Journal of Neurogastroenterology and Motility最新文献

{"title":"Protein Kinase CK2 Modulates the Calcium Sensitivity of Type 3 Small-conductance Calcium-activated Potassium Channels in Colonic Platelet-derived Growth Factor Receptor Alpha-positive Cells From Streptozotocin-induced Diabetic Mice.","authors":"Ni-Na Song,&nbsp;Xu Huang,&nbsp;Hong-Li Lu,&nbsp;Chen Lu,&nbsp;Jie Chen,&nbsp;Wen-Xie Xu","doi":"10.5056/jnm22052","DOIUrl":"https://doi.org/10.5056/jnm22052","url":null,"abstract":"<p><strong>Background/aims: </strong>The gastrointestinal symptom of diabetes mellitus, chronic constipation, seriously affects patients' life. Whereas, the mechanism of chronic constipation is still ambiguous, resulting in a lack of effective therapies for this symptom. As a part of the smooth muscle cells, interstitial cells of Cajal, and platelet-derived growth factor receptor alpha-positive (PDGFRα⁺) cells syncytium (SIP syncytium), PDGFRα⁺ cells play an important role in regulating colonic motility. According to our previous study, in PDGFRα⁺ cells in colons of diabetic mice, the function of the P2Y1 purinergic receptor/type 3 small-conductance calcium-activated potassium (SK3) channel signaling pathway is strengthened, which may lead to colonic dysmotility. The purpose of this study is to investigate the changes in SK3 channel properties of PDGFRα⁺ cells in diabetic mice.</p><p><strong>Methods: </strong>Whole-cell patch clamp, Western blotting, superoxide dismutase activity measurement, and malondialdehyde measurement were main methods in the present study.</p><p><strong>Results: </strong>The present study revealed that when dialysed with low calcium ion (Ca²⁺) solution, the SK3 current density was significantly decreased in PDGFRα⁺ cells from diabetic mice. However, the SK3 current density in PDGFRα⁺ cells was enhanced from diabetic mice when dialysed with high Ca²⁺ solution. Moreover, hydrogen peroxide-treatment mimicked this phenomenon in SK3 transgenic HEK293 cells. The subunit of SK3 channels, protein kinase CK2, was up-regulated in colonic muscle layers and hydrogen peroxide-treated HEK293 cells. Additionally, protein phosphatase 2A, the subunit of SK3 channels, was not changed in streptozotocin-treated mouse colons or hydrogen peroxide-treated HEK293 cells.</p><p><strong>Conclusion: </strong>The diabetic oxidative stress-induced upregulation of CK2 contributed to modulating SK3 channel sensitivity to Ca²⁺ in colonic PDGFRα⁺ cells, which may result in colonic dysmotility in diabetic mice.</p>","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/36/c1/jnm-29-2-250.PMC10083106.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9367509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart Rate Variability and Somatization in Adolescents With Irritable Bowel Syndrome.","authors":"Marta Semen,&nbsp;Olena Lychkovska,&nbsp;Danylo Kaminskyy,&nbsp;Ostap Yavorskyi,&nbsp;Khrystyna O Semen,&nbsp;Olha Yelisyeyeva","doi":"10.5056/jnm22019","DOIUrl":"https://doi.org/10.5056/jnm22019","url":null,"abstract":"<p><strong>Background/aims: </strong>Changes in autonomic regulation and psychological distress play an important role in the pathobiology of irritable bowel syndrome (IBS). The aim of the current study is to evaluate the autonomic function and to link it to the levels of somatization in adolescents with IBS.</p><p><strong>Methods: </strong>We enrolled 30 adolescents with various types of IBS and 35 healthy controls. Time and frequency domain indexes of heart rate variability (HRV) were measured in supine (baseline) and standing (orthostasis) positions using short-term electrocardiographic recordings. The somatic symptoms index was assessed with the modified Screening for Somatoform Symptoms questionnaire.</p><p><strong>Results: </strong>Adolescents with IBS showed no differences of HRV parameters in the supine position compared to healthy control. In orthostasis, a decrease in the standard deviation of normal RR intervals as well as main spectral index total power (TP) were observed. The reduction of TP was attributed to the reduced activities of the high- and low frequency components. Increased somatic symptoms index in IBS patients negatively correlated with TP in orthostasis (<i>r</i> = -0.485, <i>P</i> = 0.007). A subgroup analysis revealed that adolescents with IBS with TP values either < 2500 msec² or > 5500 msec² in the supine position demonstrated significantly reduced activity of the low frequency component.