Journal of Obesity最新文献_第2页

The Concentrations of Interleukin-6, Insulin, and Glucagon in the Context of Obesity and Type 2 Diabetes and Single Nucleotide Polymorphisms in IL6 and INS Genes. 肥胖和 2 型糖尿病患者体内白细胞介素-6、胰岛素和胰高血糖素的浓度与 IL6 和 INS 基因的单核苷酸多态性。

IF 3.8

Journal of Obesity Pub Date : 2024-01-12 eCollection Date: 2024-01-01 DOI: 10.1155/2024/7529779

Magdalena Król-Kulikowska, Iwona Urbanowicz, Marta Kepinska

{"title":"The Concentrations of Interleukin-6, Insulin, and Glucagon in the Context of Obesity and Type 2 Diabetes and Single Nucleotide Polymorphisms in IL6 and INS Genes.","authors":"Magdalena Król-Kulikowska, Iwona Urbanowicz, Marta Kepinska","doi":"10.1155/2024/7529779","DOIUrl":"10.1155/2024/7529779","url":null,"abstract":"Obesity and diabetes are a problem of modern medicine. Although the environmental factors contributing to the development of these diseases are widely known, research into genetic factors is still ongoing. At the same time, the role of inflammation in the pathophysiology of obesity and diabetes is increasingly emphasized. Therefore, the purpose of this study was to investigate the influence of two selected polymorphisms (rs1800795 and rs3842729) on the development of obesity and type 2 diabetes. In this study, 118 participants were examined, including a control group (nonobese and nondiabetic group), an obese group, and a diabetic group. Genotype analysis was performed using the PCR-RFLP method. It has been shown that in patients with the G/G genotype within the rs1800795 polymorphism (IL6), the chance of developing type 2 diabetes is several times lower compared to patients with the G/C and C/C genotypes. However, the rs3842729 polymorphism (INS) does not directly affect the risk of obesity or type 2 diabetes (T2D), although elevated insulin concentrations have been observed in obese and diabetic patients. These results confirm the impact of the rs1800795 polymorphism on the development of diabetes; however, this relationship is more complex and requires further research on other factors.","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":"2024 ","pages":"7529779"},"PeriodicalIF":3.8,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10798838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139513023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glucagon-Like Peptide-1 (GLP-1) during Ramadan: Narrative Review of the Published Literature. 斋月期间的胰高血糖素样肽-1 (GLP-1)：已发表文献的叙述性回顾。

IF 3.3

Journal of Obesity Pub Date : 2023-12-26 eCollection Date: 2023-01-01 DOI: 10.1155/2023/8626081

Khalid Mohammed Alayed

{"title":"Glucagon-Like Peptide-1 (GLP-1) during Ramadan: Narrative Review of the Published Literature.","authors":"Khalid Mohammed Alayed","doi":"10.1155/2023/8626081","DOIUrl":"10.1155/2023/8626081","url":null,"abstract":"Ramadan fasting, a religious practice observed by Muslims worldwide, involves abstaining from eating, drinking, smoking, and using oral medications from dawn to dusk during the ninth lunar month. Studies have demonstrated that fasting during Ramadan has been shown to increase HDL cholesterol, leptin, adiponectin, and insulin sensitivity, as well as lower several hemostatic risk factors for cardiovascular diseases. Additionally, it may result in a drop in blood sugar levels, especially in diabetics who are also on blood sugar-lowering medicine. Hypoglycemia, characterized by low blood sugar levels, could also result from fasting during Ramadan. The GLP-1 (glucagon-like peptide-1) hormone plays a significant role in regulating glucose metabolism and insulin secretion, and Ramadan fasting can affect its production and release in the gut. Research contributes to our understanding of the utilization of GL-1 medications during Ramadan among patients, broadening therapy alternatives and offering insightful information for well-informed decision-making. Therefore, this narrative review aims to explore the current evidence that studies the safety and efficacy of GLP-1 agonists during Ramadan for nondiabetic and diabetic patients to ensure healthy fasting during Ramadan.","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":"2023 ","pages":"8626081"},"PeriodicalIF":3.3,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10761230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139087297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Benefits of Low-Carbohydrate, High-Fat (LCHF) Diet on Body Composition, Leg Volume, and Pain in Women with Lipedema. 低碳水化合物，高脂肪(LCHF)饮食对女性脂肪水肿患者的身体组成，腿部体积和疼痛的益处。

