Journal of Organic Chemistry Research最新文献_第9页

赭曲霉次生代谢产物研究 Study on the Secondary Metabolites of Aspergillus ochraceus 赭曲霉次生代谢产物研究 Study on the Secondary Metabolites of Aspergillus ochraceus

Journal of Organic Chemistry Research Pub Date : 2017-05-17 DOI: 10.12677/JOCR.2017.52012

邹琼宇, 吴海峰, 黄俊, 张莉, 陈迪钊, 李欣, 贺贵妃, 梁芬芳

{"title":"赭曲霉次生代谢产物研究 Study on the Secondary Metabolites of Aspergillus ochraceus","authors":"邹琼宇, 吴海峰, 黄俊, 张莉, 陈迪钊, 李欣, 贺贵妃, 梁芬芳","doi":"10.12677/JOCR.2017.52012","DOIUrl":"https://doi.org/10.12677/JOCR.2017.52012","url":null,"abstract":"目的：研究赭曲霉次生代谢产物。方法：利用多种色谱层析方法分离出次生代谢产物，通过ESI-MS/MS及NMR等波谱方法鉴定结构。结果：共分离鉴定出9种化合物，依次是赭曲霉毒素A(1)、赭曲霉毒素B(2)、neohydroxyaspergillic acid(3)、(3R)-5-hydroxymellein(4)、5,6-dihydropenicillic acid(5)、mesaconic acid(6)、p-hydroxybenzoic acid(7)、circumdatin G(8)、(22E,24R)-ergosta-7,22-diene-3β,5α,6β- triol(9)。结论：化合物3~9为首次从赭曲霉中分离得到的化合物。 Objective: To study the secondary metabolites from Aspergillus ochraceus. Methods: The constit-uents were isolated and purified by column chromatography and preparative TLC. Their structures were identified on the basis of comprehensive spectroscopic methods including ESI-MS and spectral data (1H, 13C-NMR). Results: Nine compounds were isolated and identified as ochratoxin A (1), ochratoxin B (2), neohydroxyaspergillic acid (3), (3R)-5-hydroxymellein (4), 5,6-dihydro- penicillic acid (5), mesaconic acid (6), p-hydroxybenzoic acid (7), circumdatin G (8), (22E,24R)- ergosta-7,22-diene-3β,5α,6β-triol (9). Conclusion: The compounds 3~9 were isolated from Asper-gillus ochraceus for the first time.","PeriodicalId":16596,"journal":{"name":"Journal of Organic Chemistry Research","volume":"10 1","pages":"94-99"},"PeriodicalIF":0.0,"publicationDate":"2017-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91123300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

介孔分子筛MCM-41固载磷钨酸催化苯并三氮唑与查尔酮的氮杂迈克加成反应研究 Aza-Michael Addition of Chalcone with Benzotriazole Catalyzed by MCM-41 Immobilized H3PW12O40 介孔分子筛MCM-41固载磷钨酸催化苯并三氮唑与查尔酮的氮杂迈克加成反应研究 Aza-Michael Addition of Chalcone with Benzotriazole Catalyzed by MCM-41 Immobilized H3PW12O40

Journal of Organic Chemistry Research Pub Date : 2017-05-17 DOI: 10.12677/JOCR.2017.52014

杨敬辉, 邢刘庄, 谢绍雷, 邢雪建, 侯亚东, 吴阳, 惠永海

引用次数: 0

2-巯基吡啶配合物的合成及量子化学计算 The Synthesis and Quantum Chemistry Calculation Based on 2-Thiol Pyridine Ligand 2-巯基吡啶配合物的合成及量子化学计算 The Synthesis and Quantum Chemistry Calculation Based on 2-Thiol Pyridine Ligand

Journal of Organic Chemistry Research Pub Date : 2017-05-17 DOI: 10.12677/JOCR.2017.52013

