Journal of neonatal-perinatal medicine最新文献_第4页

Correlation of cardiac troponin T levels with inotrope requirements, HIE stages and outcome in asphyxiated neonates. 窒息新生儿心肌肌钙蛋白T水平与肌力需要量、HIE分期和结局的相关性

Journal of neonatal-perinatal medicine Pub Date : 2025-06-17 DOI: 10.1177/19345798251350998

Eman Gamal Abdelrahman, Eman Rateb Abd Almonaem, Dina Saad Abdelmotaleb, Mohamed Ahmed AbdelHafiz

{"title":"Correlation of cardiac troponin T levels with inotrope requirements, HIE stages and outcome in asphyxiated neonates.","authors":"Eman Gamal Abdelrahman, Eman Rateb Abd Almonaem, Dina Saad Abdelmotaleb, Mohamed Ahmed AbdelHafiz","doi":"10.1177/19345798251350998","DOIUrl":"https://doi.org/10.1177/19345798251350998","url":null,"abstract":"BackgroundAsphyxial event can compromise the function of many vital organs like brain, heart, and kidneys. Cardiac dysfunction results from hypoxic injury to subendocardial tissue, papillary muscle, and myocardium. The aim of this work was to assess correlation between cardiac troponin T levels, myocardial dysfunction, inotrope requirements, hypoxic ischemic encephalopathy (HIE) stages, and outcome in asphyxiated neonates.MethodsThis cohort study was conducted on 48 neonates aged (1-28) days old, both sexes, exposed to perinatal asphyxia, and admitted in NICU unit in Benha University Hospital during the period from September 2022 to August 2023. Neonates had blood drawn for CBC, liver, kidney functions, and serum troponin T levels. Also, assessment by echocardiography and MRI were done to these patients in the first 3 days.ResultsTroponin T levels were significantly higher in neonates with myocardial dysfunction (systolic or diastolic), who required inotropic support, mechanical ventilation, or who were non-survivors. Troponin T levels significantly correlated with HIE severity, as assessed by Apgar scores and Sarnat staging. ROC curve revealed that cardiac troponin T levels have high accuracy at a cutoff value of >0.18 ng/mL, >0.18 ng/mL, and >0.18 ng/mL, respectively, in detecting myocardial dysfunction, morbidity, and mortality in patients with HIE with reliable sensitivity (84.2%-92.3%) and specificity (88.2%-93.1%).ConclusionsElevated cardiac troponin T is highly suggestive of myocardial dysfunction in cases of HIE. It is significantly correlated to severity of HIE, morbidity, and mortality in asphyxiated neonate.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251350998"},"PeriodicalIF":0.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postnatal trends of surrogate anthropometric indices in infants of diabetic mothers: A prospective cohort study from South India. 糖尿病母亲的婴儿代孕人体测量指数的产后趋势：一项来自南印度的前瞻性队列研究。

Journal of neonatal-perinatal medicine Pub Date : 2025-06-17 DOI: 10.1177/19345798251350992

Kalyani Ainikkara Praful, Sanjana Hansoge Somanath, Vijayan Sharmila, Thirunavukkarasu Arun Babu, Yamini Marimuthu