</p><p><strong>Conclusions: </strong>Adolescents with IBS showed signs of autonomic dysfunction only during the orthostatic test, which were associated with increased somatization scores. Further research is needed to establish the links between emotional wellbeing and autonomic function in this population.</p>","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/62/38/jnm-29-2-208.PMC10083117.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9367512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total Transit Time and Probiotic Persistence in Healthy Adults: A Pilot Study.","authors":"Annie Tremblay,&nbsp;Jeremie Auger,&nbsp;Zainab Alyousif,&nbsp;Sara E Caballero Calero,&nbsp;Olivier Mathieu,&nbsp;Daniela Rivero-Mendoza,&nbsp;Amal Elmaoui,&nbsp;Wendy J Dahl,&nbsp;Thomas A Tompkins","doi":"10.5056/jnm22031","DOIUrl":"https://doi.org/10.5056/jnm22031","url":null,"abstract":"<p><strong>Background/aims: </strong>Motility, stool characteristics, and microbiota composition are expected to modulate probiotics' passage through the gut but their effects on persistence after intake cessation remain uncharacterized. This pilot, open-label study aims at characterizing probiotic fecal detection parameters (onset, persistence, and duration) and their relationship with whole gut transit time (WGTT). Correlations with fecal microbiota composition are also explored.</p><p><strong>Methods: </strong>Thirty healthy adults (30.4 ± 13.3 years) received a probiotic (30 × 10⁹ CFU/capsule/day, 2 weeks; containing <i>Lactobacillus helveticus</i> R0052, <i>Lacticaseibacillus paracasei</i> HA-108, <i>Bifidobacterium breve</i> HA-129, <i>Bifidobacterium longum</i> R0175, and <i>Streptococcus thermophilus</i> HA-110). Probiotic intake was flanked by 4-week washout periods, with 18 stool collections throughout the study. WGTT was measured using 80% recovery of radio-opaque markers.</p><p><strong>Results: </strong>Tested strains were detected in feces ~1-2 days after first intake and persistence after intake cessation was not significantly different for R0052, HA-108, and HA-129 (~3-6 days). We identified 3 WGTT subgroups within this population (named Fast, Intermediate, and Slow), which could be classified by machine learning with high accuracy based on differentially abundant taxa. On average, R0175 persisted significantly longer in the intermediate WGTT subgroup (~8.5 days), which was mainly due to 6 of the 13 Intermediate participants for whom R0175 persisted ≥ 15 days. Machine learning classified these 13 participants according to their WGTT cluster (≥ 15 days or < 5 days) with high accuracy, highlighting differentially abundant taxa potentially associated with R0175 persistence.</p><p><strong>Conclusion: </strong>These results support the notion that host-specific parameters such as WGTT and microbiota composition should be considered when designing studies involving probiotics, especially for the optimization of washout duration in crossover studies but also for the definition of enrollment criteria or supplementation regimen in specific populations.</p>","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1a/2c/jnm-29-2-218.PMC10083121.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9367514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypercontractile Esophagus: Clinical and Manometric Features From a Multicenter Korean Cohort.","authors":"Yang Won Min,&nbsp;Kee Wook Jung,&nbsp;Kyoungwon Jung,&nbsp;Yu Kyung Cho,&nbsp;Moo In Park","doi":"10.5056/jnm22020","DOIUrl":"https://doi.org/10.5056/jnm22020","url":null,"abstract":"<p><strong>Background/aims: </strong>Hypercontractile esophagus (HE) is a heterogeneous disorder with variable clinical presentations and a natural course, leading to management challenges. This study aims to investigate the characteristics of HE and evaluate its treatment outcomes.