Journal of neonatal-perinatal medicine最新文献_第8页

Perinatal palliative care in an infant with exencephaly: Supporting life beyond 3 years of age. 新生儿畸形的围产期姑息治疗：支持3岁以上的生命。

Journal of neonatal-perinatal medicine Pub Date : 2025-06-17 DOI: 10.1177/19345798251351003

G Bayo Varão, E Parravicini, A Aziz, S Brady

引用次数: 0

Correlation of cardiac troponin T levels with inotrope requirements, HIE stages and outcome in asphyxiated neonates. 窒息新生儿心肌肌钙蛋白T水平与肌力需要量、HIE分期和结局的相关性

Journal of neonatal-perinatal medicine Pub Date : 2025-06-17 DOI: 10.1177/19345798251350998

Eman Gamal Abdelrahman, Eman Rateb Abd Almonaem, Dina Saad Abdelmotaleb, Mohamed Ahmed AbdelHafiz

{"title":"Correlation of cardiac troponin T levels with inotrope requirements, HIE stages and outcome in asphyxiated neonates.","authors":"Eman Gamal Abdelrahman, Eman Rateb Abd Almonaem, Dina Saad Abdelmotaleb, Mohamed Ahmed AbdelHafiz","doi":"10.1177/19345798251350998","DOIUrl":"https://doi.org/10.1177/19345798251350998","url":null,"abstract":"BackgroundAsphyxial event can compromise the function of many vital organs like brain, heart, and kidneys. Cardiac dysfunction results from hypoxic injury to subendocardial tissue, papillary muscle, and myocardium. The aim of this work was to assess correlation between cardiac troponin T levels, myocardial dysfunction, inotrope requirements, hypoxic ischemic encephalopathy (HIE) stages, and outcome in asphyxiated neonates.MethodsThis cohort study was conducted on 48 neonates aged (1-28) days old, both sexes, exposed to perinatal asphyxia, and admitted in NICU unit in Benha University Hospital during the period from September 2022 to August 2023. Neonates had blood drawn for CBC, liver, kidney functions, and serum troponin T levels. Also, assessment by echocardiography and MRI were done to these patients in the first 3 days.ResultsTroponin T levels were significantly higher in neonates with myocardial dysfunction (systolic or diastolic), who required inotropic support, mechanical ventilation, or who were non-survivors. Troponin T levels significantly correlated with HIE severity, as assessed by Apgar scores and Sarnat staging. ROC curve revealed that cardiac troponin T levels have high accuracy at a cutoff value of >0.18 ng/mL, >0.18 ng/mL, and >0.18 ng/mL, respectively, in detecting myocardial dysfunction, morbidity, and mortality in patients with HIE with reliable sensitivity (84.2%-92.3%) and specificity (88.2%-93.1%).ConclusionsElevated cardiac troponin T is highly suggestive of myocardial dysfunction in cases of HIE. It is significantly correlated to severity of HIE, morbidity, and mortality in asphyxiated neonate.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251350998"},"PeriodicalIF":0.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postnatal trends of surrogate anthropometric indices in infants of diabetic mothers: A prospective cohort study from South India. 糖尿病母亲的婴儿代孕人体测量指数的产后趋势：一项来自南印度的前瞻性队列研究。

Journal of neonatal-perinatal medicine Pub Date : 2025-06-17 DOI: 10.1177/19345798251350992

Kalyani Ainikkara Praful, Sanjana Hansoge Somanath, Vijayan Sharmila, Thirunavukkarasu Arun Babu, Yamini Marimuthu

