Journal of Neurogastroenterology and Motility最新文献

{"title":"Amitriptyline for the Treatment of Extra-esophageal Symptoms in Proton Pump Inhibitor-refractory Patients With Suspected Gastroesophageal Reflux Disease.","authors":"Jieun Woo, Eun Jeong Gong, Chang Seok Bang, Jae Jun Lee","doi":"10.5056/jnm25121","DOIUrl":"10.5056/jnm25121","url":null,"abstract":"<p><strong>Background/aims: </strong>Gastroesophageal reflux disease (GERD) is a chronic, heterogeneous condition that impairs quality of life. Extra-esophageal symptoms (eg, globus sensation, chronic cough, hoarseness, wheezing) often persist despite proton pump inhibitor (PPI) therapy. Tricyclic antidepressants are recommended for such refractory cases, but supporting evidence is limited. This study aims to evaluate the efficacy of low-dose amitriptyline in treating extra-esophageal GERD symptoms.</p><p><strong>Methods: </strong>We conducted a single-center, single-blind, randomized, controlled crossover pilot trial. Forty patients with both typical GERD symptoms and one or more atypical symptom unresponsive to ≥ 4 weeks of PPI therapy were randomized to receive either lansoprazole 30 mg daily plus amitriptyline 10 mg at bedtime or lansoprazole alone for 4 weeks, followed by crossover to the alternate regimen. The primary outcome was symptom improvement assessed by numeric rating scale. Secondary outcome included changes in quality of life (QoL) measured by the 36-item Short Form survey.</p><p><strong>Results: </strong>All 40 patients completed the trial. Overall, 75% reported symptom improvement: 65% in the amitriptyline group vs 85% in the PPI group (<i>P</i> = 0.273). Both groups showed significant reductions in symptom severity (between-group <i>P</i> = 0.904) and improvements in QoL (physical and mental summary scores; <i>P</i> = 0.600 and 0.410, respectively). These improvements persisted post-crossover.</p><p><strong>Conclusions: </strong>Adding low-dose amitriptyline to PPI therapy did not offer a short-term advantage over PPI alone. Both treatments improved symptoms and QoL. Given the challenging nature of GERD's extra-esophageal manifestations and mixed evidence for neuromodulator therapy, further studies are needed to identify patient subgroups that may benefit from adjunctive neuromodulator therapy.</p>","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":" ","pages":"534-542"},"PeriodicalIF":3.3,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12527959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2025 Focused Update of the Seoul Consensus on Gastroesophageal Reflux Disease: Evidence-based Recommendations on Acid Suppressive Therapy.","authors":"Cheal Wung Huh, Jin Won Chang, Nak-Hoon Son, Da Hyun Jung, Hye-Kyung Jung, Seung Joo Kang, Seung Young Kim, Miyoung Choi, Da Mi Jeong, Hyun Jin Kim, Moo In Park, In-Kyung Sung, Young Hoon Youn, Kwang Jae Lee","doi":"10.5056/jnm25128","DOIUrl":"https://doi.org/10.5056/jnm25128","url":null,"abstract":"<p><p>Gastroesophageal reflux disease (GERD) is a chronic and relapsing gastrointestinal disorder characterized by the reflux of gastric contents into the esophagus, leading to troublesome symptoms and/or complications. Since the publication of the 2020 Seoul Consensus on GERD, significant new evidence has emerged, particularly regarding acid-suppressive therapies and diagnostic approaches. This 2025 focused update aims to refine GERD management strategies by incorporating the latest evidence on acid suppressive therapies and regional considerations in Asian populations. This study builds on the 2020 Seoul Consensus by integrating systematic reviews, meta-analyses, and expert consensuses to offer updated recommendations for the definition and medical treatment of GERD. These guidelines incorporate recent advances in acidsuppressive therapies, particularly potassium-competitive acid blockers, and adopt updated diagnostic frameworks in accordance with the Lyon Consensus 2.0. Key clinical questions were identified and structured using the following format: population, intervention, comparator, and outcome. The resulting recommendations address the initial treatment, long-term maintenance strategies, and role of personalized therapy based on disease severity, such as the grade of reflux esophagitis. Six key statements are presented: updated definition and classification of GERD (Statement 1); initial and long-term treatment strategies tailored to GERD phenotypes, such as non-erosive reflux disease, mild erosive esophagitis, and severe erosive esophagitis (Statements 2-5); and dose optimization strategies for long-term safety (Statement 6). These guidelines aim to support gastroenterologists and general healthcare providers in making individualized evidence-based decisions for GERD management.