Journal of neonatal-perinatal medicine最新文献

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Neonatal calvarial osteomyelitis secondary to perinatal skin infection. 新生儿颅骨骨髓炎继发于围产期皮肤感染。
IF 0.9
Journal of neonatal-perinatal medicine Pub Date : 2025-08-27 DOI: 10.1177/19345798251372535
L Santos Gómez, E Fernández Morán, C Calvo Penín, S Amat Valero, N Vega Mata, S Rubín Roger, J M Vázquez Villa, B Fernández Colomer
{"title":"Neonatal calvarial osteomyelitis secondary to perinatal skin infection.","authors":"L Santos Gómez, E Fernández Morán, C Calvo Penín, S Amat Valero, N Vega Mata, S Rubín Roger, J M Vázquez Villa, B Fernández Colomer","doi":"10.1177/19345798251372535","DOIUrl":"https://doi.org/10.1177/19345798251372535","url":null,"abstract":"","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251372535"},"PeriodicalIF":0.9,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progressive respiratory failure in a term neonate with ABCA3 surfactant deficiency: Beyond the common causes of respiratory distress. ABCA3表面活性剂缺乏的足月新生儿进行性呼吸衰竭:超出呼吸窘迫的常见原因。
IF 0.9
Journal of neonatal-perinatal medicine Pub Date : 2025-08-25 DOI: 10.1177/19345798251371042
Andrew M Beverstock, Hillary C Lee, David S Moreno McNeill, Morcos Hanna
{"title":"Progressive respiratory failure in a term neonate with ABCA3 surfactant deficiency: Beyond the common causes of respiratory distress.","authors":"Andrew M Beverstock, Hillary C Lee, David S Moreno McNeill, Morcos Hanna","doi":"10.1177/19345798251371042","DOIUrl":"https://doi.org/10.1177/19345798251371042","url":null,"abstract":"<p><p>BackgroundMost cases of respiratory distress in term neonates are due to transient tachypnea of the newborn (TTN), respiratory distress syndrome (RDS), or air leak syndromes. Genetic surfactant deficiencies are rare causes of respiratory distress. Among these, mutations in the <i>ABCA3</i> gene disrupt surfactant metabolism and can lead to severe, treatment-refractory respiratory failure. While commonly considered in preterm infants, surfactant dysfunction should also be considered in term infants with unexplained and persistent hypoxemia.CaseWe present a case of a 38-weeks term female infant with fetal growth restriction who developed respiratory distress shortly after birth. She initially responded to continuous positive airway pressure (CPAP) and surfactant but required escalating respiratory support and multiple re-doses of surfactant. Standard infectious and cardiopulmonary evaluations were unrevealing. Given her persistent oxygen requirement and small-for-gestational-age status, genetic testing was pursued. Whole genome sequencing identified bi-allelic pathogenic variants in the <i>ABCA3</i> gene, consistent with pulmonary surfactant metabolism dysfunction type 3. Despite six doses of surfactant, antibiotics, and inhaled nitric oxide, the patient's respiratory status deteriorated. Lung transplantation was not feasible due to size and clinical condition. The family elected to transition to comfort care.ConclusionThis case highlights the importance of considering genetic surfactant disorders, including ABCA3 mutations, in term neonates with refractory respiratory distress. Early genetic testing can guide management and avoid potentially harmful or ineffective interventions. While some therapies offer transient improvement, outcomes remain poor, and definitive treatment via lung transplantation is limited by size and disease progression. Future research should focus on gene-specific therapies and earlier diagnosis.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251371042"},"PeriodicalIF":0.9,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Duration of monitoring for withdrawal in neonates exposed to in-utero opioids. 暴露于宫内阿片类药物的新生儿戒断的监测时间。
IF 0.9
Journal of neonatal-perinatal medicine Pub Date : 2025-08-25 DOI: 10.1177/19345798251365202
Ayda Soltanian Tiranchi, Dina El Metwally, Katrina Mark