</p><p><strong>Methods: </strong>Four Korean referral centers recruited subjects with at least 1 hypercontractile swallow (distal contraction integral > 8000 mmHg·s·cm) in this retrospective observational study. Subjects were classified according to the Chicago classification version 2.0 (CC v2.0), CC v3.0, and CC v4.0. criteria. The clinical and manometric features were also investigated. The treatment modalities and outcomes of subjects with CC v4.0 were evaluated.</p><p><strong>Results: </strong>In total, 59 subjects with at least 1 hypercontractile swallow were analyzed. Among them, 30 (50.8%) had increased integrated relaxation pressure values without meeting the criteria for achalasia. Among the remaining 29 patients, 6 (20.7%) had only 1 hypercontractile swallowing symptom (CC v2.0) and 23 (79.3%) met both the CC v3.0 and v4.0 criteria for HE. Dysphagia (91.3%) was the most prevalent symptom, followed by chest pain (56.5%), regurgitation (52.2%), globus (34.8%), heartburn (21.7%), and belching (8.7%). Twenty (87.0%) patients received medical treatment, and 8 (47.1%) and 5 (29.4%) showed moderate and significant improvements, respectively. Proton pump inhibitors were the most common option (n = 15, 65.2%), followed by calcium channel blockers (n = 6, 26.1%). One patient received peroral endoscopic myotomy and showed significant symptom improvement.</p><p><strong>Conclusions: </strong>Sixty-one percent of patients who meet the diagnostic criteria for the high-resolution manometry are diagnosed with symptomatic HE based CC v4.0. Chest pain and regurgitation were also observed in over half of them. The overall medical treatment efficacy was moderate.</p>","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/11/3c/jnm-29-2-166.PMC10083115.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9361274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Duodenojejunal Manometric Abnormalities in a Patient With Mesenterium Commune.","authors":"Gabrio Bassotti,&nbsp;Roberto Cirocchi","doi":"10.5056/jnm22169","DOIUrl":"https://doi.org/10.5056/jnm22169","url":null,"abstract":"","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/21/df/jnm-29-2-262.PMC10083107.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9367510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Long and Winding Road to the Best Clinical Research and Personalized Therapy With Probiotics: Do Not Forget Host Physiology.","authors":"Yong Sung Kim,&nbsp;Suck Chei Choi","doi":"10.5056/jnm23034","DOIUrl":"https://doi.org/10.5056/jnm23034","url":null,"abstract":"host-specific factors such as gut transit time and gut microbiota composition determines the persistence of ingested probiotics. This study suggests several implications for clinicians and researchers using probiotics. The first is the difficulty in clinical research conducted using a probiotic. The results of previously re-ported clinical trials with probiotics are heterogeneous, even in the same disease, such as irritable bowel syndrome. 5 The claimed effects of probiotics have recently been questioned owing to the low quality of previous clinical trials by current stringent methodological standards. The low concordance between clinical studies using probiotics was mainly due to their characteristics. To date, a wide variety of","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/22/7e/jnm-29-2-129.PMC10083108.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9361271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracolonic Administration of Mosapride Citrate Significantly Increases Colonic Motility Compared With Oral Administration.","authors":"Moon Young Lee,&nbsp;Min Seob Kim,&nbsp;Yong Sung Kim","doi":"10.5056/jnm23045","DOIUrl":"https://doi.org/10.5056/jnm23045","url":null,"abstract":"c 2023 The Korean Society of Neurogastroenterology and Motility J Neurogastroenterol Motil, Vol. 29 No. 2 April, 2023 www.jnmjournal.org TO THE EDITOR: The 5-hydroxytryptamine 4 (5-HT4) receptor in the enteric nervous system is involved in enhanced neurotransmission, leading to increased gastrointestinal motility, and its agonists, such as prucalopride and mosapride, are currently used in clinical practice as prokinetic drugs. Although both drugs are 5-HT4 agonists, their indications vary as chronic constipation and functional dyspepsia, respectively. Compared to prucalopride, mosapride exhibited