Journal of neonatal-perinatal medicine最新文献

{"title":"Feeding practices for infants with gastroschisis: A survey of neonatal intensive care units in Canada.","authors":"Hareshan Suntharalingam, Daniel Briatico, Nathalie Carey, Ali McBryde, Erik Skarsgard, Esther Huisman, Michael H Livingston","doi":"10.1177/19345798251327370","DOIUrl":"10.1177/19345798251327370","url":null,"abstract":"<p><p>BackgroundFeeding practices for infants with gastroschisis are often based on institutional protocols, clinician judgement, and usual practice. The purpose of this study was to describe the range of feeding practices used in neonatal intensive care units across Canada.MethodsWe developed an 18-item survey with open-ended questions focused on feeding and nutrition among infants with gastroschisis. Clinicians from neonatal intensive care units that manage infants with gastroschisis were invited to participate. Interviews were completed via virtual meeting or email. Data were analyzed using descriptive statistics.ResultsSemi-structured interviews were conducted with 14 of 17 centers (82% response rate). Participants included neonatologists (12/14 centers) and dieticians (10/14 centers). Pediatric surgeons from 3/14 centers participated at the request of neonatologists. None of the centers reported using a gastroschisis feeding protocol routinely, although two centers noted occasional use of a protocol from another hospital, and another indicated that a gastroschisis feeding protocol is in development. All centers reported that patients with gastroschisis qualify for donor human milk if maternal breast milk is unavailable. Routine use of sham feeding, contrast studies, rectal irrigations, or motility agents was not reported. There was variation between centers regarding feeding advancement, type of formula used if breast milk is unavailable, use of probiotics, and strategies to introduce breastfeeding.ConclusionThere is variation in some but not all aspects of enteral feeding among infants with gastroschisis at neonatal intensive care units in Canada. The development of institutional feeding protocols and clinical practice guidelines may help standardize practice.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"312-320"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of COVID-19 on maternal mental health and social support in the postpartum period: A case-control study.","authors":"Khaoula Khemakhem, Chiraz Regaieg, Khadija Chiha, Maryam Chaabane, Amira Bouraoui, Donia Ben Touhemi, Nedia Hamida, Yousr Moalla","doi":"10.1177/19345798251354969","DOIUrl":"https://doi.org/10.1177/19345798251354969","url":null,"abstract":"<p><p>BackgroundThe main objectives of this study were to assess depression, fear of COVID-19, and perceived social support in postpartum mothers during both groups during the COVID-19 pandemic and to study their impact on the psychological state of affected mothers and their perception of social support.Study designThis was a case-control, and analytical cohort study spanning 2021, including mothers with and without COVID-19 in the perinatal period.ResultsA sample of 140 mothers was included (73 tested COVID-19 positive, and 67 tested COVID-19 negative). The prevalence of postpartum depression was 90.40% among mothers with COVID-19 against 77.60% in the control group (<i>p</i> = 0.002). The mean score of fear of COVID-19 was comparable between the two groups. The affected mothers perceived less entourage availability (<i>p</i> = 0.001), while the satisfaction feeling was almost the same.ConclusionThe implementation of mental health services in maternal and child health units can help to provide psychological support and reduce the symptoms of psychological distress in mothers.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251354969"},"PeriodicalIF":0.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Right atrial thrombus in neonates following hyperosmolar glucose infusion: A case series.","authors":"Prakash Duraisamy, Anand Nandakumar, Harikrishnan Kelamangalam NeelakantaKurup, Aswathy Rahul, Radhika Sujatha, Aishwarya Venugopal, Anupriya Ayshabai Vijayan, Meghna Nema","doi":"10.1177/19345798251354970","DOIUrl":"https://doi.org/10.1177/19345798251354970","url":null,"abstract":"<p><p>BackgroundCardiac thrombus in neonates is an uncommon but life-threatening condition that may result in significant morbidity and mortality. Factors such as invasive procedures, metabolic disturbances, and the use of high-osmolarity fluids can contribute to thrombus formation, particularly in critically ill neonates. This case series aims to highlight the clinical characteristics, potential risk factors, and outcomes of right atrial thrombus in neonates, with particular emphasis on the role of high-concentration glucose infusions administered through umbilical venous catheters.MethodsThis is a retrospective case series of five neonates who developed right atrial thrombus between January 2022 and December 2024.ResultsAll five neonates have a history of receiving