Journal of Obesity最新文献

{"title":"Comparative Analysis of Diabetic Ketoacidosis in Adults With Type 1 and Type 2 Diabetes Mellitus: Insights From a Saudi Arabian Cohort.","authors":"Sadiq A Alali, Saqib A Ghulam, Khlood A Bukhamsin, Khadijah Al Nas, Aliaa Alhashim, Danna AlMoaber, Maryam Al-Khalifah, Ebtehal Almarzooq, Alzhra H Albin Alshaikh, Sadiq M AlHowdar, Bader A Alhammad","doi":"10.1155/jobe/3964619","DOIUrl":"10.1155/jobe/3964619","url":null,"abstract":"<p><p><b>Background:</b> Diabetic ketoacidosis (DKA) is a life-threatening complication commonly seen in Type 1 diabetes mellitus (T1DM) but also affects Type 2 diabetes mellitus (T2DM). <b>Objectives:</b> To compare the clinical presentation, biochemical parameters, and precipitating factors of DKA in adult patients with T1DM and T2DM. <b>Methodology:</b> This retrospective cohort study was conducted at King Salman Hospital, Riyadh, involving medical records of diabetic patients aged 14 years or older who attended the Diabetic Center from September 1, 2021, to August 1, 2022. Data collection included sociodemographic, clinical, biochemical, and management details using a standardized checklist. <b>Results:</b> The study included 285 patients with DKA, aged 14-70 years (mean: 23.1 ± 11.5 years), with 52.5% being male. The most common symptoms were nausea (91.1%), abdominal pain (86.1%), vomiting (83.6%), polyuria/polydipsia (74.1%), and shortness of breath (72.4%). Vomiting and abdominal pain were more frequent in T1DM (85.9% and 88.3%) compared to T2DM (65.6% and 68.8%), <i>p</i>=0.004 and 0.003, respectively, while dizziness was more common in T2DM (56.3% vs. 33.2%), <i>p</i>=0.011. Uric acid and creatinine levels were significantly higher in T2DM, whereas hemoglobin and hematocrit were elevated in T1DM. Poor compliance was the most common precipitating factor (70.2%), followed by upper respiratory tract infection (21.1%) and inadequate treatment (15.6%). <b>Conclusion:</b> This study highlights key differences in DKA presentation between T1DM and T2DM. While symptoms such as nausea and abdominal pain were common in both types, vomiting was more frequent in T1DM and dizziness in T2DM. Biochemical markers such as uric acid and creatinine were elevated in T2DM, while hemoglobin and hematocrit were higher in T1DM. Poor compliance was a more common precipitating factor in T1DM, whereas inadequate treatment prevailed in T2DM. Tailored management approaches for each diabetes type may improve DKA outcomes.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":"2025 ","pages":"3964619"},"PeriodicalIF":3.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11964707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in Weight Loss Postsleeve Gastrectomy Among Patients With Various Types of Obesity Based on Waist-To-Hip Ratio Classification.","authors":"Pengxiang Luan, Yunmiao Pan, Sanyuan Hu, Mingwei Zhong","doi":"10.1155/jobe/4236484","DOIUrl":"10.1155/jobe/4236484","url":null,"abstract":"<p><p><b>Background:</b> In recent years, laparoscopic sleeve gastrectomy (LSG) has become the main surgical procedure for weight loss, and most clinical studies have focused on the postoperative complications and treatment of metabolic syndrome after LSG. However, it is not clear whether there is a difference in the postoperative weight loss effect between patients with central and noncentral obesity after LSG. <b>Purpose:</b> To investigate the effect of LSG on weight loss in patients with central obesity and relationship between preoperative waist-hip ratio and weight loss effect. <b>Methods:</b> We conducted a retrospective study comprising 360 patients who underwent LSG at the Qianfoshan Hospital, Jinan, Shandong Province, China, between 2019 and 2024. Based on the preoperative waist-to-hip ratio (WHR), the participants were divided into central and noncentral obesity groups, and various quantitative and preoperative biochemical indices were measured. Most patients were followed up for at least 6 months. <b>Results:</b> There were significant differences in weight loss outcomes between women in the central and noncentral obesity groups in the first and third months after surgery; however, no significant differences were observed in the sixth and twelfth months. No significant differences were observed in weight loss outcomes between men in the central and noncentral obesity groups. There were significant differences in the development of central obesity between the two sexes and between those with and without type 2 diabetes. There were significant differences in body mass index (BMI) and white blood cell counts between women in the central and noncentral obesity groups, with patients with central obesity having higher BMI values and white blood cell counts before surgery. There were significant differences in the platelet count (PLT), gamma-glutamyl transferase (GGT), glycosylated hemoglobin A1c (HbA1c), and fasting plasma glucose (FPG) levels between men in the central and noncentral obesity groups, with patients with central obesity having lower PLT, higher GGT, HbA1c, and FPG levels. There was a significant correlation between WHR and early weight loss outcomes after surgery.