Journal of neonatal-perinatal medicine最新文献

{"title":"Effectiveness of oro-motor sensory stimulation in preterm neonates: A systematic review and meta-analysis.","authors":"Abhishek Sharma, Aksh Chahal, Richa Hirendra Rai, Bartosz Maciej Wójcik, Raykhan Razakova, Nidhi Sharma","doi":"10.1177/19345798251394352","DOIUrl":"10.1177/19345798251394352","url":null,"abstract":"<p><p>BackgroundPreterm neonates often face challenges with feeding ability, neuromotor behavior, weight gain, and prolonged hospital stays. Oral Sensory-Motor Stimulation (OSMS) has been suggested as a beneficial intervention to address these issues. This systematic review and meta-analysis aim to evaluate the effectiveness of OSMS compared with standard care on feeding ability, motor function, weight gain, and length of hospital stay in preterm neonates admitted to Neonatal Intensive Care Units (NICUs).MethodsA thorough literature search was conducted across databases including PubMed, Scopus, Web of Science, Cochrane Library, CINAHL, and Embase focusing on studies published between 1, January 2000 and 10 December 2024. Randomized controlled trials (RCTs) and cohort studies examining the impact of OSMS on the specified outcomes in preterm neonates were included. Neonates with severe medical, neurological, congenital, or cardiorespiratory complications, along with those on assisted ventilation, formula feeding, or presenting clinical instability, were excluded. Data extraction and quality assessment were performed independently by two reviewers, and meta-analyses were conducted using random-effects models to account for heterogeneity among studies. Results were synthesized using random-effects models and presented through forest plots, with heterogeneity assessed using I² and Cochran's Q tests. Subgroup analyses were performed to evaluate result stability and explore potential sources of variability. RevMan 5.4.1 was used to conduct data analysis.ResultsA total of nine studies met the inclusion criteria with total 611 participants. Across studies, random sequence generation and selective reporting were consistently low risk, while allocation concealment was adequate in seven of nine studies. The meta-analysis revealed that OSMS significantly improved feeding ability, as evidenced by a reduction in time to achieve voluntary feeding (mean difference: -3.5 days; 95% CI: -4.2 to -2.8). Weight gain was positively affected, with an average increase of 7 g per day (95% CI: 6-10 g). Additionally, OSMS was associated with a reduced length of hospital stay (mean difference: -5.1 days; 95% CI: -6.4 to -3.8). Improvements in neuromotor behavior were observed based on qualitative synthesis, rather than meta-analytic pooled estimates.ConclusionOSMS is an effective intervention for improving feeding ability, motor function, weight gain, and reducing the length of hospital stay in preterm neonates admitted to NICUs. In addition to the meta-analytically supported benefits of OSMS on feeding ability, weight gain, and reduced hospital stay, qualitative evidence from select studies suggests potential improvements in neuromotor behavior.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"341-353"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145452278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between placenta abruption and congenital anomalies: A systematic review and meta-analysis.","authors":"Amir Mohammad Salehi, Ensiyeh Jenabi, Sima Kamkari","doi":"10.1177/19345798251398835","DOIUrl":"10.1177/19345798251398835","url":null,"abstract":"<p><p>BackgroundCongenital abnormalities (CAs) are a significant cause of death and disability among children worldwide. Identifying risk factors can help reduce the incidence and mortality associated with CAs. This study aimed to explore the relationship between placental abruption (PA) and congenital abnormalities (CAs).MethodsA systematic search was conducted in PubMed (Medline), Web of Science, Scopus, and Science Direct, up to July 10, 2025. The analysis utilized a random-effects model. To evaluate heterogeneity among the studies, we applied the chi-square test (χ²) and the I² statistic. Additionally, regression tests, including Egger's and Begg's tests, were carried out to assess publication bias. The quality of observational studies was evaluated using the modified Newcastle-Ottawa Scale (NOS). A p-value of less than 0.05 was considered statistically significant, and the analysis was performed using Stata software, version 13.ResultsIn total, six studies met the inclusion criteria and were included in this systematic