Journal of Oral Microbiology最新文献

{"title":"Combined treatment with bacteriophages and sodium hypochlorite against <i>E. faecalis</i> biofilm in an <i>in vitro</i> root canal model with evaluation of bacterial resistance.","authors":"Konstantin Steffen, Kerstin Bitter, Sebastian Schlafer, Sebastian Paris, Marie Bauer","doi":"10.1080/20002297.2026.2687225","DOIUrl":"10.1080/20002297.2026.2687225","url":null,"abstract":"<p><strong>Aim: </strong>To assess the time-dependent antimicrobial activity of a newly isolated bacteriophage against <i>Enterococcus faecalis</i> biofilms in two <i>in vitro</i> models, aloneand combinedwith sodium hypochlorite, followed by the evaluation of potential resistance development.</p><p><strong>Methodology: </strong>Bacteriophage CUB_EF02 was isolated from sewage water using <i>E. faecalis</i> ATCC 29212 as host, visualized by TEM, and sequenced. Its antimicrobial effect against biofilms grown on porous glass beads was assessed in a time-killing assay. Additionally, 10-day-old biofilms were established in 36 extracted single-rooted human teeth and treated with 0.9% NaCl, 1% NaOCl, phages, or their combination. Dentine-adherent biofilm was quantified by plate counts at baseline, after treatment, and after 48 h re-incubation. Logarithmic reduction factors were analyzed using one-way ANOVA and Tukey HSD. Phage resistance was evaluated by Top-Agar overlay spot assay.</p><p><strong>Results: </strong>Phage treatment reduced biofilm by 1.35 ± 0.2 SD-log after 6 h compared to control. Irrigation of the root canals using NaOCl achieved a significantly higher reduction (LRF_red. = 2.98 ± 0.77 SD) than phages alone(LRF_red. = 1.50 ± 0.23 SD). Combined treatment showed the strongest antimicrobial effect (LRF_red. = 4.05 ± 1.17 SD). Bacterial regrowth occurred in all groups. Resistance developed after phage incubationfor ≥6 h.</p><p><strong>Conclusion: </strong>Bacteriophages represent a promising adjunctive in root canal disinfection, but remain less effective than NaOCl and may inducebacterial resistance.</p>","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"18 1","pages":"2687225"},"PeriodicalIF":6.7,"publicationDate":"2026-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13270871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148270544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell-type-specific actions of carnosic acid against <i>Porphyromonas gingivalis</i>-induced proliferation in liver cancer cells.","authors":"Ting Wang, Toshimi Chiba, Taichi Ishikawa, Hidekatsu Kuroda, Keisuke Kakisaka","doi":"10.1080/20002297.2026.2684127","DOIUrl":"10.1080/20002297.2026.2684127","url":null,"abstract":"<p><strong>Background and aim: </strong>The periodontal pathogen <i>Porphyromonas gingivalis</i> (Pg) has been linked to systemic diseases, including cancer.</p><p><strong>Objective: </strong>To investigate the oncogenic effects of Pg and its lipopolysaccharide (LPS) on liver cancer cells and evaluate the anti‑cancer potential of carnosic acid (CA).</p><p><strong>Design: </strong>HepG2, HuH7 and pancreatic cancer cells were treated with Pg, Pg‑LPS or CA. Proliferation was assessed by viability assay. Key phosphorylated signaling molecules and their total proteins (TLR4, ERK, Akt, NF‑κB, Nrf2) were examined by western blot and immunofluorescence.</p><p><strong>Results: </strong>Pg promoted proliferation in HepG2 and pancreatic cancer cells in an MOI‑dependent manner and upregulated TLR4, p‑ERK, p‑Akt and p‑NF‑κB. Pg‑LPS enhanced proliferation, but CA did not inhibit this effect. In HuH7 cells, CA inhibited proliferation, associated with Nrf2 activation; in HepG2 cells, CA showed no inhibition or Nrf2 activation.</p><p><strong>Conclusions: </strong>Pg promotes oncogenic processes. CA modulates proliferation in a cell‑type‑ and concentration‑dependent manner, likely through Nrf2 activation.</p>","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"18 1","pages":"2684127"},"PeriodicalIF":6.7,"publicationDate":"2026-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13267039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Capsaicin inhibits cariogenic <i>Streptococcus mutans-Candida albicans</i> cross-kingdom biofilms.","authors":"Xinyan Huang, Jianhang Bao, Jiaqi Zhu, Shuangyue Wu, Yuankun Zhai, Yanfang Ren","doi":"10.1080/20002297.2026.2681274","DOIUrl":"10.1080/20002297.2026.2681274","url":null,"abstract":"<p><strong>Objective: </strong>This research aimed to determine whether capsaicin (CAP), a phytochemical in chilli peppers, inhibits cariogenic <i>Streptococcus mutans-Candida albicans</i> cross-kingdom biofilms and their key virulence factors, and to explore underlying mechanisms.