a relatively weak effect on colonic motility, but the reason is not apparent. After absorption in the small intestine, mosapride is metabolized to M1 by the first-pass mechanism, which has a 5-HT3 antagonistic effect. We speculated that metabolite M1 could offset the prokinetic effect of mosapride. Therefore, it was hypothesized that direct colonic administration of mosapride could increase motility by acting directly on the colon before conversion to M1 compared with oral administration. We performed a proof-of-concept experiment using a rat model that established an intracolonic administration route. After anesthesia, the right lower abdomen was incised, and the cecum was exteriorized. A PE 90 (BD company, Franklin Lakes, NJ, USA) tube was inserted into cecum and fixed by suture. After abdomen closure, the opposite end of the tube was exteriorized at the back of the neck via a subcutaneous tunnel from the right lower abdomen. The rats were fed freely during the experimental period and 20 mg/ kg of mosapride or vehicle in 0.5 mL volume was administered by oral or intracolonic route on different days. A total of 7 animals were tested 2 times in a cross-over manner with a 3-day washout period. After either oral or intracolonic administration of mosapride, the number of fecal pellets that were expelled within 1 hour and 2 hours was counted. Accordingly, we could confirm that the number of expelled fecal pellets was significantly higher after colonic administration than oral administration, both at 1 hour and 2 hours (Figure). This result indicated that the intracolonic application of mosapride is more effective in increasing colon movement than oral intake. We proposed that the colon-specific drug delivery formulation of mosapride could be used as an effective and safe treatment for constipation.","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3f/c8/jnm-29-2-265.PMC10083110.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9737428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distal Mean Nocturnal Baseline Impedance Predicts Pathological Reflux of Isolated Laryngopharyngeal Reflux Symptoms.","authors":"Hua-Nong Luo,&nbsp;Chen-Chi Wang,&nbsp;Ying-Cheng Lin,&nbsp;Chun-Yi Chuang,&nbsp;Yung-An Tsou,&nbsp;Ja-Chih Fu,&nbsp;Sheng-Shun Yang,&nbsp;Chi-Sen Chang,&nbsp;Han-Chung Lien","doi":"10.5056/jnm22049","DOIUrl":"https://doi.org/10.5056/jnm22049","url":null,"abstract":"<p><strong>Background/aims: </strong>Diagnosis of isolated laryngopharyngeal reflux symptoms (ILPRS), ie, without concomitant typical reflux symptoms (CTRS), remains difficult. Mean nocturnal baseline impedance (MNBI) reflects impaired mucosal integrity. We determined whether esophageal MNBI could predict pathological esophagopharyngeal reflux (pH+) in patients with ILPRS.</p><p><strong>Methods: </strong>In this cross-sectional study conducted in Taiwan, non-erosive or low-grade esophagitis patients with predominant laryngopharyngeal reflux symptoms underwent combined hypopharyngeal multichannel intraluminal impedance-pH monitoring when off acid suppressants. Participants were divided into the ILPRS (n = 94) and CTRS (n = 63) groups. Asymptomatic subjects without esophagitis (n = 25) served as healthy controls. The MNBI values at 3 cm and 5 cm above the lower esophageal sphincter (LES) and the proximal esophagus were measured.</p><p><strong>Results: </strong>Distal but not proximal esophageal median MNBI values were significantly lower in patients with pH+ than in those with pH- (ILPRS in pH+ vs pH-: 1607 Ω vs 2709 Ω and 1885 Ω vs 2563 Ω at 3 cm and 5 cm above LES, respectively; CTRS in pH+ vs pH-: 1476 vs 2307 Ω and 1500 vs 2301 Ω at 3 cm and 5 cm above LES, respectively, <i>P</i> < 0.05 for all). No significant differences of any MNBI exist between any pH- subgroups and healthy controls. The areas under the receiver operating characteristic curve in the ILPRS group were 0.75 and 0.80, compared to the pH- subgroup and healthy controls (<i>P</i> < 0.001 for both), respectively. Interobserver reproducibility was good (Spearman correlation 0.93, <i>P</i> < 0.0001).</p><p><strong>Conclusion: </strong>Distal esophageal MNBI predicts pathological reflux in patients with ILPRS.