Journal of neonatal-perinatal medicine最新文献_第5页

Comparative study of individuals born with orofacial clefts in the United States and Brazil. 美国与巴西先天性唇腭裂之比较研究。

Journal of neonatal-perinatal medicine Pub Date : 2025-05-15 DOI: 10.1177/19345798251343829

Adriana M da Silva, V S Freitas, A R Vieira

{"title":"Comparative study of individuals born with orofacial clefts in the United States and Brazil.","authors":"Adriana M da Silva, V S Freitas, A R Vieira","doi":"10.1177/19345798251343829","DOIUrl":"https://doi.org/10.1177/19345798251343829","url":null,"abstract":"BackgroundIn Brazil, little attention has been focused on gestational complications related to orofacial cleft. The objective was to characterize the burden of orofacial clefts in Brazil by comparing the prevalence, risk factors, and birth health conditions of children born with clefts in Brazil and the United States.MethodsThis was a population-based cross-sectional study conducted using national data from 13,297 to 8853 individuals born with orofacial cleft in Brazil and the United States, respectively, between 2017 and 2021. Risk factors (maternal ethnicity, maternal age, infant sex, and plurality) and birth health conditions (number of prenatal care appointments, delivery method, Apgar score at 5 minutes, gestational age, and birthweight) were gathered from national data in both countries. The prevalence of clefts in both countries and prevalence ratios were calculated.ResultsThe prevalence of clefts was 7.1/10,000 in the United States and 6.2/10,000 in Brazil. Newborns with clefts in Brazil were significantly more likely to have a cleft palate (PR = 1.32, p = 0.000), be premature (PR = 1.37, p = 0.000), be born by cesarean section (PR = 1.00, p = 0.000), and have low birth weight (PR = 1.49, p = 0.000). Their mothers tended to be older (PR = 1.09, p = 0.001), non-white (PR = 0.48, p = 0.000), and had fewer than 10 prenatal care appointments (PR = 2.14, p = 0.000), compared to the United States cohort.ConclusionThe frequency of risk factors and adverse outcomes associated with being born with clefts was higher in the Brazilian cohort, suggesting that social determinants of health play a significant role in increasing individuals' susceptibility to risk factors for clefts and poor birth health conditions.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251343829"},"PeriodicalIF":0.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combination therapy for patent ductus arteriosus in preterm infants: Narrative review. 早产儿动脉导管未闭的综合治疗：叙述性回顾。

Journal of neonatal-perinatal medicine Pub Date : 2025-05-07 DOI: 10.1177/19345798251337433

Eyad Bitar, Aimann Surak, Kumar Kumaran, Abbas Hyderi

引用次数: 0

Observed hepatic dysfunction following diazoxide administration in a neonate with liver impairment: A case report. 观察到二氮氧化合物给药后肝功能障碍新生儿肝损害：1例报告。

Journal of neonatal-perinatal medicine Pub Date : 2025-05-01 Epub Date: 2025-03-18 DOI: 10.1177/19345798251327371

Hani Ajrina Zulkeflee, Nur Atiqah Zulkefli, Aliyyah Mohammad Khuzaini

{"title":"Observed hepatic dysfunction following diazoxide administration in a neonate with liver impairment: A case report.","authors":"Hani Ajrina Zulkeflee, Nur Atiqah Zulkefli, Aliyyah Mohammad Khuzaini","doi":"10.1177/19345798251327371","DOIUrl":"10.1177/19345798251327371","url":null,"abstract":"Diazoxide is commonly used to treat neonatal hypoglycaemia when first-line treatment fails by inhibiting insulin secretion. We present a case of a full-term female infant with refractory hypoglycaemia who developed elevated liver enzymes and worsening jaundice following diazoxide administration. After discontinuation of diazoxide, her liver enzyme levels rapidly improved. Although liver impairment has not been commonly reported as a side effect of diazoxide, previous reports, such as one by Tas et al. in 2015, have documented similar findings in patients with hypoalbuminemia, where altered drug metabolism may play a role. Diazoxide undergoes metabolism in the liver, raising the possibility that preexisting liver impairment could affect its clearance and potentially exacerbate hepatic dysfunction. These observations suggest that careful consideration is required when using diazoxide in neonates with compromised liver function. Further studies are needed to explore the mechanisms that may contribute to this association and to establish guidelines for its use in this vulnerable population. This case challenges the conventional understanding of diazoxide as a safe intervention for neonatal hypoglycaemia. Additional research is required to elucidate the mechanisms leading to hepatotoxicity and to establish clear guidelines for the use of diazoxide in this vulnerable population.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"274-278"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Implications of maternal health status on term and close to term neonates in a socioeconomically high-risk population. 产妇健康状况对社会经济高危人群足月和接近足月新生儿的影响