{"title":"Postnatal trends of surrogate anthropometric indices in infants of diabetic mothers: A prospective cohort study from South India.","authors":"Kalyani Ainikkara Praful, Sanjana Hansoge Somanath, Vijayan Sharmila, Thirunavukkarasu Arun Babu, Yamini Marimuthu","doi":"10.1177/19345798251350992","DOIUrl":"https://doi.org/10.1177/19345798251350992","url":null,"abstract":"BackgroundInfants of diabetic mothers (IDMs) are shown to have predisposition for obesity and metabolic complications in childhood and adolescence. While several studies found growth differences in IDMs during childhood, data on growth in early infancy are scarce. This study aimed to assess the surrogate anthropometric parameters which evaluate physical growth in more detail during first 6 weeks of life in IDMs.MethodsA prospective cohort study was conducted among late preterm and term IDMs with infants of non-diabetic mothers taken as controls. Basic demographics, delivery characteristics, maternal anthropometry and birth anthropometry including auxologic parameters were recorded postnatally. Follow-up measurements were taken till 6 weeks. Statistical analysis was performed using STATA.ResultsIDMs showed higher weight for length at 6 weeks and higher BMI at birth and at 6 weeks of age. MUAC was significant at birth but not at 6 weeks age. Birth weight and large-for-gestational age were significantly higher in diabetic group. At 6 weeks, 14% of infants of diabetic mothers were overweight, though not statistically significant.ConclusionThe IDMs seemed to have significant difference in their auxologic parameters and had greater prevalence of overweight in early postnatal period as early as at 6 weeks postnatal age in this study albeit small sample size. Close monitoring of growth and metabolic parameters in infants of diabetic mothers in larger sample sizes are necessary for better monitoring for complications and better long-term outcomes as their body composition possibly seems to differ from those of IDMs in early infancy.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251350992"},"PeriodicalIF":0.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In-hospital outcomes of early versus late transcatheter closure of patent ductus arteriosus in preterm infants. 早产儿动脉导管未闭早期与晚期经导管闭合的住院结果。

Journal of neonatal-perinatal medicine Pub Date : 2025-06-16 DOI: 10.1177/19345798251350986

Mohamed F Elsisy, George T Nicholson, Elizabeth H Stephens, Gayathri Sreenivasan, Arpit Gupta

{"title":"In-hospital outcomes of early versus late transcatheter closure of patent ductus arteriosus in preterm infants.","authors":"Mohamed F Elsisy, George T Nicholson, Elizabeth H Stephens, Gayathri Sreenivasan, Arpit Gupta","doi":"10.1177/19345798251350986","DOIUrl":"https://doi.org/10.1177/19345798251350986","url":null,"abstract":"BackgroundTranscatheter closure of patent ductus arteriosus (PDA) in small, premature infants is increasingly performed in the contemporary practice. Data regarding optimal timing of PDA closure are scarce. We therefore decided to compare morbidity and mortality of early and late device closure in preterm infants.MethodsHospitalizations of 166,583 newborn infants diagnosed with PDA were identified from the Kids' Inpatient Database (KID) in 2009, 2012, 2016, and 2019. Of these, 299 preterm infants (gestational age (GA) ≤32 weeks, birth weight <1500 grams) underwent percutaneous PDA closure. Characteristics and periprocedural outcomes were compared between early (≤30 days) (n = 120) and late PDA closure (>30 days) (n = 179).ResultsMean age (±standard deviation) for early PDA closure was 18.6 days ± 7 and 67.3 days ± 36.5 in late PDA closure. Comorbidities including respiratory distress syndrome/bronchopulmonary dysplasia, heart failure, and pulmonary hypertension were comparable between the two groups. There was no difference in mortality or referral for surgical ligation between early and late closure. Postprocedural vascular complications were low, but higher in patients with early PDA closure (3.3% vs 0%; p = 0.025). While the total length of hospital stay was longer in late PDA closure group (121.1 days ± 51.7 vs 81.5 days ± 48.8; p = <0.01), postprocedural length of stay was paradoxically longer in the early closure group (69 days ± 43.6 vs 57.5 days ± 43, p = 0.03).ConclusionThere was no statistical difference in in-hospital mortality; however, there is a trend toward higher mortality in the early closure group. Major periprocedural complications are comparable between early and late PDA closure, except vascular complications that were higher with early PDA closure.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251350986"},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding and addressing bias in urine drug screening protocols on high-volume labor and delivery units. 理解和解决在大容量产程和分娩单位尿液药物筛选方案中的偏见。

Journal of neonatal-perinatal medicine Pub Date : 2025-06-16 DOI: 10.1177/19345798251349418

Megan Kalata, G Sotolongo, L Ahlers, L Byrne, O Doll, O Foley, G Folino, K Hermann, M Maglasang, N Perme, A Van Cleave

