Acta medica portuguesa最新文献_第2页

Interactions between Insomnia, Sleep Disordered Breathing and Cardiometabolic Risk in Patients Complaining of Pain in the Orofacial Region.

IF 0.8 4区医学

Acta medica portuguesa Pub Date : 2025-01-02 DOI: 10.20344/amp.22350

Miguel Meira E Cruz, David Gozal, Cristina Salles, Isabel Rocha, Dominik Ettlin

{"title":"Interactions between Insomnia, Sleep Disordered Breathing and Cardiometabolic Risk in Patients Complaining of Pain in the Orofacial Region.","authors":"Miguel Meira E Cruz, David Gozal, Cristina Salles, Isabel Rocha, Dominik Ettlin","doi":"10.20344/amp.22350","DOIUrl":"https://doi.org/10.20344/amp.22350","url":null,"abstract":"The existence of intersected pathways between the mechanisms of insomnia, sleep-disordered breathing and persistent/chronic pain has been documented. Such concurrence will eventually contribute to a higher burden of cardiometabolic diseases, a main cause of death worldwide. The aim of this study was to evaluate the interactions between insomnia, sleep-disordered breathing, cardiometabolic risk, and psychosocial stress in patients seeking care at an orofacial pain clinic. Anonymized data of 1236 patients seeking care at the orofacial pain unit of the University of Zurich were analysed. Prevalence data was estimated for insomnia, sleep disordered breathing/sleep apnea and increased risk of a combination of insomnia and sleep disordered breathing/sleep apnea, both regarding demographics and cardiometabolic risk factors. Psychosocial stress factors acting as additional cardiometabolic risk factors were assessed. Among patients with persistent orofacial pain, increased risk of combination of insomnia and sleep disordered breathing/ sleep apnea was present in 11.5% of cases, and it was likely to increase psychosocial stress as an aditional independent risk factor for cardiometabolic disorder.","PeriodicalId":7059,"journal":{"name":"Acta medica portuguesa","volume":"38 1","pages":"37-41"},"PeriodicalIF":0.8,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142918963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Disease Caused by Filoviruses: An Update]. [丝状病毒引起的疾病：最新情况]。

IF 0.8 4区医学

Acta medica portuguesa Pub Date : 2025-01-02 Epub Date: 2024-11-20 DOI: 10.20344/amp.21911

Rafael Marx de Andrade, Andreia Paulos, Emília Valadas, Vitor Laerte Pinto Junior

{"title":"[Disease Caused by Filoviruses: An Update].","authors":"Rafael Marx de Andrade, Andreia Paulos, Emília Valadas, Vitor Laerte Pinto Junior","doi":"10.20344/amp.21911","DOIUrl":"10.20344/amp.21911","url":null,"abstract":"The Marburg and Ebola viruses belong to the Filoviridae family and are known to cause emerging zoonotic diseases. These viruses have a high case fatality rate and are easily transmissible from person to person, which makes them capable of triggering outbreaks, including in non-endemic regions, and are also considered agents of bioterrorism. Fruit bats are the natural reservoirs of these filoviruses. Transmission to humans occurs through direct contact with bodily fluids or tissues from infected animals or humans. The most severe form of filovirus disease manifests as mucocutaneous hemorrhage, often accompanied by multiorgan failure, which is the main cause of death. Traditionally, these diseases are classified in the group of viral hemorrhagic fevers, although this term is being abandoned, as there are not always hemorrhagic manifestations or fever in the patient's clinical history. Currently, no specific antiviral treatment for filovirus disease exists, and the therapeutic approach consists of supportive measures. However, for the Zaire Ebola virus (EBOV), monoclonal antibodies have already been licensed for treatment and post-exposure prophylaxis, in addition to three vaccines available. Due to the public health importance and the possibility of cases outside Africa, this review aims to improve clinical knowledge and the approach to suspected cases of FD. Improved surveillance and preparedness for potential global outbreaks are essential measures to effectively respond to these public health threats and to ensure that healthcare professionals are well-informed and prepared to deal with these diseases.","PeriodicalId":7059,"journal":{"name":"Acta medica portuguesa","volume":" ","pages":"42-48"},"PeriodicalIF":0.8,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Performance of ChatGPT in the Portuguese National Residency Access Examination. ChatGPT 在葡萄牙国家住院医师准入考试中的表现。

IF 0.8 4区医学

Acta medica portuguesa Pub Date : 2024-12-20 DOI: 10.20344/amp.22506

Gonçalo Ferraz-Costa, Mafalda Griné, Manuel Oliveira-Santos, Rogério Teixeira

引用次数: 0

[Preserving the Autonomy in Intensive Care Units: Patients Voting for General Elections in Portugal].

IF 0.8 4区医学

Acta medica portuguesa Pub Date : 2024-12-18 DOI: 10.20344/amp.22168

Ana Cochicho Ramalho, Madalena Costa, Pedro Gaspar Da Costa, Simão C Rodeia, Philip Fortuna

引用次数: 0

[Cutaneous Metastases of Renal Cell Carcinoma: Report of Two Clinical Cases]. [肾细胞癌的皮肤转移：两个临床病例的报告]。

IF 0.8 4区医学

Acta medica portuguesa Pub Date : 2024-12-13 DOI: 10.20344/amp.22240

Mélissa M de Carvalho, Margarida Moura Valejo Coelho, Rui Bajanca

引用次数: 0

[Equity in Access to Health Care in Portugal: What Do We Know?]