张连生, 万玮, 王萃娟, 熊霄阳, 赵鑫, 李泽贤, 陈志斌

{"title":"2-巯基吡啶配合物的合成及量子化学计算 The Synthesis and Quantum Chemistry Calculation Based on 2-Thiol Pyridine Ligand","authors":"张连生, 万玮, 王萃娟, 熊霄阳, 赵鑫, 李泽贤, 陈志斌","doi":"10.12677/JOCR.2017.52013","DOIUrl":"https://doi.org/10.12677/JOCR.2017.52013","url":null,"abstract":"基于配体2,2’-二硫二吡啶(简称Dpds)，采用分层扩散法，合成出六核簇状配位化合物Cu6(C5H4NS)6。采用密度泛函理论(DFT)下的B3LYP计算方法、NBO计算方法对该配合物进行量子化学计算，同时进行了前线轨道的研究。结果表明：每个配合物含六个铜离子、六个2-巯基吡啶阴离子，优化后的理论值与实验值比较吻合，误差在允许的范围内，理论计算的完成证明了实验数据的可靠性。 A six-core cluster compound Cu6(C5H4NS)6, was prepared by layered a N, N-Dimethylformamide solution of Cu(CH3COO)2•H2O on a dichloromethane solution of Dpds. The quantum chemistry cal-culation of the complex was carried out by using the B3LYP calculation method of density functional theory (DFT) and the NBO calculation method; at the same time, the research of frontier orbital is carried out. The results showed that the six-core copper (II) cluster complex contains six crystallographically unique Cu (II) ions and six 2-mercapto pyridine anions. It is found that the theoretical values are in agreement with the experimental ones, and the error is within the al-lowable range. And the completion of theoretical calculations proved the reliability of the experi-mental data.","PeriodicalId":16596,"journal":{"name":"Journal of Organic Chemistry Research","volume":"31 1","pages":"100-103"},"PeriodicalIF":0.0,"publicationDate":"2017-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90803035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

离子液体[C2O2BBTA][TFA]催化合成3,4-二氢嘧啶-2-(1H)-酮/硫酮离子液体[C2O2BBTA][TFA]催化合成3,4-二氢嘧啶-2-(1H)-酮/硫酮

Journal of Organic Chemistry Research Pub Date : 2017-05-17 DOI: 10.12677/JOCR.2017.52010

张增鹏, 刘晨江

引用次数: 0

荧光染料的简介及BODIPY类的发展历程 Introduction to Fluorescent Dyes and Development of BODIPY Classes 荧光染料的简介及BODIPY类的发展历程 Introduction to Fluorescent Dyes and Development of BODIPY Classes

Journal of Organic Chemistry Research Pub Date : 2017-03-08 DOI: 10.12677/JOCR.2017.51004

甄文, 王南翔, 祁欣

引用次数: 0

玛咖超临界提取物中的抗衰老活性物质 Anti-Aging Substances from Maca Supercritical Extract 玛咖超临界提取物中的抗衰老活性物质 Anti-Aging Substances from Maca Supercritical Extract

Journal of Organic Chemistry Research Pub Date : 2017-03-08 DOI: 10.12677/JOCR.2017.51007

程丽红, 林燕飞, 王艳惠, 朴金株, 金泰硕, 向兰, 吕翼炫, 戚建华

{"title":"玛咖超临界提取物中的抗衰老活性物质 Anti-Aging Substances from Maca Supercritical Extract","authors":"程丽红, 林燕飞, 王艳惠, 朴金株, 金泰硕, 向兰, 吕翼炫, 戚建华","doi":"10.12677/JOCR.2017.51007","DOIUrl":"https://doi.org/10.12677/JOCR.2017.51007","url":null,"abstract":"本研究采用酵母突变株K6001作为生物活性筛选系统，对韩国圃美多公司多个产品进行筛选，发现玛咖超临界提取粉末具有较好的抗衰老活性。因此对该原料中的抗衰老活性物质进行了研究并从中分离得到了两个活性化合物(1, 2)。这两个化合物都能显著延长酵母突变株的复制性寿命。通过波谱分析以及文献数据比对，推测活性化合物1的结构为n-benzyl-(9Z)-octadecenamide(1)，确定活性化合物2的结构为n-benzylmyristamide(2)。为了进一步确认化合物1的结构，合成了n-benzyl-(9Z)-octadecena- mide(1)，并且测定了其生物活性，结果表明合成得到的n-benzyl-(9Z)-octadecenamide的波谱数据及生物活性与天然来源的化合物1相同。 Extracts of several products of Pulmuone were screened for their anti-aging activity using the K6001 yeast strain bioassay system. Maca supercritical extract significantly exhibited anti-aging activity and two active compounds were isolated from the extract. The structures were elucidated by the spectroscopic data and comparison with those reported. One structure was proposed to be n-benzyl-(9Z)-octadecenamide (1), and another was identified as n-benzylmyristamide (2). Both compounds significantly extended the replicative lifespan of K6001 yeast strain. To confirm the structure of compound 1, n-benzyl-(9Z)-octadecenamide (1) was synthesized and biological activity was evaluated. The synthesized n-benzyl-(9Z)-octadecenamide (1) is identical to natural compound 1 from spectroscopic data and biological activity.","PeriodicalId":16596,"journal":{"name":"Journal of Organic Chemistry Research","volume":"9 1","pages":"45-50"},"PeriodicalIF":0.0,"publicationDate":"2017-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88463618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

