A method for determining workers' exposure concentration to airborne nitrilotriacetic acid.

IF 2.6 4区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Journal of Occupational Health Pub Date : 2025-01-07 DOI:10.1093/joccuh/uiaf025

Ai Yamada, Kenta Ishii, Akito Takeuchi, Tomiko Tashiro, Ginji Endo, Mariko Ono-Ogasawara

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引用次数: 0

Abstract

Objectives: This study aimed to establish a method to determine workers' exposure concentrations to airborne nitrilotriacetic acid (NTA).

Methods: The sampler used an air sampling cassette containing a glass-fiber filter (GFF). After sampling, NTA extracted from the GFF using ultrapure water was derivatized using a boron trifluoride-methanol complex methanol solution and analyzed using a gas chromatograph-mass spectrometer. The developed method was validated for the following parameters: retention efficiency, storage stability, method quantitation limit, and reproducibility.

Results: The retention efficiency for NTA on the GFF was 94%-101%, with the relative SD indicating the overall reproducibility (range 0.9%-2.4%). NTA on the GFF was stable at 4°C for at least 7 days. The method quantitation limit was 4.8 μg per sample.

Conclusions: The developed method will be useful for risk assessments because it can determine workers' exposure concentrations to NTA ranging from 0.02 to 4 mg/m3 in a 240 L sampling volume; the quantitation limit is 4.8 μg per sample.

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测定工人空气中硝基三乙酸暴露浓度的方法。

目的：建立工人空气中硝基三乙酸（NTA）暴露浓度测定方法。方法：采用装有玻璃纤维过滤器（GFF）的空气采样盒。取样后，用超纯水提取GFF中的NTA，用三氟化硼-甲醇络合物甲醇溶液衍生化，用气相色谱-质谱仪分析。验证了该方法的保留效率、保存稳定性、定量限和重现性。结果：NTA在GFF上的保留率为94 ~ 101%，相对标准偏差表明总体重现性（范围为0.9 ~ 2.4%）。GFF上的NTA在4°C下稳定至少7天。方法定量限为4.8 μg/份。结论：该方法可测定240 L样品体积下工人NTA暴露浓度为0.02 ~ 4 mg/m3，定量限为4.8 μg/份，可用于风险评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Occupational Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

5.60

自引率

3.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The scope of the journal is broad, covering toxicology, ergonomics, psychosocial factors and other relevant health issues of workers, with special emphasis on the current developments in occupational health. The JOH also accepts various methodologies that are relevant to investigation of occupational health risk factors and exposures, such as large-scale epidemiological studies, human studies employing biological techniques and fundamental experiments on animals, and also welcomes submissions concerning occupational health practices and related issues.