Journal of Occupational Health最新文献_第3页

Health effects of indium compounds in animal experiments.

IF 2.6 4区医学

Journal of Occupational Health Pub Date : 2025-01-07 DOI: 10.1093/joccuh/uiaf007

Akiyo Tanaka

{"title":"Health effects of indium compounds in animal experiments.","authors":"Akiyo Tanaka","doi":"10.1093/joccuh/uiaf007","DOIUrl":"10.1093/joccuh/uiaf007","url":null,"abstract":"Before 2000, very little attention had been paid to the health effects of indium, a rare metal, because there was very little information in the literature on its toxicity. A fatal case of indium-tin oxide (ITO) inhalation occurred in 2001, followed by concerns regarding occupational exposure to indium compounds and their health effects. Epidemiological studies and case reports have established a causal relationship between the inhalation of insoluble indium compounds, mainly ITO, and the development of lung damage. This review focuses on the results of animal studies of ITO and other insoluble indium compounds. Available data indicate that insoluble indium compounds such as ITO, indium arsenide (InAs), indium phosphide (InP), and copper indium gallium diselenide (CIGS) solar cell materials are toxic to the lungs of animals. In addition to lung damage, ITO nanoparticles have been found to cause kidney damage, whereas InAs, InP, and ITO cause testicular damage. Furthermore, there is compelling evidence for the carcinogenic potential of InP in long-term inhalation studies using rats and mice, which was evident in rats exposed to ITO. Based on the results of these animal experiments, the International Agency for Research on Cancer evaluated InP as probably carcinogenic to humans (Group 2A) and ITO as possibly carcinogenic to humans (Group 2 B). Based on the results of animal studies, it should be noted that occupational exposure of humans to insoluble indium compounds not only may cause lung damage, but also lung carcinogenesis and kidney or testicular damage in the future. Greater attention should be directed towards human occupational exposure to insoluble indium compounds.","PeriodicalId":16632,"journal":{"name":"Journal of Occupational Health","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding the molecular enigma behind asbestos and fibrous nanomaterial-induced carcinogenesis.

IF 2.6 4区医学

Journal of Occupational Health Pub Date : 2025-01-07 DOI: 10.1093/joccuh/uiae064

Shinya Toyokuni, Yingyi Kong

{"title":"Decoding the molecular enigma behind asbestos and fibrous nanomaterial-induced carcinogenesis.","authors":"Shinya Toyokuni, Yingyi Kong","doi":"10.1093/joccuh/uiae064","DOIUrl":"10.1093/joccuh/uiae064","url":null,"abstract":"Objectives: The natural fibrous mineral, asbestos, has been useful in industry for many centuries. In the 1960s, epidemiology recognized the association between asbestos exposure and mesothelioma, and in 1987 the International Agency for Research on Cancer designated all kinds of asbestos as Group 1 carcinogens. However, various scientific enigmas remained regarding the molecular mechanisms of asbestos-induced mesothelial carcinogenesis. This review article was undertaken to reveal and summarize recent discoveries to resolve those enigmas.Methods: We collected recent important findings from our own laboratory and others to explain why mesothelial cells are the target for asbestos-induced carcinogenesis and what are the key molecular mechanisms.Results: The long incubation period of 30-40 years for mesothelial carcinogenesis after asbestos exposure allows the asbestos fibers to go through the pulmonary parenchyma from the central to peripheral portions and ultimately reach the parietal mesothelium by piercing visceral pleura. Asbestos fibers have affinity for hemoglobin and histones, thus accumulating iron on the surface while traveling through the lung. Mesothelial cells are phagocytic cells, engulfing iron-coated asbestos fibers. Accordingly, homozygous deletion of the p16INK4a tumor suppressor gene, a signature of excess iron-induced carcinogenesis, is acquired through oxidative DNA damage. Recently, exosome-dependent iron transfer from asbestos-fed macrophages to mesothelial cells was reported. Similar molecular mechanisms are observed with multiwalled carbon nanotubes of ~50-nm diameter.Conclusions: Physical dimensions, biopersistence, and affinity to iron/histones are essential for fibrous material to be carcinogenic to mesothelial cells. Therefore, local iron reduction may be a strategy to prevent mesothelial carcinogenesis.","PeriodicalId":16632,"journal":{"name":"Journal of Occupational Health","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxidative and nitrative DNA damage induced by industrial chemicals in relation to carcinogenesis.

