Journal of neonatal-perinatal medicine最新文献_第7页

Evaluation of systemic inflammatory indices in the diagnosis of early onset neonatal sepsis in very low birth weight infants. 在诊断极低出生体重儿早发新生儿败血症时评估全身炎症指数。

Journal of neonatal-perinatal medicine Pub Date : 2024-04-06 DOI: 10.3233/npm-230174

U. Cakir, C. Tayman

{"title":"Evaluation of systemic inflammatory indices in the diagnosis of early onset neonatal sepsis in very low birth weight infants.","authors":"U. Cakir, C. Tayman","doi":"10.3233/npm-230174","DOIUrl":"https://doi.org/10.3233/npm-230174","url":null,"abstract":"BACKGROUND\u0000Previously, not six systemic inflammatory indices were evaluated in the diagnosis of early onset sepsis (EOS) in very low birth weight (VLBW, <1500g) premature infants.\u0000\u0000\u0000OBJECTIVES\u0000We evaluated the effectiveness of systemic inflammatory indices in the diagnosis of EOS in VLBW infants.\u0000\u0000\u0000METHODS\u0000Premature infants with birth weight <1500 g were included in the study. Six systemic inflammatory indices including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), pan-immune-inflammation value (PIV), and systemic inflammation response index (SIRI) were compared in patients with EOS (treatment group) and without EOS (control group).\u0000\u0000\u0000RESULTS\u0000Of 917 infants enrolled, 204 infants were in the EOS group and 713 infants comprised the control group. NLR, MLR and SIRI values were significantly higher in the EOS group than in the control group (p < 0.001). The AUC value of SIRI for the predictivity of EOS was 0.803.\u0000\u0000\u0000CONCLUSIONS\u0000The SIRI can be used together with other parameters as both an easily accessible and the reliable systemic inflammatory indices in the diagnosis of EOS in VLBW preterm infants.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":"30 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140734629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heart rate and oxygen saturation patterns in very low birth weight infants with early onset sepsis and histologic chorioamnionitis. 患有早发型败血症和组织学绒毛膜羊膜炎的极低出生体重儿的心率和血氧饱和度模式。

Journal of neonatal-perinatal medicine Pub Date : 2024-04-02 DOI: 10.3233/npm-230093

Charlene R. Bultmann, Jiaxang Qiu, Briana Belmonte, Karen D Fairchild, B. Sullivan

{"title":"Heart rate and oxygen saturation patterns in very low birth weight infants with early onset sepsis and histologic chorioamnionitis.","authors":"Charlene R. Bultmann, Jiaxang Qiu, Briana Belmonte, Karen D Fairchild, B. Sullivan","doi":"10.3233/npm-230093","DOIUrl":"https://doi.org/10.3233/npm-230093","url":null,"abstract":"BACKGROUND\u0000Chorioamnionitis and early onset sepsis (EOS) in very low birth weight (VLBW,< 1500 g) infants may cause a systemic inflammatory response reflected in patterns of heart rate (HR) and oxygenation measured by pulse oximetry (SpO2). Identification of these patterns might inform decisions about duration of antibiotic therapy after birth.\u0000\u0000\u0000OBJECTIVE\u0000Compare early HR and SpO2 patterns in VLBW infants with or without early onset sepsis (EOS) or histologic chorioamnionitis (HC).\u0000\u0000\u0000STUDY DESIGN\u0000Retrospective study of placental pathology and HR and SpO2 in the first 72 h from birth in relation to EOS status for inborn VLBW NICU patients 2012-2019.\u0000\u0000\u0000RESULT\u0000Among 362 VLBW infants with HR and SpO2 data available, clinical, or culture-positive EOS occurred in 91/362 (25%) and HC in 81/355 (22%). In univariate analysis, EOS was associated with higher mean HR, lower mean SpO2, and less negative skewness of HR in the first 3 days after birth. HC was associated with higher standard deviation and skewness of HR but no difference in SpO2. In multivariable modeling, significant risk factors for EOS were mean HR, gestational age, HC, mean SpO2, and skewness of SpO2.\u0000\u0000\u0000CONCLUSION\u0000HR and SpO2 patterns differ shortly after birth in VLBW infants exposed to HC or with EOS, likely reflecting a systemic inflammatory response.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140754191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk factors for postoperative complications in preterm infants with surgical necrotizing enterocolitis and associated outcomes 早产儿手术坏死性小肠结肠炎术后并发症的风险因素及相关结果