review. A significant association was found, with PA increasing the risk of CAs (OR = 2.83; 95% CI: 1.88 to 3.79). Substantial heterogeneity was observed among the studies (I² = 91.9%, P < 0.001). After subgrouping, a significant association between PA and the risk of CAs was observed in both case-control studies (OR = 1.95, 95% CI: 1.51 to 2.38; I² = 0.0%, P = 0.523) and cohort studies (OR = 3.28, 95% CI: 1.68 to 4.88; I² = 95.1%, P < 0.001). Notably, homogeneity was found among the case-control studies.ConclusionOur study demonstrates a significant positive association between PA and CAs, but causality cannot be inferred. Thus, it is suggested to monitor for CAs in the fetus of mothers with PA.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"354-362"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145541245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of abdominal ultrasound in surgical decision making for necrotizing enterocolitis.","authors":"Parvesh M Garg, Jeffrey S Shenberger, Mitchell R Ladd, Matthew O Thompson, Ricardo J Rodriguez","doi":"10.1177/19345798251405212","DOIUrl":"10.1177/19345798251405212","url":null,"abstract":"<p><p>Despite advances in neonatal care, Necrotizing enterocolitis (NEC) remains one of the most devastating gastrointestinal complications affecting most often preterm infants and full -term infants with congenital heart disease. Early and accurate diagnosis is vital to reduce morbidity and mortality. While abdominal radiography has traditionally served as the cornerstone of diagnosis, abdominal ultrasound (AUS) emerges as an additional tool offering the benefits of a real-time, radiation-free and functional assessment of the bowel. However, the role of AUS in the assessment of need for surgery remains less clear. This commentary addresses some of the available observational studies and existing evidence on the role of AUS for the diagnosis of NEC and the challenges associated with implementation of this practice, and the lack of well-designed prospective trials.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"438-440"},"PeriodicalIF":1.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12718000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145701303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extreme preterm infants of birth weight <750 g and gestational age <26 weeks, survival trends and morbidity predictors over nearly two decades, single centre experience.","authors":"Mansour Al Qurashi, Ehab Hanafi, Mohammed Alhindi, Yaser Faden, Ahmad Mustafa, Abrar Ahmed, Jubara Alallah, Ashraf Sahafi, Hashem Al Marzouki, Hend AlNajjar, Mohammad Hassosah, Muhammad Anwar Khan","doi":"10.1177/19345798251405222","DOIUrl":"10.1177/19345798251405222","url":null,"abstract":"<p><p>IntroductionExtreme preterm infants (EPI), born at <26 weeks' gestation and weighing <750 g, represent the most vulnerable subset of preterm neonates with the highest risk of mortality and major morbidities. Despite significant advances in neonatal/perinatal care, outcomes for this population remain a major clinical challenge.ObjectiveTo evaluate temporal trends in survival, morbidity profiles, and predictors of in-hospital survival among inborn extreme preterm infants of birth weight <750 g and gestational age < 26 weeks over an 18-year period in a tertiary-level neonatal intensive care unit (NICU).MethodsThis retrospective cohort study included 134 inborn EP infants admitted between 2002 and 2019. The primary outcome was survival to hospital discharge; secondary outcomes included rates of several prematurity-related morbidities. Multivariable logistic regression was used to identify independent predictors of survival.ResultsSurvival to discharge increased over time from 29% (2002-2007) to 61% (2014-2019) (<i>p</i> = 0.009). Antenatal corticosteroid (ACS) (a OR 2.9, 95% CI 1.05-8.04, <i>p</i> = 0.049) and cesarean delivery (aOR 2.88, 95% CI 1.03-8.07, <i>p</i> = 0.044) were independently associated with increased odds of survival. Early hypotension (aOR 0.28, 95% CI 0.12-0.67, <i>p</i> = 0.004) and severe IVH (aOR 0.39, 95% CI 0.16-0.94, <i>p</i> = 0.035) were significantly associated with increased mortality. The incidence of severe IVH declined from 46% to 26% over the study period, while rates of PVL and surgical NEC showed downward trends. BPD (51%) and severe ROP (19%) remained relatively unchanged.ConclusionsOver nearly two decades, survival among extreme preterm infants of birth weight <750 g ang gestational age <26 weeks improved significantly. ACS administration and cesarean birth were associated with an increased rate of survival. Early hypotension and severe IVH were predictors of mortality. Severe IVH, PVL, and surgical NEC declined during the last period. Ongoing advances in perinatal care and targeted neonatal interventions are essential to further improve outcomes in this high-risk population.