Journal of neonatal-perinatal medicine最新文献

{"title":"Pigtail catheter versus classic straight intercostal tube for draining of pneumothorax in neonates: A systematic review and meta-analysis.","authors":"Leina Shabaan, Nada Mohsen, Gonzalo Solis-Garcia, Mohamed El-Helaly, Islam Nour","doi":"10.1177/19345798261466198","DOIUrl":"https://doi.org/10.1177/19345798261466198","url":null,"abstract":"<p><p>BackgroundA controversy exists regarding the efficacy and safety of pigtail catheters (PC) versus classic straight chest tubes (SCT) for treating pneumothorax (PTX) in newborn infants. Our aim is to assess the efficacy and safety of PC compared to SCT in the treatment of PTX in newborn infants.MethodsWe systematically searched Medline, Embase, Cochrane, International Clinical Trials Registry Platform (ICTRP), WHO, ClinicalTrials.gov, and Google Scholar from database inception to December 2024 for randomized controlled trials, quasi control trials, and observational cohort studies. The assessed outcomes were complete radiological resolution, length of hospital stay, total days of placement, recurrence of PTX, drain dislodgment, and mortality.ResultsWe included 3 observational studies (138 infants). Regarding the complete radiological resolution of PTX, there was no significant difference between PC and SCT [OR: 2.32; 95% CI (0.29-16.95)]. The length of hospital stay was significantly less in patients treated with PC compared to SCT [MD -14.98; 95% CI (-28.09, -1.87)] while other outcomes including total days of tube placement, recurrence of PTX, drain dislodgment, and mortality were not significantly different between the two interventions.ConclusionsOur meta-analysis found no statistically significant difference in complete radiological resolution of neonatal PTX between PC and SCT. A statistically significant shorter length of hospital stay was observed with PC; however, this is heavily confounded by multiple clinical factors. Well-designed randomized controlled trials are highly recommended to establish the efficacy and safety of PCs compared to classic SCT for PTX drainage in neonates.RegistrationThe protocol for the present systematic review was registered online with PROSPERO, the international prospective register of systematic reviews (CRD42025630790).</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798261466198"},"PeriodicalIF":1.0,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148421757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of length of hospital stay in non-infectious neonatal jaundice: A large retrospective cohort study.","authors":"Quoc Trung Ly, Thi Bich Quyen Do, J Luis Espinoza","doi":"10.1177/19345798261468666","DOIUrl":"https://doi.org/10.1177/19345798261468666","url":null,"abstract":"<p><p>BackgroundNeonatal jaundice is a leading cause of newborn hospitalization in low- and middle-income countries (LMICs), yet factors influencing length of hospital stay (LOS) in non-infectious cases remain poorly characterized.MethodsWe retrospectively analyzed 1262 neonates with confirmed non-infectious jaundice admitted to a tertiary referral hospital in southern Vietnam between January 2024 and June 2025. Demographic characteristics, admission bilirubin levels, complete blood count (CBC) parameters, and derived inflammatory indices were evaluated. LOS was analyzed primarily as a continuous outcome, with prolonged hospitalization (≥3 days) assessed as a secondary outcome. Robust OLS, Poisson, and logistic regression models identified independent predictors after adjustment for age, sex, and ethnicity.ResultsHigher total and indirect bilirubin levels were associated with longer LOS in univariable analyses. Across all multivariable models, total bilirubin independently predicted longer hospitalization and increased odds of prolonged stay. Higher monocyte count showed a modest inverse association with LOS, although this finding should be considered exploratory. Other CBC-derived inflammatory indices (NLR, MLR, PLR, SII, and SIRI) and demographic factors, including ethnicity, were not independently associated with LOS.ConclusionsBilirubin burden was the dominant determinant of hospitalization duration in neonates with non-infectious jaundice. Routine CBC-derived inflammatory indices provided little incremental prognostic value beyond bilirubin concentration. The modest association between monocyte count and shorter LOS warrants prospective validation, while additional clinical and health-system factors not captured in this study are also likely to influence hospitalization duration.