</p>","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Fexuprazan and Esomeprazole for the Control of Nocturnal Gastroesophageal Reflux Symptoms: A Randomized, Crossover Study.","authors":"Dong Jun Oh, Dong Hwan Park, Jiyun Jung, Yun Jeong Lim","doi":"10.5056/jnm25119","DOIUrl":"https://doi.org/10.5056/jnm25119","url":null,"abstract":"<p><strong>Background/aims: </strong>Nocturnal acid reflux disrupts sleep and impairs quality of life. Proton pump inhibitors (PPIs) provide insufficient suppression of nocturnal acid secretion, whereas fexuprazan offers prolonged acid suppression. We compared the efficacy of fexuprazan and esomeprazole in controlling nocturnal reflux.</p><p><strong>Methods: </strong>In a randomized and crossover study, patients received fexuprazan or esomeprazole daily for 4 weeks, followed by a washout and crossover to the alternate medication for another 4 weeks, with a final washout completing the sequence. Severity (scores 0-10), frequency, sleep disturbance, and medication preferences were evaluated.</p><p><strong>Results: </strong>Thirty-nine patients were enrolled and randomized to receive either fexuprazan (n = 20) or esomeprazole (n = 19) first. After the first treatment, fexuprazan reduced severity from 7.5 ± 1.2 to 1.4 ± 1.0 (81% decrease), versus 7.5 ± 1.1 to 2.8 ± 1.5 (64% decrease) with esomeprazole (p = 0.012). In patients with severe symptoms (scores ≥ 7), fexuprazan led to significantly greater improvement than esomeprazole (p = 0.008). Following the first washout, the second crossover treatment resulted in greater improvement in symptom severity with fexuprazan (p = 0.001). During the second washout, nocturnal symptoms severity and frequencies were better controlled with fexuprazan than with esomeprazole (p = 0.005 and 0.019). Patients who switched from esomeprazole to fexuprazan preferred fexuprazan (p = 0.018).</p><p><strong>Conclusions: </strong>Fexuprazan was more effective than esomeprazole in controlling nocturnal reflux symptom, particularly in patients with severe symptoms. Fexuprazan may offer a therapeutic advantage for patients with severe and persistent nocturnal reflux despite PPI therapy.</p>","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cyclic Vomiting Syndrome Versus Cannabinoid Hyperemesis Syndrome.","authors":"Bipneet Singh, Palak Grover, Gurleen Kaur","doi":"10.5056/jnm25033","DOIUrl":"10.5056/jnm25033","url":null,"abstract":"","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":" ","pages":"399-400"},"PeriodicalIF":3.3,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12241911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Psychological Burden and Unexplained High Upper Esophageal Sphincter Basal Pressure.","authors":"Dianxuan Jiang, Qianjun Zhuang, Songfeng Chen, Xingyu Jia, Jing Chen, Niandi Tan, Mengyu Zhang, Yinglian Xiao","doi":"10.5056/jnm24101","DOIUrl":"10.5056/jnm24101","url":null,"abstract":"<p><strong>Background/aims: </strong>Proximal esophageal dysmotility and high psychological burden are common in individuals with esophageal or laryngopharyngeal reflux symptoms. However, the clinical significance of abnormal proximal motility remains unclear. Given that proximal esophagus consists of skeletal muscle, proximal esophageal motility may be influenced by psychological burden. This study aims to explore the relationship between psychological burden and proximal esophageal motility.</p><p><strong>Methods: </strong>Patients with esophageal or laryngopharyngeal reflux symptoms were retrospectively included. Esophageal hypervigilance and anxiety scale (EHAS) was used to evaluate the psychological burden in patients. Demographics, endoscopic findings, proximal and distal esophageal manometric parameters, and reflux burden were compared between patients with and without esophageal hypervigilance and anxiety. Multivariate logistic regression analysis was conducted to determine the relationship between psychological burden and proximal esophageal motility.