Journal of Oral Microbiology最新文献

{"title":"Anticandidal effect of multiple sessions of erythrosine and potassium iodide-mediated photodynamic therapy.","authors":"Pran Pitaksanurat, Nirawat Mayeah, Pattranun Saithong, Surachai Pimha, Prapatsara Sirikarn, Teerasak Damrongrungruang","doi":"10.1080/20002297.2024.2369357","DOIUrl":"10.1080/20002297.2024.2369357","url":null,"abstract":"<p><strong>Background: </strong>Erythrosine+potassium iodide-mediated photodynamic therapy has shown an anticandidal effect. Single session, however, has inadequate fungal inhibition.</p><p><strong>Objectives: </strong>We aimed to examine the effects of multiple aPDT sessions on <i>Candida albicans</i> inhibition and singlet oxygen formation.</p><p><strong>Methods: </strong>220 μM erythrosine +/-100 mM potassium iodide was applied to <i>C. albicans</i> biofilms for 1 min prior to irradiation at 530±10 nm using a 250 mW/cm² light-emitting diode. Negative and positive controls were phosphate buffer saline and nystatin, respectively. Single, double and triple irradiation sessions with a 5 min resting time between sessions were performed. Post-treatment candidal counts were done at 0, 1 6 and 24 hr while log₁₀ colony forming unit/ml was calculated and compared using a Kruskal-Wallis with Dunn's post hoc test at a <i>p</i><0.05 - Singlet oxygen amount was compared using one-way ANOVA with a post hoc test at a <i>p</i>< 0.05.</p><p><strong>Results: </strong>Two and three irradiation sessions to erythrosine+potassium iodide could inhibit <i>Candida albicans</i> at 7.92 log₁₀CFU/ml (<i>p</i> < 0.001) . Singlet oxygen from a combination groups was significantly higher than for erythrosine (positive control). Moreover, the correlation coefficient (r) between singlet oxygen production and decreased <i>Candida albicans</i> counts was equal to 1.</p><p><strong>Conclusion: </strong>Multiple sessions PDT of 220 μM erythrosine+100 mM potassium iodide effectively inhibited a <i>Candida</i> biofilm.</p>","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"16 1","pages":"2369357"},"PeriodicalIF":3.7,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11188948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141432091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supragingival microbiome variations and the influence of <i>Candida albicans</i> in adolescent orthodontic patients with gingivitis.","authors":"Hao Yang, Yansong Ma, Hongyu Gao, Xianju Xie, Hongmei Wang, Xiaowei Li, Yuxing Bai","doi":"10.1080/20002297.2024.2366056","DOIUrl":"10.1080/20002297.2024.2366056","url":null,"abstract":"<p><strong>Introduction: </strong>Gingivitis is a prevalent complication in adolescents undergoing fixed orthodontic treatments. However, changes in the supragingival microbiome associated with gingivitis and the impact of <i>Candida albicans</i> remain elusive. Therefore, we investigated supragingival microbiome discrepancy and <i>C. albicans</i> colonization in adolescent orthodontic patients with gingivitis.</p><p><strong>Methods: </strong>Dental plaques were collected from 30 gingivitis patients and 24 healthy adolescents, all undergoing fixed orthodontic treatment. The supragingival microbiome composition was analyzed using 16S rRNA sequencing. <i>C. albicans</i> colonization was determined using fungal culture and real-time quantitative polymerase chain reaction.</p><p><strong>Results: </strong>Our analysis revealed significantly heightened microbial diversity in the Gingivitis group. Notably, patients with gingivitis exhibited an enrichment of periodontal pathogens, such as <i>Saccharibacteria (TM7) [G-1]</i>, <i>Selenomonas</i>, <i>Actinomyces dentalis</i>, and <i>Selenomonas sputigena</i>. Additionally, 33% of the gingivitis patients tested positive for <i>C. albicans</i>, exhibiting significantly elevated levels of absolute abundance, while all healthy patients tested negative. Significant differences in microbial composition were also noted between <i>C. albicans</i>-positive and -negative samples in the Gingivitis group.</p><p><strong>Conclusion: </strong>Significant disparities were observed in the supragingival microbiome of adolescent orthodontic patients with and without gingivitis. The presence of <i>C. albicans</i> in the supragingival plaque may alter the microbiome composition and potentially contribute to gingivitis pathogenesis.</p>","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"16 1","pages":"2366056"},"PeriodicalIF":4.5,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11177713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141331204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of honokiol combined with resveratrol on bacteria responsible for oral malodor and their biofilm.","authors":"Shiqian Zheng, Rongrong Deng, Gengjiu Huang, Zhiwen Ou, Zhibin Shen","doi":"10.1080/20002297.2024.2361402","DOIUrl":"10.1080/20002297.2024.2361402","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the effect of honokiol combined with resveratrol on bacteria responsible for oral malodor and their biofilm.