Journal of Obesity最新文献

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Prevalence of GCKR rs1260326 Variant in Subjects with Obesity Associated NAFLD and T2DM: A Case-Control Study in South Punjab, Pakistan. 肥胖相关NAFLD和T2DM受试者GCKR rs1260326变体的患病率:巴基斯坦旁遮普省南部的一项病例对照研究。
IF 3.3
Journal of Obesity Pub Date : 2023-10-04 eCollection Date: 2023-01-01 DOI: 10.1155/2023/6661858
Tayyaba Nisar, Kashan Arshad, Zahid Abbas, Maira Ali Khan, Sohail Safdar, Rehan Sadiq Shaikh, Ali Saeed
{"title":"Prevalence of <i>GCKR</i> rs1260326 Variant in Subjects with Obesity Associated NAFLD and T2DM: A Case-Control Study in South Punjab, Pakistan.","authors":"Tayyaba Nisar, Kashan Arshad, Zahid Abbas, Maira Ali Khan, Sohail Safdar, Rehan Sadiq Shaikh, Ali Saeed","doi":"10.1155/2023/6661858","DOIUrl":"10.1155/2023/6661858","url":null,"abstract":"<p><p>The glucokinase regulatory protein (GCKR) regulates glycogen metabolism and insulin secretion, and the <i>GCKR</i> rs1260326 is a putative single nucleotide polymorphism (SNP) associated with metabolic disorders including nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM). This study was conducted to investigate the genetic association of the <i>GCKR</i> rs1260326 in NAFLD and T2DM in our population. NAFLD (<i>n</i> = 103), T2DM (<i>n</i> = 100), and control (<i>n</i> = 100) samples were collected and genotyped for <i>GCKR</i> rs1260326 by tetra-arm PCR. The genetic variant <i>GCKR</i> rs1260326 was significantly linked with NAFLD and T2DM, while the <i>GCKR</i> rs1260326 was significantly associated with the progression of obesity only in NAFLD subjects. The frequency of the C allele (mutant) was higher in both NAFLD (<i>f</i> = 0.69) and T2DM (<i>f</i> = 0.66) subjects as compared to healthy controls of NAFLD (0.52) and T2DM (<i>f</i> = 0.32). The frequency of the C allele was also positively linked with the progression of obesity in both diseases. The frequency of the C allele was 0.66, 0.67, and 0.74 in NAFLD normal weight, overweight, and obese subjects, respectively, while the frequency of the C allele was 0.60, 0.60, and 0.74 in T2DM in normal weight, overweight, and obese subjects, respectively. Homozygous mutant (CC) was 53% in both NAFLD and T2DM subjects, while heterozygous mutant (CT) was 15.53% in NAFLD and 22% in T2DM subjects. Wild-type allele (TT) was 31.06% in NAFLD and 25% in T2DM subjects. In conclusion, the <i>GCKR</i> rs1260326 is a highly prevalent SNP in NAFLD and T2DM subjects, which possibly contributed to obesity, insulin resistance, and metabolic disorders in our population.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41203640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond the Scale: Investigating Adiponectin, ICAM-1, and VCAM-1 as Metabolic Markers in Obese Adolescents with Metabolic Syndrome. 超越尺度:研究肥胖青少年代谢综合征中脂联素、ICAM-1和VCAM-1作为代谢标志物。
IF 3.3
Journal of Obesity Pub Date : 2023-10-03 eCollection Date: 2023-01-01 DOI: 10.1155/2023/4574042
Nur Aisiyah Widjaja, Leonardo Alexander Caesar, Suhasta Nova, Eva Ardianah
{"title":"Beyond the Scale: Investigating Adiponectin, ICAM-1, and VCAM-1 as Metabolic Markers in Obese Adolescents with Metabolic Syndrome.","authors":"Nur Aisiyah Widjaja, Leonardo Alexander Caesar, Suhasta Nova, Eva Ardianah","doi":"10.1155/2023/4574042","DOIUrl":"10.1155/2023/4574042","url":null,"abstract":"<p><strong>Background: </strong>Adiponectin acts to prevent vascular dysfunction due to obesity by inhibiting ICAM-1 and VCAM-1 expressions.</p><p><strong>Objective: </strong>We investigate adiponectin ICAM-1, VCAM-1, and metabolic syndrome (MetS) in obese adolescents.</p><p><strong>Methods: </strong>A cross-sectional study with healthy obese adolescents aged 13 to 18 years was conducted from October 2019 to January 2020. Statistical analysis conducted was a test of normality and homogeneity tests, ANOVA/Kruskal-Wallis, independent sample <i>T</i>-test/Mann-Whitney <i>U</i> test, and Spearman correlation and determined as significant if <i>p</i> value <0.05.</p><p><strong>Results: </strong>125 obese adolescents were recruited. 42 (33.6%) were obese with MetS (we grouped as MetS) and 83 (66.4%) subjects without MetS (non-MetS group). VCAM-1 was significantly higher on boys with MetS compared to girls with MetS, and even girls with MetS had lower levels of VCAM-1 than boys with non-MetS. ICAM-1 was significantly higher in boys with low-level HDL-c (<i>p</i> < 0.05) and correlated weakly with HDL-c, while adiponectin levels were significantly lower in girls with central obesity and hypertriglyceridemia. Path analysis showed that triglyceride had a direct effect on ICAM-1 but not VCAM-1 in both obese boys and girls. Adiponectin had a negative direct effect on ICAM-1 and VCAM-1 in girls. However, on boys, diastole blood pressure had a negative direct effect, which might be the role of sex hormones indirectly.