{"title":"Understanding and addressing bias in urine drug screening protocols on high-volume labor and delivery units.","authors":"Megan Kalata, G Sotolongo, L Ahlers, L Byrne, O Doll, O Foley, G Folino, K Hermann, M Maglasang, N Perme, A Van Cleave","doi":"10.1177/19345798251349418","DOIUrl":"https://doi.org/10.1177/19345798251349418","url":null,"abstract":"BackgroundThe purpose of this study was to understand the current demographics and characteristics of patients undergoing urine drug screening on labor and delivery units with the intention of using this data to create a more evidence-based, equitable policy to reduce bias in the screening process.MethodsA retrospective chart review was performed of 509 instances of drug screening occurring for pregnant and recently delivered patients across three hospitals in Omaha, Nebraska. Demographics of patients, including age, race, ethnicity, and insurance status, as well as reasons for drug screening, patient consent, screening results, and disclosure of results, were analyzed to assess patterns in screening.Results509 screening instances were evaluated with 324 unique patients. While Black patients made up 11.6% of the overall patient population, they accounted for 26.2% of the patients undergoing urine drug screenings. 2.88% of all patients self-identified as Hispanic; however, they comprised 13.4% of all patients screened. Consent was documented in 11.3% of cases and a reason for obtaining UDS was documented in 61.5% of cases. The most common reasons cited were history of substance use or current use, medical indications, and suspected use without documented history of use.ConclusionsEstablishment of more specific, evidence-based policies for urine drug screening may reduce the impact of implicit biases on current screening practices and serve as one avenue to rebuild trust with patients who have historically been marginalized by the medical community.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251349418"},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can B-type natriuretic peptide be used diagnostically for patent ductus arteriosus in extremely preterm infants? b型利钠肽能诊断极早产儿动脉导管未闭吗？

Journal of neonatal-perinatal medicine Pub Date : 2025-06-16 DOI: 10.1177/19345798251349746

Juan Longhi, Maxwell Corrigan

{"title":"Can B-type natriuretic peptide be used diagnostically for patent ductus arteriosus in extremely preterm infants?","authors":"Juan Longhi, Maxwell Corrigan","doi":"10.1177/19345798251349746","DOIUrl":"https://doi.org/10.1177/19345798251349746","url":null,"abstract":"BackgroundB-type natriuretic peptide (BNP) can help define the hemodynamic significance of patent ductus arteriosus (PDA). The aim of this study was to examine if BNP can be used independently to discriminate between large and small PDAs even in extremely premature humans of less than 25 weeks of gestational age.MethodsThis was a retrospective observational study of 102 infants with a gestational age (GA) <30 weeks and more specifically of 42 infants with GA <25 weeks. BNP measurement and echocardiograms performed within 72 hours of each other were reviewed. Receiver operating characteristic curves were generated to assess diagnostic significance and optimal use thresholds.ResultsInfants with moderate to large PDAs (n = 79) had significantly higher BNP levels compared to infants with small or closed PDAs (n = 25) (median [IQ range]): 550 (277-1106) pg/mL versus 62 (33-164) pg/mL, p < 0.001). The optimal threshold for the recognition of moderate and large PDAs was 201 pg/mL (sensitivity 86%, specificity 87%, AUC: 0.89, p < 0.001) for infants <30 weeks GA and 188 pg/mL (sensitivity 88%, specificity 87%, AUC: 0.93, p < 0.001) for infants <25 weeks GA.ConclusionsBNP is an accurate PDA diagnostic tool for extremely preterm infants of less than 25 weeks in GA. Clinicians may consider BNP in preliminary determination of the significance of PDA and in settings with limited echocardiogram capabilities.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251349746"},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low birth weight among neonates: Investigating incidence, risk factors, and AI-enabled predictive modeling for risk estimation. 新生儿低出生体重：调查发病率、风险因素和用于风险估计的人工智能预测模型。

Journal of neonatal-perinatal medicine Pub Date : 2025-06-16 DOI: 10.1177/19345798251349745

