Journal of Occupational Health最新文献

Health effects of indium compounds in animal experiments.

IF 2.6 4区医学

Journal of Occupational Health Pub Date : 2025-02-05 DOI: 10.1093/joccuh/uiaf007

Akiyo Tanaka

{"title":"Health effects of indium compounds in animal experiments.","authors":"Akiyo Tanaka","doi":"10.1093/joccuh/uiaf007","DOIUrl":"https://doi.org/10.1093/joccuh/uiaf007","url":null,"abstract":"Before 2000, very little attention had been paid to the health effects of indium, a rare metal, because there was very little information in the literature on its toxicity. A fatal case of indium-tin oxide (ITO) inhalation occurred in 2001, followed by concerns regarding occupational exposure to indium compounds and their health effects. Epidemiological studies and case reports have established a causal relationship between the inhalation of insoluble indium compounds, mainly ITO and the development of lung damage. This review has focused on the results of animal studies of ITO and other insoluble indium compounds. Available data indicate that insoluble indium compounds such as ITO, indium arsenide (InAs), indium phosphide (InP), copper indium gallium, and diselenium (CIGS) solar cell materials are toxic to the lungs of animals. In addition to lung damage, ITO nanoparticles have been found to cause kidney damage, while InAs, InP, and ITO cause testicular damage. Furthermore, InP has demonstrated compelling evidence of its carcinogenic potential in long-term inhalation studies using rats and mice, which was evident in rats exposed to ITO. Based on the results of these animal experiments, the International Agency for Research on Cancer evaluated InP as probably carcinogenic to humans (Group 2A) and ITO as possibly carcinogenic to humans (Group 2 B). Hence, occupational exposure of humans to insoluble indium compounds not only causes lung damage, but also lung carcinogenesis and kidney or testicular damage. Greater attention should be directed towards human occupational exposure to insoluble indium compounds.","PeriodicalId":16632,"journal":{"name":"Journal of Occupational Health","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of lung disorders following intratracheal instillation of polystyrene microplastics with different surface functional groups.

IF 2.6 4区医学

Journal of Occupational Health Pub Date : 2025-02-03 DOI: 10.1093/joccuh/uiaf006

Taisuke Tomonaga, Hidenori Higashi, Hiroto Izumi, Chinatsu Nishida, Kazuma Sato, Yuiko Nakamura, Toshiki Morimoto, Yasuyuki Higashi, Takuma Kojima, Kazuo Sakurai, Kazuhiro Yatera, Yasuo Morimoto

{"title":"Comparison of lung disorders following intratracheal instillation of polystyrene microplastics with different surface functional groups.","authors":"Taisuke Tomonaga, Hidenori Higashi, Hiroto Izumi, Chinatsu Nishida, Kazuma Sato, Yuiko Nakamura, Toshiki Morimoto, Yasuyuki Higashi, Takuma Kojima, Kazuo Sakurai, Kazuhiro Yatera, Yasuo Morimoto","doi":"10.1093/joccuh/uiaf006","DOIUrl":"https://doi.org/10.1093/joccuh/uiaf006","url":null,"abstract":"Objectives: Microplastics have been detected in the atmosphere, raising concerns about their impact on the lungs. There have been reports on the effects of surface functional groups in evaluating the physicochemical properties of microplastics, but no reports have evaluated their chronic effects. We performed intratracheal installation in rats to evaluate the acute and chronic effects of microplastics with different surface functional groups on the lungs.Methods: Unmodified, NH2-modified, and COOH-modified polystyrene particles with a particle size of 1 μm were intratracheally instilled into the lungs of rats. Rats were dissected at 3 days, 1 week, 1 month, 3 months, and 6 months after exposure to analyze inflammatory cells and lung injury factors in bronchoalveolar lavage fluid (BALF) and to observe histopathological findings in the lungs.Results: A significant increase in the number of inflammatory cells in BALF was observed up to 1 week after exposure to the NH2-based modified polystyrene compared to the negative control group. A significant increase was observed 3 days after exposure, and histopathological findings in the lungs also showed an influx of inflammatory cells into the alveolar space in the acute phase, but not in the chronic phase. In in vitro studies using RAW cell lines, NH2-based modified polystyrene also induced the highest oxidative stress compared to unmodified and COOH-based modified polystyrene.Conclusions: These results suggest that these polystyrenes do not have high pulmonary toxicity, although there are differences in toxicity due to differences in surface functional groups only in the acute phase.","PeriodicalId":16632,"journal":{"name":"Journal of Occupational Health","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Workplace loneliness and job turnover: A 6-month prospective study.