</p><p><strong>Conclusion: </strong>VCAM-1 was significantly higher in boys than girls, which showed that boys had a higher risk of atherosclerosis. ICAM-1 showed no significant difference in both gender and metabolic states. Adiponectin showed a protective effect by lowering ICAM-1 and VCAM-1 directly on girls.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41203627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gestational Early-Time Restricted Feeding Results in Sex-Specific Glucose Intolerance in Adult Male Mice. 妊娠早期限制性喂养导致成年雄性小鼠性别特异性葡萄糖不耐受。
IF 3.8
Journal of Obesity Pub Date : 2023-09-29 eCollection Date: 2023-01-01 DOI: 10.1155/2023/6666613
Molly C Mulcahy, Noura El Habbal, Detrick Snyder, JeAnna R Redd, Haijing Sun, Brigid E Gregg, Dave Bridges
{"title":"Gestational Early-Time Restricted Feeding Results in Sex-Specific Glucose Intolerance in Adult Male Mice.","authors":"Molly C Mulcahy, Noura El Habbal, Detrick Snyder, JeAnna R Redd, Haijing Sun, Brigid E Gregg, Dave Bridges","doi":"10.1155/2023/6666613","DOIUrl":"10.1155/2023/6666613","url":null,"abstract":"<p><p>The timing of food intake is a novel dietary component that impacts health. Time-restricted feeding (TRF), a form of intermittent fasting, manipulates food timing. The timing of eating may be an important factor to consider during critical periods, such as pregnancy. Nutrition during pregnancy, too, can have a lasting impact on offspring health. The timing of food intake has not been thoroughly investigated in models of pregnancy, despite evidence that interest in the practice exists. Therefore, using a mouse model, we tested body composition and glycemic health of gestational early TRF (eTRF) in male and female offspring from weaning to adulthood on a chow diet and after a high-fat, high-sucrose (HFHS) diet challenge. Body composition was similar between groups in both sexes from weaning to adulthood, with minor increases in food intake in eTRF females and slightly improved glucose tolerance in males while on a chow diet. However, after 10 weeks of HFHS, male eTRF offspring developed glucose intolerance. Further studies should assess the susceptibility of males, and apparent resilience of females, to gestational eTRF and assess mechanisms underlying these changes in adult males.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41124266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vitamin D Concentration Changes after Bariatric Surgery. 减肥手术后维生素D浓度的变化。
IF 3.3
Journal of Obesity Pub Date : 2023-09-20 eCollection Date: 2023-01-01 DOI: 10.1155/2023/4828052
Vanessa Mayana Alves Baad, Narriane Chaves Pereira de Holanda, Juliana Fonseca Nogueira Alves, Francisco Bandeira, Ana Célia Oliveira Dos Santos, Amanda Alves Marcelino da Silva, Taisy Cinthia Ferro Cavalcante
{"title":"Vitamin D Concentration Changes after Bariatric Surgery.","authors":"Vanessa Mayana Alves Baad,&nbsp;Narriane Chaves Pereira de Holanda,&nbsp;Juliana Fonseca Nogueira Alves,&nbsp;Francisco Bandeira,&nbsp;Ana Célia Oliveira Dos Santos,&nbsp;Amanda Alves Marcelino da Silva,&nbsp;Taisy Cinthia Ferro Cavalcante","doi":"10.1155/2023/4828052","DOIUrl":"https://doi.org/10.1155/2023/4828052","url":null,"abstract":"<p><strong>Introduction: </strong>Bariatric surgery causes physiological and anatomical changes in the gastrointestinal tract that interfere with intestinal absorption and, consequently, with the nutritional status, especially about vitamin D. The aim of the study was to evaluate the vitamin D levels and body composition of these patients in the Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG) types of surgery.</p><p><strong>Methods: </strong>The retrospective cohort study included a population of 120 patients aged between 18 and 65 years, with class II or III obesity, undergoing bariatric surgery procedures (VSG or RYGB-type). Data were collected on the degree of obesity, age, average time since surgery, and gender. The individuals underwent a complete physical examination, measuring blood pressure, weight, height, waist, and neck circumference. In addition to calculating the percentage of loss of body weight and assessing body fat, the food frequency and physical activity of these patients were evaluated. Blood was collected, and the insulin variables, hydroxyvitamin D (25OHD), were analyzed.