high-concentration glucose infusions via umbilical venous catheters for hyperinsulinemic hypoglycemia before the development of right atrial thrombus. Unexplained tachycardia prompted the diagnosis, with echocardiography revealing thrombi. Three of them were successfully treated with anticoagulation, while the other two babies unfortunately succumbed to complications despite intensive treatment.ConclusionLarge cardiac thrombus in neonates leads to high mortality due to the risk of embolization and sepsis. High-concentration glucose infusion via umbilical venous catheter is a potential risk factor for cardiac thrombus formation in neonates. Early detection and appropriate intervention, including anticoagulation and thrombolysis, are crucial for preventing further complications and improving survival rates.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251354970"},"PeriodicalIF":0.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct microbiota profiles in non-survivors in preterm infants with surgical necrotizing enterocolitis: Insights from FFPE intestinal tissue analysis.","authors":"Pengbo Zhang, Padma P Garg, Liang Liu, Wei Zhang, Kylie Kavanagh, Avinash Shetty, Tim Howard, Neha Varshney, David Sawaya, Greg Hawkins, Drew J Schwartz, Parvesh Mohan Garg","doi":"10.1177/19345798251353777","DOIUrl":"10.1177/19345798251353777","url":null,"abstract":"<p><p>BackgroundThe variant microbiome is associated with necrotizing enterocolitis (NEC). We aimed to analyze remnant formalin fixed paraffin-embedded (FFPE) intestine tissue for microbiome profiling in preterm infants with surgical NEC.MethodsWe analyzed FFPE small intestine tissues from 16 infants with NEC (8 survivors and 8 non-survivors). Extracted DNA from FFPE tissue blocks underwent 16S rRNA sequencing. We compared the microbiota profiles in survivors and non-survivors. Alpha- and beta diversity metrics were calculated using QIIME2. To assess differences in overall microbial community structure, we performed a Permutational Multivariate Analysis of Variance (PERMANOVA). The analysis was performed in MaAsLin2 R package to determine the specific microbial taxa whose relative abundances were significantly associated with survival status in a multivariable linear model.ResultsSequencing of FFPE extracted DNA resulted in high-quality sequence reads in 16 cases.AnalysisAnalysis of microbial communities from 16 cases revealed a significant association between microbiome structure and survival status. Beta diversity analysis demonstrated distinct clustering of microbiome profiles between survivor and non-survivor groups. Alpha diversity metrics further characterized these differences: the non-survivor group exhibited a more complex and even microbiota (Shannon entropy, <i>p</i> = 0.02; Pielou's evenness, <i>p</i> = 0.017), whereas the survivor group's microbiome was significantly richer in observed features (<i>p</i> = 0.004). Notably, this association was specific to survival outcome, as overall community structure did not significantly differ when grouped by histological features of disease severity such as necrosis, inflammation, or hemorrhage. Linear mixed effect models and direct comparisons further identified numerous taxa potentially associated with survival status.ConclusionFFPE intestinal tissue enabled retrospective and spatially relevant microbiota assessment at the disease site. The non-survivors had complex microbiota and had distinct bacterial communities compared to survivors. Our findings suggest that the gut microbiome is a key factor related to prognosis, independent of other measures of NEC severity.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251353777"},"PeriodicalIF":0.9,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12290843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of protein intake on IGF1 and ROP.","authors":"Divya Keerthy, Angela Holuba, David Bateman, Sudha Kashyap","doi":"10.1177/19345798251351004","DOIUrl":"https://doi.org/10.1177/19345798251351004","url":null,"abstract":"<p><p>BackgroundInsulin-like growth factor 1 has been implicated in neural and retinal cell maturation. Optimizing insulin-like growth factor 1 may prevent morbidities, like retinopathy of prematurity. Our objective was to determine the effects of higher protein in parenteral nutrition for very low birth weight infants on insulin-like growth factor 1 and retinopathy of prematurity.MethodsThis was a post-hoc analysis of a prospective, double blind, randomized control trial of appropriate for gestational age, preterm infants (<1250 grams) randomized to high protein (<i>N</i> = 53) or conventional protein (<i>N</i> = 47) in early parenteral nutrition. Goal protein intake was 4 g/kg/d for high protein group and 3 g/kg/d for conventional protein group. Weekly insulin-like growth factor 1 and standard retinal examinations were evaluated.ResultsInsulin-like growth factor 1 was significantly associated with protein intake group controlling for postnatal age, gestational age and sex. Insulin-like growth factor 1 increased by 21.9% (<i>p</i> = 0.03) in the high protein group. Any retinopathy of prematurity or severe retinopathy of prematurity (grade ≥3 and/or plus disease) was not associated with group, actual daily protein intake or insulin-like growth factor 1. However, high protein group was associated with lower risk of plus disease (OR 0.17, <i>p</i> = 0.02). Infants with plus disease had 25% lower mean insulin-like growth factor 1 (<i>p</i> = 0.052).ConclusionHigher protein in parenteral nutrition was associated with increased insulin-like growth factor 1 and lower risk of plus disease in very low birth weight infants.