{"title":"Duration of monitoring for withdrawal in neonates exposed to in-utero opioids.","authors":"Ayda Soltanian Tiranchi, Dina El Metwally, Katrina Mark","doi":"10.1177/19345798251365202","DOIUrl":"https://doi.org/10.1177/19345798251365202","url":null,"abstract":"<p><p>ObjectiveThis study aims to determine the duration of NOWS symptom onset that leads to pharmacologic intervention in order to inform hospital discharge protocols and provide better guidance for patients.Patients and methodsA retrospective chart review was conducted evaluating neonates with documented NOWS monitoring at the University of Maryland Medical Center from January 2017 to November 2022. Infants at 36 weeks gestation and above who were exposed to opioids in-utero were included. Paired maternal and neonatal charts were reviewed. Medical history, drug screen results, and time lapse from day of birth to the day of initiation of treatment were documented.ResultsOf 357 neonates monitored for NOWS, 215 (60.5%) received pharmacologic treatment. All neonates requiring treatment were identified by day of life (DOL) 5. Neonates exposed to multiple opioids were at the highest risk of requiring treatment. When compared to buprenorphine exposure, those exposed to oxycodone and multiple opioids were more likely to need treatment on DOL 0, while methadone-exposed neonates were more likely to require treatment on DOL 1 and 2.ConclusionsThis study provides valuable information for risk-stratification and safe discharge planning for neonates at risk for NOWS. The findings suggest that a 5-day monitoring period may be sufficient to identify neonates requiring pharmacologic treatment for NOWS, potentially allowing for earlier discharge in some cases. However, the timing of symptom onset varies based on the type of opioid exposure, highlighting the need for individualized care and anticipatory guidance for families.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251365202"},"PeriodicalIF":0.9,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of global preterm labor in pregnant women infected with coronavirus: A systematic review and meta-meta-analysis. 感染冠状病毒孕妇的全球早产患病率:系统综述和meta-meta分析
IF 0.9
Journal of neonatal-perinatal medicine Pub Date : 2025-08-15 DOI: 10.1177/19345798251365165
Sedigheh Abdollahpour, Talat Khadivzadeh, Mahla Shafeei, Mahdieh Arian
{"title":"Prevalence of global preterm labor in pregnant women infected with coronavirus: A systematic review and meta-meta-analysis.","authors":"Sedigheh Abdollahpour, Talat Khadivzadeh, Mahla Shafeei, Mahdieh Arian","doi":"10.1177/19345798251365165","DOIUrl":"https://doi.org/10.1177/19345798251365165","url":null,"abstract":"<p><p>BackgroundPreterm labor is a key factor in neonatal morbidity and mortality globally. Therefore, in the crisis of the coronavirus pandemic, it is important to investigate the prevalence of preterm labor in mothers with COVID-19 infection.Materials and methodsWe performed, according to the PRISMA guideline, a search of the PubMed and Web of Science database on September 1, 2022, to identify systematic reviews and meta-analyses that have summarized studies that report the prevalence of preterm labor in pregnant women with COVID-19. Based on the focused search strategy and eligibility criteria, finally, 66 studies were included in this review. After critical appraisal, using Comprehensive Meta Analysis V3 software, data analysis was done. A random-effects model was employed to account for heterogeneity among studies, and publication bias was assessed. Pooled estimates and their 95% confidence intervals were reported using forest plots.ResultsSixty-six meta-analysis studies, involving a total of 335,964 preterm labors among a sample of 2,260,032 women pregnant with coronavirus infection, were analyzed. Prevalence of preterm delivery in women infected with COVID-19 is 18.8% (lower limit = 0.148; upper limit = 0.235; CI = 95%' df = 65; I-Squared = 99.87; Egger test = 0.40).ConclusionsThe pooled global prevalence of preterm delivery in women infected with COVID-19 is higher than the global estimate in the era before the coronavirus pandemic. Given the global burden of preterm birth, efforts should be intensified to improve the quality of care for all COVID-infected pregnant women.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251365165"},"PeriodicalIF":0.9,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Newborn hypernatremic dehydration: A prospective study reducing the usage of intravenous liquids in moderate cases. 新生儿高钠血症性脱水:一项减少中度静脉液体使用的前瞻性研究。
