Journal of Oral Microbiology最新文献_第7页

Aggregatibacter actinomycetemcomitans NadN contributes to neutrophil extracellular trap degradation. 聚集菌放线菌的NadN有助于中性粒细胞胞外陷阱的降解。

IF 6.7 2区医学

Journal of Oral Microbiology Pub Date : 2026-07-06 eCollection Date: 2026-01-01 DOI: 10.1080/20002297.2026.2694756

Yaowapa Puanglai, Anongnard Kasorn, Oranart Matangkasombut, Dujduan Waraho-Zhmayev, Soraya Chaturongakul, Fabien Loison

{"title":"Aggregatibacter actinomycetemcomitans NadN contributes to neutrophil extracellular trap degradation.","authors":"Yaowapa Puanglai, Anongnard Kasorn, Oranart Matangkasombut, Dujduan Waraho-Zhmayev, Soraya Chaturongakul, Fabien Loison","doi":"10.1080/20002297.2026.2694756","DOIUrl":"10.1080/20002297.2026.2694756","url":null,"abstract":"Background: Neutrophils Extracellular Traps (NET) immobilize and kill extracellular pathogens. Aggregatibacter actinomycetemcomitans (Aa), associated with aggressive forms of periodontitis, has been shown to induce NET release. However, it remains unknown whether Aa evades extracellular traps.Materials and methods: NETs were incubated with wild-type Aa (Aa-WT, strain Y4) or Aa-ΔCdtB, lacking a toxin inducing DNA breaks. NET degradation was measured by imaging and fluorometry. Aa survival and growth was measured by biofilm formation. Aa-WT membrane was fractionated on a sucrose gradient, and fractions positive for NET degradation were subjected to LC-MS/MS. The top protein candidate was expressed as a recombinant protein in Lactococcus lactis to confirm its NET-degrading activity.Results: Aa-WT and Aa-ΔCdtB strains were captured by NETs but degraded the extracellular traps after three hours. Aa survival in the presence of NETs was independent of CdtB expression. NET degrading activity was not release but associated with cells. NAD nucleotidase (NadN) was identified via mass spectrometry from membrane fraction. In vitro, recombinant NadN degraded NETs, and heterologous expression of NadN in L. lactis was sufficient to confer a NET-degrading phenotype.Conclusions: Aa degrades NETs to evade host immunity. NadN is a primary mediator of the NET-degrading activity of Aggregatibacter actinomycetemcomitans.","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"18 1","pages":"2694756"},"PeriodicalIF":6.7,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13347837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148421850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbiome and metabolome integrated analysis reveals oral microbiota alterations and associated metabolic pathways in allergic rhinitis. 微生物组和代谢组的综合分析揭示了变应性鼻炎患者口腔微生物群的改变和相关的代谢途径。

IF 6.7 2区医学

Journal of Oral Microbiology Pub Date : 2026-07-06 eCollection Date: 2026-01-01 DOI: 10.1080/20002297.2026.2697535

Weiwei Zhang, Ping Li, Shuang Zhao, Yue Song, Yan Zhao, Zhenhua Yu, Wenjie Zhao, Shuang Pan