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":"2025 ","pages":"4236484"},"PeriodicalIF":3.8,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential Impacts of Prenatal Supplement Intake on Childhood Obesity Markers, Stratified by Gender and Other Prenatal Factors.","authors":"M Batra, Y Bekele, A Halilagic, Y Manios, G Moschonis, B Erbas","doi":"10.1155/jobe/3257488","DOIUrl":"10.1155/jobe/3257488","url":null,"abstract":"<p><p><b>Objective:</b> To assess the association between maternal iron, folic acid and combined iron-folic acid (IFA) oral supplementation during pregnancy and childhood obesity markers in 9- to 13-year-olds. <b>Methods:</b> Data from the 2007-2009 Healthy Growth Study were analysed. The study assessed obesity markers, i.e., body mass index (BMI), skinfold thickness and waist circumference. The research question was examined using generalised linear models stratified by the child's sex, maternal prepregnancy weight and gestational age. <b>Results:</b> Folic acid and IFA supplements, but not iron alone, were significantly associated with lower waist circumference in all children (coef. -1.35, 95% CI: -2.47 to -0.23; coef. -1.01, 95% CI: -2.21 to -0.23, <i>p</i> < 0.05). These associations were observed only in girls with lower BMI (coef. -0.88), skinfold thickness (coef. -4.92) and waist circumference (coef. -2.99) with folic acid and similar IFA effects. Interestingly, in boys born to obese mothers before pregnancy, a significant negative association was observed for folic acid alone with BMI (coef. -3.55) and waist circumference (coef. -7.09) and IFA for the sum of skinfold thickness (coef. -19.68). <b>Conclusion:</b> Maternal folic acid and IFA supplementation may contribute to a lower likelihood of childhood obesity, especially in girls and children of underweight or obese mothers, emphasising the importance of proper prenatal nutrition.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":"2025 ","pages":"3257488"},"PeriodicalIF":3.8,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11832260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Ethnobotanical Survey and Pharmacological and Toxicity Review of Medicinal Plants Used in the Management of Obesity in the North Central Zone of Nigeria.","authors":"Gabriel O Anyanwu, Dorathy Anzaku, Yanga J Bulus, Jemimah N Girgi, Chinda C Donwell, Jerome O Ihuma, Eusebius C Onyeneke, Giovanna Bermano, Vanessa Steenkamp","doi":"10.1155/jobe/5568216","DOIUrl":"10.1155/jobe/5568216","url":null,"abstract":"<p><p><b>Introduction:</b> Obesity is increasing worldwide. Due to the unavailability of affordable obesity drugs in most parts of Nigeria, many overweight and obese people rely on medicinal plants to manage obesity. Thus, the aim of this study is to document medicinal plants traditionally used in the treatment and management of obesity in the North Central Zone of Nigeria, determine the plants to which pharmacological assessment of their use in obesity management has not been reported, and assess their toxicity based on the literature. <b>Methods:</b> Semistructured questionnaires and interviews were used to assess sociodemographic information of the 700 herb sellers/practitioners (100 for each state) who consented to participate in the study. Information gathered on plants that are traditionally used in the management of obesity included administration/dosage, method of preparation, plant part used, method of growth, and plant type. The field study was conducted over a one-year period, from March 2018 to March 2019. Reports of pharmacological activity pertaining to obesity as well as toxicity of the plants were obtained from the literature via scientific databases (Scopus, Web of Science, PubMed, Google Scholar, SciFinder, AJOL, PubChem, and other web sources) after the field survey. <b>Results:</b> A total of 39 families and 70 plant species were used to treat or manage obesity. The majority of plant species used resulted in the family Leguminosae. The relative frequency of citation (RFC) and percentage values for the five most frequently used plants were as follows: <i>Citrus aurantifolia</i> (0.0500; 3.56%), <i>Citrus limon</i> (0.0457; 