{"title":"Postnatal trends of surrogate anthropometric indices in infants of diabetic mothers: A prospective cohort study from South India.","authors":"Kalyani Ainikkara Praful, Sanjana Hansoge Somanath, Vijayan Sharmila, Thirunavukkarasu Arun Babu, Yamini Marimuthu","doi":"10.1177/19345798251350992","DOIUrl":"https://doi.org/10.1177/19345798251350992","url":null,"abstract":"BackgroundInfants of diabetic mothers (IDMs) are shown to have predisposition for obesity and metabolic complications in childhood and adolescence. While several studies found growth differences in IDMs during childhood, data on growth in early infancy are scarce. This study aimed to assess the surrogate anthropometric parameters which evaluate physical growth in more detail during first 6 weeks of life in IDMs.MethodsA prospective cohort study was conducted among late preterm and term IDMs with infants of non-diabetic mothers taken as controls. Basic demographics, delivery characteristics, maternal anthropometry and birth anthropometry including auxologic parameters were recorded postnatally. Follow-up measurements were taken till 6 weeks. Statistical analysis was performed using STATA.ResultsIDMs showed higher weight for length at 6 weeks and higher BMI at birth and at 6 weeks of age. MUAC was significant at birth but not at 6 weeks age. Birth weight and large-for-gestational age were significantly higher in diabetic group. At 6 weeks, 14% of infants of diabetic mothers were overweight, though not statistically significant.ConclusionThe IDMs seemed to have significant difference in their auxologic parameters and had greater prevalence of overweight in early postnatal period as early as at 6 weeks postnatal age in this study albeit small sample size. Close monitoring of growth and metabolic parameters in infants of diabetic mothers in larger sample sizes are necessary for better monitoring for complications and better long-term outcomes as their body composition possibly seems to differ from those of IDMs in early infancy.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251350992"},"PeriodicalIF":0.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In-hospital outcomes of early versus late transcatheter closure of patent ductus arteriosus in preterm infants. 早产儿动脉导管未闭早期与晚期经导管闭合的住院结果。

Journal of neonatal-perinatal medicine Pub Date : 2025-06-16 DOI: 10.1177/19345798251350986

Mohamed F Elsisy, George T Nicholson, Elizabeth H Stephens, Gayathri Sreenivasan, Arpit Gupta

{"title":"In-hospital outcomes of early versus late transcatheter closure of patent ductus arteriosus in preterm infants.","authors":"Mohamed F Elsisy, George T Nicholson, Elizabeth H Stephens, Gayathri Sreenivasan, Arpit Gupta","doi":"10.1177/19345798251350986","DOIUrl":"https://doi.org/10.1177/19345798251350986","url":null,"abstract":"BackgroundTranscatheter closure of patent ductus arteriosus (PDA) in small, premature infants is increasingly performed in the contemporary practice. Data regarding optimal timing of PDA closure are scarce. We therefore decided to compare morbidity and mortality of early and late device closure in preterm infants.MethodsHospitalizations of 166,583 newborn infants diagnosed with PDA were identified from the Kids' Inpatient Database (KID) in 2009, 2012, 2016, and 2019. Of these, 299 preterm infants (gestational age (GA) ≤32 weeks, birth weight <1500 grams) underwent percutaneous PDA closure. Characteristics and periprocedural outcomes were compared between early (≤30 days) (n = 120) and late PDA closure (>30 days) (n = 179).ResultsMean age (±standard deviation) for early PDA closure was 18.6 days ± 7 and 67.3 days ± 36.5 in late PDA closure. Comorbidities including respiratory distress syndrome/bronchopulmonary dysplasia, heart failure, and pulmonary hypertension were comparable between the two groups. There was no difference in mortality or referral for surgical ligation between early and late closure. Postprocedural vascular complications were low, but higher in patients with early PDA closure (3.3% vs 0%; p = 0.025). While the total length of hospital stay was longer in late PDA closure group (121.1 days ± 51.7 vs 81.5 days ± 48.8; p = <0.01), postprocedural length of stay was paradoxically longer in the early closure group (69 days ± 43.6 vs 57.5 days ± 43, p = 0.03).ConclusionThere was no statistical difference in in-hospital mortality; however, there is a trend toward higher mortality in the early closure group. Major periprocedural complications are comparable between early and late PDA closure, except vascular complications that were higher with early PDA closure.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251350986"},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative study of individuals born with orofacial clefts in the United States and Brazil. 美国与巴西先天性唇腭裂之比较研究。