Journal of neonatal-perinatal medicine Pub Date : 2024-01-08 DOI: 10.3233/npm-230076

P. Garg, R. Riddick, M.A.Y. Ansari, I. Pittman, M. R. Ladd, P. Porcelli, P. M. Garg

{"title":"Risk factors for postoperative complications in preterm infants with surgical necrotizing enterocolitis and associated outcomes","authors":"P. Garg, R. Riddick, M.A.Y. Ansari, I. Pittman, M. R. Ladd, P. Porcelli, P. M. Garg","doi":"10.3233/npm-230076","DOIUrl":"https://doi.org/10.3233/npm-230076","url":null,"abstract":"BACKGROUND: We aim to determine clinical risk factors for postoperative complications in preterm infants with surgical necrotizing enterocolitis (NEC) or spontaneous intestinal perforation (SIP). METHODS: A retrospective cohort study of preterm infants with surgical NEC or SIP to compare clinical factors between those with and without postoperative complications. RESULTS: 78/109 (71.5%) infants had any complication following surgical NEC. Adhesions (20/35, 57.1%) and wound infection (6/35, 17.1%) were the most common single surgical complications. Patients with a single surgical complication (35/66, 53%) were significantly less likely to be exposed to antenatal steroids, more frequently had a jejunostomy, needed a central line longer, and had a longer length of stay than those without any surgical complication. Infants with > 1 surgical complication (43/71, 60.5%) included mainly females, and had AKI more frequently at NEC onset, lower weight z-scores and lower weight for length z- scores at 36 weeks PMA than those without any complications. On multinomial logistic regression, antenatal steroids exposure (OR 0.23 [CI 0.06, 0.84]; p = 0.027) was independently associated with lower risk and jejunostomy 4.81 (1.29, 17.9) was independently associated with higher risk of developing a single complication. AKI following disease onset (OR 5.33 (1.38, 20.6), P = 0.015) was independently associated with > 1 complication in surgical NEC/SIP infants. CONCLUSION: Infants with postoperative complications following surgical NEC were more likely to be female, have additional morbidities, and demonstrate growth failure at 36 weeks PMA than those without surgical complications. There was no difference in mortality between those with and without surgical complications.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":"5 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139445392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The HeRO score: Enhancing prognosis and predicting nosocomial infections in newborns – insights from the neonatal intensive care unit HeRO 评分：加强预后和预测新生儿院内感染--来自新生儿重症监护室的启示

Journal of neonatal-perinatal medicine Pub Date : 2024-01-06 DOI: 10.3233/npm-230060

F. Bennaoui, A. Lalaoui, N. Slitine, Nabila Soraa, F. Maoulainine

{"title":"The HeRO score: Enhancing prognosis and predicting nosocomial infections in newborns – insights from the neonatal intensive care unit","authors":"F. Bennaoui, A. Lalaoui, N. Slitine, Nabila Soraa, F. Maoulainine","doi":"10.3233/npm-230060","DOIUrl":"https://doi.org/10.3233/npm-230060","url":null,"abstract":"BACKGROUND: Nosocomial infections pose a significant health risk to neonates, and traditional biomarkers used for diagnosis often fall short in predicting such infections. In this study, we evaluate the efficacy of the HeRO (Heart Rate Observation score), a novel predictive tool for late-onset neonatal sepsis, in improving neonatal prognosis and reducing morbidity and mortality rates. METHODS: A prospective study was conducted from September 2020 to May 2021, reviewing patient evaluation for all neonates admitted to the neonatal intensive care unit during this period after the implementation of the HeRO score. RESULTS: Of the 100 cases studied, preterm neonates accounted for the majority (51%), with 65% being born at gestational age greater than 32 weeks and 35% born at less than 32 weeks. A male-to-female sex ratio of 1.56. Perinatal asphyxia was the primary reason for initial hospitalization, often accompanied by pulmonary neonatal infection. The HeRO score showed an increase within 24 hours of the onset of clinical signs of sepsis in 52% of cases and after 24 hours in 47% of cases. In 51% of cases, the score exhibited an increase greater than 2. Blood cultures were positive in 91% of cases. The duration of hospital stays for newborns ranged from 7 to 42 days, with an average stay for newborns whose score rose 24 hours before clinical signs. CONCLUSION: This study highlights the significance of utilizing the HeRO score for predicting nosocomial infections in neonates, despite the possibility of false assumptions. Implementing the HERO score enables early intervention, thereby improving the assumption of responsibility and reducing neonatal morbidity and mortality rates.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":"51 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139449460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fetal circular shunt in Ebstein’s anomaly and non-steroidal anti-inflammatory treatment 埃布斯坦氏畸形的胎儿环形分流与非类固醇抗炎治疗