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798261468666"},"PeriodicalIF":1.0,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148421121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: \"Oral-first rehydration for moderate neonatal hypernatremic dehydration: a protocol-driven advance with lessons for practice\".","authors":"Deniz Yaprak, Belma Saygılı Karagöl","doi":"10.1177/19345798261468691","DOIUrl":"https://doi.org/10.1177/19345798261468691","url":null,"abstract":"","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798261468691"},"PeriodicalIF":1.0,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148421714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral-first rehydration for moderate neonatal hypernatremic dehydration: A protocol-driven advance with lessons for practice.","authors":"C Hari Prasath, P Anil Kumar","doi":"10.1177/19345798261468692","DOIUrl":"https://doi.org/10.1177/19345798261468692","url":null,"abstract":"","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798261468692"},"PeriodicalIF":1.0,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148421733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive factors for successful extubation in preterm infants: Relationship with weight, PaCO₂ and heart rate.","authors":"Thalita Vilaboim Santos, Ednaldo d'Angelis Chaves, Marcos Giovanni Santos Carvalho, Simone Nascimento Santos Ribeiro, Fernanda de Cordoba Lanza","doi":"10.1177/19345798261466197","DOIUrl":"10.1177/19345798261466197","url":null,"abstract":"<p><p>ObjectiveTo identify variables associated with extubation success in preterm infants undergoing first elective extubation and to determine cutoff values to support clinical decision-making.MethodsThis retrospective cohort study included preterm infants (gestational age ≤36 weeks and 6 days) admitted to a neonatal intensive care unit who underwent first elective extubation after orotracheal intubation. Extubation failure was defined as reintubation within 48 h. Bivariate and multivariate analyses were performed. Discriminant analysis defined cutoff values, and bootstrapping (500 replicates) supported comparisons.ResultsAmong 218 eligible infants, 73.9% achieved extubation success. In multivariate analysis, weight at extubation (OR 1.02; 95% CI 1.01-1.04), PaCO₂ (OR 0.93; 95% CI 0.89-0.98), and heart rate (OR 0.97; 95% CI 0.94-0.99) were independently associated with success. Cutoff values were 34.7 mmHg for PaCO₂ and 156 bpm for heart rate, both with modest sensitivity and specificity.ConclusionsWeight at extubation, PaCO₂, and heart rate were independently associated with extubation success. Although their discriminatory performance was modest, these variables may provide clinically relevant information when interpreted within the context of early extubation. Their integration into a multidimensional assessment may support more individualized decision-making.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798261466197"},"PeriodicalIF":1.0,"publicationDate":"2026-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148382254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A simple, low-cost bubble CPAP system for use in the delivery room and during transport to the NICU for infants with respiratory distress: A feasibility study.","authors":"Danieli M K Leandro, Elisa S B Medeiros, Lidiaine N Oliveira, Gabriel F T Variane, Mariana Werneck, Tayane do Vale Bertanha, Rafaela F R Pietrobom, Juliana Q Teixeira, Anna K S Nazareth, Daniela P Rodrigues, Maurício Magalhaes, Guilherme Sant'Anna","doi":"10.1177/19345798261464969","DOIUrl":"https://doi.org/10.1177/19345798261464969","url":null,"abstract":"<p><p>BackgroundTo assess the feasibility and efficacy of Vayu continuous positive airway pressure (vCPAP) for preterm and term infants with respiratory distress in the delivery room.MethodsFeasibility study of infants of any gestational age presenting with respiratory distress defined as a Silverman-Anderson Score (SAS) ≥4 in the delivery room, who were started on vCPAP prior to transfer to the NICU and maintained during transport. Efficacy was assessed by comparing SAS, FiO₂, and SpO₂ before initiation of vCPAP, 1 min after initiation, and at the time of NICU admission. Secondary outcomes were feasibility accessed by a survey applied to all health care professionals (HCP), and safety (pneumothorax or clinical deterioration). Descriptive analysis and parametric and non-parametric tests were applied (alpha of 5%).Results10 preterm and 10 term infants were initially enrolled, but one term was excluded because of a protocol deviation. The median gestational age was 37.6 ± 1.1 weeks for preterm and 34.2 ± 1.6 weeks for term infants. A significant improvement in SAS from five prior to vCPAP initiation (IQR 4-6) to three 1 min after initiation (IQR 2-4, <i>p</i> < 0.01), to two on NICU admission (IQR 1-3, <i>p</i> < 0.001). No significant differences in FiO₂, SpO₂, or CPAP pressure over these time periods were identified. Among HCP, ease of use and satisfaction were highlighted. No complications were observed.ConclusionIn neonates with respiratory distress after birth, a clinical improvement was noted after initiation of vCPAP in the DR and during transport to the NICU.