Journal of neonatal-perinatal medicine Pub Date : 2025-05-15 DOI: 10.1177/19345798251343829

Adriana M da Silva, V S Freitas, A R Vieira

{"title":"Comparative study of individuals born with orofacial clefts in the United States and Brazil.","authors":"Adriana M da Silva, V S Freitas, A R Vieira","doi":"10.1177/19345798251343829","DOIUrl":"https://doi.org/10.1177/19345798251343829","url":null,"abstract":"BackgroundIn Brazil, little attention has been focused on gestational complications related to orofacial cleft. The objective was to characterize the burden of orofacial clefts in Brazil by comparing the prevalence, risk factors, and birth health conditions of children born with clefts in Brazil and the United States.MethodsThis was a population-based cross-sectional study conducted using national data from 13,297 to 8853 individuals born with orofacial cleft in Brazil and the United States, respectively, between 2017 and 2021. Risk factors (maternal ethnicity, maternal age, infant sex, and plurality) and birth health conditions (number of prenatal care appointments, delivery method, Apgar score at 5 minutes, gestational age, and birthweight) were gathered from national data in both countries. The prevalence of clefts in both countries and prevalence ratios were calculated.ResultsThe prevalence of clefts was 7.1/10,000 in the United States and 6.2/10,000 in Brazil. Newborns with clefts in Brazil were significantly more likely to have a cleft palate (PR = 1.32, p = 0.000), be premature (PR = 1.37, p = 0.000), be born by cesarean section (PR = 1.00, p = 0.000), and have low birth weight (PR = 1.49, p = 0.000). Their mothers tended to be older (PR = 1.09, p = 0.001), non-white (PR = 0.48, p = 0.000), and had fewer than 10 prenatal care appointments (PR = 2.14, p = 0.000), compared to the United States cohort.ConclusionThe frequency of risk factors and adverse outcomes associated with being born with clefts was higher in the Brazilian cohort, suggesting that social determinants of health play a significant role in increasing individuals' susceptibility to risk factors for clefts and poor birth health conditions.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251343829"},"PeriodicalIF":0.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Observed hepatic dysfunction following diazoxide administration in a neonate with liver impairment: A case report. 观察到二氮氧化合物给药后肝功能障碍新生儿肝损害：1例报告。

Journal of neonatal-perinatal medicine Pub Date : 2025-05-01 Epub Date: 2025-03-18 DOI: 10.1177/19345798251327371

Hani Ajrina Zulkeflee, Nur Atiqah Zulkefli, Aliyyah Mohammad Khuzaini

{"title":"Observed hepatic dysfunction following diazoxide administration in a neonate with liver impairment: A case report.","authors":"Hani Ajrina Zulkeflee, Nur Atiqah Zulkefli, Aliyyah Mohammad Khuzaini","doi":"10.1177/19345798251327371","DOIUrl":"10.1177/19345798251327371","url":null,"abstract":"Diazoxide is commonly used to treat neonatal hypoglycaemia when first-line treatment fails by inhibiting insulin secretion. We present a case of a full-term female infant with refractory hypoglycaemia who developed elevated liver enzymes and worsening jaundice following diazoxide administration. After discontinuation of diazoxide, her liver enzyme levels rapidly improved. Although liver impairment has not been commonly reported as a side effect of diazoxide, previous reports, such as one by Tas et al. in 2015, have documented similar findings in patients with hypoalbuminemia, where altered drug metabolism may play a role. Diazoxide undergoes metabolism in the liver, raising the possibility that preexisting liver impairment could affect its clearance and potentially exacerbate hepatic dysfunction. These observations suggest that careful consideration is required when using diazoxide in neonates with compromised liver function. Further studies are needed to explore the mechanisms that may contribute to this association and to establish guidelines for its use in this vulnerable population. This case challenges the conventional understanding of diazoxide as a safe intervention for neonatal hypoglycaemia. Additional research is required to elucidate the mechanisms leading to hepatotoxicity and to establish clear guidelines for the use of diazoxide in this vulnerable population.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"274-278"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Implications of maternal health status on term and close to term neonates in a socioeconomically high-risk population. 产妇健康状况对社会经济高危人群足月和接近足月新生儿的影响