3.26%), <i>Garcinia kola</i> (0.0429; 3.05%), <i>Zingiber officinale</i> (0.0429; 3.05%), and <i>Allium sativum</i> (0.0414; 2.95%). The majority of the medications were prepared as decoctions (50.5%), and cultivated plants (62.86%) were in the majority of plants used. Results showed that 23 plants have no pharmacological report for antiobesity activities while among the five frequently used plants, only <i>Garcinia kola</i> was reported toxic in preclinical models. <b>Conclusions:</b> This paper provides a valuable compilation of the plants used in obesity treatment in the study area by indigenous healers, highlights plants with no reported pharmacological activity pertaining to obesity, and indicates the toxicity profile of used plants. However, further studies on the mechanism of action are warranted, especially where no reports were obtained.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":"2025 ","pages":"5568216"},"PeriodicalIF":3.8,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11870763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Obesity and Pregnancy Weight Gain on Maternal and Child Health.","authors":"Richard Gearhart, Nyakundi M Michieka, Lyudmyla Sonchak-Ardan, Evan Stutzman","doi":"10.1155/2024/8816878","DOIUrl":"10.1155/2024/8816878","url":null,"abstract":"<p><p>In this study, we estimate the effect of prepregnancy obesity and excessive pregnancy weight gain on infant and maternal health outcomes. We rely on a large sample of maternally linked restricted data from 2004 to 2019 South Carolina birth certificates, which allow us to track the same mothers during multiple pregnancies over a period of more than 15 years. To address possible limitations of previous research, we account for genetic confounders and unobservable maternal and environmental factors by relying on a maternal fixed effects strategy. We find that gaining above recommended amounts of weight increases the likelihood of delivering a high weight infant by 2.34 percentage points, while being obese increases this likelihood by 2.58 percentage points. These large negative effects of weight gain outside recommended ranges, as well as the effects of being obese, are present in White and Black mothers. Also, our results indicate that mothers who gained too much weight, or were obese, had a higher likelihood of cesarean section and higher likelihood of being induced. Finally, among the subsample of Medicaid mothers, excessive pregnancy weight gain as well as inadequate weight gain increased the likelihood of NICU admission.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":"2024 ","pages":"8816878"},"PeriodicalIF":3.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11602520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behavioral Determinants of Childhood Obesity in the United States: An Exploratory Study.","authors":"Soumitra Palit, Tahia Sufyani, Joseph N Inungu, Chin-I Cheng, Emmanuel Nartey","doi":"10.1155/2024/9224425","DOIUrl":"10.1155/2024/9224425","url":null,"abstract":"<p><p>Childhood obesity is a complex and multifactorial phenomenon. Understanding these factors is crucial in developing effective interventions to prevent and treat childhood obesity. The purpose of this study is to provide an update on factors related to childhood obesity in the United States. This cross-sectional study analyzed data from the 2021 Youth Risk Behavior Surveillance System (YRBSS) survey to assess factors associated with childhood obesity among US children aged 12 to 17 years. Logistic regression analysis was used to identify the sociodemographic factors associated with overweight and obesity. Data were analyzed using <i>R</i> studio (4.3.2). A total of 12,836 respondents were enrolled in this study. Among them, the prevalence of overweight, obesity, and morbid obesity was found to be 17.66%, 11.21%, and 1.76%, respectively. Respondents with a BMI over 25 were mostly male (17.63%) and of White race (32.77%). The main sociodemographic factors associated with overweight and obesity were being 14 or 15 years old, male, non-White, having a history of alcohol or marijuana consumption, and not practicing physical activity. These findings can inform targeted interventions for prevention and management. This research sheds light on critical sociodemographic factors related to childhood obesity in the U.S., highlighting its complexity. The findings emphasize the influence of age, gender, ethnicity, and lifestyle behaviors, such as substance use and physical inactivity, on obesity rates among youth. These insights are crucial for developing targeted interventions. Addressing these factors offers a real chance to enhance future health outcomes, and underscoring the need for comprehensive strategies that include both health education and broader community support to instill healthy habits early on. In addition, unexpected results concerning vegetable consumption and the omission of genetic and familial data suggest areas for further research.