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"429-437"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145714586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contemporary management and surgical outcomes of sacrococcygeal teratoma.","authors":"Caitlin J Cain-Trivette, Yeu Sanz Wu, Alysala Malik, Brooks Melnyk, Christopher Nemeh, Jennifer Defazio, Erica M Fallon, Steven Stylianos, William Middlesworth, Vincent P Duron","doi":"10.1177/19345798251405210","DOIUrl":"10.1177/19345798251405210","url":null,"abstract":"<p><p>BackgroundSacrococcygeal teratoma (SCT) is a rare but significant neonatal tumor. Increasingly, SCTs are diagnosed prenatally, with fetal imaging playing a pivotal role in planning and management.MethodsWe conducted a retrospective review of five neonates with SCT treated at our institution between 2020 and 2025. Clinical presentation, imaging, surgical management, pathology, postoperative outcomes, and follow-up were analyzed.ResultsFour patients were diagnosed prenatally by ultrasound and underwent fetal MRI for detailed characterization of tumor anatomy and assessment of intrapelvic extension. MRI findings influenced risk stratification which guided delivery and surgical planning, complementing serial ultrasound monitoring for maternal-fetal well-being and tumor progression. One patient required in utero intervention for hydrops with polyhydramnios. Despite high-resolution imaging, one patient's tumor was intraoperatively reclassified to a higher Altman type, highlighting limitations of prenatal imaging in predicting exact tumor extent. All patients underwent coccygectomy, with surgical approaches tailored to tumor complexity; two required plastic surgery closure due to large or ruptured lesions. Pathology revealed mature or immature teratoma in four patients and a higher-grade immature teratoma in one patient. Complications were limited to wound dehiscence. At follow-up (8-36 months), there was no recurrence, and all patients demonstrated excellent cosmetic and functional outcomes.ConclusionsThis case series highlights the importance of prenatal diagnosis, individualized surgical planning, and multidisciplinary care in the management of neonatal SCT. Fetal MRI is a critical adjunct to prenatal ultrasound in the evaluation of SCT, offering superior anatomic detail, enhancing perinatal counseling, and guidance of surgical preparedness.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"411-417"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145634736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prophylactic probiotic combinations and their effect on the course of neonatal jaundice: A comparative cohort study.","authors":"Tatyana Itova","doi":"10.1177/19345798251398834","DOIUrl":"10.1177/19345798251398834","url":null,"abstract":"<p><p>BackgroundNeonatal hyperbilirubinemia is one of the most common conditions in the early neonatal period. Recent evidence suggests that intestinal microbiota plays a key role in bilirubin metabolism, and probiotic supplementation may influence its regulation.ObjectiveTo evaluate the effect of prophylactic administration of different probiotic combinations on transcutaneous bilirubin levels and clinical outcomes in term neonates.MethodsA total of 255 full-term neonates born at the Neonatology Department of University Hospital Medica Ruse Ltd, Bulgaria, throughout 2022 were included. Infants were divided into four groups according to the administered probiotic combination: (1) Group A (n = 25): L. lactis, B. lactis, B. bifidum; (2) Group B (n = 25): L. acidophilus, B. longum, L. reuteri; (3) Group C (n = 42): L. rhamnosus, L. reuteri, L. acidophilus; (4) Group D (n = 163): control group without probiotic supplementation. Probiotic intake began between the 6th and 12th postnatal hour and continued until Day 14. Transcutaneous bilirubin levels were measured daily until Day 5 (in-hospital) and on Day 14 (outpatient).ResultsNo significant baseline differences were observed between groups. Probiotic groups (A, B, and C) showed significantly lower mean bilirubin levels compared with controls (<i>p</i> < 0.05). Phototherapy in groups A, B, and C was initiated later (<i>p</i> < 0.001) and lasted for a shorter period (<i>p</i> = 0.080), which was associated with a reduced hospital stay (<i>p</i> = 0.001) compared with the control group. No adverse events were reported.ConclusionProphylactic probiotic supplementation during the early neonatal period was associated with lower bilirubin levels, reduced need for phototherapy, and shorter hospital stays. Combinations containing Bifidobacterium showed the strongest effect, suggesting their role in bilirubin elimination and intestinal stabilization.