2-(l-取代-1H-[1,2,3]-三氮唑-4-甲硫基)-5-甲基苯并噁唑化合物的合成及其抗肿瘤活性研究 Synthesis and Antitumor Activities of 2-(1-Substitute-1H-[1,2,3]-Triazol-4-Methylthio)-5-Methylbenzoxazole 2-(l-取代-1H-[1,2,3]-三氮唑-4-甲硫基)-5-甲基苯并噁唑化合物的合成及其抗肿瘤活性研究 Synthesis and Antitumor Activities of 2-(1-Substitute-1H-[1,2,3]-Triazol-4-Methylthio)-5-Methylbenzoxazole

Journal of Organic Chemistry Research Pub Date : 2017-03-08 DOI: 10.12677/JOCR.2017.51002

莫松, 王帅, 张刚, 杓学蓓, 李清寒, 杨学军

引用次数: 0

3,5-二氨基-4’-(α-萘基)萘基二苯甲酮的合成与表征 Synthesis and Characterization of (4-([1,1'-Binaphthalen]-4-yl)Phenyl)(3,5-Diaminophenyl)Methanone 3,5-二氨基-4’-(α-萘基)萘基二苯甲酮的合成与表征 Synthesis and Characterization of (4-([1,1'-Binaphthalen]-4-yl)Phenyl)(3,5-Diaminophenyl)Methanone

Journal of Organic Chemistry Research Pub Date : 2017-03-08 DOI: 10.12677/JOCR.2017.51005

朱雅亮, 段英香, 沈应中

引用次数: 0

1,1-双(6-甲氧基-4'-(萘-1-基)-[1,1'-联苯]-3-基)丙-2-炔-1-醇的合成与分析 Synthesis and Analysis of 1,1-Bis(6-Methoxy-4'-(Naphthalen-1-Yl)-[1,1'-Biphenyl]-3-Yl)Prop-2-Yn-1-Ol 1,1-双(6-甲氧基-4'-(萘-1-基)-[1,1'-联苯]-3-基)丙-2-炔-1-醇的合成与分析 Synthesis and Analysis of 1,1-Bis(6-Methoxy-4'-(Naphthalen-1-Yl)-[1,1'-Biphenyl]-3-Yl)Prop-2-Yn-1-Ol

Journal of Organic Chemistry Research Pub Date : 2017-03-08 DOI: 10.12677/JOCR.2017.51006

宋阳君, 赵倩, 朱雅亮, 王立君, 沈应中

引用次数: 0

酚参与的不对称C-O键形成研究进展 Progress on Asymmetric C-O Bond Formation with Phenols 酚参与的不对称C-O键形成研究进展 Progress on Asymmetric C-O Bond Formation with Phenols

Journal of Organic Chemistry Research Pub Date : 2017-03-08 DOI: 10.12677/JOCR.2017.51008

张剑, 魏一飞, 罗人仕

{"title":"酚参与的不对称C-O键形成研究进展 Progress on Asymmetric C-O Bond Formation with Phenols","authors":"张剑, 魏一飞, 罗人仕","doi":"10.12677/JOCR.2017.51008","DOIUrl":"https://doi.org/10.12677/JOCR.2017.51008","url":null,"abstract":"手性芳基氧杂化合物在药物化学和临床治疗上有着及其重要的作用。酚与不同的反应底物发生不对称反应是获得此类化合物的重要途径。在手性催化剂的作用下，以酚为亲核试剂，与不同的反应底物可发生不对称取代、Oxa-Michael加成、开环、Wacker-Type环化、O-H插入等获得手性芳基氧杂化合物。近年来，酚参与不对称C-O键形成取得了较大的进展，本文将对该进展做重点介绍。 Chiral aryl oxa-compounds are extremely important in medicinal chemistry and clinical therapies. The asymmetric reactions of phenols with different substrates are important methodologies to synthesize such species. With phenols as nucleophilic reagents, the chiral catalysts-catalyzed asymmetric reactions, such as substitution, Oxa-Michael addition, ring-opening, Wacker-Type cy-clization, O-H insertion, can be developed by reacting with different substrates to obtain such compounds. Recently, the asymmetric C-O bond formation with phenols has made a great progress. This paper will focus on the progress of the asymmetric C-O bond formation with phenols.","PeriodicalId":16596,"journal":{"name":"Journal of Organic Chemistry Research","volume":"87 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75231146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0