IF 2.6 4区医学

Journal of Occupational Health Pub Date : 2025-01-07 DOI: 10.1093/joccuh/uiaf003

Yusuke Hiraku

{"title":"Oxidative and nitrative DNA damage induced by industrial chemicals in relation to carcinogenesis.","authors":"Yusuke Hiraku","doi":"10.1093/joccuh/uiaf003","DOIUrl":"10.1093/joccuh/uiaf003","url":null,"abstract":"Objectives: Many chemicals have been used for industrial purposes, and some of them are carcinogenic to humans. However, the molecular mechanisms of their carcinogenetic effects have not been well understood. Reactive oxygen species are generated from industrial chemicals and contribute to carcinogenesis. Particles and fibers are accumulated in respiratory systems by inhalation exposure and cause chronic inflammation. Under inflammatory conditions, reactive nitrogen species are generated from inflammatory and epithelial cells. These species cause oxidative and nitrative DNA damage, leading to carcinogenesis. We carried out experiments on DNA damage induced by various industrial chemicals and investigated their molecular mechanisms.Methods: We examined oxidative DNA damage induced by industrial chemicals using DNA fragments derived from human cancer-relevant genes by polyacrylamide gel electrophoresis. Using immunohistochemistry and immunocytochemistry we also examined the formation of 8-nitroguanine (8-nitroG), a DNA lesion formed under inflammatory conditions, in lung tissues and cultured cells exposed to industrial chemicals.Results: Benzene and o-toluidine metabolites caused oxidative damage to DNA fragments in the presence of Cu(II). H2O2 and Cu(I) were generated during oxidation of these chemicals and involved in DNA damage. 8-NitroG formation was observed in lung tissues of asbestos-exposed mice and humans. Carbon nanomaterials and indium compounds induced 8-nitroG formation in human lung epithelial cells via the release of damage-associated molecular patterns from exposed cells.Conclusions: Various industrial chemicals are considered to induce carcinogenesis by causing oxidative and nitrative DNA damage. These findings provide an insight into risk assessment of industrial chemicals and prevention of carcinogenesis in workplaces.","PeriodicalId":16632,"journal":{"name":"Journal of Occupational Health","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Workplace loneliness and job turnover: a 6-month prospective study.

IF 2.6 4区医学

Journal of Occupational Health Pub Date : 2025-01-07 DOI: 10.1093/joccuh/uiaf009

Natsu Sasaki, Kanami Tsuno, Reiko Kuroda, Kotaro Imamura, Hisashi Eguchi, Akihito Shimazu, Norito Kawakami

{"title":"Workplace loneliness and job turnover: a 6-month prospective study.","authors":"Natsu Sasaki, Kanami Tsuno, Reiko Kuroda, Kotaro Imamura, Hisashi Eguchi, Akihito Shimazu, Norito Kawakami","doi":"10.1093/joccuh/uiaf009","DOIUrl":"10.1093/joccuh/uiaf009","url":null,"abstract":"Objectives: This longitudinal study examined the associations of workplace loneliness with job turnover at 6-month follow-up among Japanese full-time employees.Methods: This study employed a 6-month prospective design as part of the Employee Cohort Study in Japan. Data from wave 15 (February 2024; baseline, T1) and wave 16 (August 2024; follow-up, T2) were used. Only participants who were employed at baseline and completed the follow-up survey were included in the analysis. Workplace loneliness at T1 was measured using 3 scales: the Loneliness at Work Scale (LAWS), a single-item workplace loneliness scale, and a 3-item scale developed by modifying the short UCLA (University College, Los Angeles) Loneliness Scale for workplace loneliness. Job turnover at T2 was defined based on responses indicating either leaving a job or moving to a different company within the preceding 6 months. Multivariable logistic regression analysis assessed the association between workplace loneliness and job turnover, adjusting for sociodemographic variables.Results: In total, 706 employees who were employed at baseline were included in the analysis. Observed turnover at follow-up was n = 47 (6.7%). Participants who experienced turnover had significantly higher baseline scores for LAWS and the 3-item scale (P = .044 and P = .012, respectively). In the multivariable logistic regression, all 3 workplace loneliness scales demonstrated similar and significant associations with turnover at follow-up.Conclusions: Workplace loneliness leads to job turnover. Further research is needed to address the generalization and explore mechanisms of the present findings.","PeriodicalId":16632,"journal":{"name":"Journal of Occupational Health","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Techno-strain and techno-insecurity are associated with poor mental well-being in specific age and occupation groups. 在特定年龄和职业群体中，技术紧张和技术不安全感与心理健康状况不佳有关。