{"title":"Microbiome and metabolome integrated analysis reveals oral microbiota alterations and associated metabolic pathways in allergic rhinitis.","authors":"Weiwei Zhang, Ping Li, Shuang Zhao, Yue Song, Yan Zhao, Zhenhua Yu, Wenjie Zhao, Shuang Pan","doi":"10.1080/20002297.2026.2697535","DOIUrl":"10.1080/20002297.2026.2697535","url":null,"abstract":"Background: Allergic rhinitis is a globally prevalent condition characterized by an increase in incidence. This study aimed to characterize differences in supragingival plaque microbial composition between patients with allergic rhinitis and healthy controls, and to explore the differential metabolites and enriched metabolic pathways to provide reference data for subsequent in-depth investigations into the pathogenesis and potential therapeutic targets of allergic rhinitis.Material and methods: We employed 16S rRNA gene high-throughput sequencing technology and untargeted metabolomics to analyze the supragingival plaque microbiota of 35 healthy individuals and 35 patients with allergic rhinitis.Results: At the genus level, Abiotrophia, Rothia, and Actinobacillus showed significant inter-group differences. Ten species, including Prevotella melaninogenica and Capnocytophaga sputigena, exhibited markedly differential abundances. Microbial co-occurrence network analysis revealed a simpler topological architecture in the allergic rhinitis group than that in the healthy control group. Metabolomic profiling identified 106 differentially expressed metabolites that were enriched across 13 associated metabolic pathways.Conclusion: Under the current inclusion criteria, this study identified significant alterations in the microbial composition of supragingival plaques in patients with allergic rhinitis. Additionally, using the current sample size, this study preliminarily characterised differential metabolites and pathways, providing initial clues for identifying therapeutic targets in allergic rhinitis.","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"18 1","pages":"2697535"},"PeriodicalIF":6.7,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13348113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148421877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carceral settings as institutional exposures in caries microbiome research. 龋齿微生物组研究中机构暴露的龋齿环境。

IF 6.7 2区医学

Journal of Oral Microbiology Pub Date : 2026-06-26 eCollection Date: 2026-01-01 DOI: 10.1080/20002297.2026.2694733

Ahmad Yusroni, Muhammad Khairul Anwar, Yuyun Eka Kartika Sari

引用次数: 0

AdcBC-dependent zinc uptake influences physiological responses in Streptococcus mutans. adcbc依赖性锌摄取影响变形链球菌的生理反应。

IF 6.7 2区医学

Journal of Oral Microbiology Pub Date : 2026-06-25 eCollection Date: 2026-01-01 DOI: 10.1080/20002297.2026.2691469

Marlus da Silva Pedrosa, Charles Stephen Schuls, Leonardo Luca Iannaccone, Apoena Aguiar Ribeiro

{"title":"AdcBC-dependent zinc uptake influences physiological responses in Streptococcus mutans.","authors":"Marlus da Silva Pedrosa, Charles Stephen Schuls, Leonardo Luca Iannaccone, Apoena Aguiar Ribeiro","doi":"10.1080/20002297.2026.2691469","DOIUrl":"10.1080/20002297.2026.2691469","url":null,"abstract":"Background: Zinc is widely used in oral care products due to its antimicrobial and anti-biofilm properties; however, the molecular mechanisms by which zinc influences Streptococcus mutans (S. mutans) physiology remain incompletely understood. The AdcABC system is the primary high-affinity zinc transporter in S. mutans. We investigated whether loss of adcBC is associated with altered physiological responses in S. mutans.Material and methods: Wild-type (WT), ΔadcBC mutant, and complemented S. mutans UA159 strains were evaluated under zinc-replete and zinc-limited conditions using zinc sulphate (ZnSO4) at defined concentrations. Growth, carbohydrate utilization, acidogenicity, acid tolerance, aggregation, biofilm formation, and expression of stress response and regulatory genes were assessed.Results: Loss of adcBC impaired growth and reduced utilization of multiple carbohydrates, including key glycolytic substrates, indicating altered metabolism. Zinc supplementation restored growth but did not consistently recover redox-based metabolic activity. Expression of pflA, associated with fermentative metabolism, was reduced in the mutant. Acid tolerance was unaffected by AdcBC. Zinc enhanced aggregation and surface attachment independently of AdcBC, whereas biofilm biomass showed partial dependence on AdcBC-mediated zinc uptake. The ΔadcBC mutant also exhibited altered expression of genes involved in oxidative stress, metal homeostasis, and regulatory pathways.Conclusion: Loss of adcBC is associated with altered physiological responses in S. mutans. Zinc influences bacterial physiology through both uptake-dependent and uptake-independent mechanisms, highlighting its context-dependent role in oral environments.","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"18 1","pages":"2691469"},"PeriodicalIF":6.7,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13307382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148345683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral fungal microbiome in gout: composition, cross-kingdom interactions, and effects of intervention. 痛风的口腔真菌微生物组：组成、跨界相互作用和干预效果。

