Journal of Oral Microbiology最新文献_第9页

The oral microbiome and oral and upper gastrointestinal diseases. 口腔微生物群与口腔和上消化道疾病。

IF 4.5 2区医学

Journal of Oral Microbiology Pub Date : 2024-06-03 eCollection Date: 2024-01-01 DOI: 10.1080/20002297.2024.2355823

Sifan Liu, Shidong Wang, Nan Zhang, Peng Li

{"title":"The oral microbiome and oral and upper gastrointestinal diseases.","authors":"Sifan Liu, Shidong Wang, Nan Zhang, Peng Li","doi":"10.1080/20002297.2024.2355823","DOIUrl":"10.1080/20002297.2024.2355823","url":null,"abstract":"Background: Microbiomes are essential components of the human body, and their populations are substantial. Under normal circumstances, microbiomes coexist harmoniously with the human body, but disturbances in this equilibrium can lead to various diseases. The oral microbiome is involved in the occurrence and development of many oral and gastrointestinal diseases. This review focuses on the relationship between oral microbiomes and oral and upper gastrointestinal diseases, and therapeutic strategies aiming to provide valuable insights for clinical prevention and treatment.Methods: To identify relevant studies, we conducted searches in PubMed, Google Scholar, and Web of Science using keywords such as \"oral microbiome,\" \"oral flora, \" \"gastrointestinal disease, \" without any date restrictions. Subsequently, the retrieved publications were subject to a narrative review.Results: In this review, we found that oral microbiomes are closely related to oral and gastrointestinal diseases such as periodontitis, dental caries, reflux esophagitis, gastritis, and upper gastrointestinal tumors (mainly the malignant ones). Oral samples like saliva and buccal mucosa are not only easy to collect, but also display superior sample stability compared to gastrointestinal tissues. Consequently, analysis of the oral microbiome could potentially serve as an efficient preliminary screening method for high-risk groups before undergoing endoscopic examination. Besides, treatments based on the oral microbiomes could aid early diagnosis and treatment of these diseases.Conclusions: Oral microbiomes are essential to oral and gastrointestinal diseases. Therapies centered on the oral microbiomes could facilitate the early detection and management of these conditions.","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"16 1","pages":"2355823"},"PeriodicalIF":4.5,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11149586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141248075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Salivary microbiome is associated with the response to chemoradiotherapy in initially inoperable patients with esophageal squamous cell carcinoma. 唾液微生物组与最初无法手术的食管鳞状细胞癌患者对化疗放疗的反应有关。

IF 4.5 2区医学

Journal of Oral Microbiology Pub Date : 2024-05-27 eCollection Date: 2024-01-01 DOI: 10.1080/20002297.2024.2359887

Yuan He, Xiao-Yang Li, An-Qi Hu, Dong Qian

{"title":"Salivary microbiome is associated with the response to chemoradiotherapy in initially inoperable patients with esophageal squamous cell carcinoma.","authors":"Yuan He, Xiao-Yang Li, An-Qi Hu, Dong Qian","doi":"10.1080/20002297.2024.2359887","DOIUrl":"10.1080/20002297.2024.2359887","url":null,"abstract":"Background: The salivary microbiome may interact with chemoradiotherapy through dynamic changes in microbial composition and systemic immunity. We aimed to explore the association between the salivary microbiome and response to chemoradiotherapy in initially inoperable patients with local advanced esophageal squamous cell carcinoma (LAESCC).Methods: Salivary and peripheral blood samples were collected before and after chemoradiotherapy. The microbiome and metabolic pathways were analyzed by 16S ribosomal RNA sequencing and liquid chromatography tandem mass spectrometry/Mass spectrometry analyses.Results: The salivary microbiome exhibited characteristic variations between patients and healthy controls. A significant correlation was found between Prevotella_salivae, Saccharibacteria_TM7_G3_bacterium_HMT_351, and Veillonellaceae_G1_bacterium_HMT_129 and pathological complete response (pCR) in initially inoperable patients who underwent surgery. The PICRUSt suggested that immune diseases and cell motility were different in tumor compared to normal groups. KEGG enrichment analysis showed enriched lipid metabolism, signal transduction, and membrane transport in the tumor group. CD3+CD8 T cells, IL6, IL10, and IFNγ exhibited an increasing trend during the treatment process of chemoradiotherapy.Conclusions: Our study demonstrated that variations in specific saliva taxa associated with host immunomodulatory cells and cytokines could be promising for early efficacy prediction of chemoradiotherapy in initially inoperable patients with LAESCC.","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"16 1","pages":"2359887"},"PeriodicalIF":4.5,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11134033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141175643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 更正。