</p><p><strong>Results: </strong>There was a significant difference between groups only for PTH, total BMD, and insulin variables. A significant intragroup difference was found in the variables' body mass index (BMI) and vitamin D for the vertical sleeve gastrectomy group and BMI for the RYGB group.</p><p><strong>Conclusion: </strong>The analysis between the groups of procedures, similarity in body composition and postsurgical vitamin D levels, with significant differences only for PTH, BMD, and insulin variables, demonstrates that both procedures are effective in reducing fat mass.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41179177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Delay Discounting and the Income-Food Insecurity-Obesity Paradox in Mothers. 延迟折扣与母亲的收入食品不安全肥胖悖论。
IF 3.3
Journal of Obesity Pub Date : 2023-09-19 eCollection Date: 2023-01-01 DOI: 10.1155/2023/8898498
Leonard H Epstein, Ashfique Rizwan, Rocco A Paluch, Jennifer L Temple
{"title":"Delay Discounting and the Income-Food Insecurity-Obesity Paradox in Mothers.","authors":"Leonard H Epstein, Ashfique Rizwan, Rocco A Paluch, Jennifer L Temple","doi":"10.1155/2023/8898498","DOIUrl":"10.1155/2023/8898498","url":null,"abstract":"<p><p>Food insecurity, defined as unpredictable access to food that may not meet a person's nutritional needs, is paradoxically associated with higher BMI (kg/m<sup>2</sup>) and obesity. Research has shown delay discounting, a behavioral economic measure of the preference for immediate rather than delayed rewards, is related to higher BMI, and moderates the relationship between income and food insecurity. Based on this research, we used regression models to test whether delay discounting, consideration of future consequences, and perceived stress were atemporal mediators of the food insecurity-BMI relation in 313 mothers, controlling for demographic variables. A secondary aim was to replicate the finding that delay discounting moderates the relationship between low income and high food insecurity. Results showed that low income was associated with higher food insecurity, and higher food insecurity was associated with higher BMI. Delay discounting was the only variable that was indirectly related to both paths of the food-insecurity-BMI relation. Delay discounting accounted for 22.2% of the variance in the low-income-food insecurity-obesity relation, and the total model accounted for 38.0% of the variance. The relation between low income and food insecurity was moderated by delay discounting. These data suggest that delay discounting is a potential mediator of the relationship between food insecurity and high BMI, which suggests reducing discounting in the future could be a novel target to reduce food insecurity and help people with food insecurity to reduce their excess body weight. Trial Registration. This trial is registered with NCT02873715.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10522429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41133710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Food Environments on Obesity Rates: A State-Level Analysis. 食物环境对肥胖率的影响:一项州层面的分析。
IF 3.3
Journal of Obesity Pub Date : 2023-06-20 eCollection Date: 2023-01-01 DOI: 10.1155/2023/5052613
Elizabeth Cerceo, Elena Sharma, Anne Boguslavsky, Jean-Sebastien Rachoin
{"title":"Impact of Food Environments on Obesity Rates: A State-Level Analysis.","authors":"Elizabeth Cerceo,&nbsp;Elena Sharma,&nbsp;Anne Boguslavsky,&nbsp;Jean-Sebastien Rachoin","doi":"10.1155/2023/5052613","DOIUrl":"10.1155/2023/5052613","url":null,"abstract":"<p><strong>Introduction: </strong>Limited access to healthy food in areas that are predominantly food deserts or food swamps may be associated with obesity. Other unhealthy behaviors may also be associated with obesity and poor food environments.</p><p><strong>Methods: </strong>We calculated Modified Retail Food Environment Index (mRFEI) to assess food retailers. Using data collected from the Behavioral Risk Factor Surveillance System (BRFSS) survey, the NJ Department of Health (NJDOH), and the US Census Bureau, we conducted a cross-sectional analysis of the interaction of obesity with the food environment and assessed smoking, leisure-time physical activity (LPA), and poor sleep.