IF 6.7 2区医学

Journal of Oral Microbiology Pub Date : 2026-06-25 eCollection Date: 2026-01-01 DOI: 10.1080/20002297.2026.2680789

Menghui Yao, Yingdong Han, Chengjin Huang, Mengmeng Dai, Xiaohan Zhang, Yun Zhang, Xuejun Zeng

{"title":"Oral fungal microbiome in gout: composition, cross-kingdom interactions, and effects of intervention.","authors":"Menghui Yao, Yingdong Han, Chengjin Huang, Mengmeng Dai, Xiaohan Zhang, Yun Zhang, Xuejun Zeng","doi":"10.1080/20002297.2026.2680789","DOIUrl":"10.1080/20002297.2026.2680789","url":null,"abstract":"Background: Oral fungi, despite their low abundance, may influence microbial interactions, host responses, and disease progression; however, their role in gout remains poorly understood.Materials and methods: Between March and December 2024, patients with chronic gouty arthritis (CGA), acute gouty arthritis (AGA), and age- and sex-matched healthy controls (HC) were enrolled. Unstimulated saliva underwent ITS2 sequencing. Analyses included α/β-diversity, differential abundance, and genus-level co-occurrence networks. Cross-kingdom associations were assessed using partial Spearman correlation integrating 16S rRNA data. A subset received lifestyle intervention and urate-lowering therapy with follow-up.Results: A total of 76 participants (35 CGA, 17 AGA, 24 HC) were included. Alpha-diversity showed no significant difference, while β-diversity distinguished patients from HC ( P = 0.0018). Ascomycota and Basidiomycota predominated. Alternaria, Eutypella, and Saccharomyces was enriched in CGA. Whereas Eutypella was enriched in AGA. Network analysis revealed progressive loss of fungal-fungal and fungal-bacterial interactions, with strengthened pathogenic fungi-bacteria associations. Follow-up indicated partial restoration of fungal-fungal networks preceding compositional recovery.Conclusion: This study provides the first characterization of the oral mycobiome in gout, highlighting weakened microbial connectivity and reinforced pathogen associations. Interventions may restore network integrity before compositional normalization, suggesting the oral mycobiome as a potential target in gout.","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"18 1","pages":"2680789"},"PeriodicalIF":6.7,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13312830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148352221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between oral microbiota and chronic kidney disease: facts and perspectives. 口腔微生物群与慢性肾脏疾病的关系：事实和观点。

IF 6.7 2区医学

Journal of Oral Microbiology Pub Date : 2026-06-23 eCollection Date: 2026-01-01 DOI: 10.1080/20002297.2026.2687208

Xinyi Fang, Mengyi Wang, Kaidiliya Yalikun, Xue Luo, Xiliang Jiang, Moussa Ide Nasser, Chi Liu, Lei Pu