IF 0.9
Journal of neonatal-perinatal medicine Pub Date : 2025-08-07 DOI: 10.1177/19345798251363457
Deniz Yaprak, Belma Saygılı Karagöl
{"title":"Newborn hypernatremic dehydration: A prospective study reducing the usage of intravenous liquids in moderate cases.","authors":"Deniz Yaprak, Belma Saygılı Karagöl","doi":"10.1177/19345798251363457","DOIUrl":"https://doi.org/10.1177/19345798251363457","url":null,"abstract":"<p><p>ObjectivesThe rehydration approach for hypernatremic dehydration in newborns is challenging. A new treatment protocol was introduced in the NICU for moderate hypernatremic dehydrated (MHD) newborns to achieve safer and more effective serum sodium (Na+) correction.MethodsA prospective study in a four-level NICU examined term and near term MHD (150-169 mEq/L) newborns. In a novel hypernatremic dehydration treatment protocol, 49 newly diagnosed MHD patients were in group 1, while 54 previously treated control MHD patients were in group 2.Results49 neonates received the novel treatment protocol (group 1), and data from 54 neonates were obtained from hospital records (group 2). Serum Na+ correction rate was significantly lower in group 1 compared to group 2, with a median serum Na+ level of 0.66 versus 1.05 mEq/L/h, <i>p</i> = 0.001. The proportion of patients who were treated with pure oral rehydration was significantly higher in group 1 compared to group 2 (67.3% vs 25.9%, <i>p<0.001</i>). Multiple regression analysis was performed to determine factors associated with use of intravenous rehydration: initial serum Na+ [odds ratio (OR):1.515, 95% confidence interval (CI) 1.17-1.94, <i>p</i><0.001] and serum uric acid [OR: 1.495, 95% CI 1.092-2.00, <i>p</i> = 0.012] in model 2; belonging to Group 2 [OR: 28.267, 95% CI 10.321-53.69, <i>p</i><0.001]; each additional delay in the day of postnatal admission [OR: 1.381, 95% CI 1.011-1.888, <i>p</i> = 0.043]; and initial serum Na+ [OR: 1.574, 95% CI 1.216-2.037, <i>p</i> = 0.001] in model 4 were significantly associated with intravenous rehydration.ConclusionsOral rehydration therapy offers slower sodium reduction and has a low treatment failure rate in MHD newborns. It can be the primary treatment approach, while intravenous therapy should be considered based on the patient's overall clinical and biochemical status, not just initial sodium levels.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251363457"},"PeriodicalIF":0.9,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144794754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiac output during flow-titrated high-flow nasal cannula support in a neonatal porcine model. 新生儿猪模型中流量滴定高流量鼻插管支持期间的心输出量。
IF 0.9
Journal of neonatal-perinatal medicine Pub Date : 2025-08-06 DOI: 10.1177/19345798251363449
Cory Templeton, Yosef Levenbrown, Anne M Hesek, James P Keith, Lynell S Jones, Kelly E Massa, Marina Watson, Md Jobayer Hossain, Thomas H Shaffer
{"title":"Cardiac output during flow-titrated high-flow nasal cannula support in a neonatal porcine model.","authors":"Cory Templeton, Yosef Levenbrown, Anne M Hesek, James P Keith, Lynell S Jones, Kelly E Massa, Marina Watson, Md Jobayer Hossain, Thomas H Shaffer","doi":"10.1177/19345798251363449","DOIUrl":"https://doi.org/10.1177/19345798251363449","url":null,"abstract":"<p><p>BackgroundNeonates are more susceptible to acute respiratory failure than older children. It is unknown to what extent high-flow nasal cannula (HFNC) alters intrathoracic pressure (ITP), potentially decreasing cardiac output (CO) due to cardiopulmonary interactions. This study evaluated the impact of flow titration on tracheal pressure (a surrogate for ITP) and CO via HFNC in an established porcine model of neonatal