</p><p><strong>Results: </strong>A total of 341 subjects were enrolled. A greater proportion of patients with high EHAS had elevated upper esophageal sphincter (UES) basal pressure than those with normal EHAS (21.5% vs 11.8%, <i>P</i> = 0.024), while no significant difference was found in other proximal manometric parameters between the 2 groups. On multivariate analysis, high EHAS was independently associated with elevated UES basal pressure (OR, 2.19, <i>P</i> = 0.034).</p><p><strong>Conclusions: </strong>Elevated UES basal pressure is more frequently seen in symptomatic patients with high esophageal hypervigilance and anxiety. When encountering patients with unexplained high UES basal pressure, psychological burden may play a potential role in these cases.</p>","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":"31 3","pages":"321-329"},"PeriodicalIF":3.3,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12241926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Treatment Outcomes in Achalasia Using 4-Dimensional High-resolution Impedance Manometry.","authors":"Meng Li, Panyavee Pitisuttithum, Eric Goudie, Dustin A Carlson, John E Pandolfino, Wenjun Kou","doi":"10.5056/jnm24170","DOIUrl":"10.5056/jnm24170","url":null,"abstract":"<p><strong>Background/aims: </strong>Assessment of treatment response of achalasia often involves multiple procedures. We aim to investigate innovative metrics based on 4-dimensional high-resolution impedance manometry (4D HRM) to assess treatment response in achalasia patients.</p><p><strong>Methods: </strong>Patients with achalasia treated by pneumatic dilation or myotomy who underwent follow-up evaluations were included. All patients completed high-resolution impedance manometry before and after treatment. 4D HRM analysis based on developed python program measured clearance ratio, intrabolus pressure (IBP), maximum esophagogastric junction diameter, and distensibility index. Good treatment outcomes were defined as barium column height of < 5 cm at 5 minutes on timed barium esophagram (TBE) and Eckardt score ≤ 3.</p><p><strong>Results: </strong>Fifty-three patients with achalasia were included: 40% type I, 51% type II, and 9% type III. Change of clearance ratio and IBP on 4D HRM had superior performance in predicting abnormal TBE at 5 minutes (area under the receiver operating characteristic [AUROC] curve, 95% confidence interval: 0.76, 0.59-0.93; 0.74, 0.57-0.92). The combination of clearance ratio (increase with a threshold of 0.1) and IBP (reduction with a threshold of 8.9 mmHg) had a high positive predictive value for normal TBE outcome (93%), and a modest negative predictive value for abnormal TBE outcome (73%). Receiver operating characteristics of metrics related to poor symptomatic outcome only yielded AUROCs (95% CI) of 0.82 (0.68-0.96) for esophageal hypervigilance and anxiety scale posttreatment.</p><p><strong>Conclusions: </strong>IBP and clearance ratio help to identify abnormal barium retention in patients after treatment. 4D manometry can be an alternative or complementary approach to characterize and assess treatment response of Achalasia, in additional to TBE or functional lumen imaging probe.</p>","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":"31 3","pages":"347-356"},"PeriodicalIF":3.3,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12241924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Small Bowel Motility Using Cine-magnetic Resonance Imaging in Patients Suspected With Chronic Intestinal Pseudo-obstruction.","authors":"June Hwa Bae, Kee Wook Jung, Jung-Bin Park, Kyuwon Kim, Seung Wook Hong, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Suk-Kyun Yang, Min Hee Kim, Dong Wook Kim, Seong Ho Park, Jong-Lyul Lee, Yong Sik Yoon, Chan Wook Kim, Chang Sik Yu, Seung-Jae Myung","doi":"10.5056/jnm24130","DOIUrl":"10.5056/jnm24130","url":null,"abstract":"<p><strong>Background/aims: </strong>Chronic intestinal pseudo-obstruction (CIPO), characterized by dilated small or large intestine on CT, has a high postoperative recurrence rate. In contrast, focal hypoganglionosis with adult-onset megacolon (FHAM) generally shows a good postoperative prognosis. This study aims to evaluate the utility of cine-MRI in differentiating between these 2 diseases by assessing small bowel (SB) motility and its correlation with clinical outcomes.