Journal of neonatal-perinatal medicine Pub Date : 2024-01-06 DOI: 10.3233/npm-230040

F.L. Peña, T.W. Emanuelson, S.H. Todman, R.C. Jones, S. Mahajan

引用次数: 0

Ventilation practices in the neonatal intensive care units in Saudi Arabia, survey of the utilization of volume-targeted ventilation among practicing neonatologists. 沙特阿拉伯新生儿重症监护室的通气实践，对执业新生儿科医生使用容量目标通气的调查。

Journal of neonatal-perinatal medicine Pub Date : 2024-01-01 DOI: 10.3233/NPM-240054

M Al Qurashi, A Al Qahtani, M Al Hindi, A Mustafa, A Ahmed, S S Aga, A Al Khotani, H Kandil, J Alallah, A Sallam

{"title":"Ventilation practices in the neonatal intensive care units in Saudi Arabia, survey of the utilization of volume-targeted ventilation among practicing neonatologists.","authors":"M Al Qurashi, A Al Qahtani, M Al Hindi, A Mustafa, A Ahmed, S S Aga, A Al Khotani, H Kandil, J Alallah, A Sallam","doi":"10.3233/NPM-240054","DOIUrl":"10.3233/NPM-240054","url":null,"abstract":"Objective: To assess the current practice in using volume-targeted ventilation among neonatologists working at the Neonatal Intensive Care Units (NICU) of Saudi Arabia.Methods: The questionnaire was provided electronically to 153 practicing Neonatologists working in 39 NICUs. The survey's results were received and statistically analyzed.Results: One hundred nineteen (119) responses were received with, a 78% response rate. Volume Targeted Ventilation (VTV) was used routinely by 67.2%, whereas 21.8% still use only pressure control (PC)/pressure limited (PL) mode. During the acute phase of ventilation support, Assist Control was the most popular synchronized mode, whereas Synchronized Intermittent Mandatory Ventilation (SIMV) with pressure support (PS) or PSV were the two most common modes during the weaning phase, 31.8%, and 31% respectively. The majority of the neonatologists used a tidal volume of 4 ml/kg as the lowest and 6 ml/kg as the highest. The major reasons for not implementing VTV were the limited availability of ventilator devices that have an option of VTV, followed by lack of experience.Conclusion: VTV is the predominant ventilation practice approach among neonatologists working in the KSA. Limited availability and lack of experience in using are the main challenges. Efforts to equip NICUs with the most advanced ventilation technology, enhance practitioners' experience and sufficient training in its use are warranted.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"653-660"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141321010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors determining outcome of tactile kinesthetic stimulation in preterm neonates. 早产新生儿触觉动觉刺激效果的决定因素。

Journal of neonatal-perinatal medicine Pub Date : 2024-01-01 DOI: 10.3233/NPM-240018