</p><p><strong>Method: </strong>This study investigated drug's MIC, FICI and dynamic bactericidal susceptibility activities against Pg and Fn. The effects of drugs on biofilm metabolic activity, biofilm total amount, and biofilm microstructure were determined by CCK-8 experiment, semi-quantitative adhesion experiment and SEM, respectively. The effects of drugs on biofilm genes, extracellular polysaccharides, proteins and DNA content were determined by qRT-PCR, phenol-sulfuric acid method, BCA method and Nano Drop one C, respectively.</p><p><strong>Results: </strong>The combination had synergistic antibacterial effect on Pg and Fn. 1/2×MIC and 1×MIC combination inhibit the whole process of Pg and Fn growth. The results showed that the combination effectively reduce biofilm metabolic activity and total amount, and destroy biofilm microstructure. The results showed that the combination downregulate the gene expression both Pg and Fn, reduce extracellular polysaccharides and DNA of Pg, and reduce extracellular proteins and DNA of Fn.</p><p><strong>Conclusion: </strong>This study showed that the combination had a synergistic antibacterial effect on Pg and Fn, reduced the biofilm extracellular matrix, inhibited biofilm formation, and downregulated the expression of genes related to biofilm formation.</p>","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"16 1","pages":"2361402"},"PeriodicalIF":4.5,"publicationDate":"2024-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11164056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141300864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silica nanoparticles containing nano-silver and chlorhexidine to suppress <i>Porphyromonas gingivalis</i> biofilm and modulate multispecies biofilms toward healthy tendency.","authors":"Lixin Fang, Yishuang Zhang, Long Cheng, Hao Zheng, Yiyi Wang, Lu Qin, Yingchun Cai, Lei Cheng, Wen Zhou, Fei Liu, Suping Wang","doi":"10.1080/20002297.2024.2361403","DOIUrl":"10.1080/20002297.2024.2361403","url":null,"abstract":"<p><strong>Objectives: </strong>This research first investigated the effect of mesoporous silica nanoparticles (nMS) carrying chlorhexidine and silver (nMS-nAg-Chx) on periodontitis-related biofilms. This study aimed to investigate (1) the antibacterial activity on <i>Porphyromonas gingivalis</i> (<i>P. gingivalis</i>) biofilm; (2) the suppressing effect on virulence of <i>P. gingivalis</i> biofilm; (3) the regulating effect on periodontitis-related multispecies biofilm.</p><p><strong>Methods: </strong>Silver nanoparticles (nAg) and chlorhexidine (Chx) were co-loaded into nMS to form nMS-nAg-Chx. Inhibitory zone test and minimum inhibitory concentration (MIC) against <i>P. gingivalis</i> were tested. Growth curves, crystal violet (CV) staining, live/dead staining and scanning electron microscopy (SEM) observation were performed. Biofilm virulence was assessed. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay and Quantitative Real Time-PCR (qPCR) were performed to validate the activity and composition changes of multispecies biofilm (<i>P. gingivalis</i>, <i>Streptococcus gordonii</i> and <i>Streptococcus sanguinis</i>).</p><p><strong>Results: </strong>nMS-nAg-Chx inhibited <i>P. gingivalis</i> biofilm dose-dependently (<i>p</i><0.05), with MIC of 18.75 µg/mL. There were fewer live bacteria, less biomass and less virulence in nMS-nAg-Chx groups (<i>p</i><0.05). nMS-nAg-Chx inhibited and modified periodontitis-related biofilms. The proportion of pathogenic bacteria decreased from 16.08 to 1.07% and that of helpful bacteria increased from 82.65 to 94.31% in 25 μg/mL nMS-nAg-Chx group for 72 h.</p><p><strong>Conclusions: </strong>nMS-nAg-Chx inhibited <i>P. gingivalis</i> growth, decreased biofilm virulence and modulated periodontitis-related multispecies biofilms toward healthy tendency. pH-sensitive nMS-nAg-Chx inhibit the pathogens and regulate oral microecology, showing great potential in periodontitis adjunctive therapy.</p>","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"16 1","pages":"2361403"},"PeriodicalIF":4.5,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11155433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141283897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive analysis of the oral microbiota and metabolome change in patients of burning mouth syndrome with psychiatric symptoms.","authors":"Shihong Luo, Fangzhi Lou, Li Yan, Yunmei Dong, Yingying Zhang, Yang Liu, Ping Ji, Xin Jin","doi":"10.1080/20002297.2024.2362313","DOIUrl":"10.1080/20002297.2024.2362313","url":null,"abstract":"<p><strong>Background: </strong>Burning mouth syndrome (BMS) is a chronic idiopathic facial pain with intraoral burning or dysesthesia. BMS patients regularly suffer from anxiety/depression, and the association of psychiatric symptoms with BMS has received considerable attention in recent years. The aims of this study were to investigate the potential interplay between psychiatric symptoms and BMS.</p><p><strong>Methods: </strong>Using 16S rRNA sequencing and liquid chromatography-mass spectrometry (LC/MS) to evaluate the oral microbiota and saliva metabolism of 40 BMS patients [including 29 BMS patients with depression or anxiety symptoms (DBMS)] and 40 age matched healthy control (HC).