respiratory failure. Unlike prior research, this study examines both ITP and CO demonstrating that although the ITP increased with higher HFNC flows, CO did not decrease.MethodsTwenty-three neonatal Landrace-Yorkshire pigs (2-4 kg) were anesthetized, and monitoring lines were placed. Baseline vital signs, CO, mean intratracheal pressure (Ptr), and PaO<sub>2</sub> were measured. CO was assessed via computerized COstatus cardiac system. Lung injury was induced using oleic acid (0.08 mL/kg), resulting in ≤50% reduction in preinjury PaO<sub>2</sub> on 1 L/min oxygen. After injury, in random order, pigs received HFNC flows of 1, 2, and 3 L/kg/min at 100% FiO<sub>2</sub> for 30 min each. Measurements were repeated, and data were analyzed via mixed-effects repeated measures ANOVA.ResultsAfter OA injury, PaO<sub>2</sub> significantly decreased (414 to 125 mmHg; <i>p</i> < 0.001). Mean Ptr and PaO<sub>2</sub> increased significantly (<i>p</i> < .001) with increasing HFNC flow rates. CO showed no significant changes; thus, no correlation between CO with Ptr and/or HFNC flow levels was demonstrated.ConclusionsIn neonatal respiratory distress, higher HFNC flows improved oxygenation without negatively impacting CO in this neonatal porcine lung injury model, despite increasing intra-thoracic pressure (1-3 L/min/kg).</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251363449"},"PeriodicalIF":0.9,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thoracic fluid content by electric cardiometry versus lung ultrasound in preterm neonates with respiratory distress: A prospective study. 电心电测量与肺超声对呼吸窘迫早产儿胸腔液体含量的影响:一项前瞻性研究。
IF 0.9
Journal of neonatal-perinatal medicine Pub Date : 2025-08-05 DOI: 10.1177/19345798251365199
Maha Hassan Mohamed, Basma Mohamed Shehata, Nesmahar Tarek Azaam, Mohamed Mahmoud Khalifa, Ahmed Ashraf Okba, Hebatallah Ali Shaaban
{"title":"Thoracic fluid content by electric cardiometry versus lung ultrasound in preterm neonates with respiratory distress: A prospective study.","authors":"Maha Hassan Mohamed, Basma Mohamed Shehata, Nesmahar Tarek Azaam, Mohamed Mahmoud Khalifa, Ahmed Ashraf Okba, Hebatallah Ali Shaaban","doi":"10.1177/19345798251365199","DOIUrl":"https://doi.org/10.1177/19345798251365199","url":null,"abstract":"<p><p>BackgroundRespiratory distress (RD) is a major cause of admission to neonatal intensive care units (NICUs), highlighting the need for prompt and accurate assessment. Lung ultrasound (LUS) has emerged as a rapid, non-invasive, radiation-free tool with superior sensitivity to chest X-ray. Thoracic Fluid Content (TFC), measured via electrical cardiometry, may serve as a complementary parameter by reflecting pulmonary fluid load. Consequently, this study aimed to evaluate the predictive accuracy of TFC and LUS in determining the need for surfactant therapy or initiation of positive pressure ventilation in preterm neonates with respiratory distress.Patients and MethodsIn this prospective observational cohort study, 70 preterm neonates with RD were enrolled between April 2022 and April 2024 in the NICU of Ain Shams University, Cairo, Egypt. LUS and TFC were measured on day 1 and day 3 of life. Clinical outcomes, including surfactant need and escalation of ventilation, were recorded.ResultsAn LUS score >5 strongly predicted surfactant need, showing 88.89% sensitivity and 86.05% specificity (AUC: 0.941; PPV: 80%; NPV: 92.5%). TFC values were higher in neonates who received surfactant, though not statistically significant (<i>p</i> = 0.053). A significant positive correlation was observed between TFC and LUS scores (r = 0.311, <i>p</i> = 0.009).ConclusionLUS is a reliable predictor of surfactant need and respiratory support in preterm neonates with RD. While TFC correlates with LUS in assessing pulmonary fluid status, it alone did not independently predict clinical intervention requirements.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251365199"},"PeriodicalIF":0.9,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of volume guarantee-high frequency oscillatory ventilation on cerebral blood flow in preterm neonates. 容积保证-高频振荡通气对早产儿脑血流量的影响。