IF 4.5 2区医学

Journal of Oral Microbiology Pub Date : 2024-05-15 eCollection Date: 2024-01-01 DOI: 10.1080/20002297.2024.2350309

引用次数: 0

Impact of HbA1c control and type 2 diabetes mellitus exposure on the oral microbiome profile in the elderly population. HbA1c 控制和 2 型糖尿病暴露对老年人口腔微生物组特征的影响。

IF 4.5 2区医学

Journal of Oral Microbiology Pub Date : 2024-05-15 eCollection Date: 2024-01-01 DOI: 10.1080/20002297.2024.2345942

Xin Zeng, Shuqi Huang, Xin Ye, Siping Song, Jing He, Liwei Hu, Sicheng Deng, Fan Liu

{"title":"Impact of HbA1c control and type 2 diabetes mellitus exposure on the oral microbiome profile in the elderly population.","authors":"Xin Zeng, Shuqi Huang, Xin Ye, Siping Song, Jing He, Liwei Hu, Sicheng Deng, Fan Liu","doi":"10.1080/20002297.2024.2345942","DOIUrl":"https://doi.org/10.1080/20002297.2024.2345942","url":null,"abstract":"Objective: To investigate the associations of the oral microbiome status with diabetes characteristics in elderly patients with type 2 diabetes mellitus.Methods: A questionnaire was used to assess age, sex, smoking status, drinking status, flossing frequency, T2DM duration and complications, and a blood test was used to determine the glycated haemoglobin (HbA1c) level. Sequencing of the V3-V4 region of the 16S rRNA gene from saliva samples was used to analyze the oral microbiome.Results: Differential analysis revealed that Streptococcus and Weissella were significantly enriched in the late-stage group, and Capnocytophaga was significantly enriched in the early-stage group. Correlation analysis revealed that diabetes duration was positively correlated with the abundance of Streptococcus (r= 0.369, p= 0.007) and negatively correlated with the abundance of Cardiobacterium (r= -0.337, p= 0.014), and the level of HbA1c was not significantly correlated with the oral microbiome. Network analysis suggested that the poor control group had a more complex microbial network than the control group, a pattern that was similar for diabetes duration. In addition, Streptococcus has a low correlation with other microorganisms.Conclusion: In elderly individuals, Streptococcus emerges as a potential biomarker linked to diabetes, exhibiting elevated abundance in diabetic patients influenced by disease exposure and limited bacterial interactions.","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"16 1","pages":"2345942"},"PeriodicalIF":4.5,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11097700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140958132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinct oral DNA viral signatures in rheumatoid arthritis: a Pilot study. 类风湿性关节炎中不同的口腔 DNA 病毒特征：一项试点研究。

IF 4.5 2区医学

Journal of Oral Microbiology Pub Date : 2024-05-01 eCollection Date: 2024-01-01 DOI: 10.1080/20002297.2024.2348260

Mahin Ghorbani, Nooshin Khoshdoozmasouleh

{"title":"Distinct oral DNA viral signatures in rheumatoid arthritis: a Pilot study.","authors":"Mahin Ghorbani, Nooshin Khoshdoozmasouleh","doi":"10.1080/20002297.2024.2348260","DOIUrl":"https://doi.org/10.1080/20002297.2024.2348260","url":null,"abstract":"Background: Despite evidence linking viruses and oral microbiome to rheumatoid arthritis (RA), limited whole genome sequencing research has been conducted on the oral virome (a viral component of the microbiome) of untreated RA patients. This pilot research seeks to address this knowledge gap by comparing the oral virome of untreated rheumatoid arthritis patients (RAs) and healthy individuals (HCs).Method: Whole genome DNA sequence of saliva samples from 45 participants including 21 RAs and 24 age and gender matched HCs was obtained from the BioProject: PRJEB6997. Metaphlan3 pipeline and LEfSe analysis were used for the viral signature detection. Wilcoxon pairwise test and ROC analysis were used to validate and predict signatures.Results: RA exhibits higher alpha diversity compared to HCs. Callitrichine gammaherpesvirus 3, Human gammaherpesvirus 4 (EBV), Murid betaherpesvirus 8, and Suid alphaherpesvirus 1 were enriched in RAs, while Aotine betaherpesvirus 1 from the Cytomegalovirus genus was enriched in HCs. In addition, Saccharomyces cerevisiae killer virus M1 (ScV-M1) was found to be enriched in RAs, whereas bacteriophage Hk97virus (Siphoviridae) and Cd119virus (Myoviridae) were enriched in HCs.Conclusion: This study identifies significant DNA oral viral signatures at species level as potential biomarkers for the early detection and diagnosis of rheumatoid arthritis.","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"16 1","pages":"2348260"},"PeriodicalIF":4.5,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11064737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140851361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review and new perspective on oral bacteriophages: manifestations in the ecology of oral diseases. 口腔噬菌体回顾与新视角：口腔疾病生态学中的表现形式。

