period of 30-40 years for mesothelial carcinogenesis after asbestos exposure allows the asbestos fibers to go through the pulmonary parenchyma from the central to peripheral portions and ultimately reach the parietal mesothelium by piercing visceral pleura. Asbestos fibers have affinity for hemoglobin and histones, thus accumulating iron on the surface while traveling through the lung. Mesothelial cells are phagocytic cells, engulfing iron-coated asbestos fibers. Accordingly, homozygous deletion of the p16INK4a tumor suppressor gene, a signature of excess iron-induced carcinogenesis, is acquired through oxidative DNA damage. Recently, exosome-dependent iron transfer from asbestos-fed macrophages to mesothelial cells was reported. Similar molecular mechanisms are observed with multiwalled carbon nanotubes of ~50-nm diameter.Conclusions: Physical dimensions, biopersistence, and affinity to iron/histones are essential for fibrous material to be carcinogenic to mesothelial cells. Therefore, local iron reduction may be a strategy to prevent mesothelial carcinogenesis.","PeriodicalId":16632,"journal":{"name":"Journal of Occupational Health","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxidative and nitrative DNA damage induced by industrial chemicals in relation to carcinogenesis. 工业化学品引起的与致癌有关的氧化性和硝化性DNA损伤。

IF 2.6 4区医学

Journal of Occupational Health Pub Date : 2025-01-07 DOI: 10.1093/joccuh/uiaf003

Yusuke Hiraku

{"title":"Oxidative and nitrative DNA damage induced by industrial chemicals in relation to carcinogenesis.","authors":"Yusuke Hiraku","doi":"10.1093/joccuh/uiaf003","DOIUrl":"10.1093/joccuh/uiaf003","url":null,"abstract":"Objectives: Many chemicals have been used for industrial purposes, and some of them are carcinogenic to humans. However, the molecular mechanisms of their carcinogenetic effects have not been well understood. Reactive oxygen species are generated from industrial chemicals and contribute to carcinogenesis. Particles and fibers are accumulated in respiratory systems by inhalation exposure and cause chronic inflammation. Under inflammatory conditions, reactive nitrogen species are generated from inflammatory and epithelial cells. These species cause oxidative and nitrative DNA damage, leading to carcinogenesis. We carried out experiments on DNA damage induced by various industrial chemicals and investigated their molecular mechanisms.Methods: We examined oxidative DNA damage induced by industrial chemicals using DNA fragments derived from human cancer-relevant genes by polyacrylamide gel electrophoresis. Using immunohistochemistry and immunocytochemistry we also examined the formation of 8-nitroguanine (8-nitroG), a DNA lesion formed under inflammatory conditions, in lung tissues and cultured cells exposed to industrial chemicals.Results: Benzene and o-toluidine metabolites caused oxidative damage to DNA fragments in the presence of Cu(II). H2O2 and Cu(I) were generated during oxidation of these chemicals and involved in DNA damage. 8-NitroG formation was observed in lung tissues of asbestos-exposed mice and humans. Carbon nanomaterials and indium compounds induced 8-nitroG formation in human lung epithelial cells via the release of damage-associated molecular patterns from exposed cells.Conclusions: Various industrial chemicals are considered to induce carcinogenesis by causing oxidative and nitrative DNA damage. These findings provide an insight into risk assessment of industrial chemicals and prevention of carcinogenesis in workplaces.","PeriodicalId":16632,"journal":{"name":"Journal of Occupational Health","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Workplace loneliness and job turnover: a 6-month prospective study. 职场孤独感与工作流动率：一项为期6个月的前瞻性研究。

IF 2.6 4区医学

Journal of Occupational Health Pub Date : 2025-01-07 DOI: 10.1093/joccuh/uiaf009

Natsu Sasaki, Kanami Tsuno, Reiko Kuroda, Kotaro Imamura, Hisashi Eguchi, Akihito Shimazu, Norito Kawakami

