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Clinical Outcomes of Chemo-Immunotherapy for Extensive Stage Small Cell Lung Cancer: A Real-World Single Centre Study in Portugal.
IF 0.8 4区 医学
Acta medica portuguesa Pub Date : 2025-03-10 DOI: 10.20344/amp.22546
David Noivo, Maria Bragança, Ana Sofia Vilariça, Filipa Ferro, Andrea Lopes Machado, Direndra Hasmucrai, Paula Alves
{"title":"Clinical Outcomes of Chemo-Immunotherapy for Extensive Stage Small Cell Lung Cancer: A Real-World Single Centre Study in Portugal.","authors":"David Noivo, Maria Bragança, Ana Sofia Vilariça, Filipa Ferro, Andrea Lopes Machado, Direndra Hasmucrai, Paula Alves","doi":"10.20344/amp.22546","DOIUrl":"https://doi.org/10.20344/amp.22546","url":null,"abstract":"<p><p>Small cell lung cancer (SCLC) is an aggressive type of lung cancer. Recent studies have provided a new hope by adding atezolizumab to the standard treatment of extensive disease SCLC (E-SCLC). The aim of our study was to evaluate the real-life performance of atezolizumab plus chemotherapy in extensive stage SCLC in a Portuguese setting. Data was collected on twenty patients (70% were male with a mean age of 66.9 years) in treatment at a tertiary hospital in Portugal with E-SCLC treated with chemotherapy and atezolizumab between July 2022 and February 2024. All patients received a carboplatin plus etoposide regimen in combination with atezolizumab. The overall response rate was 55% (95% CI: 31.5 - 76.9) and the disease control rate was 70% (95% CI: 45.7 - 88.1). The median overall survival (OS) and progression-free survival (PFS) was 9.7 (95% CI:5.08 - 14.32) and 7.17 (95% CI:3.28 - 11.05) months, respectively. In total, 13 (65%) patients experienced disease progression and 10 (50%) died during follow-up from events related to the disease. Patients with a performance status score ≥ 2 had lower PFS (p = 0.003) and OS (p = 0.001). To the best of our knowledge, this is the first real-world clinical study in Portugal to evaluate real life outcomes for this combination therapy.</p>","PeriodicalId":7059,"journal":{"name":"Acta medica portuguesa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Renal Safety Issues of Intravenous Iodinated Contrast Media Are Questionable.
IF 0.8 4区 医学
Acta medica portuguesa Pub Date : 2025-03-07 DOI: 10.20344/amp.22484
Bernardo Vidal Pimentel, Pedro Caiado Ferreira, Mariana Barosa
{"title":"Renal Safety Issues of Intravenous Iodinated Contrast Media Are Questionable.","authors":"Bernardo Vidal Pimentel, Pedro Caiado Ferreira, Mariana Barosa","doi":"10.20344/amp.22484","DOIUrl":"https://doi.org/10.20344/amp.22484","url":null,"abstract":"","PeriodicalId":7059,"journal":{"name":"Acta medica portuguesa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143571648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recurrent Syncope During Migraine Attacks. 偏头痛发作时的复发性晕厥
IF 0.8 4区 医学
Acta medica portuguesa Pub Date : 2025-03-03 Epub Date: 2024-11-28 DOI: 10.20344/amp.22134
Mariana Dias da Costa, Beatriz Nunes Vicente, Filipa Dourado Sotero, Isabel Pavão Martins
{"title":"Recurrent Syncope During Migraine Attacks.","authors":"Mariana Dias da Costa, Beatriz Nunes Vicente, Filipa Dourado Sotero, Isabel Pavão Martins","doi":"10.20344/amp.22134","DOIUrl":"10.20344/amp.22134","url":null,"abstract":"<p><p>Migraine is a cyclic condition with attacks consisting mainly of intense headaches, sensory intolerance, and nausea or vomiting. Loss of consciousness during attacks is often attributed exclusively to a neurally mediated reflex to pain, although it may also be due to migraine's autonomic impairment, with cardiac conduction abnormalities, probably in relation to a degree of reduced sympathetic function. We report the case of a 51-year-old woman presenting episodes of syncope exclusively after vomiting during migraine attacks. A 24-hour Holter monitoring performed during a migraine attack disclosed an intermittent complete atrioventricular block coincident with an episode of syncope. The patient was implanted with a pacemaker without further syncopes on subsequent attacks. This case highlights the importance of clinical suspicion and investigation of syncope during migraine attacks. Recurrent syncope during migraine should not be attributed to pain to avoid misdiagnosis and ensure the treatment of other important causes of syncope.</p>","PeriodicalId":7059,"journal":{"name":"Acta medica portuguesa","volume":" ","pages":"182-184"},"PeriodicalIF":0.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cutaneous Manifestations Related to Glycemic Control.
