Journal of Occupational Health最新文献

{"title":"Differences in Occupational and Health Accommodations for Older Workers by Workplace Size: A Text Mining Analysis of Open-Ended Responses.","authors":"Yuchi Maeda, Sayaka Kubota, Yukiko Nishita, Yoshiji Katoh, Masaaki Matsunaga, Yuito Hosaka, Midori Takada, Young Jae Hong, Kanno Fujikawa, Atsuhiko Ota, Hiroshi Yatsuya, Rei Otsuka","doi":"10.1093/joccuh/uiag066","DOIUrl":"https://doi.org/10.1093/joccuh/uiag066","url":null,"abstract":"<p><strong>Objectives: </strong>As labor force participation among older workers continues to increase, the nature of workplace accommodations may vary according to workplace size. In this study, we aimed to clarify the current status and characteristics of workplace accommodations that address the age-related declines in physical function among older workers, including declines resulting from personal illness or injury, across workplaces of different sizes.</p><p><strong>Methods: </strong>A questionnaire survey was conducted from October to November 2024 among 500 workplaces affiliated with the Meihoku Labour Standards Association. Free-text responses regarding workplace accommodations for workers aged ≥65 years, with additional analyses for those aged 60-64 years, were analyzed using text mining, correspondence and co-occurrence network analyses.</p><p><strong>Results: </strong>Responses were obtained from 260 workplaces (52.0%). Among these, 101 workplaces (38.8%) reported providing workplace accommodations for workers aged ≥65 years to address age-related declines in physical function, and 66 workplaces (25.4%) employed workers aged ≥65 years with personal illnesses or injuries. In small workplaces, terms related to physically demanding tasks, such as \"working at heights,\" \"heavy loads,\" and \"night work,\" were identified. In medium-sized workplaces, terms related to individual adjustments, such as \"individual,\" \"preferences,\" and \"number of days,\" were characteristic. In large workplaces, terms indicating institutional measures, such as \"systems,\" \"restrictions,\" and \"environment,\" were identified.</p><p><strong>Conclusion: </strong>The nature of workplace accommodations for workers aged ≥65 years differed by workplace size. Although small workplaces primarily focused on task-level adjustments, large workplaces were more likely to establish institutional support systems. Developing support systems tailored to workplace size is important.</p>","PeriodicalId":16632,"journal":{"name":"Journal of Occupational Health","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149193927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatigue in Different Groups of Disaster Responders after the 2024 Noto Peninsula Earthquake: Group-Specific Associations and Priorities for Intervention.","authors":"Daisuke Koreeda, Chimed-Ochir Odgerel, Megumi Takenaka, Tatsuhiro Nagata, Hanako Murayama, Yui Yumiya, Ami Fukunaga, Seiichiro Tateishi, Tatsuhiko Kubo","doi":"10.1093/joccuh/uiag065","DOIUrl":"https://doi.org/10.1093/joccuh/uiag065","url":null,"abstract":"<p><strong>Objective: </strong>To compare fatigue in the external supporters and local public officers who responded to the January 1, 2024 Noto Peninsula Earthquake, identify group-specific factors associated with fatigue, and estimate population-level differences under hypothetical scenarios.</p><p><strong>Methods: </strong>A repeated-measures observational study was conducted using responder health surveillance data collected between January and March 2024. Generalized estimating equations were used to compare fatigue levels and examine group-specific associations with operational and health-related factors. G-computation was used to estimate model-based population-level differences in fatigue under hypothetical scenarios in which each factor was set to zero.</p><p><strong>Results: </strong>There were 23,865 observations from 7,135 responders. Local public officers reported greater fatigue than external supporters (β = 2.32, 95% CI: 2.22-2.43). The inability to take meals and breaks and unclear command/task structure were associated with greater fatigue in both groups. Sleep disturbance and irritability had stronger associations with fatigue in external supporters. G-computation showed larger model-based population-level differences under the hypothetical scenarios in local public officers, primarily because operational and health-related problems were more prevalent in this group.