IF 0.8 4区医学

Acta medica portuguesa Pub Date : 2024-12-09 DOI: 10.20344/amp.21668

Joana Fernandes, Cláudia Furtado, João Pereira

引用次数: 0

Warthin's Tumor: A Rare Case Report of a Bilateral Multifocal Parotid Tumor Associated with an Ectopic Tumor.

IF 0.8 4区医学

Acta medica portuguesa Pub Date : 2024-12-06 DOI: 10.20344/amp.22147

Joana Silva, Nelson Teixeira, Nuno Ramos, Sância Ramos

引用次数: 0

Atypical Leg Ulcer in an Elderly Patient.

IF 0.8 4区医学

Acta medica portuguesa Pub Date : 2024-12-02 Epub Date: 2024-11-11 DOI: 10.20344/amp.22117

Keyla Sousa, João Teixeira, Joana Calvão

引用次数: 0

[Diagnostic, Therapeutic and Monitoring Approach in Suspected Neurosyphilis: Proposal for a Clinical Guideline].

IF 0.8 4区医学

Acta medica portuguesa Pub Date : 2024-12-02 DOI: 10.20344/amp.21847

Bárbara Martins, Gabriela Canelas, Rafael Dias, Beatriz Prista-Leão, Cláudio Silva, Andreia Costa, André Silva-Pinto

{"title":"[Diagnostic, Therapeutic and Monitoring Approach in Suspected Neurosyphilis: Proposal for a Clinical Guideline].","authors":"Bárbara Martins, Gabriela Canelas, Rafael Dias, Beatriz Prista-Leão, Cláudio Silva, Andreia Costa, André Silva-Pinto","doi":"10.20344/amp.21847","DOIUrl":"https://doi.org/10.20344/amp.21847","url":null,"abstract":"This clinical guideline was designed to serve as a hospital guide in the diagnostic, therapeutic, and monitoring approach to neurosyphilis, considering whether there is positivity or not for the human immunodeficiency virus. Syphilis is a sexually transmitted notifiable disease, known as the great imitator. In around 30% of cases of untreated disease, there is a persistent central nervous system infection. Neurosyphilis is a severe and progressive form of syphilis, which can occur at any stage of the disease, with frequent delays in diagnosis and treatment. It is classified as early neurosyphilis (syphilitic meningitis, meningovascular neurosyphilis, or syphilitic gummas) and late neurosyphilis (syphilitic gummas, general paresis, or tabes dorsalis). The importance of lumbar puncture lies not only in its diagnostic value but also in evaluating the effectiveness of treatment. The treatment of this disease in all stages consists of parenteral penicillin. With this guideline, our aim is to facilitate clinical decision-making in cases of suspected neurosyphilis through a systematized, individualized, and multidisciplinary approach.","PeriodicalId":7059,"journal":{"name":"Acta medica portuguesa","volume":"37 12","pages":"871-882"},"PeriodicalIF":0.8,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fatal Case of Immune-Related Myocarditis and Myositis Due to Treatment with Immune Checkpoint and Tyrosine Kinase Inhibitors. 因使用免疫检查点和酪氨酸激酶抑制剂治疗而引发免疫相关性心肌炎和肌炎的致命病例

IF 0.8 4区医学

Acta medica portuguesa Pub Date : 2024-12-02 Epub Date: 2024-10-14 DOI: 10.20344/amp.21306

João Queirós Coelho, Joana Simões, Tomás Fonseca, Sérgio Xavier Azevedo, António Araújo

{"title":"Fatal Case of Immune-Related Myocarditis and Myositis Due to Treatment with Immune Checkpoint and Tyrosine Kinase Inhibitors.","authors":"João Queirós Coelho, Joana Simões, Tomás Fonseca, Sérgio Xavier Azevedo, António Araújo","doi":"10.20344/amp.21306","DOIUrl":"10.20344/amp.21306","url":null,"abstract":"Immune checkpoint inhibitor and tyrosine kinase inhibitor combinations have become the new standard of care in the first-line treatment of metastatic clear cell renal cell carcinoma. However, there is a growing concern regarding severe immune-related adverse events. A 78-year-old man with metastatic clear cell renal cell carcinoma, treated with pembrolizumab and axitinib, was admitted to the emergency department 30 days after initiating treatment due to rapidly progressive myositis. Myocarditis with severe ventricular dysfunction was identified. Muscular biopsy findings were compatible with inflammatory myopathy associated with immune checkpoint inhibitors. Initial treatment with high-dose corticosteroids showed an insufficient response. Therapeutic escalation on the third day with methylprednisolone, immunoglobulin, and abatacept resulted in clinical improvement. On the eleventh day, a sudden malignant arrhythmia occurred, followed by cardiac arrest. This represents one of the first case reports describing myocarditis and myositis during treatment with pembrolizumab-axitinib. While immune checkpoint inhibitor may play a major role, it is also possible that the tyrosine kinase inhibitor, while attempting to promote immune modulation, also increases severe toxicities.","PeriodicalId":7059,"journal":{"name":"Acta medica portuguesa","volume":" ","pages":"865-868"},"PeriodicalIF":0.8,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0