IF 0.9
Journal of neonatal-perinatal medicine Pub Date : 2025-08-05 DOI: 10.1177/19345798251363451
Nehal Mohamed El-Raggal, Soha Mohamed Khafagy, Nivan Taha Ahmed, Mohamed Abdullah Moussa, Arwa Hamdy Al Sharabasy
{"title":"Effect of volume guarantee-high frequency oscillatory ventilation on cerebral blood flow in preterm neonates.","authors":"Nehal Mohamed El-Raggal, Soha Mohamed Khafagy, Nivan Taha Ahmed, Mohamed Abdullah Moussa, Arwa Hamdy Al Sharabasy","doi":"10.1177/19345798251363451","DOIUrl":"https://doi.org/10.1177/19345798251363451","url":null,"abstract":"<p><p>BackgroundPreterm neonates with respiratory distress often require advanced ventilation strategies to prevent respiratory failure. High-frequency oscillatory ventilation (HFOV) with volume guarantee (VG) can be utilized as a lung-protective modality that reduces ventilation induced lung injury. However, its effect on cerebral hemodynamics remains unclear. Our study aimed to compare the impacts of HFOV-VG versus HFOV alone on cerebral blood flow velocity among preterm neonates with respiratory failure.MethodsIn this pilot randomized controlled trial, 60 premature newborns (gestational age of 35 weeks or less) with respiratory distress who failed on conventional mechanical ventilation (CMV) were randomized to receive either HFOV or HFOV-VG as rescue respiratory therapy. Doppler cerebral blood flow velocity measurements, intraventricular hemorrhage (IVH) incidence, carbon dioxide (CO<sub>2</sub>) levels, and oxygen requirements were assessed at baseline, after 24 hours, and after 3 days of ventilation.ResultsThere were no significant differences in cerebral blood flow velocity measurements or IVH incidence between the two groups across all time points (<i>p</i> > 0.05). However, HFOV-VG demonstrated lower fluctuations in tidal volume, fewer out-of-target CO<sub>2</sub> episodes, and reduced oxygen requirements compared to HFOV alone.ConclusionHFOV-VG and HFOV alone showed comparable effects on cerebral blood flow and IVH incidence in premature neonates. HFOV-VG may offer additional advantages in maintaining stable ventilation parameters and minimizing CO<sub>2</sub> fluctuations, potentially reducing the risk of lung injury.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251363451"},"PeriodicalIF":0.9,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolated pneumopericardium in a preterm neonate with respiratory distress syndrome: A case report. 孤立性心包肺在早产新生儿呼吸窘迫综合征:1例报告。
Journal of neonatal-perinatal medicine Pub Date : 2025-07-24 DOI: 10.1177/19345798251361924
Sofie Denis, Antonius Mulder
{"title":"Isolated pneumopericardium in a preterm neonate with respiratory distress syndrome: A case report.","authors":"Sofie Denis, Antonius Mulder","doi":"10.1177/19345798251361924","DOIUrl":"https://doi.org/10.1177/19345798251361924","url":null,"abstract":"<p><p>Neonatal pneumopericardium is a rare neonatal air leak syndrome often associated with mechanical ventilation and respiratory distress syndrome (RDS). It occurs when alveolar rupture permits air to enter the pericardial sac. Although it can lead to severe complications such as cardiac tamponade, some cases remain hemodynamically stable and resolve spontaneously without invasive intervention. We report a premature infant (31 + 5 weeks gestation) with RDS who developed an isolated pneumopericardium, presenting with sudden respiratory deterioration but no hemodynamic instability. Diagnosis was confirmed radiographically, and the condition resolved with conservative management, including ventilatory adjustments. This report highlights the importance of early recognition and tailored respiratory management to mitigate the complications of pneumopericardium, while emphasizing areas for future research on optimal ventilatory strategies and non-invasive surfactant delivery techniques.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251361924"},"PeriodicalIF":0.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DCC-ET-Caesar: Feasibility and safety of delayed cord clamping with ex-utero transfusion in elective caesarean deliveries - A pilot study. DCC-ET-Caesar:选择性剖宫产延迟脐带夹紧与宫外输血的可行性和安全性-一项试点研究。