{"title":"Relationship between oral microbiota and chronic kidney disease: facts and perspectives.","authors":"Xinyi Fang, Mengyi Wang, Kaidiliya Yalikun, Xue Luo, Xiliang Jiang, Moussa Ide Nasser, Chi Liu, Lei Pu","doi":"10.1080/20002297.2026.2687208","DOIUrl":"10.1080/20002297.2026.2687208","url":null,"abstract":"Background: The human microbiome comprises the microorganisms inhabiting the body, with the oral cavity representing the second most densely colonized site after the colon. Periodontal disease-associated oral bacteria are more common in patients with kidney disorders than in the general population. Oral dysbiosis disrupts host-microbiota homeostasis and promotes destructive periodontal inflammation, which has been linked to chronic kidney disease (CKD). However, current interventional evidence, including randomized controlled trials, remains limited by small sample sizes, short follow-up, heterogeneous periodontal interventions, inconsistent renal endpoints, limited blinding, and inadequate adjustment for confounders such as smoking, glycemic control, and medication use. Thus, causality between oral microbiota modulation and CKD progression remains unproven.Methods: This review synthesizes current evidence on the mechanisms by which oral microbiota influence various forms of nephropathy, with a particular focus on the impact of periodontitis (PD) on the progression of renal disease.This review summarizes evidence on mechanisms by which oral microbiota and periodontitis may contribute to nephropathy and renal disease progression.Results: Oral dysbiosis may affect CKD through systemic inflammation, endothelial dysfunction, and oxidative stress. It may also promote abnormal IgA1 glycosylation in IgA nephropathy and contribute to immune dysregulation and persistent inflammation in glomerulonephritis.Conclusion: Periodontitis-associated oral dysbiosis may contribute to renal disease pathogenesis and progression. Clarifying these mechanisms could support preventive and therapeutic strategies for patients with nephropathy.","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"18 1","pages":"2687208"},"PeriodicalIF":6.7,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13292305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148330478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Salivary estrone and estradiol are associated with oral microbiome profiles in aging women. 唾液雌酮和雌二醇与老年妇女口腔微生物群有关。

IF 6.7 2区医学

Journal of Oral Microbiology Pub Date : 2026-06-21 eCollection Date: 2026-01-01 DOI: 10.1080/20002297.2026.2690784

Maria J Rus, Maria R Nieto, Hyo-Jung Oh, Hosuon Yoo, Victoria Areal-Quecuty, Flavio Duarte Faria, Debora Lendines-Cordero, Aurea Simon-Soro

{"title":"Salivary estrone and estradiol are associated with oral microbiome profiles in aging women.","authors":"Maria J Rus, Maria R Nieto, Hyo-Jung Oh, Hosuon Yoo, Victoria Areal-Quecuty, Flavio Duarte Faria, Debora Lendines-Cordero, Aurea Simon-Soro","doi":"10.1080/20002297.2026.2690784","DOIUrl":"10.1080/20002297.2026.2690784","url":null,"abstract":"Objectives: To explore whether salivary estrogens (estrone and estradiol) are associated with oral microbiome composition in aging women, and to assess the oral cavity as a potential sentinel of systemic hormonal changes during midlife.Materials and methods: Cross-sectional study including 30 women aged 40-65 years. Saliva and microbial specimens were collected from four oral ecological niches (buccal mucosa, tongue dorsum, supragingival plaque, subgingival plaque). Microbiome composition and diversity were assessed by 16S rRNA gene sequencing, ecological indices, and co-occurrence network analysis. Salivary estrone and estradiol were quantified, and associations with oral health and microbial profiles were evaluated.Results: Estrone levels declined significantly with age and were associated with hyposalivation and lower oral health scores. Estrone was linked to increased microbial diversity on the tongue dorsum and enrichment of taxa such as Porphyromonas. In contrast, estradiol was positively associated with commensal genera (Streptococcus, Lactobacillus) and negatively with periodontal-associated taxa (Fusobacterium, Prevotella). Co-occurrence networks revealed niche-specific microbial shifts associated with estrogen levels.Conclusions: Salivary estrogens, particularly estrone, shape oral microbial communities in aging women. The oral cavity may act as a window into systemic hormonal changes, supporting its role as a non-invasive sentinel of women's health during midlife.","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"18 1","pages":"2690784"},"PeriodicalIF":6.7,"publicationDate":"2026-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13288545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148317515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shotgun metagenomic profiling reveals ecological and functional alterations of the oral microbiome in craniosynostosis. 散弹枪宏基因组分析揭示了颅缝闭闭患者口腔微生物组的生态和功能改变。

