Journal of neonatal-perinatal medicine最新文献_第4页

"Severe transient hypertrophic cardiomyopathy in an extremely preterm infant receiving early low-dose hydrocortisone for bronchopulmonary dysplasia prevention". “早期接受低剂量氢化可的松预防支气管肺发育不良的极早产儿的严重一过性肥厚性心肌病”。

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Journal of neonatal-perinatal medicine Pub Date : 2025-09-01 Epub Date: 2025-06-16 DOI: 10.1177/19345798251349107

Kirti Gupta, Kunal Babla, Pankaj Sakhuja

{"title":"\"Severe transient hypertrophic cardiomyopathy in an extremely preterm infant receiving early low-dose hydrocortisone for bronchopulmonary dysplasia prevention\".","authors":"Kirti Gupta, Kunal Babla, Pankaj Sakhuja","doi":"10.1177/19345798251349107","DOIUrl":"10.1177/19345798251349107","url":null,"abstract":"We present a case of a 24-week gestation neonate who developed severe, reversible hypertrophic cardiomyopathy (HCM) with mid-cavity obstruction within the first 14 days of life. This occurred while the infant was receiving early low-dose hydrocortisone therapy according to the PREMILOC protocol. The patent ductus arteriosus (PDA) was small and functionally restricted following concurrent medical management with paracetamol at the time of diagnosis of HCM. Genetic, endocrine, and metabolic causes were ruled out, and the infant was not receiving any other pharmacological therapy associated with HCM. Our case highlights the need for clinical awareness of the potential association between HCM and low-dose hydrocortisone. This is a rare occurrence and may represent a multifactorial response involving heightened myocardial stress induced by hydrocortisone and increased left ventricular afterload following PDA restriction. The resulting rise in hemodynamic burden could contribute to cardiac remodeling, highlighting the need for clinical caution, close cardiac monitoring, and further research in this vulnerable population.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"491-495"},"PeriodicalIF":0.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibiotic prophylaxis for neonatal surgery: Evaluation of the implementation of a new protocol based on "less could be better". 新生儿手术的抗生素预防：基于“越少越好”的新方案实施的评估。

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Journal of neonatal-perinatal medicine Pub Date : 2025-08-30 DOI: 10.1177/19345798251374926

M José Sánchez de Toro, Mercedes Sampedro Martín, Celia Permuy Romero, Laura Sánchez García, Cristina Calvo, Teresa Del Rosal, Adelina Pellicer

{"title":"Antibiotic prophylaxis for neonatal surgery: Evaluation of the implementation of a new protocol based on \"less could be better\".","authors":"M José Sánchez de Toro, Mercedes Sampedro Martín, Celia Permuy Romero, Laura Sánchez García, Cristina Calvo, Teresa Del Rosal, Adelina Pellicer","doi":"10.1177/19345798251374926","DOIUrl":"https://doi.org/10.1177/19345798251374926","url":null,"abstract":"IntroductionSurgical site infections are associated with increased postoperative morbidity and mortality, as well as prolonged hospitalization and higher costs. Neonates have an immature immune system, rendering them a susceptible population. Evidence regarding surgical prophylaxis in this age group is limited, which has led us to employ broad-spectrum antibiotic therapy for an extended duration.ObjectivesTo evaluate the impact of a new neonatal surgical prophylaxis protocol, based on available evidence in pediatric and adult populations, aimed at restricting antibiotic prescription to this indication and for a limited period of time.Materials and MethodsA case (intervention group receiving the new protocol from March 2022 to March 2023) and a control (historical cohort from March 2019 to March 2020 that received the existing prophylaxis at that time) study was conducted. Perinatal and surgical variables, prophylactic antibiotic therapy, adherence to the protocol and infectious complications were analyzed.ResultsA total of 90 procedures from the intervention group and 116 from the control group were analyzed, with comparable characteristics. The protocol change resulted in a reduction in the duration of antibiotic therapy and a decrease in the cumulative dose (72 h vs 48 h, p < 0.001) without an increase in infectious complications (6.4% vs 10.1%, p = 0.343).ConclusionsThe use of a surgical prophylaxis protocol with a narrower spectrum and shorter duration does not increase the incidence of surgery-related infections in neonatal patients. Despite the multidisciplinary nature of the professionals caring for these patients, the development and implementation of this new protocol have been feasible in our setting.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251374926"},"PeriodicalIF":0.9,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deceptive appearances: Congenital infections simulating genetic syndromes in fetal Pathology. 欺骗性的外表：先天性感染模拟遗传综合征的胎儿病理。

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Journal of neonatal-perinatal medicine Pub Date : 2025-08-29 DOI: 10.1177/19345798251372555