IF 0.8 4区 医学
Acta medica portuguesa Pub Date : 2025-03-03 Epub Date: 2025-01-31 DOI: 10.20344/amp.22239
Alexandra Ramos Rodrigues, Ana Luísa Matos, Carlos Pedro Mendes
{"title":"Cutaneous Manifestations Related to Glycemic Control.","authors":"Alexandra Ramos Rodrigues, Ana Luísa Matos, Carlos Pedro Mendes","doi":"10.20344/amp.22239","DOIUrl":"10.20344/amp.22239","url":null,"abstract":"","PeriodicalId":7059,"journal":{"name":"Acta medica portuguesa","volume":" ","pages":"185-186"},"PeriodicalIF":0.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143073268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Papulonecrotic Tuberculid as Manifestation of Lymph Node Tuberculosis].
IF 0.8 4区 医学
Acta medica portuguesa Pub Date : 2025-03-03 Epub Date: 2025-02-10 DOI: 10.20344/amp.22669
José Ramos, Hugo Leme, Ângela Roda, João Alves
{"title":"[Papulonecrotic Tuberculid as Manifestation of Lymph Node Tuberculosis].","authors":"José Ramos, Hugo Leme, Ângela Roda, João Alves","doi":"10.20344/amp.22669","DOIUrl":"10.20344/amp.22669","url":null,"abstract":"","PeriodicalId":7059,"journal":{"name":"Acta medica portuguesa","volume":" ","pages":"199-200"},"PeriodicalIF":0.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Approach to Scabies in Children: An Update].
IF 0.8 4区 医学
Acta medica portuguesa Pub Date : 2025-03-03 Epub Date: 2025-01-29 DOI: 10.20344/amp.22450
Sofia Seabra Vieira, Diana Bernardo, Susana Machado
{"title":"[Approach to Scabies in Children: An Update].","authors":"Sofia Seabra Vieira, Diana Bernardo, Susana Machado","doi":"10.20344/amp.22450","DOIUrl":"10.20344/amp.22450","url":null,"abstract":"<p><p>Scabies is a common dermatological infection that globally affects more than 200 million people. It is caused by the parasite Sarcoptes scabiei var. hominis and its transmission primarily occurs through direct contact. Symptoms typically appear three to six weeks after infestation, with intense itching being the most characteristic manifestation. Lesions most commonly appear on the hands, wrists, armpits, periumbilical area, buttocks, and genital region, although the clinical manifestations vary with age. In infants and children, they also affect the face, scalp, palms, soles, ankles, and chest. Therefore, diagnosis is clinical but challenging due to the diversity of manifestations. Treatment aims to eliminate the parasite and relieve symptoms, using options such as topical 5% permethrin, benzyl benzoate, sulfur sulfate, or systemic ivermectin. Permethrin is recommended as the first-line treatment for children over two months, while ivermectin is used in more severe cases. Adherence to treatment and the disinfestation of clothing and bedding are crucial to prevent reinfestation. Early recognition and effective treatment are essential given its prevalence and significant impact on public health, particularly in pediatric populations.</p>","PeriodicalId":7059,"journal":{"name":"Acta medica portuguesa","volume":" ","pages":"175-181"},"PeriodicalIF":0.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Performance of ChatGPT in the Portuguese National Residency Access Examination. ChatGPT 在葡萄牙国家住院医师准入考试中的表现。
IF 0.8 4区 医学
Acta medica portuguesa Pub Date : 2025-03-03 Epub Date: 2024-12-20 DOI: 10.20344/amp.22506
Gonçalo Ferraz-Costa, Mafalda Griné, Manuel Oliveira-Santos, Rogério Teixeira