</p><p><strong>Design: </strong>The anti-caries potential of CAP was assessed in <i>S. mutans-C. albicans</i> co-cultures by quantifying viable cell counts, biomass and biofilm metabolic activity. Biofilm microstructure was visualized by confocal laser scanning microscopy with COMSTAT quantification, and CAP-induced transcriptional changes were profiled by qRT-PCR. Matched ethanol vehicle controls were included.</p><p><strong>Results: </strong>CAP inhibited the growth of both organisms (MIC = 320 µg/mL). At 1/2 MIC (160 µg/mL) and MIC, CAP significantly suppressed biofilm formation, disrupted pre-formed biofilms and decreased acid production and extracellular polysaccharide (EPS) accumulation. In mature biofilms, CAP downregulated key virulence genes associated with EPS biosynthesis (<i>gtfB, gtfC, gtfD</i>) and fungal pathogenicity (<i>HWP1, ERG4, CHT2, SOD3),</i> suggesting potential interference with glucosyltransferase activity, hyphal morphogenesis and membrane-cell wall integrity.</p><p><strong>Conclusion: </strong>CAP attenuated key virulence attributes of <i>S. mutans-C. albicans</i> biofilms <i>in vitro,</i> suggesting its potential as a natural adjunct in caries management. However, its efficacy and deliverability require optimization of oral formulations and rigorous <i>in vivo</i>/clinical validation.</p>","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"18 1","pages":"2681274"},"PeriodicalIF":6.7,"publicationDate":"2026-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13267022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral health and infective endocarditis among high-risk individuals: a nationwide register-based study.","authors":"Niko Vähäsarja, Bodil Lund","doi":"10.1080/20002297.2026.2684117","DOIUrl":"10.1080/20002297.2026.2684117","url":null,"abstract":"<p><strong>Background: </strong>Poor oral health has long been hypothesized as a contributor to infective endocarditis caused by <i>Viridans</i> group streptococci (VGS-IE), particularly among individuals at increased risk of the disease. However, large-scale population-based evidence remains sparse.</p><p><strong>Objective: </strong>Assess the association between severe oral disease and IE among high-risk individuals using Swedish nationwide health registers.</p><p><strong>Design: </strong>Nested case-control study conducted within a national cohort of 64,634 individuals at high risk of IE due to prior IE, prosthetic heart valves, or congenital heart disease (CHD), followed between July 1, 2008, and December 31, 2018. 881 cases of IE and 8,810 controls were identified using the National Patient Register and the Swedish Registry of Infective Endocarditis. Poor oral health was defined using the Swedish Dental Health Register. Conditional logistic regression was used to estimate odds ratios (ORs) for poor oral health in cases versus controls, adjusted for age, sex, educational attainment and comorbidities.</p><p><strong>Results: </strong>Among individuals with prior IE, poor oral health was associated with both all-cause IE and VGS-IE. All-cause IE: adjusted OR 3.02 (95% CI 1.95-4.69). VGS-IE: adjusted OR 2.23 (95% CI 1.02-4.90). Among those with prosthetic valves, no significant associations were observed (all-cause IE: adjusted OR 1.47 [95% CI 0.94-2.30]; VGS-IE: adjusted OR 1.09 [95% CI 0.44-2.71]). No conclusions could be drawn for the CHD-group due to a lack of data.</p><p><strong>Conclusions: </strong>Poor oral health was associated with IE recurrence among individuals with a history of IE, suggesting a role for oral health in prevention strategies.</p>","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"18 1","pages":"2684117"},"PeriodicalIF":6.7,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13267036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suprathreshold non-volatile flavour perception is associated with multiple species rather than any single species via bacterial metabolism.","authors":"Shuyuan Zhang, Saeed Shoaie, Guy H Carpenter","doi":"10.1080/20002297.2026.2686537","DOIUrl":"10.1080/20002297.2026.2686537","url":null,"abstract":"<p><strong>Background: </strong>The microbiome is the characteristic microbial community inhabiting a well-defined habitat with distinct physicochemical properties. During eating, food is masticated and mixed with saliva to form a bolus; non-volatile flavour molecules are released into the saliva and delivered to receptors on the tongue. Throughout this process, the oral microbiome is in direct contact with non-volatile flavour molecules. In this cross-sectional study, we hypothesised that the oral microbiome interacts with non-volatile flavour molecules to modulate suprathreshold taste perception.