Mishu Mangla, Seetu Palo

{"title":"Deceptive appearances: Congenital infections simulating genetic syndromes in fetal Pathology.","authors":"Mishu Mangla, Seetu Palo","doi":"10.1177/19345798251372555","DOIUrl":"https://doi.org/10.1177/19345798251372555","url":null,"abstract":"Transplacental infections such as cytomegalovirus, Zika virus, toxoplasmosis, and rubella, especially if acquired in the perinatal period, are well-known causes of congenital anomalies. However, their phenotypic overlap with certain genetic syndromes can pose significant diagnostic challenges during fetal autopsy and prenatal counseling. With an objective to review and highlight the clinical and pathological similarities between congenital infections and genetic syndromes, and emphasizing diagnostic pitfalls in fetal autopsy and the importance of integrated approaches, a comprehensive literature review was performed of articles that discussed congenital infections, fetal autopsy findings, and differential diagnosis with genetic syndromes. We found that several transplacental infections mimic the phenotype of genetic syndromes through features such as microcephaly, intracranial calcifications, cardiac anomalies, and hydrops fetalis. Placental pathology, maternal serology, and targeted molecular testing are essential to delineate the cause. An awareness of overlapping features between congenital infections and genetic syndromes is crucial to avoid misdiagnosis. A multidisciplinary approach combining clinical, histopathological, and molecular insights is necessary to reach an accurate diagnosis, guide recurrence risk counseling, and inform management in future pregnancies.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251372555"},"PeriodicalIF":0.9,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cord blood cytokines as early predictors for retinopathy of prematurity. 脐带血细胞因子作为早产儿视网膜病变的早期预测因子。

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Journal of neonatal-perinatal medicine Pub Date : 2025-08-29 DOI: 10.1177/19345798251372547

Yasser Farouk Abdel Raheem, Jaafar Ibrahim Mohamad, Eman Reda Mohammed, Rewaa Mohammed Ibrahiem, Aliaa Mohamed Yousef, Ahmed Mohammed Ali Ahmed, Amira M Shalaby

{"title":"Cord blood cytokines as early predictors for retinopathy of prematurity.","authors":"Yasser Farouk Abdel Raheem, Jaafar Ibrahim Mohamad, Eman Reda Mohammed, Rewaa Mohammed Ibrahiem, Aliaa Mohamed Yousef, Ahmed Mohammed Ali Ahmed, Amira M Shalaby","doi":"10.1177/19345798251372547","DOIUrl":"https://doi.org/10.1177/19345798251372547","url":null,"abstract":"BackgroundRetinopathy of prematurity (ROP) is a significant cause of childhood blindness. Since ROP typically presents no clinical symptoms or signs in early infancy, timely screening of preterm infants is essential for diagnosis. However, fundus examinations cannot always be performed at the optimal time. Elevated cord blood cytokines may help identify infants at higher risk for ROP development, enabling earlier screening and potentially predicting the need for treatment. A deeper understanding of clinical risk factors and biomarkers of ROP could aid in preventing abnormal retinal vascularization and its complications. The study aimed to evaluate the predictive efficacy of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-8 (IL-8) in early ROP development and treatment necessity.MethodsThis prospective study included 88 preterm neonates. Cord blood samples were collected immediately after birth, and timely fundus screening for ROP was conducted. Selected perinatal risk factors were retrospectively analyzed. Cord blood cytokine levels were correlated with ROP development and treatment requirements.ResultsAmong the 88 preterm neonates, 33 (37.5%) developed ROP. The key finding was that infants with ROP had significantly higher cord blood levels of IL-6, IL-8, and TNF-α compared to those without ROP.ConclusionCord blood cytokines show promise as early biomarkers for predicting ROP development and the need for treatment.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251372547"},"PeriodicalIF":0.9,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neonatal calvarial osteomyelitis secondary to perinatal skin infection. 新生儿颅骨骨髓炎继发于围产期皮肤感染。

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Journal of neonatal-perinatal medicine Pub Date : 2025-08-27 DOI: 10.1177/19345798251372535

L Santos Gómez, E Fernández Morán, C Calvo Penín, S Amat Valero, N Vega Mata, S Rubín Roger, J M Vázquez Villa, B Fernández Colomer

引用次数: 0

Successful management of pneumopericardium in an extremely low birth weight preterm using a 22-gauge intravenous catheter as a pericardial drain. 使用22号静脉导管作为心包引流成功治疗极低出生体重早产儿心包气肿。

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Journal of neonatal-perinatal medicine Pub Date : 2025-08-26 DOI: 10.1177/19345798251350996