Archana Maju, Sarita Shokandha, Sugandha Arya

{"title":"Low birth weight among neonates: Investigating incidence, risk factors, and AI-enabled predictive modeling for risk estimation.","authors":"Archana Maju, Sarita Shokandha, Sugandha Arya","doi":"10.1177/19345798251349745","DOIUrl":"https://doi.org/10.1177/19345798251349745","url":null,"abstract":"BackgroundLow birth weight serves as a vital measure of maternal health and the efficacy of prenatal care globally. The study was aimed to assess the incidence and risk factors of low birth weight among neonates. Further to develop a predictive model that identifies the risk factors contributing to low birth weight using artificial intelligence.MethodsThe study employed a dual research design, incorporating both descriptive and case-control methodologies. The data was analyzed using descriptive and inferential statistics. Further a predictive model was developed using logistic regression through artificial intelligence.ResultsThe incidence rate of low-birth-weight babies was approximately 304.7 (30.47%) per 1000 live births. Logistic regression analysis identified significant risk factors for low birth weight (LBW), with notably high adjusted odds ratios (AOR). Key factors included inadequate weight gain during pregnancy <9 kg (AOR = 11.89, 95% CI: 6.03-23.44), gestational age <37 weeks (AOR = 12.81, 95% CI: 6.55-25.02), fetal complications reported during pregnancy (AOR = 13.25, 95% CI: 6.81-25.77), and multiple gestation (AOR = 26.88, 95% CI: 3.31-217.99). The developed AI-enabled predictive model demonstrates a high overall accuracy of 90%.ConclusionMost identified risk factors are modifiable, and early prenatal care can greatly reduce LBW incidence and improve neonatal outcomes. The predictive model demonstrated strong accuracy in classifying newborns by birth weight. Integrating the model into healthcare systems can aid early risk detection, reducing low birth weight and improving neonatal outcomes.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251349745"},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"Severe transient hypertrophic cardiomyopathy in an extremely preterm infant receiving early low-dose hydrocortisone for bronchopulmonary dysplasia prevention". “早期接受低剂量氢化可的松预防支气管肺发育不良的极早产儿的严重一过性肥厚性心肌病”。

Journal of neonatal-perinatal medicine Pub Date : 2025-06-16 DOI: 10.1177/19345798251349107

Kirti Gupta, Kunal Babla, Pankaj Sakhuja

{"title":"\"Severe transient hypertrophic cardiomyopathy in an extremely preterm infant receiving early low-dose hydrocortisone for bronchopulmonary dysplasia prevention\".","authors":"Kirti Gupta, Kunal Babla, Pankaj Sakhuja","doi":"10.1177/19345798251349107","DOIUrl":"https://doi.org/10.1177/19345798251349107","url":null,"abstract":"We present a case of a 24-week gestation neonate who developed severe, reversible hypertrophic cardiomyopathy (HCM) with mid-cavity obstruction within the first 14 days of life. This occurred while the infant was receiving early low-dose hydrocortisone therapy according to the PREMILOC protocol. The patent ductus arteriosus (PDA) was small and functionally restricted following concurrent medical management with paracetamol at the time of diagnosis of HCM. Genetic, endocrine, and metabolic causes were ruled out, and the infant was not receiving any other pharmacological therapy associated with HCM. Our case highlights the need for clinical awareness of the potential association between HCM and low-dose hydrocortisone. This is a rare occurrence and may represent a multifactorial response involving heightened myocardial stress induced by hydrocortisone and increased left ventricular afterload following PDA restriction. The resulting rise in hemodynamic burden could contribute to cardiac remodeling, highlighting the need for clinical caution, close cardiac monitoring, and further research in this vulnerable population.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251349107"},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Little Bookworms: Examining participation in a NICU reading program and parental attachment and anxiety. 小书虫：检查参加新生儿重症监护室阅读计划和父母的依恋和焦虑。

Journal of neonatal-perinatal medicine Pub Date : 2025-06-16 DOI: 10.1177/19345798251349416