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":"2024 ","pages":"9224425"},"PeriodicalIF":3.8,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11584255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Socioeconomic Position of the Family and Adolescent Obesity in Germany-Analysis of the Mediating Role of Familial Determinants.","authors":"Miriam Blume, Anja Schienkiewitz, Lina Wollgast, Stephanie Hoffmann, Lydia Sander, Jacob Spallek, Raphael M Herr, Irene Moor, Claudia R Pischke, Iryna Iashchenko, Claudia Hövener, Petra Rattay","doi":"10.1155/2024/7903972","DOIUrl":"https://doi.org/10.1155/2024/7903972","url":null,"abstract":"<p><strong>Background: </strong>Obesity's negative impact on young people's health has long been known. The family and its socioeconomic position (SEP) are key determinants in adolescent obesity. However, understanding which familial determinants explain the association remains limited.</p><p><strong>Method: </strong>The analyses are based on data from the \"German Health Interview and Examination Survey for Children and Adolescents\" (KiGGS) (1,384 females and 1,332 males aged 11 to 17 years). Logistic regression models explored how familial determinants (family stress, family cohesion, parental smoking, parental sporting activity, and parental overweight) mediated the association between family SEP (parental education, occupational status, and household income) and adolescent obesity.</p><p><strong>Results: </strong>Significant total effects for the associations between family SEP in childhood and adolescent obesity were found. Splitting the total effect of the family SEP on obesity into direct and indirect effects, all direct effects turned out to be significant. However, all associations involved also indirect effects of familial determinants, except for household income for female adolescents. Parental smoking and overweight were the most relevant mediators for males and females. For male adolescents, parental sporting activity additionally mediated the association between SEP and obesity.</p><p><strong>Conclusion: </strong>A low SEP in childhood was associated with adolescent obesity. Parental health and health behaviors partly explained the association. For increasing health equality in adolescent health, the consideration of parental health behavior in the planning and implementation of health promotion programs seem to be important.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":"2024 ","pages":"7903972"},"PeriodicalIF":3.8,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11557177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body Mass Index and Prevalence of Obesity in Brazilian Adult Women: Temporal Comparison of Repeated Population-Based Cross-Sectional Surveys.","authors":"Anderson Garcez, Juvenal Soares Dias-da-Costa, Fernanda Souza de Bairros, Maria Teresa Anselmo Olinto","doi":"10.1155/2024/9950895","DOIUrl":"10.1155/2024/9950895","url":null,"abstract":"<p><p><b>Background:</b> Obesity is a complex multifactorial disease that has been associated with higher morbidity and mortality. <b>Objectives:</b> This study aimed to compare changes in body mass index (BMI) and obesity prevalence between two cross-sectional samples of Brazilian women. Furthermore, retrospective assessments of lifetime body weight changes were explored. <b>Methods:</b> Two independent population-based cross-sectional surveys were conducted in 2003 (first survey) and 2015 (second survey) with women living in the urban area city in southern Brazil. Both surveys had a similar design and included 981 women aged 20-60 years. Mean BMI and the presence of obesity (BMI ≥ 30 kg/m²) were estimated. Additionally, lifetime body weight change was obtained for the retrospective longitudinal assessment. <b>Results:</b> After 12 years, there was a significant increase from 25.9 ± 5.3 kg/m² to 28.1 ± 6.2 kg/m² in mean BMI. Between 2003 and 2015, the prevalence of obesity increased by 73% (18.0%; 95% CI: 15.8-20.6 vs. 31.2%; 95% CI: 28.3-34.1; <i>p</i> < 0.001). The means of estimated cumulative body weight gain from 15 to 50 years were 15.2 kg (95% CI: 13.3-17.1) and 17.2 kg (95% CI: 15.5-18.9) in 2003 and 2015, respectively; the greater cumulative difference between the two periods was observed at 40 years of age (3.3 kg). <b>Conclusions:</b> There was a significant increase in the mean BMI and prevalence of obesity between 2003 and 2015. Moreover, women experienced higher body weight gain during their lives in both survey periods, mainly in early adulthood.