</p>","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/40/27/jnm-29-2-174.PMC10083114.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9367508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Irritable Bowel Syndrome in Japan, China, and South Korea: An International Cross-sectional Study.","authors":"Atsushi Takeoka,&nbsp;Takuya Kimura,&nbsp;Shintaro Hara,&nbsp;Toyohiro Hamaguchi,&nbsp;Shin Fukudo,&nbsp;Jun Tayama","doi":"10.5056/jnm22037","DOIUrl":"https://doi.org/10.5056/jnm22037","url":null,"abstract":"<p><strong>Background/aims: </strong>Symptoms of irritable bowel syndrome (IBS), a common gut-brain interaction disorder, deteriorate patients' quality of life and increase medical needs; therefore, IBS represents a significant global burden. The estimated global prevalence is approximately 10%; however, accumulated evidence shows international heterogeneity. In this study, we have described and compared the prevalence of IBS in 3 East Asian countries: Japan (Tokyo and Fukuoka), China (Beijing), and South Korea (Seoul).</p><p><strong>Methods: </strong>We conducted an internet-based cross-sectional survey of the urban population aged > 20 years in the abovementioned countries. We recruited equal numbers of age- (20s-60s) and sex-matched participants (3910 residents). IBS was diagnosed according to the Rome III criteria, and the subtypes were analyzed.</p><p><strong>Results: </strong>The overall prevalence of IBS with 95% CI was 12.6% (11.6-13.7); the prevalence was significantly different across Japan, China, and South Korea (14.9% [13.4-16.5], 5.5% [4.3-7.1], and 15.6% [13.3-18.3], respectively) (<i>P</i> < 0.001). Furthermore, 54.9% of patients were male. IBS-mixed was the most prevalent subtype; the prevalence of other subtypes varied.</p><p><strong>Conclusions: </strong>The overall prevalence of IBS in the 3 countries was slightly higher than the global prevalence, and it was significantly lower in China than in Japan and South Korea. IBS prevalence was the highest and lowest among individuals in their 40s and 60s, respectively. Male individuals had a higher prevalence of IBS with diarrhea. Further studies are needed to elucidate the factors associated with this regional heterogeneity.</p>","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5b/d0/jnm-29-2-229.PMC10083109.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9737425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disorders of Gut-Brain Interaction in a National Cohort of Children With Down Syndrome.","authors":"Steven L Ciciora,&nbsp;Kandamurugu Manickam,&nbsp;Miguel Saps","doi":"10.5056/jnm22055","DOIUrl":"https://doi.org/10.5056/jnm22055","url":null,"abstract":"<p><strong>Background/aims: </strong>Disorders of brain-gut interaction (DGBIs) are present in adults and children around the world. Down syndrome (DS) is the most common chromosomal condition in humans. While DS has associations with many organic medical conditions, the frequency of DGBIs in children and adolescents with DS has not previously been studied. We assess the rate of DGBIs in children and adolescents 4-18 years of age with DS in the United States using the Rome IV criteria by caregiver report.</p><p><strong>Methods: </strong>This is a cross-sectional national survey study in which caregivers (n = 114) of children with DS completed an online survey about their child's gastrointestinal symptoms and quality of life (QoL).</p><p><strong>Results: </strong>Using the Rome IV parent-report diagnostic questionnaire, 51.8% of children met symptom-based criteria for at least 1 DGBI. Functional constipation (36.0%) and irritable bowel syndrome (14.9%) were the most common disorders identified. QoL was lower in children with at least 1 disorder as compared to children who did not meet criteria for any disorders (mean QoL = 62.3 vs mean QoL = 72.9, <i>P</i> < 0.001). Almost all children with DS and concomitant autism (87.5%) had at least 1 DGBI.</p><p><strong>Conclusions: </strong>DGBIs are common in children with DS and are associated with diminished QoL.</p>","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c3/c7/jnm-29-1-94.PMC9837545.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10643603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}