The Interplay between Adipose Tissue Properties and Levels of NT-proBNP in People with HIV

IF 3.8 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Obesity Pub Date : 2023-11-04 DOI:10.1155/2023/6199388

Mads-Holger Bang Jacobsen, Anne Marie Reimer Jensen, Andreas Dehlbæk Knudsen, Thomas Benfield, Ruth Frikke-Schmidt, Børge Nordestgaard, Shoaib Afzal, Klaus Fuglsang Kofoed, Marco Gelpi, Susanne Dam Nielsen

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引用次数: 0

Abstract

Objective. We aimed to assess the association between low N-terminal pro-brain natriuretic peptide (NT-proBNP) and body mass index (BMI), adipose tissue distribution, adiponectin, and HIV-specific risk factors among people with HIV (PWH). Methods. We included 811 PWH with measurement of height, weight and waist circumference, blood samples analyzed for NT-proBNP, and visceral-(VAT) and subcutaneous (SAT) adipose tissue areas measured from CT-scans. Low concentrations of NT-proBNP were defined as concentrations below the limit of quantification (5.9 pmol/L). Associations were explored with multivariable logistic regression analyses adjusted for relevant confounders. Results. We identified 471 (58%) individuals with low concentrations of NT-proBNP. Increasing BMI was associated with higher odds of low NT-proBNP (adjusted OR (aOR) 1.06 (95% CI: 1.01–1.11) per 1 kg/m2). Central obesity and large areas of VAT were associated with higher odds of low NT-proBNP (aOR 1.66 (1.16–2.36) and aOR 1.69 (1.09–2.62), respectively). Higher adiponectin was associated with lower odds of low NT-proBNP (aOR 0.86 (0.79–0.95) per 10% increase). No associations were found between low NT-proBNP and HIV-specific risk factors. Conclusions. In PWH, low NT-proBNP is associated with an adverse adipose tissue profile with high BMI, central obesity, accumulation of VAT, and low adiponectin.

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HIV感染者脂肪组织特性与NT-proBNP水平之间的相互作用

目标。我们旨在评估低n端前脑利钠肽(NT-proBNP)与HIV感染者(PWH)体重指数(BMI)、脂肪组织分布、脂联素和HIV特异性危险因素之间的关系。方法。我们纳入了811名PWH，测量了身高、体重和腰围，分析了血液样本的NT-proBNP，并通过ct扫描测量了内脏(VAT)和皮下(SAT)脂肪组织面积。NT-proBNP浓度低于定量限(5.9 pmol/L)定义为低浓度。通过调整相关混杂因素的多变量逻辑回归分析来探讨相关性。结果。我们确定了471例(58%)NT-proBNP浓度低的个体。BMI增加与NT-proBNP低的几率增加相关(调整OR (aOR) 1.06 (95% CI: 1.01-1.11) / kg/m2)。中心性肥胖和大面积VAT与NT-proBNP低的几率较高相关(aOR分别为1.66(1.16-2.36)和1.69(1.09-2.62))。较高的脂联素与较低的NT-proBNP发生率相关(aOR为0.86(0.79-0.95)/ 10%升高)。未发现低NT-proBNP与hiv特异性危险因素之间存在关联。结论。在PWH中，低NT-proBNP与不利的脂肪组织特征相关，包括高BMI、中枢性肥胖、VAT积累和低脂联素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Obesity ENDOCRINOLOGY & METABOLISM-

CiteScore

7.50

自引率

3.00%

发文量

审稿时长

21 weeks

期刊介绍： Journal of Obesity is a peer-reviewed, Open Access journal that provides a multidisciplinary forum for basic and clinical research as well as applied studies in the areas of adipocyte biology & physiology, lipid metabolism, metabolic syndrome, diabetes, paediatric obesity, genetics, behavioural epidemiology, nutrition & eating disorders, exercise & human physiology, weight control and health risks associated with obesity.