IF 6.7 2区医学

Journal of Oral Microbiology Pub Date : 2026-06-21 eCollection Date: 2026-01-01 DOI: 10.1080/20002297.2026.2687219

Annop Krasaesin, Yanisa Wongbanthit, Thitaya Chaiboonyarak, Ding-Han Wang, Hamid Alinejad-Rokny, Lakshman Samaranayake, Monnat Pongpanich, Thantrira Porntaveetus

{"title":"Shotgun metagenomic profiling reveals ecological and functional alterations of the oral microbiome in craniosynostosis.","authors":"Annop Krasaesin, Yanisa Wongbanthit, Thitaya Chaiboonyarak, Ding-Han Wang, Hamid Alinejad-Rokny, Lakshman Samaranayake, Monnat Pongpanich, Thantrira Porntaveetus","doi":"10.1080/20002297.2026.2687219","DOIUrl":"10.1080/20002297.2026.2687219","url":null,"abstract":"Objective: To elucidate the microbial drivers underlying of craniosynostosis (CS) , which involves premature suture fusion and secondary dentofacial malformations likely to increase dental disease burden.Methods: Shotgun metagenomic sequencing of supragingival plaque from 44 participants (22 CS patients and 22 matched healthy controls, aged 6-17 years) were performed, following by bioinformatics evaluation.Results: Beta diversity demonstrated significant differences between groups ( p < 0.01), whereas alpha diversity trended lower in the CS cohort. Taxonomic profiling revealed a dysbiotic signature in CS with high caries burden, defined by the enrichment of saccharolytic and anaerobic taxa (Scardovia, Actinomyces sp. oral taxon 448, Selenomonas sp. F0473, and Treponema lecithinolyticum)) alongside reduced health-associated genera like Haemophilus and Neisseria. Functional pathway analysis indicated metabolic remodeling, with upregulated fructan biosynthesis and starch degradation III pathways, consistent with caries-active biofilms.Conclusion: These findings demonstrate that orofacial anomalies in CS favor the assembly of an acidogenic, virulent plaque biofilm. The first shotgun metagenomic profile of the oral microbiome in CS establishes a foundation for future investigations. Furthermore, clinical management of CS should extend beyond structural correction to incorporate microbiological monitoring and preventive strategies, reducing the elevated risk of dental disease in this vulnerable population.","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"18 1","pages":"2687219"},"PeriodicalIF":6.7,"publicationDate":"2026-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13288908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148317475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluoride varnish application and the temporal evolution of supragingival microbiota in children with differential caries risk. 氟化物清漆应用与不同龋风险儿童龈上微生物群的时间演变。

IF 6.7 2区医学

Journal of Oral Microbiology Pub Date : 2026-06-18 eCollection Date: 2026-01-01 DOI: 10.1080/20002297.2026.2682471

Fanghong Liu, Haiyan Xue, Yiling Jiang, Shaoyong Chen, Yishan Zhang, Jinmei Yu, Yu Qin, Xiaohua Dong, Yangshan Ou, Rongmin Qiu