</p><p><strong>Methods: </strong>The clinical features and outcomes of 41 prospectively enrolled patients suspected of having CIPO who underwent cine-MRI were reviewed. Multi-slice cine-MRI was conducted.</p><p><strong>Results: </strong>Of 41 patients suspected of having CIPO, 17 showed SB dilatation on CT, while 24 did not. According to cine-MRI, 3 exhibited decreased SB motility, while 38 showed no motility reduction. Among the 17 patients with dilated SB on CT, only 3 demonstrated decreased SB motility on cine-MRI. By contrast, all patients with nondilated SB on CT exhibited normal SB motility on cine-MRI. Patients with decreased SB motility showed a higher rate of postoperative disease recurrence (<i>P</i> = 0.011) and continuation of medication after surgery (<i>P</i> = 0.020) than in those with normal SB motility.</p><p><strong>Conclusions: </strong>Cine-MRI is useful in assessing SB motility that cannot be detected on CT. Its usefulness extends to aiding surgical decision-making, particularly in differentiating between FHAM and CIPO.</p>","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":"31 3","pages":"374-383"},"PeriodicalIF":3.3,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12241919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world Application of the Chicago Classification Version 4.0 for Esophageal Manometry: Asian Multicenter Study.","authors":"Soo In Choi, Jong Wook Kim, Kee Wook Jung, Boram Cha, Ga Hee Kim, Myeongsook Seo, Han Hee Lee, Ju Yup Lee, Seung Young Kim, Seon-Young Park, Yu Kyung Cho, Chong Il Sohn, Suck Chei Choi","doi":"10.5056/jnm25010","DOIUrl":"10.5056/jnm25010","url":null,"abstract":"<p><strong>Background/aims: </strong>The Chicago classification version 4.0 (CC v4.0) proposes a standardized high-resolution manometry protocol for more sophisticated diagnosis of esophageal motility disorders. We aim to investigate the real-world application of CC v4.0 through multi-institutional surveys in Asian countries.</p><p><strong>Methods: </strong>We requested a total of 161 questionnaires from members of the Asian Neurogastroenterology and Motility Association via Google Survey from March to June 2023. The questionnaire assessed CC v4.0 protocol compliance and diagnosis.</p><p><strong>Results: </strong>Responses were received from 33 centers in 9 countries (18 in Korea, 5 in Japan, and 10 in others). Among these, anticholinergics were investigated in 14 centers (42.4%), and narcotic drugs in 16 centers (48.5%). Eight centers (24.2%) fully adhered to CC v4.0 protocol for single wet swallows and provocation tests. Nine centers (27.3%) had an adaptation period < 60 seconds, 13 centers (39.4%) had < 3 breath counts, and 15 centers (45.5%) had swallowing intervals < 30 seconds (42.4% had 10-29 seconds and 3% had < 10 seconds). Twenty-four centers (72.7%) started the examination in a supine position and 13 centers (39.4%) did not change their position. Among 27 centers (81.8%) applying provocation tests, all applied multiple rapid swallows, whereas rapid drink challenge was applied in 19 (57.6%). Timed barium esophagography and functional lumen imaging probe were available in 16 (48.5%) and 6 centers (18.2%), respectively.</p><p><strong>Conclusions: </strong>We observed heterogeneity among centers in the application of CC v4.0 protocol. To increase inter-center reliability and minimize diagnostic ambiguity, efforts should continue toward the practical clinical application of standard protocols.