IF 4.5 2区医学

Journal of Oral Microbiology Pub Date : 2024-05-01 eCollection Date: 2024-01-01 DOI: 10.1080/20002297.2024.2344272

Xinyu Guo, Xiaowan Wang, Jia Shi, Jiayi Ren, Jumei Zeng, Jinquan Li, Yuqing Li

{"title":"A review and new perspective on oral bacteriophages: manifestations in the ecology of oral diseases.","authors":"Xinyu Guo, Xiaowan Wang, Jia Shi, Jiayi Ren, Jumei Zeng, Jinquan Li, Yuqing Li","doi":"10.1080/20002297.2024.2344272","DOIUrl":"https://doi.org/10.1080/20002297.2024.2344272","url":null,"abstract":"Objective: To explore the manifestations of bacteriophages in different oral disease ecologies, including periodontal diseases, dental caries, endodontic infections, and oral cancer, as well as to propel phage therapy for safer and more effective clinical application in the field of dentistry.Methods: In this literature review, we outlined interactions between bacteriophages, bacteria and even oral cells in the oral ecosystem, especially in disease states. We also analyzed the current status and future prospects of phage therapy in the perspective of different oral diseases.Results: Various oral bacteriophages targeting at periodontal pathogens as Porphyromonas gingivalis, Fusobacterium nucleatum, Treponema denticola and Aggregatibacter actinomycetemcomitans, cariogenic pathogen Streptococcus mutans, endodontic pathogen Enterococcus faecalis were predicted or isolated, providing promising options for phage therapy. In the realm of oral cancer, aside from displaying tumor antigens or participating in tumor-targeted therapies, phage-like particle vaccines demonstrated the potential to prevent oral infections caused by human papillomaviruses (HPVs) associated with head-and-neck cancers.Conclusion: Due to their intricate interactions with bacteria and oral cells, bacteriophages are closely linked to the progression and regression of diverse oral diseases. And there is an urgent need for research to explore additional possibilities of bacteriophages in the management of oral diseases.","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"16 1","pages":"2344272"},"PeriodicalIF":4.5,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11064738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140856172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of tongue coating microbiome from patients with colorectal cancer. 大肠癌患者舌苔微生物组的特征。

IF 4.5 2区医学

Journal of Oral Microbiology Pub Date : 2024-04-26 eCollection Date: 2024-01-01 DOI: 10.1080/20002297.2024.2344278

Qubo Chen, Xiaoting Huang, Haiyan Zhang, Xuanting Jiang, Xuan Zeng, Wanhua Li, Hairong Su, Ying Chen, Fengye Lin, Man Li, Xiangyu Gu, Huihui Jin, Ruohan Wang, Dechang Diao, Wei Wang, Jin Li, Sufen Wei, Weizheng Zhang, Wofeng Liu, Zhiping Huang, Yusheng Deng, Wen Luo, Zuofeng Liu, Beiping Zhang