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798261464969"},"PeriodicalIF":1.0,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148382226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronary artery dilatation in neonates: A novel case series.","authors":"Irfan Bashir Bhat, Aswathy Rahul, Harikrishnan Kn, Binsi Charulatha, Amal Mohan, Anand Nandakumar","doi":"10.1177/19345798261464974","DOIUrl":"https://doi.org/10.1177/19345798261464974","url":null,"abstract":"<p><p>BackgroundCoronary artery dilatation (CAD) in neonates is an uncommon but clinically important finding on echocardiography. Reported associations include multisystem inflammatory syndrome in the newborn (MIS-N) following COVID-19 infection, congenital cardiac malformations, and perinatal inflammatory states. In the post-COVID era, CAD has been reported more frequently.MethodsThis retrospective, record-based case series conducted at a Government Medical College in South India describes the clinical profile of neonates with CAD who were admitted between January 2023 and December 2024.ResultsA total of 24 neonates with CAD were identified during the study period. They were admitted in NICU for different conditions like respiratory distress syndrome, congenital pneumonia, sepsis, or perinatal asphyxia. The mean (SD) gestational age was 35.5 (2.2) weeks, and the mean birth weight was 2557 (646) g. Respiratory distress was the most common presenting feature (95.8%) followed by shock (75%). CAD was detected incidentally during echocardiography which was performed to evaluate persistent pulmonary hypertension of the newborn (PPHN), assess ventricular dysfunction during shock, and exclude congenital heart disease, particularly in those with an unexpected clinical course. One-third of the neonates (<i>n</i> = 8) met the diagnostic criteria for MIS-N and all of them responded to intravenous immunoglobulin therapy, with no mortality. Mortality was 31.25% (<i>n</i> = 5) among the others. Complete resolution of coronary dilatation was observed in all infants within 3-6 months.ConclusionAssessment of coronary arteries for dilatation should be considered in any sick neonate with an inadequate response to conventional management. It may be a pointer for MIS-N.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798261464974"},"PeriodicalIF":1.0,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148382277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The diagnostic and prognostic values of soluble CD14 subtype (presepsin) in detection of early onset neonatal sepsis in preterm newborns.","authors":"Dalia Fathi Ali El Sherif, Ahmed Nasser Ibrahim Elkholy, Heba Mohamed Atif Ismail, Mariam John Amin Ibrahim","doi":"10.1177/19345798261464975","DOIUrl":"https://doi.org/10.1177/19345798261464975","url":null,"abstract":"<p><p>BackgroundNeonatal early onset sepsis [EOS] continues to impact the neonatal morbidity and mortality rates worldwide. The diagnosis of suspected EOS in the neonatal intensive care unit (NICU) remains an important challenge for clinicians as the signs of sepsis are often nonspecific and the laboratory investigations may be unreliable or not routinely available.Presepsin (P-SEP) or soluble clusture of Differentiation 14 Subtype (SCD14-ST) is generated as a part of the body's response to bacterial infection, being effective in the early phase of inflammation and detected as an early marker of neonatal sepsis.This study aimed to evaluate the diagnostic value of presepsin in early-onset sepsis, and its prognostic value regarding disease severity, and duration of hospital stay. Moreover, the study aimed to assess the possible predictive ability of presepsin in identifying the type of bacterial organism causing early-onset sepsis in preterm neonates.Materials and methodsThe study recruited 36 preterm neonates with risk factors for early onset sepsis. Control group included 20 sepsis free neonates. Serum Presepsin levels, CRP and blood culture were tested in all studied neonates.ResultsThe predictive performance of presepsin levels between 640 and 970 ng/L was evaluated, and the associated clinical implications were analyzed. The serum baseline presepsin was significantly elevated in Sepsis group (<i>p</i> < 0.001). Moreover, it showed the best diagnostic performance at a cutoff value ≥640 ng/L.Day 3 Presepsin levels demonstrated better performance than day 1 levels in gram negative infections with the best Predictive performance at a cutoff value ≥970 ng/L.ConclusionPresepsin evaluation in preterm neonates may serve as a valuable early marker in detection of early onset sepsis and in distinguishing gram-negative bacteria.