E V N Akshitha, B Choubey, J Shrivastava

{"title":"Factors determining outcome of tactile kinesthetic stimulation in preterm neonates.","authors":"E V N Akshitha, B Choubey, J Shrivastava","doi":"10.3233/NPM-240018","DOIUrl":"10.3233/NPM-240018","url":null,"abstract":"Background: Tactile kinesthetic stimulation (TKS) has been the subject of clinical research since the 1960 s, when it was proposed as a way to promote preterm growth and development.Objective: To find out the effect of TKS on weight gain in preterm neonates and the factors affecting TKS in relation to outcome.Methods: TKS was demonstrated to mothers in department of paediatrics. 124 Preterm neonates fulfilling inclusion criteria were enrolled. The time for which they are doing TKS was noted. Their weight was monitored daily by digital weighing scale till discharge and at one month of age and then average weight gain was calculated and correlated with various factors.Results: There is a significant increase in weight of neonates at discharge (1.73 kg; p < 0.001) and at one month (1.96 kg; p < 0.001) when compared to enrollment (1.686 kg). There was a significant positive correlation between TKS session duration and mean weight change at 1 month follow up (r = 0.269; P = 0.003) and per day weight gain (r = 0.889; p < 0.001), as well as a positive correlation between average TKS session and weight gain when pearson correlation was performed. TKS sessions of 15 minutes or three sessions per day were effective in increasing the weight of preterm neonates. It was noticed that those who received three sessions per day had a shorter hospital stay (7.68 days) than two sessions per day (10.23 days). The education level of the mother, care giver, type of feed, and gender of the preterm have no significant effect on weight gain.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"519-526"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141731219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of maternal 25 (OH) vitamin D levels between premature infants with/without asphyxia. 有/无窒息的早产儿母体 25 (OH) 维生素 D 水平的比较。

Journal of neonatal-perinatal medicine Pub Date : 2024-01-01 DOI: 10.3233/NPM-230229

M Zakerihamidi, F Rakhshanizadeh, A Moradi, H Boskabadi

{"title":"Comparison of maternal 25 (OH) vitamin D levels between premature infants with/without asphyxia.","authors":"M Zakerihamidi, F Rakhshanizadeh, A Moradi, H Boskabadi","doi":"10.3233/NPM-230229","DOIUrl":"10.3233/NPM-230229","url":null,"abstract":"Objectives: Perinatal asphyxia is the main risk factor for mortality and morbidity in neonates and neurological disorders in survived infants. We compared the neonatal and maternal 25 (OH) vitamin D levels in neonates with/without asphyxia.Materials and methods: This cross-sectional research was done on 229 neonates (including 158 neonates [69%] without asphyxia [control group] and 71 neonates [31%] with asphyxia [case group]) from 2020 to 2023 using the available sampling method. 25 (OH) Vit D levels in mothers and neonates were assessed and compared in the 2 groups. The data collection instrument was a researcher-made checklist, containing the maternal and neonatal characteristics and laboratory evaluations. Data were analyzed by SPSS 23 using the t-test.Results: The mean maternal 25 (OH) Vit D levels in the case and control groups were 16.34±11.87 and 22.80±12.67 ng/mL, respectively. The mean neonatal 25 (OH) Vit D levels in the case and control groups were respectively 12.13±8.62 and 19.55±11.62 ng/mL (P = 0.002). The case group showed severer maternal and neonatal 25 (OH) Vit D deficiency (P = 0.000) compared to the control group.Conclusions: Neonatal and maternal 25 (OH) Vit D deficiency can increase the risk of perinatal asphyxia. Therefore, administration of 25 (OH) Vit D supplements to pregnant mothers may reduce the incidence of asphyxia.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"583-588"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141437029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive values and correlation of CRIB Score II and perfusion index in assessment of severity of illness in sick preterm neonates: An observational study. CRIB 评分 II 和灌注指数在评估患病早产新生儿病情严重程度中的预测值和相关性：一项观察性研究。

Journal of neonatal-perinatal medicine Pub Date : 2024-01-01 DOI: 10.3233/NPM-240084