Journal of neonatal-perinatal medicine Pub Date : 2025-05-01 Epub Date: 2025-03-01 DOI: 10.1177/19345798251324450

Rita P Verma, Neeti Luke, Joshua Fogel

{"title":"Implications of maternal health status on term and close to term neonates in a socioeconomically high-risk population.","authors":"Rita P Verma, Neeti Luke, Joshua Fogel","doi":"10.1177/19345798251324450","DOIUrl":"10.1177/19345798251324450","url":null,"abstract":"ObjectiveTo investigate maternal morbidities and their implications on term neonates in a socioeconomically underprivileged population.MethodsIn a retrospective population-based study, maternal morbidities were associated with neonatal birth weight (BW), gestational age (GA), Apgar scores, respiratory distress (RD), admission to Neonatal intensive care nursery (NICU), feeding difficulties, and the length of hospital stay (LOS) in infants admitted to the level 1 nursery via multivariate regression analyses.ResultsIn the 508 mother-infant pairs, 61.4% were Hispanic, 18.4% were African American, 9.6% were non-Hispanic white, and 10.6 % were Asian/Pacific islanders. 8.7% of the neonates [GA 38.63 (1.3) weeks and BW 3196.3 (574.6) g] had Apgar scores <7 at 1 and 2.2% at 5 minutes of life. The prevalence of maternal hypertension (8.5%), Preeclampsia-eclampsia (10.1%), Apgar scores <7 (8.7, 2.2 % at 1 and 5 minutes), NICU admission (20.4%), and feeding difficulty (7.5%) were higher than reported. Mean LOS at 4.29 days was higher than documented in term infants. Apgar scores were associated with eclampsia/preeclampsia, C-section, and antepartum hemorrhage; NICU admission with chorioamnionitis, C-section, and substance abuse; feeding difficulties with maternal alcohol consumption; and longer LOS with preeclampsia/eclampsia, chorioamnionitis, C-section, and tobacco abuse. Maternal hematocrit had positive associations with BW and GA and negative associations with LOS, feeding difficulties, and NICU admission rates.ConclusionsIn the underprivileged multiethnic maternal-neonatal population, term neonates exhibited low-intensity complications attributable to adverse maternal conditions. Optimizing maternal hematocrit may improve neonatal birth weight and maturational status and decrease adverse outcomes.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"211-217"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends and racial differences in hypoxic ischemic encephalopathy-related mortality in newborns in the United States, 2007-2022. 2007-2022年美国新生儿缺氧缺血性脑病相关死亡率的趋势和种族差异

Journal of neonatal-perinatal medicine Pub Date : 2025-05-01 Epub Date: 2025-03-04 DOI: 10.1177/19345798251325496