IF 3.3

Journal of Obesity Pub Date : 2023-11-18 eCollection Date: 2023-01-01 DOI: 10.1155/2023/5826630

Małgorzata Jeziorek, Angelika Chachaj, Monika Sowicz, Agnieszka Adaszyńska, Aleksander Truszyński, Justyna Putek, Krzysztof Kujawa, Andrzej Szuba

{"title":"The Benefits of Low-Carbohydrate, High-Fat (LCHF) Diet on Body Composition, Leg Volume, and Pain in Women with Lipedema.","authors":"Małgorzata Jeziorek, Angelika Chachaj, Monika Sowicz, Agnieszka Adaszyńska, Aleksander Truszyński, Justyna Putek, Krzysztof Kujawa, Andrzej Szuba","doi":"10.1155/2023/5826630","DOIUrl":"10.1155/2023/5826630","url":null,"abstract":"This study aimed to assess the potential benefits of a low-carbohydrate, high-fat (LCHF) diet on body composition, leg volume, and pain reduction in women with lipedema compared to overweight or women with obesity. The study included 113 female participants, 56 with lipedema and 57 with overweight/obesity (BMI >25 kg/m2) without lipedema. All subjects were prescribed a low-carbohydrate, high-fat (LCHF) diet with anti-inflammatory properties to adhere to for a duration of 7 months. Measurements of anthropometry, body weight, composition, and pain (VAS) were conducted at the study's commencement and conclusion. 52 participants completed the study. Both groups experienced a similar weight reduction, amounting to 12.9% compared to the baseline (-10.8 kg vs. -11.9 kg; p = 0.14, for lipedema and women with overweight/obesity, respectively). The most reduction was in body fat mass. Improvements in various parameters were observed, except for ankle circumferences, which decreased more in the lipedema group. Lipedema participants showed significantly reduced pain levels following the LCHF diet (4.6 ± 2.6 vs 3.0 ± 2.3; p < 0.001). The LCHF diet holds promise for weight loss, body fat reduction, leg volume management, and pain alleviation in women with lipedema. These findings provide valuable insights into potential therapeutic strategies for lipedema management.","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":"2023 ","pages":"5826630"},"PeriodicalIF":3.3,"publicationDate":"2023-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138465388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Defining and Diagnosing Obesity in India: A Call for Advocacy and Action 定义和诊断印度的肥胖:呼吁倡导和行动

Journal of Obesity Pub Date : 2023-11-07 DOI: 10.1155/2023/4178121

Sanjay Kalra, Nitin Kapoor, Madhur Verma, Shehla Shaikh, Sambit Das, Jubbin Jacob, Rakesh Sahay

{"title":"Defining and Diagnosing Obesity in India: A Call for Advocacy and Action","authors":"Sanjay Kalra, Nitin Kapoor, Madhur Verma, Shehla Shaikh, Sambit Das, Jubbin Jacob, Rakesh Sahay","doi":"10.1155/2023/4178121","DOIUrl":"https://doi.org/10.1155/2023/4178121","url":null,"abstract":"The prevalence of overweight and obesity has more than doubled since 1980, and it is predicted that around two-thirds of the global burden of the disease will be attributed to chronic non-communicable diseases. Developing countries are experiencing a more dramatic rise in the prevalence of obesity in recent years. As per National Family Health Survey-5 (NFHS-5), one in every four Indians is now having obesity. It has been reported that being overweight and obese is a significant problem among different socioeconomic spectrums of men and women in India, especially among the elderly, people residing in urban regions, and diverse socioeconomic strata. There is an urgent need to identify obesity as a chronic disease requiring immediate attention, mandating timely screening, timely treatment, and economical ways of achieving and managing weight loss across the country. In this review, the authors have discussed various aspects of overweight and obesity and critically appraised the current status of obesity in India, its public health implications, the significance of screening, the role of BMI and other parameters in diagnosing obesity, and the need for treatment and cost-effective prescriptions.","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":"36 19","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135432779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Interplay between Adipose Tissue Properties and Levels of NT-proBNP in People with HIV HIV感染者脂肪组织特性与NT-proBNP水平之间的相互作用