{"title":"Fluoride varnish application and the temporal evolution of supragingival microbiota in children with differential caries risk.","authors":"Fanghong Liu, Haiyan Xue, Yiling Jiang, Shaoyong Chen, Yishan Zhang, Jinmei Yu, Yu Qin, Xiaohua Dong, Yangshan Ou, Rongmin Qiu","doi":"10.1080/20002297.2026.2682471","DOIUrl":"10.1080/20002297.2026.2682471","url":null,"abstract":"Background: Fluoride varnish is used to prevent early childhood caries, but its longitudinal ecological impact on the supragingival microbiome beyond enamel remineralization remains poorly understood, especially long-term.Objective: To characterize 24‑month supragingival plaque microbiome evolution in young children under biannual fluoride varnish, stratified by caries risk, and fluoride's ecological effect on microbial structure, interactions, and metabolism.Design: A total of 48 children were categorized into low‑, moderate‑, and high‑caries‑risk groups using the modified caries-risk assessment tool for preschool children (PSC-MCAT). All received fluoride varnish every six months. Supragingival plaque collected at five timepoints over 24 months. 16S rRNA sequencing assessed diversity, key taxa, co-occurrence networks, and PICRUSt2 metabolic pathways.Results: Baseline alpha‑ and beta‑diversity differed significantly across risk groups (p<0.05). After sustained fluoride, intergroup differences diminished. High‑risk group retained caries‑associated genera (e.g. Leptotrichia, Prevotella, Veillonella) with suppressed abundance. Fluoride increased network complexity and negative correlations in moderate‑/high‑risk groups. Glycolysis, TCA cycle, and starch/sucrose metabolism were inhibited in the high‑risk group post‑intervention.Conclusions: Regular fluoride varnish reduces ecological disparities across risk groups, suppresses cariogenic taxa, and alters microbial interactions and carbohydrate metabolism, promoting homeostasis. High‑risk children may require more frequent interventions.","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"18 1","pages":"2682471"},"PeriodicalIF":6.7,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13288540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148317524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plant-based diet quality is associated with esophageal mucosa-associated microbiome profiles and disease severity in a high-risk Chinese population. 在中国高危人群中，植物性饮食质量与食管黏膜相关微生物群特征和疾病严重程度相关。

IF 6.7 2区医学

Journal of Oral Microbiology Pub Date : 2026-06-17 eCollection Date: 2026-01-01 DOI: 10.1080/20002297.2026.2682962

Yueying Zhang, Minjuan Li, Zhiyuan Fan, Feifan He, Xinqing Li, Shaoming Wang, Wenqiang Wei

{"title":"Plant-based diet quality is associated with esophageal mucosa-associated microbiome profiles and disease severity in a high-risk Chinese population.","authors":"Yueying Zhang, Minjuan Li, Zhiyuan Fan, Feifan He, Xinqing Li, Shaoming Wang, Wenqiang Wei","doi":"10.1080/20002297.2026.2682962","DOIUrl":"10.1080/20002297.2026.2682962","url":null,"abstract":"Background: Esophageal squamous cell carcinoma (ESCC) remains a major public health challenge in China. Diet is a modifiable risk factor, and the esophageal mucosa-associated microbiome may contribute to esophageal disease progression. However, population-based evidence integrating plant-based diet quality, esophageal microbiome profiles anddisease severity remains limited.Methods: We conducted a cross-sectional study including 236 participants undergoing upper gastrointestinal screening in Linzhou, a high-risk region for ESCC. Dietary intake was assessed using a food frequency questionnaire, and plant-based diet indices, including the overall plant-based diet index (PDI), healthful plant-based diet index (hPDI) and unhealthful plant-based diet index (uPDI), were calculated. Esophageal mucosal swabs were profiled by 16S rRNA gene sequencing. Associations among diet indices, microbiome features, and esophageal disease severity were evaluated using regression and risk stratification models.Results: Higher hPDI was inversely associated with esophageal disease severity, whereas higher uPDI were positively associated. Higher hPDI was associated with greater relative abundance of Rothia and Prevotellaceae-related taxa, whereas higher uPDI was associated with enrichment of Streptobacillus and Fretibacterium. Integrating dietary indices with microbiome features modestly but consistently improved risk stratification beyond epidemiological factors alone (e.g. AUC for the combined hPDI-microbiome model was 0.93, 95%CI: 0.89-0.98).Conclusions: Healthful and unhealthful plant-based diet patterns showed opposite associations with esophageal disease severity and distinct mucosa-associated microbiome profiles, supporting an exploratory diet-microbiome framework for ESCC risk stratification.","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"18 1","pages":"2682962"},"PeriodicalIF":6.7,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13276813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148295554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0