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251351004"},"PeriodicalIF":0.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of probiotics supplementation in neonatal jaundice therapy: A systematic review.","authors":"Lisa Amelia Wijaya, Putu Wila Widiastuti, Ni Nyoman Metriani Nesa, I Gusti Ngurah Sanjaya Putra","doi":"10.1177/19345798251350382","DOIUrl":"10.1177/19345798251350382","url":null,"abstract":"<p><p>BackgroundNeonatal jaundice affects 60% of term and 80% of preterm newborns due to high levels of unconjugated bilirubin, leading to significant health issues. Currently, probiotics were used as a promising agent to enhance phototherapy outcomes.ObjectivesThe purpose of this systematic review is to assess the effect of probiotics supplementation in neonatal jaundice therapy.MethodsFour reviewers extracted randomized controlled trial (RCT) studies from Google Scholar, PubMed, and the Cochrane Library as per PRISMA guidelines. The risk of bias will be assessed using the Cochrane risk of bias tool for randomized trials (RoB 2). Inclusion criteria comprised term or preterm neonates diagnosed with any type of jaundice warranting phototherapy, outcome comparison between probiotic supplementation in phototherapy and control group. Study including healthy neonates, prophylaxis effect, non-RCT, and non-English studies were excluded in this study.ResultsNine out of 14 RCT studies showed significant reduction of total serum bilirubin levels with various duration after receiving probiotic supplementation during phototherapy. Some of RCT studies reported significant changes in indirect bilirubin levels, duration of phototherapy, duration of hospital stay. Moreover, there were four studies that found no significant changes on total serum bilirubin levels. No adverse effects or complications are found among those studies.ConclusionProbiotics supplementation in neonatal jaundice therapy was promising beneficial outcome for neonatal jaundice. Further research is required to confirm the consistency of therapeutic effects and adverse reactions.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251350382"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human breast milk fortification with human milk fortifier vs preterm infant formula: A systematic review and meta-analysis.","authors":"Ni Nyoman Berlian Aryadevi, Rosita Saumi Imanta Putri, Putri Maharani Tristanita Marsubrin","doi":"10.1177/19345798251350987","DOIUrl":"https://doi.org/10.1177/19345798251350987","url":null,"abstract":"<p><p>BackgroundThe limited availability and high cost of human milk fortifier (HMF) in developing countries represent significant challenges. Preterm formula (PTF) fortification of breast milk is a potential alternative, but its safety and impact on growth are still uncertain. This study compares the safety and effect of breast milk fortification with PTF versus HMF on growth velocity in very low birth weight preterm infants.MethodsA thorough literature search was conducted in the PubMed, Scopus, Google Scholar, ClinicalTrials.gov, and Europe PMC databases up to March 24, 2024. Relevant randomized controlled trials (RCTs) studying fortifying breast milk with PTF or HMF were identified and their quality assessed using the Cochrane Risk of Bias 2 tool. Statistical analysis was performed in Review Manager Web, and certainty of evidence was assessed with GRADE.ResultsSix RCTs were included, of which one exhibited low bias risk, three had moderate concerns, and two were classed as high risk. The six RCTs, involving 434 preterm infants, revealed no significant differences in the gain of weight (SMD 0, 95% CI -0.19 to 0.19), length (MD -0.01 cm/wk, 95% CI -0.06 to 0.05), or head circumference (MD -0.01 cm/wk, 95% CI -0.06 to 0.04) between PTF and HMF. There were comparable risks of morbidities.ConclusionVery low certainty evidence suggests that breast milk fortification with PTF may be a safe alternative to HMF, with similar safety profiles and effects on growth.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251350987"},"PeriodicalIF":0.