Journal of Obesity Pub Date : 2023-11-04 DOI: 10.1155/2023/6199388

Mads-Holger Bang Jacobsen, Anne Marie Reimer Jensen, Andreas Dehlbæk Knudsen, Thomas Benfield, Ruth Frikke-Schmidt, Børge Nordestgaard, Shoaib Afzal, Klaus Fuglsang Kofoed, Marco Gelpi, Susanne Dam Nielsen

{"title":"The Interplay between Adipose Tissue Properties and Levels of NT-proBNP in People with HIV","authors":"Mads-Holger Bang Jacobsen, Anne Marie Reimer Jensen, Andreas Dehlbæk Knudsen, Thomas Benfield, Ruth Frikke-Schmidt, Børge Nordestgaard, Shoaib Afzal, Klaus Fuglsang Kofoed, Marco Gelpi, Susanne Dam Nielsen","doi":"10.1155/2023/6199388","DOIUrl":"https://doi.org/10.1155/2023/6199388","url":null,"abstract":"Objective. We aimed to assess the association between low N-terminal pro-brain natriuretic peptide (NT-proBNP) and body mass index (BMI), adipose tissue distribution, adiponectin, and HIV-specific risk factors among people with HIV (PWH). Methods. We included 811 PWH with measurement of height, weight and waist circumference, blood samples analyzed for NT-proBNP, and visceral-(VAT) and subcutaneous (SAT) adipose tissue areas measured from CT-scans. Low concentrations of NT-proBNP were defined as concentrations below the limit of quantification (5.9 pmol/L). Associations were explored with multivariable logistic regression analyses adjusted for relevant confounders. Results. We identified 471 (58%) individuals with low concentrations of NT-proBNP. Increasing BMI was associated with higher odds of low NT-proBNP (adjusted OR (aOR) 1.06 (95% CI: 1.01–1.11) per 1 kg/m2). Central obesity and large areas of VAT were associated with higher odds of low NT-proBNP (aOR 1.66 (1.16–2.36) and aOR 1.69 (1.09–2.62), respectively). Higher adiponectin was associated with lower odds of low NT-proBNP (aOR 0.86 (0.79–0.95) per 10% increase). No associations were found between low NT-proBNP and HIV-specific risk factors. Conclusions. In PWH, low NT-proBNP is associated with an adverse adipose tissue profile with high BMI, central obesity, accumulation of VAT, and low adiponectin.","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":"25 7","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135774179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

White Matter Integrity Abnormalities in Healthy Overweight Individuals Revealed by Whole Brain Meta-Analysis of Diffusion Tensor Imaging Studies. 扩散张量成像研究的全脑荟萃分析揭示了健康超重个体的白质完整性异常。

IF 3.8

Journal of Obesity Pub Date : 2023-10-23 eCollection Date: 2023-01-01 DOI: 10.1155/2023/7966540