</p><p><strong>Conclusions: </strong>Operational factors and health problems were associated with fatigue in disaster responders, and the model-based population-level differences under hypothetical scenarios depended on their prevalence. Increasing the number of responders, provision of rest periods, improving command clarity, and monitoring the health of responders may reduce fatigue and improve disaster responses.</p>","PeriodicalId":16632,"journal":{"name":"Journal of Occupational Health","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Effects of a smartphone-based stress management program on work performance, sick leave, and intention to leave among nurses during COVID-19 in Vietnam and Thailand: an analysis of secondary outcomes of a randomized controlled trial.","authors":"","doi":"10.1093/joccuh/uiag059","DOIUrl":"https://doi.org/10.1093/joccuh/uiag059","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1093/joccuh/uiaf061.].</p>","PeriodicalId":16632,"journal":{"name":"Journal of Occupational Health","volume":"68 1","pages":"uiag059"},"PeriodicalIF":2.8,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13654180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiometabolic disease burden and first health-related cessation of work among middle-aged Chinese adults: a longitudinal competing-exit study.","authors":"Yibin Mei, Yingwei Gong, Jiawei Liu, Xianjun Wu","doi":"10.1093/joccuh/uiag064","DOIUrl":"https://doi.org/10.1093/joccuh/uiag064","url":null,"abstract":"<p><strong>Objectives: </strong>To examine whether a time-updated count of physician-diagnosed cardiometabolic conditions is associated with first survey-reported health-related cessation of work among adults in China.</p><p><strong>Methods: </strong>We analyzed 4,404 participants aged 45-60 years working and neither formally retired nor reporting baseline health-related work disruption in the China Health and Retirement Longitudinal Study. Across three intervals from 2011 to 2018, the exposure was the lagged, time-updated count of physician-diagnosed hypertension, diabetes, heart disease, stroke, and kidney disease. The outcome was first health-related work exit, with retirement, other exit, and death as competing states. The primary association was estimated with discrete-time cause-specific pooled logistic regression, participant-clustered standard errors, and 50 longitudinal imputations.</p><p><strong>Results: </strong>The cohort contributed 10,852 observed person-periods and 346 health-related work exits. Each additional diagnosed cardiometabolic condition was associated with higher odds of health-related work exit after adjustment for interval, age, sex, education, work type, smoking, alcohol, and body mass index (odds ratio 1.73, 95% confidence interval 1.51-1.97). Estimates were similar across clustering, weighting, and other sensitivity analyses. By Wave 4, standardized cumulative incidence was 6.4%, 10.5%, and 16.6% for condition counts 0, 1, and 2.</p><p><strong>Conclusions: </strong>A higher count of physician-diagnosed cardiometabolic conditions was prospectively associated with first survey-reported health-related cessation of work, although residual confounding by unmeasured socioeconomic and job-demand factors cannot be excluded. Replication with adjudicated employment outcomes and cross-cohort validation is needed before policy or causal interpretation.</p>","PeriodicalId":16632,"journal":{"name":"Journal of Occupational Health","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cholinesterase Inhibition Thresholds and Neurobehavioral Impairment in Agricultural Workers Exposed to Organophosphate Pesticides.","authors":"Floria Pancetti, Cristián Farías-Gómez, Sebastián Corral, Claudia Foerster, María Teresa Muñoz-Quezada, Sandra Cortés, Liliana Zúñiga-Venegas","doi":"10.1093/joccuh/uiag063","DOIUrl":"https://doi.org/10.1093/joccuh/uiag063","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate whether the cholinesterase inhibition thresholds identify neurobehavioral impairment during the spraying season among agricultural workers occupationally exposed to organophosphate pesticides.</p><p><strong>Methods: </strong>We analyzed erythrocyte acetylcholinesterase (AChE) and plasma butyrylcholinesterase (BChE) activities in 78 agricultural workers before and during the spraying season. Neurobehavioral performance was assessed using a multidomain test battery, and global neurobehavioral impairment was defined using a predefined algorithm. Sensitivity, specificity, predictive values, and receiver operating characteristic (ROC) curves were used to evaluate the classification performance of predefined cholinesterase inhibition thresholds.