Journal of neonatal-perinatal medicine Pub Date : 2025-05-01 Epub Date: 2025-03-01 DOI: 10.1177/19345798251324450

Rita P Verma, Neeti Luke, Joshua Fogel

{"title":"Implications of maternal health status on term and close to term neonates in a socioeconomically high-risk population.","authors":"Rita P Verma, Neeti Luke, Joshua Fogel","doi":"10.1177/19345798251324450","DOIUrl":"10.1177/19345798251324450","url":null,"abstract":"ObjectiveTo investigate maternal morbidities and their implications on term neonates in a socioeconomically underprivileged population.MethodsIn a retrospective population-based study, maternal morbidities were associated with neonatal birth weight (BW), gestational age (GA), Apgar scores, respiratory distress (RD), admission to Neonatal intensive care nursery (NICU), feeding difficulties, and the length of hospital stay (LOS) in infants admitted to the level 1 nursery via multivariate regression analyses.ResultsIn the 508 mother-infant pairs, 61.4% were Hispanic, 18.4% were African American, 9.6% were non-Hispanic white, and 10.6 % were Asian/Pacific islanders. 8.7% of the neonates [GA 38.63 (1.3) weeks and BW 3196.3 (574.6) g] had Apgar scores <7 at 1 and 2.2% at 5 minutes of life. The prevalence of maternal hypertension (8.5%), Preeclampsia-eclampsia (10.1%), Apgar scores <7 (8.7, 2.2 % at 1 and 5 minutes), NICU admission (20.4%), and feeding difficulty (7.5%) were higher than reported. Mean LOS at 4.29 days was higher than documented in term infants. Apgar scores were associated with eclampsia/preeclampsia, C-section, and antepartum hemorrhage; NICU admission with chorioamnionitis, C-section, and substance abuse; feeding difficulties with maternal alcohol consumption; and longer LOS with preeclampsia/eclampsia, chorioamnionitis, C-section, and tobacco abuse. Maternal hematocrit had positive associations with BW and GA and negative associations with LOS, feeding difficulties, and NICU admission rates.ConclusionsIn the underprivileged multiethnic maternal-neonatal population, term neonates exhibited low-intensity complications attributable to adverse maternal conditions. Optimizing maternal hematocrit may improve neonatal birth weight and maturational status and decrease adverse outcomes.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"211-217"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends and racial differences in hypoxic ischemic encephalopathy-related mortality in newborns in the United States, 2007-2022. 2007-2022年美国新生儿缺氧缺血性脑病相关死亡率的趋势和种族差异

Journal of neonatal-perinatal medicine Pub Date : 2025-05-01 Epub Date: 2025-03-04 DOI: 10.1177/19345798251325496

Hannah Pulido, Fredrick Dapaah-Siakwan

{"title":"Trends and racial differences in hypoxic ischemic encephalopathy-related mortality in newborns in the United States, 2007-2022.","authors":"Hannah Pulido, Fredrick Dapaah-Siakwan","doi":"10.1177/19345798251325496","DOIUrl":"https://doi.org/10.1177/19345798251325496","url":null,"abstract":"BackgroundHypoxic ischemic encephalopathy (HIE) is a significant cause of morbidity and mortality. However, the changes in HIE-related mortality and its associated racial differences, if any, have not been extensively studied. We examined the population-based temporal trends and any racial differences in the HIE-related infant mortality rate (HIE-IMR) in the United States from 2007 through 2022.MethodsThis was a retrospective cross-sectional analysis of linked birth and infant death records data from the CDC WONDER from 2007-2022. We evaluated all infants born at ≥35 weeks gestational age (GA) who died within the first year of life with HIE (ICD-10 codes P91.6 and P21) as the underlying cause of death. The exposure was the year of death, and the outcomes were the changes in overall HIE-IMR and then stratified by race. HIE-IMR was calculated as per 100,000 live births. Linear regression was used for trend analysis.ResultsAmong 59,117,761 live births, 3998 infants with GA ≥ 35 weeks died from HIE (6.7 per 100,000). The overall HIE-IMR increased significantly from 5.2 to 9.6 per 100,000 (p < .001). The rate increased significantly in White (5.3 to 7.2; p < .001) and Black (5.2 to 8.1; p = .005) infants. The overall HIE-IMR was significantly higher in Black infants (7.3) than in White infants (7.2) [p = .02].ConclusionThe HIE-IMR rate increased significantly, and the rate was higher in Black than in White infants. The drivers behind these changes require further examination in future studies.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":"18 3","pages":"270-273"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An investigation into the history of maternal risk factors in the incidence of perinatal mortality. 围产儿死亡率发生的孕产妇危险因素调查。