Xiaodong Cheng, Wenchang Wang, Chen Sun, Yana Sun, Cong Zhou

{"title":"White Matter Integrity Abnormalities in Healthy Overweight Individuals Revealed by Whole Brain Meta-Analysis of Diffusion Tensor Imaging Studies.","authors":"Xiaodong Cheng, Wenchang Wang, Chen Sun, Yana Sun, Cong Zhou","doi":"10.1155/2023/7966540","DOIUrl":"10.1155/2023/7966540","url":null,"abstract":"Objective: This study aimed to conduct a coordinate-based meta-analysis (CBMA) to investigate white matter (WM) abnormalities in healthy individuals with overweight or obesity.Methods: A systematic literature search using Web of Science and PubMed datasets was performed. Original investigations that used diffusion tensor imaging (DTI) to explore fractional anisotropy (FA) differences between healthy overweight/obese individuals and normal weight controls were collected. The meta-analysis was conducted using the seed-based d mapping (SDM) software, employing stringent thresholds for significance. Sensitivity analyses and meta-regression analysis were also performed to examine the robustness of the results and explore potential associations with age and body mass index (BMI).Results: The analysis included five studies comprising 232 overweight/obese individuals and 219 healthy normal weight controls. The findings showed that overweight/obese individuals exhibited reduced fractional anisotropy (FA) in specific regions, namely, the right superior longitudinal fasciculus (SLF), the splenium of the corpus callosum (CC), and the right median network, cingulum. Meta-regression analysis further revealed that these FA reductions were associated with age.Conclusion: These findings provided insights into the potential impact of overweight/obesity on cognition, emotion, and neural functions and highlighted the significance of early prevention and intervention for overweight on the basis of neuroimaging.","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":"2023 ","pages":"7966540"},"PeriodicalIF":3.8,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71424406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Association of Adipokines and Myokines in the Blood of Obese Children and Adolescents with Lipoprotein Lipase rs328 Gene Variants. 肥胖儿童和青少年血液中脂蛋白脂酶rs328基因变异与脂肪细胞因子和肌细胞因子的相关性。

IF 3.3

Journal of Obesity Pub Date : 2023-10-20 eCollection Date: 2023-01-01 DOI: 10.1155/2023/7392513

Alexander V Shestopalov, Vadim V Davydov, Genrik T Tumanyan, Elena D Teplyakova, Tatiana P Shkurat, Elena V Mashkina, Mikhail A Shkurat, Andrey M Gaponov, Anastasia A Sadova, Olga V Borisenko, Sergey A Roumiantsev

{"title":"The Association of Adipokines and Myokines in the Blood of Obese Children and Adolescents with Lipoprotein Lipase rs328 Gene Variants.","authors":"Alexander V Shestopalov, Vadim V Davydov, Genrik T Tumanyan, Elena D Teplyakova, Tatiana P Shkurat, Elena V Mashkina, Mikhail A Shkurat, Andrey M Gaponov, Anastasia A Sadova, Olga V Borisenko, Sergey A Roumiantsev","doi":"10.1155/2023/7392513","DOIUrl":"10.1155/2023/7392513","url":null,"abstract":"Obesity develops largely due to genetic factors, with the genetic polymorphism of lipid metabolism enzymes being of particular importance. However, it is still unclear how the genetic variants of one of the key enzymes in lipid transport, lipoprotein lipase (LPL), are associated with the endocrine function of mesenchymal tissues in obesity. The current study was aimed at the investigation of the LPL rs328 gene variant association with adipokines and myokines levels, as well as lipid metabolism indices in the blood of children and adolescents of both genders with obesity. We found that LPL polymorphism rs328 is not characterized by the differences in the levels of hormones, adipokines, and myokines and in the blood of healthy children and adolescents; however, it significantly affects these indices during obesity in gender-dependent manner. The shifts in hormones, adipokines, and myokines manifest mostly in the obese individuals with Ser447Ser genotype rather than with 447Ter genotype. Obese boys homozygous for Ser447Ser have more elevated leptin levels than girls. They also demonstrate lower adiponectin, apelin, prolactin, and osteocrine levels than those in obese girls with the same genotype. The gender-based differences are less pronounced in individuals with 447Ter genotype than in the homozygotes for 447Ser. Thus, we conclude that the polymorphism rs328 of the lipoprotein lipase gene is accompanied by the changes in hormones, adipokines, and myokines levels in the blood of children and adolescents with obesity in gender-dependent manner.","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":"2023 ","pages":"7392513"},"PeriodicalIF":3.3,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71412634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of GCKR rs1260326 Variant in Subjects with Obesity Associated NAFLD and T2DM: A Case-Control Study in South Punjab, Pakistan. 肥胖相关NAFLD和T2DM受试者GCKR rs1260326变体的患病率：巴基斯坦旁遮普省南部的一项病例对照研究。