</p><p><strong>Results: </strong>The prevalence of global neurobehavioral impairment increased from 22% before spraying to 31% during the spraying season. The current 30% threshold showed low sensitivity for detecting impairment (29.2% for AChE; 8.3% for BChE). Lowering the inhibition threshold produced only modest gains in AChE sensitivity (33.3% at 20% and 37.5% at 10%) and larger gains for BChE, but these were accompanied by progressive reductions in specificity. ROC analysis showed limited discriminative capacity for continuous relative activity-change values (AUC: 0.56 for AChE; 0.46 for BChE).</p><p><strong>Conclusions: </strong>The current 30% cholinesterase inhibition threshold showed low sensitivity for identifying neurobehavioral impairment in this sample of agricultural workers. Lowering the predefined inhibition threshold did not provide a threshold with both adequate sensitivity and specificity, consistent with the poor discrimination observed in ROC analysis. These findings suggest that adjustment of the cholinesterase inhibition threshold alone may be insufficient for identifying neurobehavioral impairment in occupational surveillance.</p>","PeriodicalId":16632,"journal":{"name":"Journal of Occupational Health","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149137063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Expanded Adverse Childhood Experiences and Presenteeism Among Japanese Workers: A Cross-Sectional Study.","authors":"Yuka Ito, Natsu Sasaki, Sawako Kamo, Hinano Yumura, Yoshihisa Fujino, Takahiro Tabuchi, Daisuke Nishi","doi":"10.1093/joccuh/uiag062","DOIUrl":"https://doi.org/10.1093/joccuh/uiag062","url":null,"abstract":"<p><strong>Background: </strong>Presenteeism is an occupational health challenge. Although adverse childhood experiences (ACEs) have been linked to adult health, evidence on comprehensive ACE exposure and presenteeism remains limited.</p><p><strong>Methods: </strong>We analyzed data from working adults in the 2022 Japan COVID-19 and Society Internet Survey (JACSIS). ACEs were assessed using an expanded Japanese ACE questionnaire and categorized as 0, 1, 2, 3, and ≥4 ACEs. Presenteeism was measured using the Work Functioning Impairment Scale (WFun), and high presenteeism was defined as WFun ≥21. Using logistic regression, we examined the association between ACE counts (0, 1, 2, 3, and ≥4) and high presenteeism. We further evaluated the cumulative effect of increasing ACE counts. Models were adjusted for age, sex, educational attainment, marital status, weekly working hours, and job stress. Stratified analyses were conducted by current mental disorder status.</p><p><strong>Results: </strong>Among 19,409 workers included in the analytic sample, those with any ACE exposure had higher odds of high presenteeism than those reporting no ACEs, and the association displayed a dose-response pattern with increasing ACE counts. This graded relationship was also observed in stratified analyses, irrespective of the presence or absence of a current mental disorder.</p><p><strong>Conclusions: </strong>This study suggests that expanded childhood adversity is relevant to presenteeism among working adults, regardless of current mental disorder status. These findings reveal the value of a life-course perspective in occupational health and point to the need for future research to clarify the mechanisms linking ACE exposure to presenteeism and to examine trauma-informed approaches for reducing presenteeism.</p>","PeriodicalId":16632,"journal":{"name":"Journal of Occupational Health","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149111052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of the Effectiveness of a Global Occupational Health and Safety Management System Model for Japanese Companies.","authors":"Shigeyuki Kajiki, Koji Mori, Yuichi Kobayashi, Ko Hiraoka, Naoto Ito, Yuichi Yamane, Taiki Yokoyama","doi":"10.1093/joccuh/uiag061","DOIUrl":"https://doi.org/10.1093/joccuh/uiag061","url":null,"abstract":"<p><strong>Objectives: </strong>To extend a Global Occupational Health and Safety Management System Model for Japanese companies-a hybrid model integrating the ISO 45001 standard with company-wide minimum standards set by headquarters and good practices adapted to local conditions-beyond Southeast Asia, the region covered in the original pilot study, and to verify its long-term effectiveness.