</p><p><strong>Results: </strong>There were 17.9% food deserts and 9.3% food swamps in NJ. There was a statistically significant negative correlation between mRFEI and obesity rate (Pearson's <i>r</i> -0.13, <i>p</i> < 0.001), suggesting that lack of access to healthy food is associated with obesity. Regression analysis was significantly and independently associated with increased obesity prevalence (adjusted <i>R</i> square 0.74 and <i>p</i>=0.008). Obesity correlated positively with unhealthy behaviors. Each unhealthy behavior was negatively correlated with mRFEI. The mean prevalence for smoking, LPA, and sleep <7 hours was 15.4 (12.5-18.6), 26.5 (22.5-32.3), and 37.3 (34.9-40.4), respectively.</p><p><strong>Conclusion: </strong>Obesity tracks with food deserts and especially food swamps. It is also correlated with other unhealthy behaviors (smoking, LPA, and poor sleep).</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10546892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41105956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unpredictable Malnutrition and Short-Term Outcomes after Single Anastomosis Sleeve Ileal (SASI) Bypass in Obese Patients. 肥胖患者单次吻合套式回肠(SASI)旁路术后不可预测的营养不良和短期结果
IF 3.8
Journal of Obesity Pub Date : 2023-06-19 eCollection Date: 2023-01-01 DOI: 10.1155/2023/5582940
Ayman Kamal, Mahmoud El Azawy, Tarik A A Hassan
{"title":"Unpredictable Malnutrition and Short-Term Outcomes after Single Anastomosis Sleeve Ileal (SASI) Bypass in Obese Patients.","authors":"Ayman Kamal, Mahmoud El Azawy, Tarik A A Hassan","doi":"10.1155/2023/5582940","DOIUrl":"10.1155/2023/5582940","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study is to present the clinical outcomes of SASI bypass as a treatment alternative for patients with morbid obesity.</p><p><strong>Methods: </strong>This study was a prospective follow-up of morbidly obese patients who underwent SASI bypass at Helwan University Hospital between March 1, 2019, and March 2020. The surgical procedure involved sleeve gastrectomy, followed by the anastomosis of the ileum, which was brought and hand-sewn 4 cm length side to side with the antrum, at a distance of 250 cm from the ileocecal valve. The data collected for the study included the resolution of comorbidities, incidence of gallstones, and one-year morbidity.</p><p><strong>Results: </strong>The mean age of the studied patients (<i>n</i> = 30) was 44.13 ± 8.9 years. The mean BMI of the studied patients was 47.3 ± 7.6 kg/ht<sup>2</sup>. All patients were morbidly obese for an average of 24 years. Postoperatively, 48% of the patients (<i>n</i> = 13) developed gallstones (GS), and the formation of GS was significantly higher in patients with longer durations of obesity (<i>P</i> = 0.009) and rapid weight loss. There was a significant decrease in the incidence of GS after 12 months postoperatively (<i>P</i> < 0.05). 63% of the patients (<i>n</i> = 19) had malnutrition, and 15 cases required revision due to the fear of further weight loss. Revision and malnutrition were significantly higher among male patients than female patients and among patients with longer durations of obesity (<i>P</i> ≤ 0.001).</p><p><strong>Conclusion: </strong>The SASI bypass may be an effective bariatric and metabolic surgery that can achieve satisfactory weight loss and improvement in medical comorbidities. However, our study highlights the potential risks of severe malnutrition and unpredictable weight loss; patient selection and duration of obesity may play a role in mitigating these risks.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11401683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48262458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brief Communication: Histological Assessment of Nonhuman Primate Brown Adipose Tissue Highlights the Importance of Sympathetic Innervation. 简讯:非人灵长类棕色脂肪组织的组织学评估凸显了交感神经支配的重要性。
IF 3.3
Journal of Obesity Pub Date : 2023-01-19 eCollection Date: 2023-01-01 DOI: 10.1155/2023/5651084
Abigail G Williams, Masha Long, Kylie Kavanagh