IF 2.6 4区医学

Journal of Occupational Health Pub Date : 2025-01-07 DOI: 10.1093/joccuh/uiae079

Hang-Ju Yang, Yawen Cheng, Yen-Ling Liu, Wan-Ju Cheng

{"title":"Techno-strain and techno-insecurity are associated with poor mental well-being in specific age and occupation groups.","authors":"Hang-Ju Yang, Yawen Cheng, Yen-Ling Liu, Wan-Ju Cheng","doi":"10.1093/joccuh/uiae079","DOIUrl":"10.1093/joccuh/uiae079","url":null,"abstract":"Objectives: Innovative technology at work can lead to stress and has been linked with adverse work and health consequences. This study aimed to examine the association of techno-insecurity and techno-strain with mental well-being in different age and occupational groups.Methods: We used a nationally representative survey of the working population and restricted our analyses to 2814 employees who reported being engaged with new technology. Techno-insecurity and techno-strain were evaluated by a single question each. Mental health status was assessed by a 5-item scale, and burnout status was assessed by the Copenhagen Burnout Inventory. We used logistic regression analysis to examine the association of techno-insecurity and techno-strain with mental well-being, adjusting for job control, psychological demands, job insecurity, and workplace violence. We further stratified study participants by age and occupational group and examined the association in each group.Results: One-fifth of the study participants reported having techno-insecurity and techno-strain. Techno-insecurity was associated with a 1.8-fold increased risk of poor mental health and high burnout, whereas techno-strain was associated with a 2.2-fold increased risk of having poor mental health and high burnout. The associations between techno-insecurity or techno-strain and poor mental health were most profound among middle-aged workers. Among all occupational groups, the associations between techno-insecurity or techno-strain and burnout were most profound among manual workers.Conclusions: Techno-strain and techno-insecurity are emerging occupational mental health threats, particularly among middle-aged and manual workers. To promote mental health, resources provided by the organization are needed to help employees cope and work with technology.","PeriodicalId":16632,"journal":{"name":"Journal of Occupational Health","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11827113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mini-review: occupational health topics series on the effects of chemicals. Occupational cholangiocarcinoma incident. 小型综述：化学品职业性胆管癌事件影响的职业健康专题系列。

IF 2.6 4区医学

Journal of Occupational Health Pub Date : 2025-01-07 DOI: 10.1093/joccuh/uiaf001

Shinji Kumagai

引用次数: 0

Neuro-reproductive toxicity and carcinogenicity of 1-bromopropane: studies for evidence-based preventive medicine. 1-溴丙烷的神经生殖毒性和致癌性--循证预防医学（EBPM）研究。

IF 2.6 4区医学

Journal of Occupational Health Pub Date : 2025-01-07 DOI: 10.1093/joccuh/uiaf004

Gaku Ichihara

{"title":"Neuro-reproductive toxicity and carcinogenicity of 1-bromopropane: studies for evidence-based preventive medicine.","authors":"Gaku Ichihara","doi":"10.1093/joccuh/uiaf004","DOIUrl":"10.1093/joccuh/uiaf004","url":null,"abstract":"Bromopropane was introduced commercially as an alternative to ozone-depleting and global-warming solvents. The identification of 1-bromopropane neurotoxicity in animal experiments was followed by reports of human cases of 1-bromopropane toxicity. In humans, the most common clinical features of 1-bromopropane neurotoxicity are decreased sensation, weakness in extremities, and walking difficulties. Moreover, decreased cognition, abnormal findings on brain magnetic resonance imaging, urinary incontinence, and numbness in the perineal area have also been described in workers exposed to 1-bromopropane. Murine histological studies showed that exposure to 1-bromopropane reduced the density of brain noradrenergic axons. Furthermore, proteome studies demonstrated 1-bromopropane-induced changes in the expression of proteins in the hippocampus of rats, similar to the changes seen in mice exposed to acrylamide, suggesting a common mechanism of electrophile-induced neurotoxicity. In addition to its neurotoxicity, 1-bromopropane also induces male reproductive toxicity in rats, although the targeted areas in the reproductive system differ from those affected by 2-bromopropane. However, exposure to high levels of 1-bromopropane was reported to induce spermatogenic cell degeneration, similar to that caused by 2-bromopropane, suggesting common mechanism(s) underlying 1- and 2-bromopropane-induced male reproductive toxicity. Plural approaches, including human, animal, and mechanistic studies, are useful for identification of 1-bromopropane neurotoxicity. The International Agency for Research on Cancer summarized that 1-bromopropane as well as 2-bromopropane share several key characteristics of carcinogens. Plural approaches can establish evidence-based preventive medicine by modification of the conventional evidence-based medicine (EBM), which has been developed for therapeutic medicine and is represented by the EBM pyramid.","PeriodicalId":16632,"journal":{"name":"Journal of Occupational Health","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of engineered nanomaterials on the cardiovascular system.