Journal of neonatal-perinatal medicine Pub Date : 2025-07-11 DOI: 10.1177/19345798251360768
Nireesha Bukke, Mishu Mangla, Sivam Thanigainathan, Anusha Devalla, Naina Kumar, Annapurna Srirambhatla, Nabnita Patnaik
{"title":"DCC-ET-Caesar: Feasibility and safety of delayed cord clamping with ex-utero transfusion in elective caesarean deliveries - A pilot study.","authors":"Nireesha Bukke, Mishu Mangla, Sivam Thanigainathan, Anusha Devalla, Naina Kumar, Annapurna Srirambhatla, Nabnita Patnaik","doi":"10.1177/19345798251360768","DOIUrl":"https://doi.org/10.1177/19345798251360768","url":null,"abstract":"&lt;p&gt;&lt;p&gt;BackgroundDelayed cord clamping (DCC) and placental transfusion techniques have been associated with improved neonatal outcomes, including enhanced haemodynamic stability and increased haemoglobin levels. Physiological cord clamping (PCC) also ensures a smoother cardiovascular transition at birth by maintaining placental circulation until the neonate establishes independent respiration. However, the optimal timing for clamping in cases of delayed cord clamping remains unclear. This pilot study aims to evaluate the feasibility and safety of delayed cord clamping with ex-utero transfusion (DCC-ET), after Doppler-confirmed cessation of umbilical blood flow in elective caesarean deliveries.MethodsA prospective, single-arm pilot feasibility study was conducted on women undergoing elective caesarean sections at term. The DCC technique used in this study, delayed cord clamping with ex-utero transfusion (DCC-ET), is a modification of the methods previously described in literature. Following delivery, the uterine incision was inspected, and bleeding points were secured without urgency to clamp the cord. The placenta was allowed to separate spontaneously and was removed with controlled cord traction. The newborn remained attached to the placenta, which was elevated approximately 30 cm above the baby to facilitate ex-utero transfusion. Cord clamping was performed only after complete cessation of umbilical blood flow, confirmed by Doppler assessment at a fixed point 10 cm from the cord insertion. Maternal-neonatal outcomes, including Apgar scores, haemoglobin levels, neonatal intensive care unit admissions, maternal blood loss, and any adverse events, were recorded.ResultsA total of 40 women were included. The DCC-ET procedure was successfully completed in all cases. The mean time to umbilical cord blood flow cessation, and umbilical cord clamping was 6.60 ± 1.91 minutes post-delivery. Compared to the 1-minute DCC group, maternal blood loss was significantly lower, and postoperative haemoglobin drop was less in the DCC-ET group. Residual placental blood volume was markedly reduced (11.40 ± 2.56 mL vs 45.91 ± 13.01 mL; &lt;i&gt;p&lt;/i&gt; = 0.001). Neonatal haematocrit at 48-72 hours was significantly higher in the DCC-ET group (61.25 ± 2.39% vs 55.81 ± 5.41%; &lt;i&gt;p&lt;/i&gt; = 0.001), with no increase in neonatal hypothermia or adverse outcomes. Cord separation occurred earlier in the DCC-ET group. Apgar scores and phototherapy requirements were comparable between groups. No significant postpartum haemorrhage or maternal complications were observed.ConclusionThe present pilot study demonstrates that DCC-ET is a feasible and safe procedure during elective caesarean deliveries. The protocol was successfully implemented in the majority of cases, with no increase in maternal or neonatal complications and acceptable integration into routine clinical practice. Doppler assessment of umbilical blood flow provided a practical method to individualize cord clamping timing, althoug","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251360768"},"PeriodicalIF":0.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144618631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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