</p>","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":"31 3","pages":"357-365"},"PeriodicalIF":3.3,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12241918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of Lyon 2.0 Gastroesophageal Reflux Disease Consensus: Limited Clinical Utility of Mean Nocturnal Basal Impedance in Koreans.","authors":"Jae Hyuk Lee, Boram Cha, Kee Wook Jung, Soo In Choi, Ga Hee Kim, Myeongsook Seo, Ju Yup Lee, Seung Young Kim, Jong Wook Kim, Kee Don Choi, Hee Kyong Na, Ji Yong Ahn, JeongHoon Lee, Do Hoon Kim, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung","doi":"10.5056/jnm25001","DOIUrl":"10.5056/jnm25001","url":null,"abstract":"<p><strong>Background/aims: </strong>The Lyon Consensus 2.0 (Lyon 2.0) revised gastroesophageal reflux disease (GERD) definitions, incorporating Los Angeles (LA) grade B as diagnostic and mean nocturnal basal impedance (MNBI) as supplementary evidence. Asian populations show differing impedancepH thresholds, with lower acid exposure time (AET) and higher MNBI values. The clinical validity of MNBI in Asian GERD patients remains uncertain. This study evaluated Lyon 2.0's applicability to Korean patients.</p><p><strong>Methods: </strong>From January 2021 to August 2023, GERD-suspected patients underwent endoscopy, manometry, and pH testing. MNBI was measured 5 cm above the lower esophageal sphincter. Patients with major motor disorders, organic diseases, or prior foregut surgery were excluded. GERD was defined by AET ≥ 4% or LA grades B-D; non-GERD by AET < 4%, LA grade A or normal Z line with < 40 reflux episodes/day. The optimal MNBI threshold was determined via receiver operating characteristic curve analysis.</p><p><strong>Results: </strong>Among 427 patients (mean age 57.7 ± 13.8 years, 37.2% male), 59 (13.8%) had GERD (10 endoscopically confirmed, 54 by AET ≥ 4%). Non-GERD accounted for 63.5% (n = 271), with 22.7% (n = 97) in the borderline group. MNBI correlated negatively with AET (<i>r</i> = -0.482, <i>P</i> < 0.01) and LA grade (<i>r</i> = -1.390, <i>P</i> = 0.005). The optimal MNBI threshold for GERD was 2167 Ω (sensitivity 0.86, specificity 0.75). Three LA grade A cases were reclassified as GERD-positive using this threshold.</p><p><strong>Conclusion: </strong>MNBI significantly correlated with AET and LA grades, highlighting its diagnostic value in Korean GERD patients. However, regional variations suggest higher MNBI thresholds than Lyon 2.0 recommendations, warranting further studies to refine criteria for Asian populations.</p>","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":"31 3","pages":"340-346"},"PeriodicalIF":3.3,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12241920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Relevance of Gastric Emptying Time in Functional Dyspepsia.","authors":"Hye Lim Park, Jeongmin Lee, Soo Jin Kwon, Seonmi Lee, Inho Lee, Jung-Hwan Oh","doi":"10.5056/jnm24138","DOIUrl":"10.5056/jnm24138","url":null,"abstract":"<p><strong>Background/aims: </strong>This study evaluates the clinical significance of the gastric emptying time (GET) in patients with functional dyspepsia (FD).</p><p><strong>Methods: </strong>This retrospective study included 89 patients who visited the clinic with indigestion between 2021 and 2022. FD was diagnosed and categorized into 3 subtypes: postprandial distress syndrome, epigastric pain syndrome, and overlap type, following the Rome IV criteria. GET was assessed using ^99mTc scintigraphy. The stomach remnant was measured 1 and 2 hours after ingesting a technetium-99m labeled egg, and the time required for the remnant to decrease by half (T_1/2) was calculated.</p><p><strong>Results: </strong>Of the 89 patients studied, 46 were diagnosed with FD. The remaining 43 patients, who did not meet the Rome IV criteria, were included as the control group. Patients with FD exhibited a higher incidence of smoking, a higher body mass index, and a higher incidence of diabetes than the non-FD group. GET and T_1/2 did not show significant differences between the 2 groups (<i>P</i> = 0.240 and <i>P</i> = 0.126, respectively). However, the FD group exhibited a smaller gastric retention rate than the non-FD group at all time points. In the subtype analysis, GET and T_1/2 were not significantly different among the 3 subtypes (<i>P</i> = 1.000 and <i>P</i> = 0.173, respectively). Diabetes mellitus, current smoking status, elevated body mass index, and younger age were significantly associated with FD.</p><p><strong>Conclusion: </strong>GET did not significantly differ among FD patients or its subtypes, despite a lower gastric retention rate in FD patients.</p>","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":"31 3","pages":"366-373"},"PeriodicalIF":3.3,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12241914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}