</p><p><strong>Results: </strong>The oral microbiota composition in BMS exhibited no significant differences from HC, although DBMS manifested decreased α-diversity relative to HC. Noteworthy was the discernible elevation in the abundance of proinflammatory microorganisms within the oral microbiome of individuals with DBMS. Parallel findings in LC/MS analyses revealed discernible disparities in metabolites between DBMS and HC groups. Principal differential metabolites were notably enriched in amino acid metabolism and lipid metabolism, exhibiting associations with infectious and immunological diseases. Furthermore, the integrated analysis underscores a definitive association between the oral microbiome and metabolism in DBMS.</p><p><strong>Conclusions: </strong>This study suggests possible future modalities for better understanding the pathogenesis and personalized treatment plans of BMS.</p>","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"16 1","pages":"2362313"},"PeriodicalIF":4.5,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11149574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141248071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The oral microbiome and oral and upper gastrointestinal diseases.","authors":"Sifan Liu, Shidong Wang, Nan Zhang, Peng Li","doi":"10.1080/20002297.2024.2355823","DOIUrl":"10.1080/20002297.2024.2355823","url":null,"abstract":"<p><strong>Background: </strong>Microbiomes are essential components of the human body, and their populations are substantial. Under normal circumstances, microbiomes coexist harmoniously with the human body, but disturbances in this equilibrium can lead to various diseases. The oral microbiome is involved in the occurrence and development of many oral and gastrointestinal diseases. This review focuses on the relationship between oral microbiomes and oral and upper gastrointestinal diseases, and therapeutic strategies aiming to provide valuable insights for clinical prevention and treatment.</p><p><strong>Methods: </strong>To identify relevant studies, we conducted searches in PubMed, Google Scholar, and Web of Science using keywords such as \"oral microbiome,\" \"oral flora, \" \"gastrointestinal disease, \" without any date restrictions. Subsequently, the retrieved publications were subject to a narrative review.</p><p><strong>Results: </strong>In this review, we found that oral microbiomes are closely related to oral and gastrointestinal diseases such as periodontitis, dental caries, reflux esophagitis, gastritis, and upper gastrointestinal tumors (mainly the malignant ones). Oral samples like saliva and buccal mucosa are not only easy to collect, but also display superior sample stability compared to gastrointestinal tissues. Consequently, analysis of the oral microbiome could potentially serve as an efficient preliminary screening method for high-risk groups before undergoing endoscopic examination. Besides, treatments based on the oral microbiomes could aid early diagnosis and treatment of these diseases.</p><p><strong>Conclusions: </strong>Oral microbiomes are essential to oral and gastrointestinal diseases. Therapies centered on the oral microbiomes could facilitate the early detection and management of these conditions.</p>","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"16 1","pages":"2355823"},"PeriodicalIF":4.5,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11149586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141248075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salivary microbiome is associated with the response to chemoradiotherapy in initially inoperable patients with esophageal squamous cell carcinoma.","authors":"Yuan He, Xiao-Yang Li, An-Qi Hu, Dong Qian","doi":"10.1080/20002297.2024.2359887","DOIUrl":"10.1080/20002297.2024.2359887","url":null,"abstract":"<p><strong>Background: </strong>The salivary microbiome may interact with chemoradiotherapy through dynamic changes in microbial composition and systemic immunity. We aimed to explore the association between the salivary microbiome and response to chemoradiotherapy in initially inoperable patients with local advanced esophageal squamous cell carcinoma (LAESCC).</p><p><strong>Methods: </strong>Salivary and peripheral blood samples were collected before and after chemoradiotherapy. The microbiome and metabolic pathways were analyzed by 16S ribosomal RNA sequencing and liquid chromatography tandem mass spectrometry/Mass spectrometry analyses.</p><p><strong>Results: </strong>The salivary microbiome exhibited characteristic variations between patients and healthy controls. A significant correlation was found between Prevotella_salivae, Saccharibacteria_TM7_G3_bacterium_HMT_351, and Veillonellaceae_G1_bacterium_HMT_129 and pathological complete response (pCR) in initially inoperable patients who underwent surgery. The PICRUSt suggested that immune diseases and cell motility were different in tumor compared to normal groups. KEGG enrichment analysis showed enriched lipid metabolism, signal transduction, and membrane transport in the tumor group. CD3+CD8 T cells, IL6, IL10, and IFNγ exhibited an increasing trend during the treatment process of chemoradiotherapy.