</p><p><strong>Materials and methods: </strong>Fifty-three participants were included, with suprathreshold sensory data, salivary microbiome data (including both taxonomic and functional profiles), and salivary metabolome data. Associations were explored using fixed-effects linear-regression models and unsupervised clustering.</p><p><strong>Results: </strong>Suprathreshold non-volatile flavour perception was associated with the salivary microbiome via multispecies interactions rather than single-species effects. Taurine (an amino acid and confirmed bacterial metabolite) and ethanolamine (a phospholipid-related metabolite and confirmed bacterial metabolite) showed the greatest number of associations with suprathreshold taste perception in this study (6 of 8 sensory solution each).</p><p><strong>Conclusion: </strong>This study suggested that suprathreshold taste perception was associated with inferred microbial metabolic pathways via multispecies interactions. Because inferred microbial metabolic pathways are encoded by multiple bacteria, they may better capture multispecies contributions than species-level taxonomic profiles.</p>","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"18 1","pages":"2686537"},"PeriodicalIF":6.7,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13255194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148251996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibacterial and anti-biofilm effects of postbiotic mediator derived from <i>Jeotgal</i> isolate <i>Lactiplantibacillus plantarum</i> KMC12 against <i>Streptococcus mutans</i>.","authors":"Hyunjin Oh, Jihoon Kim, Jaewoo Bai","doi":"10.1080/20002297.2026.2684130","DOIUrl":"10.1080/20002297.2026.2684130","url":null,"abstract":"<p><strong>Background: </strong>Dental caries, commonly known as tooth decay, is a progressive breakdown of tooth tissues caused by the biofilm-producing bacteria, <i>Streptococcus mutans</i>. <i>S. mutans</i> plays a primary role in the initiation and progression of dental caries by producing a biofilm called dental plaque.</p><p><strong>Aim: </strong>This study aimed to evaluate the antibacterial and anti-biofilm effects of the neutralized postbiotic mediator (nPM) derived from <i>Lactiplantibacillus plantarum</i> KMC12 and to assess its potential as a therapeutic agent against <i>S. mutans</i>.</p><p><strong>Methods: </strong>KMC12 nPM was prepared through centrifugation, filtration and lyophilization. Its antibacterial and anti-biofilm effects were investigated through MIC/MBC assays, membrane permeability tests, biofilm formation quantification, EPS production measurement, RT-qPCR analysis of biofilm-related genes, and cytotoxicity assays using Caco-2 cells.</p><p><strong>Results: </strong>KMC12 nPM exhibited antibacterial activity with MIC and MBC values of 128 and 256  mg/mL, respectively, and caused approximately 87% membrane damage at 512 mg/mL. Biofilm formation was inhibited by 36% at 256 mg/mL and 83% at 512 mg/mL. Furthermore, KMC12 nPM significantly downregulated <i>gtfB, gtfD, ftf, aguD</i> and <i>atpD</i> gene expression and reduced EPS production without showing cytotoxicity.</p><p><strong>Conclusion: </strong>These results suggest KMC12 nPM as a promising, novel therapeutic agent for inhibiting <i>S. mutans</i> biofilm formation and caries prevention.</p>","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"18 1","pages":"2684130"},"PeriodicalIF":6.7,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13255195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148251967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of probiotic bacteria on community composition, microscale pH and matrix architecture in a saliva-derived model of oral biofilm.","authors":"Elisabeth Reichardt, Sahar Assar, Mathilde Frost Kristensen, Marie Braad Lund, Sebastian Schlafer","doi":"10.1080/20002297.2026.2682457","DOIUrl":"10.1080/20002297.2026.2682457","url":null,"abstract":"<p><strong>Background: </strong><i>Streptococcus salivarius</i> K12 and M18 have recently gained interest as probiotic organisms for caries control. This study investigated the impact of <i>S. salivarius</i> K12 and M18 supplementation on biofilm virulence in a complex saliva-derived <i>in vitro</i> model compared to treatment with <i>Limosilactobacillus reuteri</i> DSM17938 and no treatment.