IF 2.6 4区医学

Journal of Occupational Health Pub Date : 2025-02-03 DOI: 10.1093/joccuh/uiaf009

Natsu Sasaki, Kanami Tsuno, Reiko Kuroda, Kotaro Imamura, Hisashi Eguchi, Akihito Shimazu, Norito Kawakami

{"title":"Workplace loneliness and job turnover: A 6-month prospective study.","authors":"Natsu Sasaki, Kanami Tsuno, Reiko Kuroda, Kotaro Imamura, Hisashi Eguchi, Akihito Shimazu, Norito Kawakami","doi":"10.1093/joccuh/uiaf009","DOIUrl":"https://doi.org/10.1093/joccuh/uiaf009","url":null,"abstract":"Objectives: This longitudinal study examined the associations of workplace loneliness with job turnover at 6-month follow-up among Japanese full-time employees.Methods: This study employed a 6-month prospective design as part of the Employee Cohort Study in Japan (E-COCO-J). Data from wave 15 (February 2024; baseline, T1) and wave 16 (August 2024; follow-up, T2) were used. Only participants who were employed at baseline and completed the follow-up survey were included in the analysis. Workplace loneliness at T1 was measured using three scales: the Loneliness at Work Scale (LAWS), a single-item workplace loneliness scale, and a 3-item scale developed by modifying the short UCLA Loneliness Scale for workplace loneliness. Job turnover at T2 was defined based on responses indicating either leaving a job or moving to a different company within the preceding six months. Multivariable logistic regression analysis assessed the association between workplace loneliness and job turnover, adjusting for sociodemographic variables.Results: In total, 706 employees who were employed at baseline were included in the analysis. Turnover at follow-up was observed n=47 (6.7%). Participants who experienced turnover had significantly higher baseline scores for LAWS and the 3-item scale (p=0.044 and p=0.012, respectively). In the multivariable logistic regression, all three workplace loneliness scales demonstrated similar and significant associations with turnover at follow-up.Conclusion: Workplace loneliness leads to job turnover. Further research is needed to address the generalization and explore mechanisms of the present findings.","PeriodicalId":16632,"journal":{"name":"Journal of Occupational Health","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adverse effects of nanoparticles on humans.

IF 2.6 4区医学

Journal of Occupational Health Pub Date : 2025-01-31 DOI: 10.1093/joccuh/uiaf002

Yasuo Morimoto, Hiroto Izumi, Taisuke Tomonaga, Chinatsu Nishida, Hidenori Higashi

引用次数: 0

Effects of engineered nanomaterials on the cardiovascular system.

IF 2.6 4区医学

Journal of Occupational Health Pub Date : 2025-01-30 DOI: 10.1093/joccuh/uiae080

Sahoko Ichihara

{"title":"Effects of engineered nanomaterials on the cardiovascular system.","authors":"Sahoko Ichihara","doi":"10.1093/joccuh/uiae080","DOIUrl":"https://doi.org/10.1093/joccuh/uiae080","url":null,"abstract":"With the explosive development of nanotechnology, engineered nanomaterials are currently being used in various industries, including food and medicine. Concern about the health effects of nanomaterials has been raised, and available research indicates that the relative surface area of nanomaterials seems to correlate with the severity of their toxicity. With regard to engineered nanomaterials, the scope of their acute and chronic toxicities and their mechanisms are not fully understood. Studies suggest that exposure to certain nanomaterials can generate reactive oxidant species and enhance permeability of the phagolysosomal membrane, which leads to inflammasome activation, causing oxidative stress and inflammation. Since the latter two are implicated in the development of cardiovascular diseases, such as hypertension and atherosclerosis, it can be presumed that exposure to engineered nanomaterials could significantly impact cardiovascular function. In this review, I raise issues that should be considered in the assessment of the effects of engineered nanomaterials on cardiovascular function and evaluate their cardiovascular toxicity as described in various in vitro and/or in vivo toxicological studies and industrial investigations.","PeriodicalId":16632,"journal":{"name":"Journal of Occupational Health","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding the Molecular Enigma Behind Asbestos and Fibrous Nanomaterial-induced carcinogenesis.