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New diagnostic criteria for clinical chorioamnionitis using only objective indicators: A retrospective study.","authors":"M Sumino, T Yoshida, T Hirata, M Yamanaka","doi":"10.1177/19345798251351002","DOIUrl":"https://doi.org/10.1177/19345798251351002","url":null,"abstract":"<p><p>BackgroundChorioamnionitis is a significant perinatal infection that adversely affects maternal and neonatal outcomes. Diagnostic criteria, including Lencki's criteria, are frequently used; however, they include subjective indicators, limiting their clinical utility. We aimed to establish diagnostic criteria using only objective indicators.MethodsThis retrospective cohort study involved patients who delivered at our hospital and underwent placental pathological examination from 2003 to 2022. Based on the Blanc classification, patients were classified into the CAM II/III (stage 2 or 3) and CAM I (stage 1) groups, followed by between-group comparisons of maternal and neonatal outcomes. Diagnostic indicators were selected through multivariate logistic regression analysis and used to develop a diagnostic model. Receiver operating characteristic curves were generated to compare the diagnostic performances of the new and previous criteria.ResultsAmong 862 included patients, 538 and 324 were classified as CAM II/III and CAM I, respectively. The CAM II/III group showed significantly higher rates of neonatal acidosis and maternal postpartum hospitalization ≥10 days. In the new model, scores were assigned as follows: body temperature ≥38.5°C (2 points), C-reactive protein ≥1.0 mg/dL (2 points), white blood cell count ≥12 × 10⁹/L (1 point), and nulliparity (1 point). A total score ≥4 points was considered the diagnostic threshold. The new criteria outperformed the existing criteria, with an area under the curve (AUC) value of 0.741 compared to 0.621 (<i>p</i> < 0.001).ConclusionsThe new criteria showed improved diagnostic accuracy for chorioamnionitis, which may facilitate early diagnosis and timely intervention for improved perinatal outcomes.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251351002"},"PeriodicalIF":0.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparotomy or peritoneal drain: Where does the evidence lead?","authors":"Parvesh Mohan Garg, Jeffrey S Shenberger","doi":"10.1177/19345798251349434","DOIUrl":"10.1177/19345798251349434","url":null,"abstract":"<p><p>Necrotizing enterocolitis (NEC) is a leading cause of death among preterm neonates, leading to increased hospital care and economic burden. Based on all the available randomized control trials and observational studies to date, the peritoneal drain placement is most likely associated with higher mortality than laparotomy when the NEC diagnosis is made prior to the intervention. Peritoneal drainage, however, may be utilized as a bridge treatment in cases where early operation is not possible due to clinical instability or not immediately available. Unfortunately, most studies lack histopathological confirmation of radiographic abnormalities corresponding to NEC or spontaneous intestinal perforation (SIP). Such large prospective studies evaluating the impact of peritoneal drain and laparotomy, which utilize pre-determined histopathologic definitions of NEC/SIP, are necessary to optimize clinical outcomes.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251349434"},"PeriodicalIF":0.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12226258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of calprotectin in diagnosis of necrotizing enterocolitis and Doppler US in detecting its severity and outcome in neonates.","authors":"Amira M Shalaby, Azhar Arabi Mohammed, Randa Abdelbadie Abdelaleem, Omran Khodary Qenawy, Abdellatif M Abdelmoeaz, Ismail L Mohamad, Deiaaeldin M Tamer","doi":"10.1177/19345798251349747","DOIUrl":"https://doi.org/10.1177/19345798251349747","url":null,"abstract":"<p><p>BackgroundNecrotizing enterocolitis (NEC) is a life-threatening gastrointestinal emergency in preterm neonates, with mortality exceeding 50% in severe cases. Early diagnosis remains challenging due to nonspecific clinical signs.ObjectivesThis study aimed to evaluate the diagnostic accuracy of fecal calprotectin (FCP) and assess Doppler ultrasound (US) for predicting disease severity and mortality.MethodsA case-control study of 54 neonates with NEC (Bell's Stages I-III) and 42 matched controls. FCP levels were measured within 48 hours of symptom onset and Doppler US was performed to evaluate bowel perfusion. It was done at Neonatal Intensive Care Unit (NICU) during the period from (January 2019 to December 2019).ResultsFecal calprotectin levels were significantly higher in NEC cases (362.6 ± 239.8 µg/g) compared to controls (61.9 ± 44.2 µg/g, <i>p</i> < 0.001). The optimal FCP cutoff was 176 µg/g (sensitivity 87%, specificity 97.6%). Doppler US showed decreased bowel perfusion in 77.8% of Stage III NEC cases, which strongly predicted mortality (OR 4.2, 95% CI 1.8-9.6).ConclusionFCP and Doppler US provide complementary, non-invasive methods for early NEC diagnosis and risk stratification. Their combined use could improve clinical decision-making in high-risk neonates.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251349747"},"PeriodicalIF":0.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}