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"373-380"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145523454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinopathy of prematurity in late preterm and early term neonates: Incidence and risk factors in a prospective cohort.","authors":"Praveen Kumar Pujar Kotrappa, Prathik Bandiya, Vijay Kumar Krishnegowda, Krishna R Murthy, Niranjan Shivanna","doi":"10.1177/19345798251394356","DOIUrl":"10.1177/19345798251394356","url":null,"abstract":"<p><p>BackgroundThe predominant risk factors and outcomes of ROP in neonates with more than 34 weeks of gestation are not well described in low- and middle-income countries despite higher incidence of ROP in these neonates.ObjectivesTo determine the incidence and risk factors of ROP in neonates between 34 weeks and 38 weeks 6 days.Material and MethodsWe conducted a prospective observational study in a tertiary care paediatric hospital from January 2020 to June 2021. Neonates with gestational age between 34 and 38 weeks 6 days were included. Standardized screening protocols were adapted, with data on demographic characteristics, risk factors, ROP findings, and treatment collected systematically.ResultsAmong 267 neonates, 224 underwent ROP screening. Fifteen (6.7%) neonates had any ROP, with 6 (2.6%) having Type I ROP requiring treatment. Among the cohort, higher proportions of late preterm neonates had ROP 12 (8.5%) compared to early term neonates 3 (3.6%) and amongst the neonates who required treatment, 6 (2.6%) all were late preterm neonates. Significant risk factors for ROP development included being small for gestational age [12 (80%) versus 58 (28%), <i>p</i> < 0.01], postnatal weight gain [Mean Difference: 9.8 gm/kg/day; 95% CI, 6.7 - 13.0, <i>p</i> < 0.001] and associated comorbidities such as respiratory support [15 (100%) versus 128 (61%), <i>p</i> < 0.01], shock [13 (86.7%) versus 118 (56.5%), <i>p</i> < 0.01] and sepsis [3 (20% vs 22 (10%); <i>p</i> < 0.01].ConclusionsOur study supports extending ROP screening to neonates ≥34 weeks with growth restriction or comorbidities, particularly in low- and middle-income settings.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"404-410"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145445066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stillbirths in Bahrain: Analysis of patients admitted to a major tertiary hospital during a five-year period.","authors":"Jamil Ahmed, Huda Abbas Isa, Arjumand Qamaruddin, Asyah Shareef, Amer Almarabheh, Layal Fadhel, Sara Alhajeri","doi":"10.1177/19345798251391442","DOIUrl":"10.1177/19345798251391442","url":null,"abstract":"<p><p>BackgroundAnalyzing stillbirth data is critical to identifying care gaps and improving pregnancy outcomes. This study investigated stillbirths at a major tertiary hospital in Bahrain over 5 years (2018-2023).Material and methodsA retrospective cross-sectional study analyzed electronic data of women with stillbirths (≥22 weeks gestation) in a tertiary hospital in Bahrain. Data included maternal demographics, pregnancy characteristics, birth details, and fetal information (n = 263). Descriptive statistics and Chi-square tests were used.ResultsThe mean maternal age was 35.8 ± 6.4 years, with 60.5% being Bahraini. The mean gestational age at stillbirth was 32.7 ± 5.8 weeks, with the highest incidence between 29 and 36 weeks. Most women had no prior miscarriages (67.1%) or stillbirths (98.1%). Intrauterine growth restriction was reported in 5.3% of cases, and only 35.4% recommended antenatal care. The majority (66.2%) had obesity, and 8.7% had gestational diabetes. Congenital anomalies were present in 10.3% of stillborn babies. Multivariable logistic regression showed no statistically significant independent associations with late gestation stillbirth; however, higher adjusted odds were observed for obesity (aOR 3.38), diabetes (aOR 2.76), and multiple gestation (aOR 2.46), while female fetal sex trended toward lower odds (aOR 0.63).ConclusionObesity and diabetes were linked to later stillbirths. While umbilical cord complications are often cited, their role in this population requires further investigation. These findings identify the need for improved prenatal care, weight management, diabetes control, and umbilical cord surveillance in Bahrain to enhance maternal and fetal health.