IF 2.6 4区医学

Journal of Occupational Health Pub Date : 2025-01-04 DOI: 10.1093/joccuh/uiae080

Sahoko Ichihara

{"title":"Effects of engineered nanomaterials on the cardiovascular system.","authors":"Sahoko Ichihara","doi":"10.1093/joccuh/uiae080","DOIUrl":"10.1093/joccuh/uiae080","url":null,"abstract":"With the explosive development of nanotechnology, engineered nanomaterials are currently being used in various industries, including food and medicine. Concern about the health effects of nanomaterials has been raised, and available research indicates that the relative surface area of nanomaterials seems to correlate with the severity of their toxicity. With regard to engineered nanomaterials, the scope of their acute and chronic toxicities and their mechanisms are not fully understood. Studies suggest that exposure to certain nanomaterials can generate reactive oxidant species and enhance permeability of the phagolysosomal membrane, which leads to inflammasome activation, causing oxidative stress and inflammation. Since the latter 2 are implicated in the development of cardiovascular diseases, such as hypertension and atherosclerosis, it can be presumed that exposure to engineered nanomaterials could significantly impact cardiovascular function. In this review, I raise issues that should be considered in the assessment of the effects of engineered nanomaterials on cardiovascular function, and evaluate their cardiovascular toxicity as described in various in vitro and/or in vivo toxicological studies and industrial investigations.","PeriodicalId":16632,"journal":{"name":"Journal of Occupational Health","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11827124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Stress experienced by dental students performing clinical training in different dental disciplines: a cross-sectional study. 更正为在不同牙科专业进行临床培训的牙科学生所经历的压力：一项横断面研究。

IF 3 4区医学

Journal of Occupational Health Pub Date : 2024-05-10 eCollection Date: 2024-01-01 DOI: 10.1093/joccuh/uiae022

引用次数: 0

Exploring the Interaction between Physical, Psychosocial, and Neck Pain Symptoms in Construction Workers. 探索建筑工人的生理、心理和颈痛症状之间的相互作用。

IF 3 4区医学

Journal of Occupational Health Pub Date : 2024-03-05 DOI: 10.1093/joccuh/uiae010

Wyke Kusmasari, Auditya Purwandini Sutarto, Nugrahaning Sani Dewi, Yassierli, Titah Yudhistira, Khoirul Muslim, Kadek Heri Sanjaya, Aridhotul Haqiyah, Wahyu Dwi Lestari

{"title":"Exploring the Interaction between Physical, Psychosocial, and Neck Pain Symptoms in Construction Workers.","authors":"Wyke Kusmasari, Auditya Purwandini Sutarto, Nugrahaning Sani Dewi, Yassierli, Titah Yudhistira, Khoirul Muslim, Kadek Heri Sanjaya, Aridhotul Haqiyah, Wahyu Dwi Lestari","doi":"10.1093/joccuh/uiae010","DOIUrl":"10.1093/joccuh/uiae010","url":null,"abstract":"Objective: Construction workers are significantly vulnerable to musculoskeletal disorders, yet the number of studies conducted in developing nations-where these workers significantly contribute to the economy-remains insufficient. This study aims at exploring the interaction between physical and psychosocial exposure to the onset of neck pain or symptoms amongst construction workers in a developing country.Methods: Using a cross-sectional study design, a total of 235 respondents from various construction projects participated in this study. Participants were assigned into one of four exposure groups: low physical and low psychosocial (which served as the reference group); low physical and high psychosocial; high physical and low psychosocial, and high physical and high psychosocial. To quantitatively assess the interaction, we calculated the relative excess risk due to interaction (RERI), attributable proportion (AP), and synergy index (SI).Results: Workers experiencing high levels of both physical and psychosocial risk factors had the highest odds ratio (OR) of neck symptoms (OR: 12.63, 95% confidence interval (CI): 3.39 - 46.99) compared to other groups. The AP (AP: 0.33, 95% CI: -0.24 - 0.90), RERI (RERI: 0.40, 95% CI: -0.99 - 1.79), and SI (SI: 1.69, 95% CI: -1.77 - 5.15) revealed an interaction between physical and psychosocial factors that increases the OR of neck symptoms.Conclusions: This result suggests that physical risk factors at work become significantly more detrimental when paired with high psychosocial stress. Hence, ergonomic interventions in the construction industry aiming to reduce musculoskeletal disorders should consider both physical and psychosocial risk factors concurrently.","PeriodicalId":16632,"journal":{"name":"Journal of Occupational Health","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11060339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140039662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0