IF 3.3

Journal of Obesity Pub Date : 2023-10-04 eCollection Date: 2023-01-01 DOI: 10.1155/2023/6661858

Tayyaba Nisar, Kashan Arshad, Zahid Abbas, Maira Ali Khan, Sohail Safdar, Rehan Sadiq Shaikh, Ali Saeed

{"title":"Prevalence of GCKR rs1260326 Variant in Subjects with Obesity Associated NAFLD and T2DM: A Case-Control Study in South Punjab, Pakistan.","authors":"Tayyaba Nisar, Kashan Arshad, Zahid Abbas, Maira Ali Khan, Sohail Safdar, Rehan Sadiq Shaikh, Ali Saeed","doi":"10.1155/2023/6661858","DOIUrl":"10.1155/2023/6661858","url":null,"abstract":"The glucokinase regulatory protein (GCKR) regulates glycogen metabolism and insulin secretion, and the GCKR rs1260326 is a putative single nucleotide polymorphism (SNP) associated with metabolic disorders including nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM). This study was conducted to investigate the genetic association of the GCKR rs1260326 in NAFLD and T2DM in our population. NAFLD (n = 103), T2DM (n = 100), and control (n = 100) samples were collected and genotyped for GCKR rs1260326 by tetra-arm PCR. The genetic variant GCKR rs1260326 was significantly linked with NAFLD and T2DM, while the GCKR rs1260326 was significantly associated with the progression of obesity only in NAFLD subjects. The frequency of the C allele (mutant) was higher in both NAFLD (f = 0.69) and T2DM (f = 0.66) subjects as compared to healthy controls of NAFLD (0.52) and T2DM (f = 0.32). The frequency of the C allele was also positively linked with the progression of obesity in both diseases. The frequency of the C allele was 0.66, 0.67, and 0.74 in NAFLD normal weight, overweight, and obese subjects, respectively, while the frequency of the C allele was 0.60, 0.60, and 0.74 in T2DM in normal weight, overweight, and obese subjects, respectively. Homozygous mutant (CC) was 53% in both NAFLD and T2DM subjects, while heterozygous mutant (CT) was 15.53% in NAFLD and 22% in T2DM subjects. Wild-type allele (TT) was 31.06% in NAFLD and 25% in T2DM subjects. In conclusion, the GCKR rs1260326 is a highly prevalent SNP in NAFLD and T2DM subjects, which possibly contributed to obesity, insulin resistance, and metabolic disorders in our population.","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":"2023 ","pages":"6661858"},"PeriodicalIF":3.3,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41203640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond the Scale: Investigating Adiponectin, ICAM-1, and VCAM-1 as Metabolic Markers in Obese Adolescents with Metabolic Syndrome. 超越尺度：研究肥胖青少年代谢综合征中脂联素、ICAM-1和VCAM-1作为代谢标志物。

IF 3.3

Journal of Obesity Pub Date : 2023-10-03 eCollection Date: 2023-01-01 DOI: 10.1155/2023/4574042