</p><p><strong>Methods: </strong>Biofilms were grown under low (0.05%) and high (1%) sucrose conditions and supplemented with <i>S. salivarius</i> K12, <i>S. salivarius</i> M18 or <i>L. reuteri.</i> Microscale pH dynamics were assessed using confocal microscopy-based pH ratiometry. The biofilm matrix composition was analyzed by glucan and extracellular DNA mapping. Microbial community composition was determined by 16S rRNA gene amplicon sequencing.</p><p><strong>Results: </strong>At 0.05% sucrose, pH was significantly higher in <i>S. salivarius</i> M18 biofilms, but not in <i>S. salivarius</i> K12 biofilms, compared to control. pH in <i>L. reuteri</i> biofilms was significantly lower. At 1% sucrose, no significant effects of probiotic supplementation on biofilm pH were observed. Shifts in the bacterial composition were minor, most notably an increased abundance of lactobacilli in <i>L. reuteri</i>-treated biofilms at 1% sucrose. No significant effects on the biofilm matrix composition were observed.</p><p><strong>Conclusions: </strong>In conclusion, probiotic supplementation exerted only minor effects on biofilm composition and virulence.</p>","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"18 1","pages":"2682457"},"PeriodicalIF":6.7,"publicationDate":"2026-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13255207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148251954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiome dynamics and early microbial signatures predict bone regeneration in marsupialized jaw lesions: a longitudinal 16S sequencing cohort study.","authors":"Bin Zeng, Mailikanmuhan Maitikuerban, Linling Chen, Di-Kan Wang, Jingyuan Li, Le Yang, Xiao-Mei Lao, Si-En Zhang, Gui-Qing Liao, Yu-Jie Liang","doi":"10.1080/20002297.2026.2684137","DOIUrl":"10.1080/20002297.2026.2684137","url":null,"abstract":"<p><strong>Background: </strong>Marsupialization is a conservative treatment for odontogenic jaw lesions but is hampered by protracted, unpredictable bone regeneration, lacking early biomarkers. Furthermore, whether these intraosseous lesions harbour a unique microbiome remains unknown. We aimed to characterize microbial dynamics during treatment and develop a prognostic model to address clinical unpredictability.</p><p><strong>Methods: </strong>A prospective longitudinal study was conducted with multi-site sampling (saliva, tissue, luminal fluid and swabs) across three phases: primary surgery, 3-month follow-up and secondary surgery. Bacterial 16S rRNA gene sequencing was subsequently performed. Microbial dynamics were analyzed using diversity analysis and source tracking. A prognostic model was constructed using a hybrid feature selection strategy to predict 12-month bone regeneration using 3-month post-operative swabs.</p><p><strong>Results: </strong>Baseline analysis revealed that odontogenic jaw lesions harbour a unique, biologically selected microbiome enriched in <i>Fusobacterium</i> and <i>Clostridia</i>, which are distinct from saliva. Marsupialization induced a profound microbial remodelling, transforming this closed niche into an open, stochastic ecosystem dominated by salivary commensals. Long-term analysis indicated a secondary succession, where primary pathogens were replaced by a <i>Bacteroidia</i>-enriched community. Crucially, after a rigorous feature selection process, a streamlined microbial signature accurately predicted 12-month bone regeneration (AUC = 0.937). Poor bone regeneration was associated with the persistence of the primary <i>Clostridia</i> core, whereas favourable regeneration was linked to a shift towards <i>Bacteroidia</i> and <i>Proteobacteria</i>.</p><p><strong>Conclusion: </strong>Marsupialization drives the lesion microbiome from a pathogenic niche toward a stochastic, commensal-like state. This succession trajectory is associated with clinical outcome. Our prognostic model offers a novel precision tool to optimize lesion management.</p>","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"18 1","pages":"2684137"},"PeriodicalIF":6.7,"publicationDate":"2026-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13250861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148226114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of multiple tongue conditions on the diversity and composition of the oral microbiota.","authors":"Masakazu Hamada, Yuriko Matsuoka, Yuko Ogaya, Tamami Kadota, Shunya Ikeda, Tatsuya Akitomo, Ryota Nomura, Kazuhiko Nakano","doi":"10.1080/20002297.2026.2684141","DOIUrl":"10.1080/20002297.2026.2684141","url":null,"abstract":"<p><strong>Objective: </strong>The present study examined the effects of multiple tongue conditions on the diversity and composition of the oral microbiota to obtain a more detailed understanding of their potential role in health and disease.