{"title":"Characterization of tongue coating microbiome from patients with colorectal cancer.","authors":"Qubo Chen, Xiaoting Huang, Haiyan Zhang, Xuanting Jiang, Xuan Zeng, Wanhua Li, Hairong Su, Ying Chen, Fengye Lin, Man Li, Xiangyu Gu, Huihui Jin, Ruohan Wang, Dechang Diao, Wei Wang, Jin Li, Sufen Wei, Weizheng Zhang, Wofeng Liu, Zhiping Huang, Yusheng Deng, Wen Luo, Zuofeng Liu, Beiping Zhang","doi":"10.1080/20002297.2024.2344278","DOIUrl":"https://doi.org/10.1080/20002297.2024.2344278","url":null,"abstract":"Background: Tongue coating microbiota has aroused particular interest in profiling oral and digestive system cancers. However, little is known on the relationship between tongue coating microbiome and colorectal cancer (CRC).Methods: Metagenomic shotgun sequencing was performed on tongue coating samples collected from 30 patients with CRC, 30 patients with colorectal polyps (CP), and 30 healthy controls (HC). We further validated the potential of the tongue coating microbiota to predict the CRC by a random forest model.Results: We found a greater species diversity in CRC samples, and the nucleoside and nucleotide biosynthesis pathway was more apparent in the CRC group. Importantly, various species across participants jointly shaped three distinguishable fur types.The tongue coating microbiome profiling data gave an area under the receiver operating characteristic curve (AUC) of 0.915 in discriminating CRC patients from control participants; species such as Atopobium rimae, Streptococcus sanguinis, and Prevotella oris aided differentiation of CRC patients from healthy participants.Conclusion: These results elucidate the use of tongue coating microbiome in CRC patients firstly, and the fur-types observed contribute to a better understanding of the microbial community in human. Furthermore, the tongue coating microbiota-based biomarkers provide a valuable reference for CRC prediction and diagnosis.","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"16 1","pages":"2344278"},"PeriodicalIF":4.5,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11057396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140863347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Viral DNA in submandibular gland tissue with an inflammatory disorder. 患有炎症的颌下腺组织中的病毒 DNA。

IF 4.5 2区医学

Journal of Oral Microbiology Pub Date : 2024-04-26 eCollection Date: 2024-01-01 DOI: 10.1080/20002297.2024.2345941

Noora Keski-Säntti, Elin Waltimo, Antti Mäkitie, Jaana Hagström, Maria Söderlund-Venermo, Timo Atula, Caj Haglund, Saku T Sinkkonen, Maria Jauhiainen

{"title":"Viral DNA in submandibular gland tissue with an inflammatory disorder.","authors":"Noora Keski-Säntti, Elin Waltimo, Antti Mäkitie, Jaana Hagström, Maria Söderlund-Venermo, Timo Atula, Caj Haglund, Saku T Sinkkonen, Maria Jauhiainen","doi":"10.1080/20002297.2024.2345941","DOIUrl":"10.1080/20002297.2024.2345941","url":null,"abstract":"Background: The etiology behind different types of chronic sialadenitis (CS), some of which exhibit IgG4 overexpression, is unknown. Further, IgG4-related disease (IgG4-RD) commonly affects the submandibular gland, but its relationship to IgG4-overexpressing CS, and the antigen triggering IgG4 overexpression, remain unknown.Materials and methods: By qPCR, we assessed the presence of 21 DNA-viruses causing IgG4 overexpression in submandibular gland tissue from patients with IgG4-positive and IgG4-negative CS. Healthy submandibular glands and glands with sialolithiasis without CS were used as controls. We examined the distribution of HHV-7, HHV-6B and B19V DNA, within virus PCR-positive tissues with RNAscope in-situ hybridization (RISH).Results: We detected DNA from seven viruses in 48/61 samples. EBV DNA was more prevalent within the IgG4-positive samples (6/29; 21%) than the IgG4-negative ones (1/19; 5.3%). B19V DNA was more prevalent within the IgG4-negative samples (5/19; 26%) than the IgG4-positive ones (4/29; 14%). The differences in virus prevalence were not statistically significant. Of the IgG4-RD samples (n = 3) one contained HHV-6B DNA. RISH only showed signals of HHV-7.Conclusions: None of the studied viruses are implicated as triggering IgG4-overexpression in CS. Although our results do not confirm viral etiology in the examined conditions, they provide valuable information on the prevalence of viruses in both diseased and healthy submandibular gland tissue.","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"16 1","pages":"2345941"},"PeriodicalIF":4.5,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11073405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140859158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the performance of MiSeq and NovaSeq in oral microbiome study MiSeq 和 NovaSeq 在口腔微生物组研究中的性能比较

IF 4.5 2区医学

Journal of Oral Microbiology Pub Date : 2024-04-18 DOI: 10.1080/20002297.2024.2344293

Hyejung Han, Hyo-Jung Lee, Keun-Suh Kim, Jin Chung, Hee Sam Na

引用次数: 0

Characterization of the unique oral microbiome of children harboring Helicobacter pylori in the oral cavity 确定口腔中幽门螺旋杆菌携带者的独特口腔微生物组的特征

IF 4.5 2区医学

Journal of Oral Microbiology Pub Date : 2024-04-11 DOI: 10.1080/20002297.2024.2339158

Yuko Ogaya, Tamami Kadota, Masakazu Hamada, Ryota Nomura, Kazuhiko Nakano

引用次数: 0