Szu-Wei Huang, Zhen Liu, Liang-Ti Huang

引用次数: 0

Progressive respiratory failure in a term neonate with ABCA3 surfactant deficiency: Beyond the common causes of respiratory distress. ABCA3表面活性剂缺乏的足月新生儿进行性呼吸衰竭：超出呼吸窘迫的常见原因。

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Journal of neonatal-perinatal medicine Pub Date : 2025-08-25 DOI: 10.1177/19345798251371042

Andrew M Beverstock, Hillary C Lee, David S Moreno McNeill, Morcos Hanna

{"title":"Progressive respiratory failure in a term neonate with ABCA3 surfactant deficiency: Beyond the common causes of respiratory distress.","authors":"Andrew M Beverstock, Hillary C Lee, David S Moreno McNeill, Morcos Hanna","doi":"10.1177/19345798251371042","DOIUrl":"https://doi.org/10.1177/19345798251371042","url":null,"abstract":"BackgroundMost cases of respiratory distress in term neonates are due to transient tachypnea of the newborn (TTN), respiratory distress syndrome (RDS), or air leak syndromes. Genetic surfactant deficiencies are rare causes of respiratory distress. Among these, mutations in the ABCA3 gene disrupt surfactant metabolism and can lead to severe, treatment-refractory respiratory failure. While commonly considered in preterm infants, surfactant dysfunction should also be considered in term infants with unexplained and persistent hypoxemia.CaseWe present a case of a 38-weeks term female infant with fetal growth restriction who developed respiratory distress shortly after birth. She initially responded to continuous positive airway pressure (CPAP) and surfactant but required escalating respiratory support and multiple re-doses of surfactant. Standard infectious and cardiopulmonary evaluations were unrevealing. Given her persistent oxygen requirement and small-for-gestational-age status, genetic testing was pursued. Whole genome sequencing identified bi-allelic pathogenic variants in the ABCA3 gene, consistent with pulmonary surfactant metabolism dysfunction type 3. Despite six doses of surfactant, antibiotics, and inhaled nitric oxide, the patient's respiratory status deteriorated. Lung transplantation was not feasible due to size and clinical condition. The family elected to transition to comfort care.ConclusionThis case highlights the importance of considering genetic surfactant disorders, including ABCA3 mutations, in term neonates with refractory respiratory distress. Early genetic testing can guide management and avoid potentially harmful or ineffective interventions. While some therapies offer transient improvement, outcomes remain poor, and definitive treatment via lung transplantation is limited by size and disease progression. Future research should focus on gene-specific therapies and earlier diagnosis.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251371042"},"PeriodicalIF":0.9,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Duration of monitoring for withdrawal in neonates exposed to in-utero opioids. 暴露于宫内阿片类药物的新生儿戒断的监测时间。

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Journal of neonatal-perinatal medicine Pub Date : 2025-08-25 DOI: 10.1177/19345798251365202

Ayda Soltanian Tiranchi, Dina El Metwally, Katrina Mark

{"title":"Duration of monitoring for withdrawal in neonates exposed to in-utero opioids.","authors":"Ayda Soltanian Tiranchi, Dina El Metwally, Katrina Mark","doi":"10.1177/19345798251365202","DOIUrl":"https://doi.org/10.1177/19345798251365202","url":null,"abstract":"ObjectiveThis study aims to determine the duration of NOWS symptom onset that leads to pharmacologic intervention in order to inform hospital discharge protocols and provide better guidance for patients.Patients and methodsA retrospective chart review was conducted evaluating neonates with documented NOWS monitoring at the University of Maryland Medical Center from January 2017 to November 2022. Infants at 36 weeks gestation and above who were exposed to opioids in-utero were included. Paired maternal and neonatal charts were reviewed. Medical history, drug screen results, and time lapse from day of birth to the day of initiation of treatment were documented.ResultsOf 357 neonates monitored for NOWS, 215 (60.5%) received pharmacologic treatment. All neonates requiring treatment were identified by day of life (DOL) 5. Neonates exposed to multiple opioids were at the highest risk of requiring treatment. When compared to buprenorphine exposure, those exposed to oxycodone and multiple opioids were more likely to need treatment on DOL 0, while methadone-exposed neonates were more likely to require treatment on DOL 1 and 2.ConclusionsThis study provides valuable information for risk-stratification and safe discharge planning for neonates at risk for NOWS. The findings suggest that a 5-day monitoring period may be sufficient to identify neonates requiring pharmacologic treatment for NOWS, potentially allowing for earlier discharge in some cases. However, the timing of symptom onset varies based on the type of opioid exposure, highlighting the need for individualized care and anticipatory guidance for families.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251365202"},"PeriodicalIF":0.9,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of global preterm labor in pregnant women infected with coronavirus: A systematic review and meta-meta-analysis. 感染冠状病毒孕妇的全球早产患病率：系统综述和meta-meta分析