IF 2.6 4区医学

Journal of Occupational Health Pub Date : 2025-01-28 DOI: 10.1093/joccuh/uiae064

Shinya Toyokuni, Yingyi Kong

{"title":"Decoding the Molecular Enigma Behind Asbestos and Fibrous Nanomaterial-induced carcinogenesis.","authors":"Shinya Toyokuni, Yingyi Kong","doi":"10.1093/joccuh/uiae064","DOIUrl":"https://doi.org/10.1093/joccuh/uiae064","url":null,"abstract":"Objectives: Natural fibrous mineral, asbestos, has been useful in industry for many centuries. In the 1960's, epidemiology had recognized the association between asbestos exposure and mesothelioma and the IARC designated all kinds of asbestos as Group 1 in 1987. However, various scientific enigmas remained regarding the molecular mechanisms of asbestos-induced mesothelial carcinogenesis. This review article was undertaken to reveal and summarize the recent discoveries how the enigma has been resolved.Methods: We collected recent important findings of our own laboratory and the others to explain why mesothelial cells are the target for asbestos-induced carcinogenesis and what is the key molecular mechanisms.Results: Long incubation period of 30 ~ 40 years for mesothelial carcinogenesis after asbestos exposure is responsible for the asbestos fibers to go through the pulmonary parenchyma from the central to peripheral portions finally to reach the parietal mesothelium by piercing visceral pleura. Asbestos fibers have affinity for hemoglobin and histones, thus accumulating iron on the surface while travelling through the lung. The other important point is that mesothelial cells are phagocytic cells, engulfing iron-coated asbestos fibers. Accordingly, homozygous deletion of p16INK4a tumor suppressor gene, a signature of excess iron-induced carcinogenesis, is acquired through oxidative DNA damage. Recently, exosome-dependent iron transfer from asbestos-fed macrophages to mesothelial cells was reported. Similar molecular mechanisms are observed in multiwalled carbon nanotube of ~50-nm-diameter.Conclusion: Physical dimension, biopersistence and affinity to iron/histones are essential for fibrous material to be carcinogenic to mesothelial cells. Therefore, local iron reduction maybe a strategy to prevent mesothelial carcinogenesis.","PeriodicalId":16632,"journal":{"name":"Journal of Occupational Health","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuro-reproductive toxicity and carcinogenicity of 1-bromopropane - studies for evidence-based preventive medicine (EBPM). 1-溴丙烷的神经生殖毒性和致癌性--循证预防医学（EBPM）研究。

IF 2.6 4区医学

Journal of Occupational Health Pub Date : 2025-01-27 DOI: 10.1093/joccuh/uiaf004

Gaku Ichihara

{"title":"Neuro-reproductive toxicity and carcinogenicity of 1-bromopropane - studies for evidence-based preventive medicine (EBPM).","authors":"Gaku Ichihara","doi":"10.1093/joccuh/uiaf004","DOIUrl":"https://doi.org/10.1093/joccuh/uiaf004","url":null,"abstract":"Bromopropane was introduced commercially as an alternative to ozone-depleting and global warming solvents. The identification of 1-bromopropane neurotoxicity in animal experiments was followed by reports of human cases of 1-bromopropane toxicity. In humans, the most common clinical features of 1-bromopropane neurotoxicity are decreased sensation, weakness in extremities, and walking difficulties. Moreover, decreased cognition, abnormal findings on brain magnetic resonance imaging, urinary incontinence, and numbness in the perineal area have also been described in workers exposed to 1-bromoporopane. Murine histological studies showed that exposure to 1-bromopropane reduced the density of brain noradrenergic axons. Furthermore, proteome studies demonstrated 1-bromopropane-induced changes in the expression of proteins in the hippocampus of rats, similar to the changes seen in mice exposed to acrylamide, suggesting a common mechanism of electrophile-induced neurotoxicity. In addition to its neurotoxicity, 1-bromopropane also induces male reproductive toxicity in rats, though the targeted areas in the reproductive system differ from those affected by 2-bromopropane. However, exposure to high levels of 1-bromopropane was reported to induce spermatogenic cell degeneration, similar to that caused by 2-bromopropane, suggesting common mechanism(s) underlying 1- and 2-bromopropane-induced male reproductive toxicity. Plural approaches, including human, animal and mechanistic studies, are useful for identification of 1-bromopropane neurotoxicity. The International Agency for Research on Cancer (IARC) summarized that 1-bromopropane as well as 2-bromopropane share several key characteristics of carcinogens. Plural approaches can establish evidence-based preventive medicine (EBPM) by modification of the conventional evidence-based medicine (EBM), which has been developed for therapeutic medicine and represented by the EBM pyramid.","PeriodicalId":16632,"journal":{"name":"Journal of Occupational Health","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxidative and nitrative DNA damage induced by industrial chemicals in relation to carcinogenesis.