</p><p><strong>Method: </strong>Ninety-three subjects were classified according to tongue conditions, such as a yellow tongue coating, the presence or absence of swelling of the sublingual vein, a red tongue or red tongue tip, a fissured tongue, enlarged tongue, geographic tongue, and tooth marks. The oral microbiota was examined using <i>α</i>- and <i>β</i>-diversity metrics and taxonomic composition analyses.</p><p><strong>Results: </strong><i>α</i>-Diversity was significantly lower in subjects with a fissured tongue than in those without. A <i>β</i>-diversity analysis revealed distinct microbial community structures between these subjects. Taxonomic profiling showed a higher abundance of <i>Firmicutes</i> and sulfur-metabolizing bacteria in subjects with a fissured tongue. However, these differences were not retained after age adjustment. Age-restricted sensitivity analyses identified age-independent microbial signatures associated with a fissured tongue, including a reduced abundance of <i>Veillonella</i> and <i>Granulicatella</i> in saliva samples.</p><p><strong>Conclusion: </strong>Morphological abnormalities of the tongue are associated with distinct oral microbiome profiles. These features may reflect oral microbial dysbiosis and could be relevant for future studies exploring non-invasive markers of oral health.</p>","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"18 1","pages":"2684141"},"PeriodicalIF":6.7,"publicationDate":"2026-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13244507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148211604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crosstalk between iron metabolism dysregulation and the oral microbiome in periodontitis.","authors":"Zhenyuan Yu, Shuwei Zhang, Ze Lu, Hongyan Wang, Haijie Liu, Yuchao Li, Yaping Pan","doi":"10.1080/20002297.2026.2682975","DOIUrl":"10.1080/20002297.2026.2682975","url":null,"abstract":"<p><strong>Background: </strong>Periodontitis is a chronic inflammatory disease caused by periodontal pathogens. The impact of periodontitis is not only limited to the oral cavity, but also related to a variety of systemic diseases. Iron is a kind of redox metal, which may be deleterious to cells by producing damaging free radicals. Iron homeostasis dysregulation, especially ferroptosis, involves in the progression of periodontitis.</p><p><strong>Objective: </strong>This review aims to systematically summarize the crosstalk between iron metabolism dysregulation and the oral microbiome in periodontitis, focusing on alterations in iron-related biomarkers, iron-mediated tissue damage, the role of ferroptosis, and the potential of iron-targeted therapies.</p><p><strong>Design: </strong>A narrative review of recent advances in iron metabolism and ferroptosis, with emphasis on studies investigating molecular mechanisms, clinical correlations, and therapeutic interventions in periodontitis.</p><p><strong>Results: </strong>In periodontitis, serum iron and transferrin levels are decreased, while ferritin, hepcidin, and ceruloplasmin are elevated. Dysregulated iron metabolism promotes periodontal pathogen survival, amplifies inflammatory responses, induces ferroptosis in periodontal ligament cells, and contributes to alveolar bone resorption. Iron disorders also link periodontitis to systemic diseases such as anemia of inflammation, type 2 diabetes, and cardiovascular disease. Preclinical studies show that iron chelators (e.g. deferoxamine) and lactoferrin can inhibit bacterial growth, alleviate ferroptosis, and promote periodontal regeneration.</p><p><strong>Conclusions: </strong>Iron metabolism dysregulation and ferroptosis play critical roles in the initiation and progression of periodontitis and its systemic comorbidities. Targeting iron homeostasis represents a promising therapeutic strategy, but further well-designed clinical trials are needed to validate efficacy and safety.</p>","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"18 1","pages":"2682975"},"PeriodicalIF":6.7,"publicationDate":"2026-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13244514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148211625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}