Hannah Pulido, Fredrick Dapaah-Siakwan

{"title":"Trends and racial differences in hypoxic ischemic encephalopathy-related mortality in newborns in the United States, 2007-2022.","authors":"Hannah Pulido, Fredrick Dapaah-Siakwan","doi":"10.1177/19345798251325496","DOIUrl":"https://doi.org/10.1177/19345798251325496","url":null,"abstract":"BackgroundHypoxic ischemic encephalopathy (HIE) is a significant cause of morbidity and mortality. However, the changes in HIE-related mortality and its associated racial differences, if any, have not been extensively studied. We examined the population-based temporal trends and any racial differences in the HIE-related infant mortality rate (HIE-IMR) in the United States from 2007 through 2022.MethodsThis was a retrospective cross-sectional analysis of linked birth and infant death records data from the CDC WONDER from 2007-2022. We evaluated all infants born at ≥35 weeks gestational age (GA) who died within the first year of life with HIE (ICD-10 codes P91.6 and P21) as the underlying cause of death. The exposure was the year of death, and the outcomes were the changes in overall HIE-IMR and then stratified by race. HIE-IMR was calculated as per 100,000 live births. Linear regression was used for trend analysis.ResultsAmong 59,117,761 live births, 3998 infants with GA ≥ 35 weeks died from HIE (6.7 per 100,000). The overall HIE-IMR increased significantly from 5.2 to 9.6 per 100,000 (p < .001). The rate increased significantly in White (5.3 to 7.2; p < .001) and Black (5.2 to 8.1; p = .005) infants. The overall HIE-IMR was significantly higher in Black infants (7.3) than in White infants (7.2) [p = .02].ConclusionThe HIE-IMR rate increased significantly, and the rate was higher in Black than in White infants. The drivers behind these changes require further examination in future studies.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":"18 3","pages":"270-273"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An investigation into the history of maternal risk factors in the incidence of perinatal mortality. 围产儿死亡率发生的孕产妇危险因素调查。

Journal of neonatal-perinatal medicine Pub Date : 2025-05-01 Epub Date: 2025-04-24 DOI: 10.1177/19345798251324441

Maryam Zakerihamidi, Hassan Boskabadi

{"title":"An investigation into the history of maternal risk factors in the incidence of perinatal mortality.","authors":"Maryam Zakerihamidi, Hassan Boskabadi","doi":"10.1177/19345798251324441","DOIUrl":"https://doi.org/10.1177/19345798251324441","url":null,"abstract":"ObjectivesThe rate of perinatal mortality is an important indicator of maternal and neonatal health. Identification of risk factors for perinatal mortality may be effective in its prevention. Accordingly, this study aimed to identify maternal risk factors of perinatal mortality.MethodsA cross-sectional study was conducted on 547 stillbirths and 709 neonatal deaths at Ghaem Hospital of Mashhad, Iran, during 2008-2019. The data were collected using a researcher-made questionnaire in two parts of stillbirth (maternal diseases, main complication, and final diagnosis) and specifications of neonatal death (e.g., gender, length of hospitalization, age, first and fifth minute Apgar scores, gestational age, weight, resuscitation, mode of delivery, preterm rupture of membranes, main cause of death, and maternal diseases). Data analysis was performed by T-test and Chi-square tests using SPSS version 21 (V.21).ResultsOverall, 222 mothers (41%) had stillborn fetus and 325 (77%) with neonatal death had maternal risk factors. The 41% of neonatal deaths and 26% of stillbirths were along with maternal hypertension, 33% of neonatal deaths and 25% of stillbirths were along with maternal preeclampsia, and 9% of neonatal deaths and 12% of stillbirths were along with maternal diabetes. The cases of cesarean and neonatal resuscitation were higher in neonates with maternal risk factors (69% and 58%, respectively) than those with mothers who had no problem (43% and 32%, respectively).ConclusionHypertension, preeclampsia, and diabetes were three important diseases during pregnancy, associated with high stillbirths and neonatal deaths. Neonates of mothers with problem were pretermer or less birth weight and had more problems during delivery and died earlier.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":"18 3","pages":"203-210"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare yet preventable complication of lower extremity PICC malposition in an extreme preterm: Implications for enhanced procedural imaging standards. 一种罕见但可预防的极端早产下肢PICC错位并发症：提高程序成像标准的意义。

Journal of neonatal-perinatal medicine Pub Date : 2025-05-01 Epub Date: 2025-03-14 DOI: 10.1177/19345798251327379

Manal Mouhssine, Aimen Ben Ayad, Aiman Rahmani

引用次数: 0