IF 2.6 4区医学

Journal of Occupational Health Pub Date : 2025-01-24 DOI: 10.1093/joccuh/uiaf003

Yusuke Hiraku

{"title":"Oxidative and nitrative DNA damage induced by industrial chemicals in relation to carcinogenesis.","authors":"Yusuke Hiraku","doi":"10.1093/joccuh/uiaf003","DOIUrl":"https://doi.org/10.1093/joccuh/uiaf003","url":null,"abstract":"Objectives: Many chemicals have been used for industrial purposes, and some of them are carcinogenic to humans. However, their molecular mechanisms have not been well understood. Reactive oxygen species are generated from industrial chemicals and contribute to carcinogenesis. Particles and fibers are accumulated in respiratory systems by inhalation exposure and cause chronic inflammation. Under inflammatory conditions, reactive nitrogen species are generated from inflammatory and epithelial cells. These species cause oxidative and nitrative DNA damage, leading to carcinogenesis. We carried out experiments on DNA damage induced by various industrial chemicals and investigated their molecular mechanisms.Methods: We examined oxidative DNA damage induced by industrial chemicals using DNA fragments derived from human cancer-relevant genes by polyacrylamide gel electrophoresis. We also examined the formation of 8-nitroguanine (8-nitroG), a DNA lesion formed under inflammatory conditions, in lung tissues and cultured cells exposed to industrial chemicals by immunohistochemistry and immunocytochemistry.Results: Benzene and o-toluidine metabolites caused oxidative damage to DNA fragments in the presence of Cu(II). H2O2 and Cu(I) were generated during oxidation of these chemicals and involved in DNA damage. 8-NitroG formation was observed in lung tissues of asbestos-exposed mice and humans. Carbon nanomaterials and indium compounds induced 8-nitroG formation in human lung epithelial cells via the release of damage-associated molecular patterns from exposed cells.Conclusions: Various industrial chemicals are considered to induce carcinogenesis by causing oxidative and nitrative DNA damage. These findings would provide an insight into risk assessment of industrial chemicals and prevention of carcinogenesis that occurs in workplaces.","PeriodicalId":16632,"journal":{"name":"Journal of Occupational Health","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of machine learning for detecting high fall risk in middle aged workers using video-based analysis of the first three steps. 机器学习应用于检测中年工人的高跌倒风险，使用基于视频的前三个步骤分析。

IF 2.6 4区医学

Journal of Occupational Health Pub Date : 2025-01-10 DOI: 10.1093/joccuh/uiae075

Naoki Sakane, Ken Yamauchi, Ippei Kutsuna, Akiko Suganuma, Masayuki Domichi, Kei Hirano, Kengo Wada, Masashi Ishimaru, Mitsuharu Hosokawa, Yosuke Izawa, Yoshihiro Matsumura, Junichi Hozumi

{"title":"Application of machine learning for detecting high fall risk in middle aged workers using video-based analysis of the first three steps.","authors":"Naoki Sakane, Ken Yamauchi, Ippei Kutsuna, Akiko Suganuma, Masayuki Domichi, Kei Hirano, Kengo Wada, Masashi Ishimaru, Mitsuharu Hosokawa, Yosuke Izawa, Yoshihiro Matsumura, Junichi Hozumi","doi":"10.1093/joccuh/uiae075","DOIUrl":"https://doi.org/10.1093/joccuh/uiae075","url":null,"abstract":"Background: Falls are among the most prevalent workplace accidents, necessitating thorough screening for susceptibility to falls and customization of individualized fall prevention programs. The aim of this study was to develop and validate a high fall risk prediction model using machine learning (ML) and video-based first three steps in middle-aged workers.Methods: Train data (n=190, age 54.5±7.7 years, 48.9% male) and validation data (n=28, age 52.3±6.0 years, 53.6% male) were enrolled in this study. Pose estimation was performed using a marker-free deep pose estimation method called MediaPipe Pose. The first three steps, including the movements of the arms, legs, trunk, and pelvis, were recorded using an RGB camera, and the gait features were identified. Using these gait features and fall histories, a stratified K-fold was used to ensure balanced training and test data, and the area under the curve (AUC) and 95% confidence interval (CI) were calculated.Results: Of 77 gait features in the first three steps, we found 3 gait features in men with an AUC of 0.909 (95% CI, 0.879-0.939) for fall risk, indicating an 'Excellent' (0.9-1.0) classification, while we determined 5 gait features in women with an AUC of 0.670 (95% CI, 0.621-0.719), indicating a 'sufficient' (0.6-0.7) classification.Conclusions: These findings suggest that fall risk prediction can be developed based on ML and the first three steps in men; however, the accuracy was only sufficient in men. Further development of the formula is required for women to improve its accuracy in the middle-aged working population.","PeriodicalId":16632,"journal":{"name":"Journal of Occupational Health","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mini-review: Occupational Health Topics Series on the Effects of Chemicals Occupational cholangiocarcinoma incident. 小型综述：化学品职业性胆管癌事件影响的职业健康专题系列。

IF 2.6 4区医学

Journal of Occupational Health Pub Date : 2025-01-09 DOI: 10.1093/joccuh/uiaf001

Shinji Kumagai

引用次数: 0