{"title":"Workplace loneliness and job turnover: a 6-month prospective study.","authors":"Natsu Sasaki, Kanami Tsuno, Reiko Kuroda, Kotaro Imamura, Hisashi Eguchi, Akihito Shimazu, Norito Kawakami","doi":"10.1093/joccuh/uiaf009","DOIUrl":"10.1093/joccuh/uiaf009","url":null,"abstract":"Objectives: This longitudinal study examined the associations of workplace loneliness with job turnover at 6-month follow-up among Japanese full-time employees.Methods: This study employed a 6-month prospective design as part of the Employee Cohort Study in Japan. Data from wave 15 (February 2024; baseline, T1) and wave 16 (August 2024; follow-up, T2) were used. Only participants who were employed at baseline and completed the follow-up survey were included in the analysis. Workplace loneliness at T1 was measured using 3 scales: the Loneliness at Work Scale (LAWS), a single-item workplace loneliness scale, and a 3-item scale developed by modifying the short UCLA (University College, Los Angeles) Loneliness Scale for workplace loneliness. Job turnover at T2 was defined based on responses indicating either leaving a job or moving to a different company within the preceding 6 months. Multivariable logistic regression analysis assessed the association between workplace loneliness and job turnover, adjusting for sociodemographic variables.Results: In total, 706 employees who were employed at baseline were included in the analysis. Observed turnover at follow-up was n = 47 (6.7%). Participants who experienced turnover had significantly higher baseline scores for LAWS and the 3-item scale (P = .044 and P = .012, respectively). In the multivariable logistic regression, all 3 workplace loneliness scales demonstrated similar and significant associations with turnover at follow-up.Conclusions: Workplace loneliness leads to job turnover. Further research is needed to address the generalization and explore mechanisms of the present findings.","PeriodicalId":16632,"journal":{"name":"Journal of Occupational Health","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Importance of early detection and treatment of occupational hypersensitivity pneumonitis. 更正：职业性超敏性肺炎早期发现和治疗的重要性。

IF 2.6 4区医学

Journal of Occupational Health Pub Date : 2025-01-07 DOI: 10.1093/joccuh/uiaf033

引用次数: 0

Association between working hours, income, and work-related injury among freelancers in Japan: a cross-sectional study. 日本自由职业者工作时间、收入和工伤之间的关系：一项横断面研究。

IF 2.6 4区医学

Journal of Occupational Health Pub Date : 2025-01-07 DOI: 10.1093/joccuh/uiaf032

Kazuhiro Watanabe, Kazuhito Yokoyama, Akizumi Tsutsumi

{"title":"Association between working hours, income, and work-related injury among freelancers in Japan: a cross-sectional study.","authors":"Kazuhiro Watanabe, Kazuhito Yokoyama, Akizumi Tsutsumi","doi":"10.1093/joccuh/uiaf032","DOIUrl":"10.1093/joccuh/uiaf032","url":null,"abstract":"Objectives: Limited empirical data are available regarding the safety of self-employed workers in Japan. This study investigated the associations between working hours, income, and work-related injuries among freelancers.Methods: A cross-sectional study was conducted using data from an internet survey conducted in 2022. Self-employed individuals who did not work as employees or earn an income from their employment were recruited. Work-related injuries, working hours, and annual income were assessed using self-reported questionnaires. Prevalence ratios (PRs) of injury were estimated using modified Poisson regression models, while controlling for covariates. Additionally, PRs were analyzed for each stratum of working hours and income levels.Results: In total, 1856 freelancers met the eligibility criteria and were included in the study. Among them, 222 (12.0%) experienced at least 1 work-related injury. A significantly higher risk of injury was observed among those working long hours (≥60 h/wk: PR = 1.65; 95% CI, 1.16-2.34; P = .005) and those in the second-lowest income bracket (¥2 to <¥4 million: PR = 1.43; 95% CI, 1.05-1.94; P = .024). Furthermore, several strata exhibited significantly higher PRs, particularly among workers with high incomes who also worked long hours (≥60 h/wk).Conclusions: Long working hours, particularly exceeding 60 h/wk, are associated with a significantly higher risk of work-related injuries among freelancers. Additionally, 2 high-risk groups were identified based on the combination of working hours and income levels: those with relatively low incomes, and high-income earners who also worked extended hours.","PeriodicalId":16632,"journal":{"name":"Journal of Occupational Health","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0