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Journal of neonatal-perinatal medicine Pub Date : 2025-08-15 DOI: 10.1177/19345798251365165

Sedigheh Abdollahpour, Talat Khadivzadeh, Mahla Shafeei, Mahdieh Arian

{"title":"Prevalence of global preterm labor in pregnant women infected with coronavirus: A systematic review and meta-meta-analysis.","authors":"Sedigheh Abdollahpour, Talat Khadivzadeh, Mahla Shafeei, Mahdieh Arian","doi":"10.1177/19345798251365165","DOIUrl":"https://doi.org/10.1177/19345798251365165","url":null,"abstract":"BackgroundPreterm labor is a key factor in neonatal morbidity and mortality globally. Therefore, in the crisis of the coronavirus pandemic, it is important to investigate the prevalence of preterm labor in mothers with COVID-19 infection.Materials and methodsWe performed, according to the PRISMA guideline, a search of the PubMed and Web of Science database on September 1, 2022, to identify systematic reviews and meta-analyses that have summarized studies that report the prevalence of preterm labor in pregnant women with COVID-19. Based on the focused search strategy and eligibility criteria, finally, 66 studies were included in this review. After critical appraisal, using Comprehensive Meta Analysis V3 software, data analysis was done. A random-effects model was employed to account for heterogeneity among studies, and publication bias was assessed. Pooled estimates and their 95% confidence intervals were reported using forest plots.ResultsSixty-six meta-analysis studies, involving a total of 335,964 preterm labors among a sample of 2,260,032 women pregnant with coronavirus infection, were analyzed. Prevalence of preterm delivery in women infected with COVID-19 is 18.8% (lower limit = 0.148; upper limit = 0.235; CI = 95%' df = 65; I-Squared = 99.87; Egger test = 0.40).ConclusionsThe pooled global prevalence of preterm delivery in women infected with COVID-19 is higher than the global estimate in the era before the coronavirus pandemic. Given the global burden of preterm birth, efforts should be intensified to improve the quality of care for all COVID-infected pregnant women.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251365165"},"PeriodicalIF":0.9,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Newborn hypernatremic dehydration: A prospective study reducing the usage of intravenous liquids in moderate cases. 新生儿高钠血症性脱水：一项减少中度静脉液体使用的前瞻性研究。

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Journal of neonatal-perinatal medicine Pub Date : 2025-08-07 DOI: 10.1177/19345798251363457

Deniz Yaprak, Belma Saygılı Karagöl

{"title":"Newborn hypernatremic dehydration: A prospective study reducing the usage of intravenous liquids in moderate cases.","authors":"Deniz Yaprak, Belma Saygılı Karagöl","doi":"10.1177/19345798251363457","DOIUrl":"https://doi.org/10.1177/19345798251363457","url":null,"abstract":"ObjectivesThe rehydration approach for hypernatremic dehydration in newborns is challenging. A new treatment protocol was introduced in the NICU for moderate hypernatremic dehydrated (MHD) newborns to achieve safer and more effective serum sodium (Na+) correction.MethodsA prospective study in a four-level NICU examined term and near term MHD (150-169 mEq/L) newborns. In a novel hypernatremic dehydration treatment protocol, 49 newly diagnosed MHD patients were in group 1, while 54 previously treated control MHD patients were in group 2.Results49 neonates received the novel treatment protocol (group 1), and data from 54 neonates were obtained from hospital records (group 2). Serum Na+ correction rate was significantly lower in group 1 compared to group 2, with a median serum Na+ level of 0.66 versus 1.05 mEq/L/h, p = 0.001. The proportion of patients who were treated with pure oral rehydration was significantly higher in group 1 compared to group 2 (67.3% vs 25.9%, p<0.001). Multiple regression analysis was performed to determine factors associated with use of intravenous rehydration: initial serum Na+ [odds ratio (OR):1.515, 95% confidence interval (CI) 1.17-1.94, p<0.001] and serum uric acid [OR: 1.495, 95% CI 1.092-2.00, p = 0.012] in model 2; belonging to Group 2 [OR: 28.267, 95% CI 10.321-53.69, p<0.001]; each additional delay in the day of postnatal admission [OR: 1.381, 95% CI 1.011-1.888, p = 0.043]; and initial serum Na+ [OR: 1.574, 95% CI 1.216-2.037, p = 0.001] in model 4 were significantly associated with intravenous rehydration.ConclusionsOral rehydration therapy offers slower sodium reduction and has a low treatment failure rate in MHD newborns. It can be the primary treatment approach, while intravenous therapy should be considered based on the patient's overall clinical and biochemical status, not just initial sodium levels.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251363457"},"PeriodicalIF":0.9,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144794754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0