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"388-395"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145355041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal nicotine withdrawal in a newborn exposed to maternal e-cigarette use.","authors":"Ariana Bolumen-Lopez, Ahmad U'Wais, Komalben Patel, Sandra Priest, Shabih Manzar, Nitin Walyat, Maroun Mhanna","doi":"10.1177/19345798251387336","DOIUrl":"10.1177/19345798251387336","url":null,"abstract":"<p><p>The increasing use of e-cigarettes amongst pregnant women has raised public health concerns about the effects of nicotine exposure on neonates. Nicotine crosses the placenta, accumulates in fetal blood and amniotic fluid, and can be detected in breast milk during lactation. It may lead to withdrawal symptoms in newborns, such as irritability, tremors, high-pitched crying, and sleep disturbances, similar to those observed in opioid-induced neonatal abstinence syndrome (NAS). This case report presents a full-term male neonate who developed persistent symptoms consistent with NAS, despite negative toxicology screenings for opioid or other illicit substances. The infant was started on morphine therapy, based on elevated Finnegan scores; however, symptoms persisted despite increase in dosage. Further review of maternal history revealed heavy e-cigarette use during and after pregnancy. Symptoms were noted to worsen when breast milk was limited, raising the possibility of nicotine withdrawal related to fluctuating exposure through breastfeeding. Elevated urine cotinine level in the neonate helped to support this theory. This case highlights the potential for neonatal nicotine withdrawal and the importance of routine maternal screening for all forms of nicotine use during pregnancy and lactation. Clinicians should maintain a high index of suspicion for nicotine exposure in neonates presenting with NAS-like symptoms. Increased awareness and further research are essential to help guide management strategies and avoid mismanagement of non-opioid withdrawal syndromes.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"445-448"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare-associated Candida infections in neonates: A clinical perspective on risk and outcome.","authors":"Berfin Özgökçe Özmen, Merve Türkegün Şengül, Suna Özdem, Şefika Aldaş, Mustafa Akçalı, Hüseyin Şimşek","doi":"10.1177/19345798251405208","DOIUrl":"10.1177/19345798251405208","url":null,"abstract":"<p><p>ObjectiveHealthcare-associated infections (HAIs) remain a major cause of morbidity and mortality in neonatal intensive care units (NICUs), particularly in preterm and low birth weight infants. Candida species are among the most frequently isolated fungal pathogens in this vulnerable population.Study DesignThis retrospective study was conducted in a tertiary NICU in Turkey between January 1, 2015, and December 31, 2023. Daily active surveillance was used to detect HAIs. Neonates with Candida-positive blood cultures were identified. Demographic characteristics, clinical risk factors, laboratory findings, and treatment outcomes were analyzed.ResultsAmong 9065 neonates admitted to the NICU during the 9-year study period, 26 (0.28%) developed Candida bloodstream infections. The majority of affected infants were premature (84.6%) and had a birth weight ≤2500 g (80%), with 30.8% weighing <1000 g. Predisposing risk factors included: central venous catheter use (92.3%), total parenteral nutrition (96.2%), and exposure to broad-spectrum antibiotics (88.4%). The most frequently isolated species were <i>Candida parapsilosis</i> (46.2%) and <i>Candida albicans</i> (42.3%), while fluconazole resistance was detected in 15.4% of isolates. The overall mortality rate was 38.5%. The median hospital stay was 14.5 days.Conclusions<i>Candida bloodstream</i> infections are a serious complication in NICUs, particularly among extremely low birth weight and premature infants. Invasive procedures and parenteral nutrition remain major risk factors. The observed high mortality rate and resistance patterns underscore the need for enhanced infection control measures and antifungal stewardship programs in NICUs.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"381-387"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145661400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}