{"title":"Performance of ChatGPT in the Portuguese National Residency Access Examination.","authors":"Gonçalo Ferraz-Costa, Mafalda Griné, Manuel Oliveira-Santos, Rogério Teixeira","doi":"10.20344/amp.22506","DOIUrl":"10.20344/amp.22506","url":null,"abstract":"<p><p>ChatGPT, a language model developed by OpenAI, has been tested in several medical board examinations. This study aims to evaluate the performance of ChatGPT on the Portuguese National Residency Access Examination, a mandatory test for medical residency in Portugal. The study specifically compares the capabilities of ChatGPT versions 3.5 and 4o across five examination editions from 2019 to 2023. A total of 750 multiple-choice questions were submitted to both versions, and their answers were evaluated against the official responses. The findings revealed that ChatGPT 4o significantly outperformed ChatGPT 3.5, with a median examination score of 127 compared to 106 (p = 0.048). Notably, ChatGPT 4o achieved scores within the top 1% in two examination editions and exceeded the median performance of human candidates in all editions. Additionally, ChatGPT 4o's scores were high enough to qualify for any specialty. In conclusion, ChatGPT 4o can be a valuable tool for medical education and decision-making, but human oversight remains essential to ensure safe and accurate clinical practice.</p>","PeriodicalId":7059,"journal":{"name":"Acta medica portuguesa","volume":" ","pages":"170-174"},"PeriodicalIF":0.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the Editor: "Aphasia Screening Test (TeRAp): Construction and Validation for European Portuguese".
IF 0.8 4区 医学
Acta medica portuguesa Pub Date : 2025-03-03 Epub Date: 2025-02-07 DOI: 10.20344/amp.22777
Cláudia Mourato Silva
{"title":"Letter to the Editor: \"Aphasia Screening Test (TeRAp): Construction and Validation for European Portuguese\".","authors":"Cláudia Mourato Silva","doi":"10.20344/amp.22777","DOIUrl":"10.20344/amp.22777","url":null,"abstract":"","PeriodicalId":7059,"journal":{"name":"Acta medica portuguesa","volume":" ","pages":"201"},"PeriodicalIF":0.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Increasing Prevalence of Food Allergies in the Pediatric Populations: A Rising Concern.
IF 0.8 4区 医学
Acta medica portuguesa Pub Date : 2025-03-03 Epub Date: 2025-02-12 DOI: 10.20344/amp.22498
Beatriz Parreira de Andrade, Filipa Almeida, Jorge Romariz, Herculano Costa, Cláudia Pedrosa
{"title":"The Increasing Prevalence of Food Allergies in the Pediatric Populations: A Rising Concern.","authors":"Beatriz Parreira de Andrade, Filipa Almeida, Jorge Romariz, Herculano Costa, Cláudia Pedrosa","doi":"10.20344/amp.22498","DOIUrl":"10.20344/amp.22498","url":null,"abstract":"","PeriodicalId":7059,"journal":{"name":"Acta medica portuguesa","volume":" ","pages":"197-198"},"PeriodicalIF":0.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cutaneous Metastasis in Advanced Gastric Cancer.
IF 0.8 4区 医学
Acta medica portuguesa Pub Date : 2025-03-03 Epub Date: 2025-01-30 DOI: 10.20344/amp.22555
André Silva, Nuno Monteiro, Estanislau Mateia, Isa Santos, Margarida Correia
{"title":"Cutaneous Metastasis in Advanced Gastric Cancer.","authors":"André Silva, Nuno Monteiro, Estanislau Mateia, Isa Santos, Margarida Correia","doi":"10.20344/amp.22555","DOIUrl":"10.20344/amp.22555","url":null,"abstract":"","PeriodicalId":7059,"journal":{"name":"Acta medica portuguesa","volume":" ","pages":"202-203"},"PeriodicalIF":0.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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