</p><p><strong>Methods: </strong>At a large Japanese manufacturer of construction and mining machinery, we examined, over 2013-2026 (a net 12 years, excluding a 2-year suspension during the COVID-19 pandemic): the development of headquarters functions, and changes in 13 performance-audit item scores at 8 production sites in North America, Europe, and Asia.</p><p><strong>Results: </strong>All 9 headquarters functions were established over approximately 12 years. Total audit scores increased at 6 of the 8 production sites; 2 sites showed no improvement. The largest numbers of sites remained below the target level for risk-reduction measures and risk assessment; together with officer competency, the only item showing no change in mean score, these findings revealed a structural lag in occupational hygiene relative to safety.</p><p><strong>Conclusions: </strong>The model promoted both headquarters maturation and site-level improvement outside Southeast Asia. Strengthening occupational hygiene will require more direct headquarters interventions, such as expert dispatch and technical support, in addition to standard-setting and auditing.</p>","PeriodicalId":16632,"journal":{"name":"Journal of Occupational Health","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149111042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dimethylacetamide-Associated Liver Injury in Workers: Clinical Patterns of Latency, Selective Occurrence, and Implications for Occupational Surveillance.","authors":"Jung-Min Sung, Young Joong Kang, Woncheol Lee, Jihye Lee","doi":"10.1093/joccuh/uiag043","DOIUrl":"https://doi.org/10.1093/joccuh/uiag043","url":null,"abstract":"<p><strong>Objectives: </strong>N,N-Dimethylacetamide (DMAc) is a widely used industrial solvent and recognized occupational hepatotoxicant. Human evidence, however, appears inconsistent: clinically oriented reports describe overt liver injury in selected workers, whereas large epidemiologic studies often report null or non-specific group-level biochemical findings. This review aimed to interpret these evidence streams with attention to latency, selective occurrence, recurrence after renewed exposure, and implications for occupational surveillance.</p><p><strong>Methods: </strong>We conducted a structured critical review based on a systematic PubMed/MEDLINE search through 22 May 2026. Human occupational studies were qualitatively compared with attention to latency, selective occurrence, clinical course after exposure modification, recurrence after renewed exposure, and exposure findings. Of 22 records, 15 underwent full assessment and eight publications were included in the core synthesis.</p><p><strong>Results: </strong>Clinically oriented reports and cohorts of newly exposed workers repeatedly described DMAc-associated liver injury during the early exposure period, often within the first several weeks to months, affecting only a subset of exposed workers. Several reports described recurrence or worsening after renewed exposure. In contrast, epidemiologic studies in established worker populations primarily evaluated group-level liver enzyme outcomes and did not provide sufficient case-level information to assess latency, recurrence, or clinically overt hepatitis as a pattern-defined event.</p><p><strong>Conclusions: </strong>Published evidence remains limited and heterogeneous and does not establish DMAc-associated hepatotoxicity as a definitive idiosyncratic entity. Nevertheless, clinically apparent cases may require pattern-aware recognition, particularly during early exposure or renewed exposure. Population-level exposure control remains essential, but may be complemented by individual-level clinical vigilance.</p>","PeriodicalId":16632,"journal":{"name":"Journal of Occupational Health","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149069736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational Heat Stress Prevention Interventions: A Scoping Review of Evidence and Gaps.","authors":"Vidhya Venugopal, P K Latha, Rekha Shanmugam, Akshaya Prem Kumar, K G Gayathri, Maarthi Raja, S Ranjith, K Kailasam, C Logesh","doi":"10.1093/joccuh/uiag057","DOIUrl":"https://doi.org/10.1093/joccuh/uiag057","url":null,"abstract":"<p><strong>Background: </strong>Rising temperatures are exacerbating occupational heat stress globally, disproportionately affecting workers in resource-constrained settings in low- and middle-income countries (LMICs). While prevention strategies have been evaluated, the evidence remains scattered, limiting its utility for policy and practice.