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798261464975"},"PeriodicalIF":1.0,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148382274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salmonella meningitis due to horizontal transmission in an extremely premature neonate: A case report.","authors":"T Borger, S M Mulder-de Tollenaer, E J d'Haens, S B Debast, M A C Hemels","doi":"10.1177/19345798251411750","DOIUrl":"10.1177/19345798251411750","url":null,"abstract":"<p><p>Salmonellosis is commonly associated with foodborne illnesses in adults. Meningitis, although rare, is a severe complication of a <i>Salmonella</i> infection, associated with high rates of mortality and significant neurological complications and sequelae. Premature infants are particularly susceptible for invasive infections due to their immature immune system. In this case report, we present an unusual case of <i>Salmonella</i> group B, serotype Typhimurium sepsis and meningitis in a 27-week premature neonate on the fourth day of life, resulting from horizontal transmission from mother to child, with fatal outcome. This case report also represents unique neuroimaging findings, revealing cerebral injury that arose in consequence of the infection. It highlights the importance of diagnostic evaluation of non-specific maternal symptoms, such as fever without apparent focus or abdominal pain, when a vulnerable preterm infant is involved. We suggest that in these cases, a more precise diagnosis through maternal cultures including blood, stool, and vaginal cultures may be warranted to take adequate measures minimizing horizontal transmission.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"441-444"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145900662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of oro-motor sensory stimulation in preterm neonates: A systematic review and meta-analysis.","authors":"Abhishek Sharma, Aksh Chahal, Richa Hirendra Rai, Bartosz Maciej Wójcik, Raykhan Razakova, Nidhi Sharma","doi":"10.1177/19345798251394352","DOIUrl":"10.1177/19345798251394352","url":null,"abstract":"<p><p>BackgroundPreterm neonates often face challenges with feeding ability, neuromotor behavior, weight gain, and prolonged hospital stays. Oral Sensory-Motor Stimulation (OSMS) has been suggested as a beneficial intervention to address these issues. This systematic review and meta-analysis aim to evaluate the effectiveness of OSMS compared with standard care on feeding ability, motor function, weight gain, and length of hospital stay in preterm neonates admitted to Neonatal Intensive Care Units (NICUs).MethodsA thorough literature search was conducted across databases including PubMed, Scopus, Web of Science, Cochrane Library, CINAHL, and Embase focusing on studies published between 1, January 2000 and 10 December 2024. Randomized controlled trials (RCTs) and cohort studies examining the impact of OSMS on the specified outcomes in preterm neonates were included. Neonates with severe medical, neurological, congenital, or cardiorespiratory complications, along with those on assisted ventilation, formula feeding, or presenting clinical instability, were excluded. Data extraction and quality assessment were performed independently by two reviewers, and meta-analyses were conducted using random-effects models to account for heterogeneity among studies. Results were synthesized using random-effects models and presented through forest plots, with heterogeneity assessed using I² and Cochran's Q tests. Subgroup analyses were performed to evaluate result stability and explore potential sources of variability. RevMan 5.4.1 was used to conduct data analysis.ResultsA total of nine studies met the inclusion criteria with total 611 participants. Across studies, random sequence generation and selective reporting were consistently low risk, while allocation concealment was adequate in seven of nine studies. The meta-analysis revealed that OSMS significantly improved feeding ability, as evidenced by a reduction in time to achieve voluntary feeding (mean difference: -3.5 days; 95% CI: -4.2 to -2.8). Weight gain was positively affected, with an average increase of 7 g per day (95% CI: 6-10 g). Additionally, OSMS was associated with a reduced length of hospital stay (mean difference: -5.1 days; 95% CI: -6.4 to -3.8). Improvements in neuromotor behavior were observed based on qualitative synthesis, rather than meta-analytic pooled estimates.ConclusionOSMS is an effective intervention for improving feeding ability, motor function, weight gain, and reducing the length of hospital stay in preterm neonates admitted to NICUs. In addition to the meta-analytically supported benefits of OSMS on feeding ability, weight gain, and reduced hospital stay, qualitative evidence from select studies suggests potential improvements in neuromotor behavior.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"341-353"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145452278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}