Journal of neonatal-perinatal medicine Pub Date : 2025-05-01 Epub Date: 2025-04-24 DOI: 10.1177/19345798251324441

Maryam Zakerihamidi, Hassan Boskabadi

{"title":"An investigation into the history of maternal risk factors in the incidence of perinatal mortality.","authors":"Maryam Zakerihamidi, Hassan Boskabadi","doi":"10.1177/19345798251324441","DOIUrl":"https://doi.org/10.1177/19345798251324441","url":null,"abstract":"ObjectivesThe rate of perinatal mortality is an important indicator of maternal and neonatal health. Identification of risk factors for perinatal mortality may be effective in its prevention. Accordingly, this study aimed to identify maternal risk factors of perinatal mortality.MethodsA cross-sectional study was conducted on 547 stillbirths and 709 neonatal deaths at Ghaem Hospital of Mashhad, Iran, during 2008-2019. The data were collected using a researcher-made questionnaire in two parts of stillbirth (maternal diseases, main complication, and final diagnosis) and specifications of neonatal death (e.g., gender, length of hospitalization, age, first and fifth minute Apgar scores, gestational age, weight, resuscitation, mode of delivery, preterm rupture of membranes, main cause of death, and maternal diseases). Data analysis was performed by T-test and Chi-square tests using SPSS version 21 (V.21).ResultsOverall, 222 mothers (41%) had stillborn fetus and 325 (77%) with neonatal death had maternal risk factors. The 41% of neonatal deaths and 26% of stillbirths were along with maternal hypertension, 33% of neonatal deaths and 25% of stillbirths were along with maternal preeclampsia, and 9% of neonatal deaths and 12% of stillbirths were along with maternal diabetes. The cases of cesarean and neonatal resuscitation were higher in neonates with maternal risk factors (69% and 58%, respectively) than those with mothers who had no problem (43% and 32%, respectively).ConclusionHypertension, preeclampsia, and diabetes were three important diseases during pregnancy, associated with high stillbirths and neonatal deaths. Neonates of mothers with problem were pretermer or less birth weight and had more problems during delivery and died earlier.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":"18 3","pages":"203-210"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare yet preventable complication of lower extremity PICC malposition in an extreme preterm: Implications for enhanced procedural imaging standards. 一种罕见但可预防的极端早产下肢PICC错位并发症：提高程序成像标准的意义。

Journal of neonatal-perinatal medicine Pub Date : 2025-05-01 Epub Date: 2025-03-14 DOI: 10.1177/19345798251327379

Manal Mouhssine, Aimen Ben Ayad, Aiman Rahmani

引用次数: 0

Applications of lung ultrasound as an emerging tool in neonates. 肺超声作为新兴工具在新生儿中的应用。

Journal of neonatal-perinatal medicine Pub Date : 2025-05-01 Epub Date: 2025-03-11 DOI: 10.1177/19345798251325492

Aimann Surak, Huma Shaireen, Yasser Elsayed

引用次数: 0

Comparative study between nebulized and intravenous magnesium sulfate for treatment of persistent pulmonary hypertension in neonates. 雾化与静脉注射硫酸镁治疗新生儿持续性肺动脉高压的比较研究。

Journal of neonatal-perinatal medicine Pub Date : 2025-05-01 Epub Date: 2025-03-14 DOI: 10.1177/19345798251325510

Nashwa Farouk Mohamed, Osama Abu El Fetouh Zaki El Feky, Heba Morsy Saad El Din El Ganady, Walid Abd Elatif Abd El Halim