</p><p><strong>Objectives: </strong>This scoping review aimed to outline occupational heat-stress interventions, summarize current evidence, and identify gaps in feasibility, cost-effectiveness, and implementation across various work settings.</p><p><strong>Methods: </strong>We conducted a search of Embase, PubMed, and Scopus until June 2025, adhering to the Joanna Briggs Institute (JBI) methodology and PRISMA-ScR guidelines. Two reviewers independently evaluated studies using Covidence. Descriptive statistics and thematic analysis synthesized data regarding interventions, settings, outcomes, and implementation.</p><p><strong>Results: </strong>Out of 1847 records, 90 studies were included: Work practice and administrative controls (6), wearable cooling (clothing and cooling garments) (34), active and passive cooling (31), rehydration (15), and engineering controls (4). Most studies (73%) were conducted in developed countries and controlled laboratory settings (68%), revealing a significant evidence gap in LMICs, the informal sector, and vulnerable populations. Studies primarily assessed immediate physiological outcomes rather than long-term health, productivity, or cost-effectiveness. Wearable monitoring and Health (Mobile health) emerged as promising areas for future evaluation.</p><p><strong>Conclusion: </strong>This review reveals a significant evidence gap: most interventions are studied in laboratory environments, whereas field-based effectiveness data remain limited. Future research should prioritize intervention trials that employ participatory methods, cost-effectiveness analyses of scalable solutions, and implementation studies that address barriers to field adoption. Translating laboratory findings to field settings is urgently needed to protect vulnerable workers amid escalating climate change.</p>","PeriodicalId":16632,"journal":{"name":"Journal of Occupational Health","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149061900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protein-protein interaction network-based evaluation of lung cancer relevance and hub gene identification from in vitro crocidolite exposure signatures.","authors":"Taisuke Tomonaga, Midori Iida, Hiroto Izumi, Shinya Morimoto, Yukiko Nakamura, Jun-Ichi Takeshita, Toshiki Morimoto, Hidenori Higashi, Kazuhiro Yatera, Yasuo Morimoto, Chinatsu Nishida","doi":"10.1093/joccuh/uiag060","DOIUrl":"https://doi.org/10.1093/joccuh/uiag060","url":null,"abstract":"<p><strong>Objectives: </strong>This study evaluated whether a protein-protein interaction (PPI) network-based approach can link in vitro exposure-induced gene expression signatures to human disease modules.</p><p><strong>Methods: </strong>Crocidolite, a well-established lung carcinogen, was used as a model of inhaled dust. Human immortalized type I alveolar epithelial cells were exposed to five doses of crocidolite, and RNA sequencing was performed. 253 asbestos exposure-responsive genes showing dose-dependent responses were defined as a crocidolite module. Lung cancer-related proteins were compiled from OMIM, GWAS Catalog, PheWAS, and ClinVar, yielding a lung cancer module of 90 proteins. The network proximity between the crocidolite module and the disease modules was evaluated using a z-score. Hub genes associated with both crocidolite exposure and lung cancer were identified by Cross-betweenness, Graph Kernel, and network propagation (NP). Method performance was assessed by receiver operating characteristic curve analysis using 11 guideline- and expert-selected lung cancer driver genes.</p><p><strong>Results: </strong>The crocidolite module showed significant proximity to the lung cancer module (Zc = -2.95), but not to the thyroid cancer module used as a negative control (Zc = 2.30). NP showed the highest performance for recovering driver genes (AUC = 0.974). NP-prioritized genes were enriched in PI3K-Akt signaling, cancer-related pathways, EGFR/ErbB signaling, apoptosis, and cellular senescence. The top hub genes included PARP1, STAT3, MYC, EGR1, CYP1A1, and SMAD3.</p><p><strong>Conclusions: </strong>Integrating in vitro exposure transcriptomics with human disease modules through PPI-based network analysis may enable the computational evaluation of disease relevance and the identification of biologically meaningful hub genes for the assessment of occupational hazards.</p>","PeriodicalId":16632,"journal":{"name":"Journal of Occupational Health","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149061918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}