Nur Aisiyah Widjaja, Leonardo Alexander Caesar, Suhasta Nova, Eva Ardianah

{"title":"Beyond the Scale: Investigating Adiponectin, ICAM-1, and VCAM-1 as Metabolic Markers in Obese Adolescents with Metabolic Syndrome.","authors":"Nur Aisiyah Widjaja, Leonardo Alexander Caesar, Suhasta Nova, Eva Ardianah","doi":"10.1155/2023/4574042","DOIUrl":"10.1155/2023/4574042","url":null,"abstract":"Background: Adiponectin acts to prevent vascular dysfunction due to obesity by inhibiting ICAM-1 and VCAM-1 expressions.Objective: We investigate adiponectin ICAM-1, VCAM-1, and metabolic syndrome (MetS) in obese adolescents.Methods: A cross-sectional study with healthy obese adolescents aged 13 to 18 years was conducted from October 2019 to January 2020. Statistical analysis conducted was a test of normality and homogeneity tests, ANOVA/Kruskal-Wallis, independent sample T-test/Mann-Whitney U test, and Spearman correlation and determined as significant if p value <0.05.Results: 125 obese adolescents were recruited. 42 (33.6%) were obese with MetS (we grouped as MetS) and 83 (66.4%) subjects without MetS (non-MetS group). VCAM-1 was significantly higher on boys with MetS compared to girls with MetS, and even girls with MetS had lower levels of VCAM-1 than boys with non-MetS. ICAM-1 was significantly higher in boys with low-level HDL-c (p < 0.05) and correlated weakly with HDL-c, while adiponectin levels were significantly lower in girls with central obesity and hypertriglyceridemia. Path analysis showed that triglyceride had a direct effect on ICAM-1 but not VCAM-1 in both obese boys and girls. Adiponectin had a negative direct effect on ICAM-1 and VCAM-1 in girls. However, on boys, diastole blood pressure had a negative direct effect, which might be the role of sex hormones indirectly.Conclusion: VCAM-1 was significantly higher in boys than girls, which showed that boys had a higher risk of atherosclerosis. ICAM-1 showed no significant difference in both gender and metabolic states. Adiponectin showed a protective effect by lowering ICAM-1 and VCAM-1 directly on girls.","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":"2023 ","pages":"4574042"},"PeriodicalIF":3.3,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41203627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gestational Early-Time Restricted Feeding Results in Sex-Specific Glucose Intolerance in Adult Male Mice. 妊娠早期限制性喂养导致成年雄性小鼠性别特异性葡萄糖不耐受。

IF 3.8

Journal of Obesity Pub Date : 2023-09-29 eCollection Date: 2023-01-01 DOI: 10.1155/2023/6666613

Molly C Mulcahy, Noura El Habbal, Detrick Snyder, JeAnna R Redd, Haijing Sun, Brigid E Gregg, Dave Bridges

{"title":"Gestational Early-Time Restricted Feeding Results in Sex-Specific Glucose Intolerance in Adult Male Mice.","authors":"Molly C Mulcahy, Noura El Habbal, Detrick Snyder, JeAnna R Redd, Haijing Sun, Brigid E Gregg, Dave Bridges","doi":"10.1155/2023/6666613","DOIUrl":"10.1155/2023/6666613","url":null,"abstract":"The timing of food intake is a novel dietary component that impacts health. Time-restricted feeding (TRF), a form of intermittent fasting, manipulates food timing. The timing of eating may be an important factor to consider during critical periods, such as pregnancy. Nutrition during pregnancy, too, can have a lasting impact on offspring health. The timing of food intake has not been thoroughly investigated in models of pregnancy, despite evidence that interest in the practice exists. Therefore, using a mouse model, we tested body composition and glycemic health of gestational early TRF (eTRF) in male and female offspring from weaning to adulthood on a chow diet and after a high-fat, high-sucrose (HFHS) diet challenge. Body composition was similar between groups in both sexes from weaning to adulthood, with minor increases in food intake in eTRF females and slightly improved glucose tolerance in males while on a chow diet. However, after 10 weeks of HFHS, male eTRF offspring developed glucose intolerance. Further studies should assess the susceptibility of males, and apparent resilience of females, to gestational eTRF and assess mechanisms underlying these changes in adult males.","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":"2023 ","pages":"6666613"},"PeriodicalIF":3.8,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41124266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0