{"title":"Comparative study between nebulized and intravenous magnesium sulfate for treatment of persistent pulmonary hypertension in neonates.","authors":"Nashwa Farouk Mohamed, Osama Abu El Fetouh Zaki El Feky, Heba Morsy Saad El Din El Ganady, Walid Abd Elatif Abd El Halim","doi":"10.1177/19345798251325510","DOIUrl":"https://doi.org/10.1177/19345798251325510","url":null,"abstract":"BackgroundPersistent pulmonary hypertension of the newborn (PPHN) is a life-threatening condition resulting from elevated pulmonary vascular resistance, causing severe hypoxemia. Magnesium sulfate (MgSO4) is a potent vasodilator used in PPHN treatment, but its intravenous administration can cause systemic side effects. This study aims to compare the effects of nebulized and intravenous MgSO4 on oxygenation and hemodynamic parameters in neonates with severe PPHN.MethodsThis non-randomized controlled study was conducted on 40 mechanically ventilated neonates with severe PPHN at Benha University Hospitals. Neonates were divided into two groups: one received nebulized MgSO4 (NebMag, n = 20) and the other intravenous MgSO4 (IVMag, n = 20). Primary outcome was the change in Oxygenation Index (OI) at 12 and 24 hours. Secondary outcomes included changes in mean arterial pressure (MABP), serum magnesium levels, and vasoactive inotropic score (VIS).ResultsBoth groups showed improvements in oxygenation and ventilatory parameters. However, after 24 hours, the NebMag group had significantly lower OI (19.75 ± 2.9 vs 22.1 ± 2.19, p = 0.032) and higher PaO2 (69.45 ± 7.56 mmHg vs 60.75 ± 5.9 mmHg, p = 0.008). MABP was significantly higher and VIS was lower in the NebMag group at all time points. Serum magnesium levels were significantly lower in the NebMag group at 12 hours (3.6 ± 0.18 vs 1.2 ± 0.17 mmol/L, p < 0.001).ConclusionNebulized MgSO4 may offer a safer alternative to intravenous administration, providing effective pulmonary vasodilation with fewer systemic side effects in neonates with PPHN.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":"18 3","pages":"246-254"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Story-Telling Attention-Refocusing (STAR) intervention to alleviate acute stress in parents of infants in the NICU. 讲故事-重新聚焦（STAR）干预减轻新生儿重症监护室婴儿父母的急性应激。

Journal of neonatal-perinatal medicine Pub Date : 2025-05-01 Epub Date: 2025-03-14 DOI: 10.1177/19345798251324449

Anisia Wong, Sandra Fucile

{"title":"Story-Telling Attention-Refocusing (STAR) intervention to alleviate acute stress in parents of infants in the NICU.","authors":"Anisia Wong, Sandra Fucile","doi":"10.1177/19345798251324449","DOIUrl":"10.1177/19345798251324449","url":null,"abstract":"IntroductionAdmission of an infant to the neonatal intensive care unit (NICU) is a stressful event for parents. The physical separation and inability to hold their child due to minimal handling protocols or infection control such as in the recent COVID-19 pandemic is a major contributor to parental stress. Knowledge on a contact-free parent administered intervention to reduce the stress of parents whose infant necessitates neonatal intensive care is lacking.ObjectiveTo assess the effect of a contact-free, Story-Telling Attention-Refocusing (STAR) intervention on the acute stress of parents whose infant is in the NICU.MethodsA block-randomized controlled single-blind trial was conducted in a level II-III NICU. Parents in the experimental group provided the STAR intervention which consisted of designated prompts to share stories with their infants over a ten-minute period, three times per week, for 1 week. Parent acute stress was measured using the PSS:NICU questionnaire before and after the STAR intervention period, and differences in acute stress between mothers and fathers were assessed as well as parent satisfaction.ResultsTwenty-one parents completed the study. Results revealed that overall PSS:NICU stress scores lowered significantly within the intervention group (p = 0.04), and the intervention mediated acute stress of mothers and fathers differently (p = 0.01). Parents reported feeling overall satisfied with the STAR program and they felt less stressed in the hospital and more connected to their infants.ConclusionThe STAR program provides parents a unique opportunity to interact with their infant in a positive meaningful manner and may reduce acute stress in parents during their infants NICU stay.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":"18 3","pages":"226-234"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0