D Kumar, D Kumar, U Irfan, Y S Yadav, R K Yadav, V Kanti, P Sharma, S K Shukla

{"title":"Predictive values and correlation of CRIB Score II and perfusion index in assessment of severity of illness in sick preterm neonates: An observational study.","authors":"D Kumar, D Kumar, U Irfan, Y S Yadav, R K Yadav, V Kanti, P Sharma, S K Shukla","doi":"10.3233/NPM-240084","DOIUrl":"10.3233/NPM-240084","url":null,"abstract":"Background: Perfusion index (PI) and CRIB (Clinical risk index of babies) Score II both are minimally invasive tools for prediction of mortality and morbidity in sick neonates. This study aims to know the predictive values of both PI and CRIB Score II in assessment of severity of illness in preterm neonates of 28 to 32 weeks and their correlation.Methods: PI and CRIB II Score of 125 sick preterm neonates admitted in NICU were assessed within 12 hours of admission. Severity noted in form of outcome. Correlation between PI and CRIB Score II were observed.Results: Receiver operating characteristic (ROC) curve were plotted for PI and CIRB Score II with outcome (discharged vs expired). Area under curve for perfusion index was 0.776 at 95% confidence interval. Optimum cutoff point based on ROC curve was 1.65 with sensitivity of 84%., specificity of 37.2% with positive predictive value of 70% and negative predictive value of 57%. Area under curve for CRIB Score II was 0.622 (p value < 0.028), optimum cut off point based on ROC curve for CRIB II score was 3.5 with sensitivity 79.10% of specificity of 40% positive predictive value is 43.03% and negative predictive value of 76.9%. Spearman's correlation coefficient between PI and CRIB II score was -0.272 and p value is 0.002.Conclusion: This study concluded that perfusion index (p < 0.001) is better for predicting the severity compared to CRIB II score (p < 0.028). A weak negative correlation exists between PI and CRIB II score (r = -0.272).","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"723-730"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Placental pathology in SARS-CoV-2 infected pregnancies: A single-institution retrospective cohort analysis. 感染 SARS-CoV-2 孕妇的胎盘病理学：单一机构的回顾性队列分析。

Journal of neonatal-perinatal medicine Pub Date : 2024-01-01 DOI: 10.3233/NPM-230177

T Le, D Lee, L S Brown, B W Payton, P Sepulveda, J Sisman, R L Leon, L F Chalak, I N Mir

{"title":"Placental pathology in SARS-CoV-2 infected pregnancies: A single-institution retrospective cohort analysis.","authors":"T Le, D Lee, L S Brown, B W Payton, P Sepulveda, J Sisman, R L Leon, L F Chalak, I N Mir","doi":"10.3233/NPM-230177","DOIUrl":"https://doi.org/10.3233/NPM-230177","url":null,"abstract":"Background: Our objectives were to determine 1) the prevalence and description of placental pathologic lesions in pregnancies complicated by SARS-CoV-2 infection compared to healthy controls and 2) whether the prevalence and/ or pattern of placental pathologic lesions differed in the few neonates who tested positive for SARS-CoV-2 in the first 48 hours of life at a busy urban county hospital.Methods: This study included all pregnant mothers who tested positive for SARS-CoV-2 and delivered at our institution from March 2020 to June 2021, while control placentas were collected from term pregnancies without complications.Results: Approximately 90% (n = 380/425) of placentas from pregnancies complicated by SARS-CoV-2 infections had placental pathologic lesions, compared to 32% (n = 16/50) of controls. The predominant lesions were acute histologic chorioamnionitis with or without fetal response (n = 209/380, 55%), maternal vascular malperfusion (n = 180/380, 47%), and other inflammatory lesions (n = 148/380, 39%). Only 14 (2.5%) infants tested positive for SARS-CoV-2 within the first 48 hours of life. There were no significant differences in placental histopathology between infants who tested positive vs. those that were negative for SARS-CoV-2. Placental lesions in mothers who tested positive for SARS-CoV-2 during the first vs. second vs. third pregnancy trimesters, were significantly different in the incidence of inflammatory placental pathologic lesions (n = 9/19, 53% vs. n = 37/98, 49% vs. n = 102/439, 31%, respectively; p < 0.01).Conclusion: A significant proportion of women with SARS-CoV-2 infection during pregnancy at a single county hospital have inflammatory and vascular placental lesions at birth, raising questions regarding their downstream effects and clinical consequences.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":"17 5","pages":"623-636"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0