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":"2024 ","pages":"9950895"},"PeriodicalIF":3.8,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11537740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overweight and Obesity Among In-School Children and Adolescents (5-19 Years) in Ghana: A Scoping Review of Prevalence and Risk Factors.","authors":"Mustapha Amoadu, Paul Obeng, Jones Abekah Baah, Philomina Acquah, Godfred Cobbinah, Mary Aku Ogum, Jacob Owusu Sarfo, Edward Wilson Ansah","doi":"10.1155/2024/8895265","DOIUrl":"10.1155/2024/8895265","url":null,"abstract":"<p><p>Overweight and obesity are linked to the severity of infections and the development of chronic conditions among children and adolescents in Ghana. Hence, estimating the current prevalence and its determinants is imperative to guide public health interventions. This review mapped evidence on the prevalence and determinants of overweight and obesity among in-school children and adolescents (aged 5-19 years) in Ghana. Three main databases (PubMed, Central, and JSTOR) were searched for studies conducted in Ghana. Also, the study included only studies published online between 2010 and 2022. The search produced 1214 records, with an additional 23 identified through a search conducted in Google, Google Scholar, the WHO library, HINARI, and institutional repositories. After a thorough screening, 24 records were synthesized. The prevalence of overweight/obesity among the 23,663 in-school children and adolescents in Ghana was 0.5%-47.06%. Females have higher odds of being overweight than males. In addition, lack of nutrition and physical activity (PA) knowledge and low participation in school sports and physical activities exposed in-school children and adolescents in Ghana to overweight and obesity. Consumption of unhealthy foods, late bed, smoking, loneliness, watching television, and playing computer games exposed schoolchildren and adolescents in Ghana to overweight and obesity. There are relatively high levels of overweight and obesity among school-going children and adolescents in Ghana. Addressing sex gaps in PA, ensuring healthy eating, and limiting sedentary lifestyles is the surest way to promote healthy weight among in-school children and adolescents in Ghana.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":"2024 ","pages":"8895265"},"PeriodicalIF":3.8,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11535413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Variations in <i>AMPK</i>, <i>FOXO3A</i>, and <i>POMC</i> Increase the Risk of Extreme Obesity.","authors":"Cinthia Vila Nova Santana, Luiz Alexandre Viana Magno, Adauto Versiani Ramos, Maria Angélica Rios, Valéria Cristina Sandrim, Luiz Armando De Marco, Débora Marques de Miranda, Marco Aurélio Romano-Silva","doi":"10.1155/2024/3813621","DOIUrl":"10.1155/2024/3813621","url":null,"abstract":"<p><p><b>Objective:</b> Genetic variability significantly impacts metabolism, weight gain, and feeding behaviors, predisposing individuals to obesity. This study explored how variations in key genes related to obesity-<i>FOXO3A</i> (forkhead box O3), <i>AMPK</i> (protein kinase AMP-activated), and <i>POMC</i> (proopiomelanocortin)-are associated with extreme obesity (EOB). <b>Methods:</b> We conducted a case-control study with 251 EOB patients and 212 healthy controls with a body mass index (BMI) of less than 25 kg/m². We genotyped 10 single nucleotide variants (SNVs) using TaqMan-based assays. <b>Results:</b> Four SNVs-rs1536057 in <i>FOXO3A</i>, rs103685 in <i>AMPK</i>, rs934778, and rs6545975 in <i>POMC</i>-were associated with an increased risk of EOB. The strongest association was observed with rs934778 (<i>POMC</i>), which had a maximum odds ratio (OR) of 5.26 (95% CI: 2.86-9.09). While these genetic variations are closely linked to EOB, they do not affect serum glucose, triglycerides, HDL, LDL, BMI, or waist circumference. <b>Conclusions:</b> These findings indicate that factors beyond traditional metabolic pathways, potentially related to feeding behavior or hormonal regulation, may also link these genetic variations to obesity. Further research in a larger sample is essential to validate these findings and explore their potential to guide clinical interventions and public health strategies.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":"2024 ","pages":"3813621"},"PeriodicalIF":3.8,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11527528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}