{"title":"Brief Communication: Histological Assessment of Nonhuman Primate Brown Adipose Tissue Highlights the Importance of Sympathetic Innervation.","authors":"Abigail G Williams, Masha Long, Kylie Kavanagh","doi":"10.1155/2023/5651084","DOIUrl":"10.1155/2023/5651084","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to functionally analyze the correlation of key histological features in brown adipose tissue (BAT) with clinical metabolic traits in nonhuman primates.</p><p><strong>Methods: </strong>Axillary adipose tissue biopsies were collected from a metabolically diverse nonhuman primate cohort with clinical metabolism-related data. Expression of tyrosine hydroxylase (TH), uncoupling protein 1 (UCP1), cluster of differentiation 31 (CD31), cytochrome c oxidase subunit 4 (COX IV), beta-3 adrenergic receptor (<i>β</i>3-AR), and adipose cell size were quantified by immunohistochemical analysis. Computed tomography scans were performed to assess body composition.</p><p><strong>Results: </strong>Tyrosine hydroxylase was negatively correlated with whole body fat mass as a percentage of body weight (<i>p</i> = 0.004) and was positively correlated with the density of UCP1 (<i>p</i> = 0.02), COX IV (<i>p</i> = 0.006), CD31 (<i>p</i> = 0.007), and cell density (<i>p</i> = 0.02) of the BAT samples. Beta-3 adrenergic receptor abundance had a weak positive correlation with COX IV (<i>p</i> = 0.04) in BAT but did not significantly correlate to UCP1 or TH expression in BAT.</p><p><strong>Conclusions: </strong>Our findings highlight that there is a disparity in innervation provided to BAT based on body composition, as seen with the negative association between TH, a marker for innervation, and adiposity. These findings also support the importance of innervation in the functionality of BAT, as TH abundance not only supports leaner body composition but is also positively correlated with known structural elements in BAT (UCP1, COX IV, CD31, and cell density). Based on our observations, <i>β</i>3-AR abundance does not strongly drive these structural elements or TH, all of which are known to be important in the function of brown adipose tissue. In effect, while the role of other receptors, such as <i>β</i>2-AR, should be reviewed in BAT function, these results support the development of safe sympathetic nervous system stimulants to activate brown adipose tissue for obesity treatment.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2023-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10136018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Vitro Insulin Resistance Model: A Recent Update. 体外胰岛素抵抗模型:最新进展。
IF 3.3
Journal of Obesity Pub Date : 2023-01-01 DOI: 10.1155/2023/1964732
Ratih D Yudhani, Yulia Sari, Dwi A A Nugrahaningsih, Eti N Sholikhah, Maftuchah Rochmanti, Abdul K R Purba, Husnul Khotimah, Dian Nugrahenny, Mustofa Mustofa
{"title":"<i>In Vitro</i> Insulin Resistance Model: A Recent Update.","authors":"Ratih D Yudhani,&nbsp;Yulia Sari,&nbsp;Dwi A A Nugrahaningsih,&nbsp;Eti N Sholikhah,&nbsp;Maftuchah Rochmanti,&nbsp;Abdul K R Purba,&nbsp;Husnul Khotimah,&nbsp;Dian Nugrahenny,&nbsp;Mustofa Mustofa","doi":"10.1155/2023/1964732","DOIUrl":"https://doi.org/10.1155/2023/1964732","url":null,"abstract":"<p><p>Insulin resistance, which affects insulin-sensitive tissues, including adipose tissues, skeletal muscle, and the liver, is the central pathophysiological mechanism underlying type 2 diabetes progression. Decreased glucose uptake in insulin-sensitive tissues disrupts insulin signaling pathways, particularly the PI3K/Akt pathway. An <i>in vitro</i> model is appropriate for studying the cellular and molecular mechanisms underlying insulin resistance because it is easy to maintain and the results can be easily reproduced. The application of cell-based models for exploring the pathogenesis of diabetes and insulin resistance as well as for developing drugs for these conditions is well known. However, a comprehensive review of <i>in vitro</i> insulin resistance models is lacking. Therefore, this review was conducted to provide a comprehensive overview and summary of the latest <i>in vitro</i> insulin resistance models, particularly 3T3-L1 (preadipocyte), C2C12 (skeletal muscle), and HepG2 (liver) cell lines induced with palmitic acid, high glucose, or chronic exposure to insulin.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9079785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
The Association between Unhealthy Food Consumption and Impaired Glucose Metabolism among Adults with Overweight or Obesity: A Cross-Sectional Analysis of the Indonesian Population. 不健康食品消费与超重或肥胖成人糖代谢受损之间的关系:印度尼西亚人口的横断面分析
IF 3.3
Journal of Obesity Pub Date : 2023-01-01 DOI: 10.1155/2023/2885769
Adriyan Pramono, Deny Y Fitranti, K Heri Nugroho, M Ali Sobirin, Ahmad Syauqy
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引用次数: 1
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