</p><p><strong>Conclusions: </strong>Our study demonstrated that variations in specific saliva taxa associated with host immunomodulatory cells and cytokines could be promising for early efficacy prediction of chemoradiotherapy in initially inoperable patients with LAESCC.</p>","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"16 1","pages":"2359887"},"PeriodicalIF":4.5,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11134033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141175643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction.","authors":"","doi":"10.1080/20002297.2024.2350309","DOIUrl":"https://doi.org/10.1080/20002297.2024.2350309","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1080/20002297.2024.2322228.].</p>","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"16 1","pages":"2350309"},"PeriodicalIF":4.5,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11097697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140958131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of HbA1c control and type 2 diabetes mellitus exposure on the oral microbiome profile in the elderly population.","authors":"Xin Zeng, Shuqi Huang, Xin Ye, Siping Song, Jing He, Liwei Hu, Sicheng Deng, Fan Liu","doi":"10.1080/20002297.2024.2345942","DOIUrl":"https://doi.org/10.1080/20002297.2024.2345942","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the associations of the oral microbiome status with diabetes characteristics in elderly patients with type 2 diabetes mellitus.</p><p><strong>Methods: </strong>A questionnaire was used to assess age, sex, smoking status, drinking status, flossing frequency, T2DM duration and complications, and a blood test was used to determine the glycated haemoglobin (HbA1c) level. Sequencing of the V3-V4 region of the 16S rRNA gene from saliva samples was used to analyze the oral microbiome.</p><p><strong>Results: </strong>Differential analysis revealed that <i>Streptococcus</i> and <i>Weissella</i> were significantly enriched in the late-stage group, and <i>Capnocytophaga</i> was significantly enriched in the early-stage group. Correlation analysis revealed that diabetes duration was positively correlated with the abundance of <i>Streptococcus</i> (<i>r</i>= 0.369, <i>p</i>= 0.007) and negatively correlated with the abundance of <i>Cardiobacterium</i> (<i>r</i>= -0.337, <i>p</i>= 0.014), and the level of HbA1c was not significantly correlated with the oral microbiome. Network analysis suggested that the poor control group had a more complex microbial network than the control group, a pattern that was similar for diabetes duration. In addition, Streptococcus has a low correlation with other microorganisms.</p><p><strong>Conclusion: </strong>In elderly individuals, <i>Streptococcus</i> emerges as a potential biomarker linked to diabetes, exhibiting elevated abundance in diabetic patients influenced by disease exposure and limited bacterial interactions.</p>","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"16 1","pages":"2345942"},"PeriodicalIF":4.5,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11097700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140958132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct oral DNA viral signatures in rheumatoid arthritis: a Pilot study.","authors":"Mahin Ghorbani, Nooshin Khoshdoozmasouleh","doi":"10.1080/20002297.2024.2348260","DOIUrl":"https://doi.org/10.1080/20002297.2024.2348260","url":null,"abstract":"<p><strong>Background: </strong>Despite evidence linking viruses and oral microbiome to rheumatoid arthritis (RA), limited whole genome sequencing research has been conducted on the oral virome (a viral component of the microbiome) of untreated RA patients. This pilot research seeks to address this knowledge gap by comparing the oral virome of untreated rheumatoid arthritis patients (RAs) and healthy individuals (HCs).</p><p><strong>Method: </strong>Whole genome DNA sequence of saliva samples from 45 participants including 21 RAs and 24 age and gender matched HCs was obtained from the BioProject: PRJEB6997. Metaphlan3 pipeline and LEfSe analysis were used for the viral signature detection. Wilcoxon pairwise test and ROC analysis were used to validate and predict signatures.</p><p><strong>Results: </strong>RA exhibits higher alpha diversity compared to HCs. <i>Callitrichine gammaherpesvirus</i> 3, <i>Human gammaherpesvirus</i> 4 (EBV), <i>Murid betaherpesvirus</i> 8, and <i>Suid alphaherpesvirus</i> 1 were enriched in RAs, while Aotine betaherpesvirus 1 from the Cytomegalovirus genus was enriched in HCs. In addition, <i>Saccharomyces cerevisiae</i> killer virus M1 (ScV-M1) was found to be enriched in RAs, whereas bacteriophage Hk97virus (Siphoviridae) and Cd119virus (Myoviridae) were enriched in HCs.</p><p><strong>Conclusion: </strong>This study identifies significant DNA oral viral signatures at species level as potential biomarkers for the early detection and diagnosis of rheumatoid arthritis.</p>","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"16 1","pages":"2348260"},"PeriodicalIF":4.5,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11064737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140851361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}