A D Henry, C A Stanton, E J Plosa, J C Boles

{"title":"Little Bookworms: Examining participation in a NICU reading program and parental attachment and anxiety.","authors":"A D Henry, C A Stanton, E J Plosa, J C Boles","doi":"10.1177/19345798251349416","DOIUrl":"https://doi.org/10.1177/19345798251349416","url":null,"abstract":"BackgroundIn recent years, bedside reading programs have multiplied as an accessible means of enhancing parent/caregiver engagement in the neonatal intensive care unit (NICU). However, little is yet known about the relationship between program participation and parent/caregiver well-being. Therefore, the aim of this study was to investigate potential relationships between a parent-led, bedside NICU reading program and parent/caregiver attachment, anxiety, and satisfaction.MethodsA sample of 60 NICU parents/caregivers participated in a parent-led, bedside reading program in 2024. They completed pre- and post-intervention self-reported measures of anxiety and attachment; upon discharge, participants also completed a Program Perceptions and Experiences survey.ResultsParent-reported anxiety was observed to decrease significantly between the pre- and post-intervention time points. Overall, postnatal attachment scores, and more specifically, Quality of Attachment sub-scale scores, were seen to significantly increase in mothers between the pre- and post-intervention periods. Conversely, no significant differences in attachment were found in fathers across time points. Program Perceptions and Experiences survey responses indicated participants enjoyed the reading program and perceived that it enhanced their feelings of attachment towards their infants.ConclusionsParticipants reported significant decreases in anxiety and significant increases in postnatal attachment over time, with more pronounced change observed in mothers compared to fathers. Though these results may also align with improving medical status and movement towards discharge, participants' positive reflections on the program, combined with the minimal time and resources required to implement it, suggest that parental bedside reading interventions for NICU parents/caregivers may be a useful avenue of family-centered intervention.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251349416"},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tight junction proteins and intestinal health in preterm infants. 紧密连接蛋白与早产儿肠道健康

Journal of neonatal-perinatal medicine Pub Date : 2025-06-16 DOI: 10.1177/19345798251349394

Parvesh Mohan Garg, McKenzie X Denton, Srikanth Ravisankar, Maja Herco, Jeffrey S Shenberger, Yan-Hua Chen

{"title":"Tight junction proteins and intestinal health in preterm infants.","authors":"Parvesh Mohan Garg, McKenzie X Denton, Srikanth Ravisankar, Maja Herco, Jeffrey S Shenberger, Yan-Hua Chen","doi":"10.1177/19345798251349394","DOIUrl":"10.1177/19345798251349394","url":null,"abstract":"The intestinal epithelial barrier consists of a single layer of cells that separate the gut lumen from the rest of the body. It regulates and protects the intestinal tract immunologically and mechanically. Necrotizing enterocolitis (NEC) is one of the most common conditions requiring emergency surgery in the neonatal intensive care unit and is associated with a septic shock-like state contributing to multi-organ dysfunction. NEC affects 6-10% of very low birthweight infants and remains a leading cause of death. This review presents current evidence of the role of tight junction proteins in clinical neonatology and intestinal health using information from our own clinical and laboratory research in conjunction with information collected from an extensive search in the databases PubMed, EMBASE, and Scopus. The ability to measure the permeability of the intestinal barrier in real-time is essential to understanding the disease process of NEC and the subsequent morbidities. Detection of TJ proteins in blood and stool of preterm infants represents a potential biomarker for the early NEC diagnosis. Therapeutics targeting TJ proteins may also mitigate NEC severity and improve clinical outcomes.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251349394"},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12226259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of sequential functional echocardiography in predicting clinically apparent patent ductus arteriosus in preterm very low birth weight newborns: An observational study. 序贯功能超声心动图在预测早产儿极低出生体重新生儿临床明显动脉导管未闭中的作用：一项观察性研究。

Journal of neonatal-perinatal medicine Pub Date : 2025-05-15 DOI: 10.1177/19345798251343494

Anchala Bhardwaj, Arvind Saili, Dinesh Kumar Yadav, Ajay Kumar

{"title":"Role of sequential functional echocardiography in predicting clinically apparent patent ductus arteriosus in preterm very low birth weight newborns: An observational study.","authors":"Anchala Bhardwaj, Arvind Saili, Dinesh Kumar Yadav, Ajay Kumar","doi":"10.1177/19345798251343494","DOIUrl":"https://doi.org/10.1177/19345798251343494","url":null,"abstract":"BackgroundThe prolonged ductal patency in preterm newborns despite being associated with short- and long-term morbidities has failed to show significant improvement in the long-term outcome with routine ductal treatment. Echocardiography has been shown to have a predictive and diagnostic role in identifying the significant patent ductus arteriosus (PDA) before its clinical detection and providing selective treatment for PDA to avoid unnecessary therapy or delay of necessary therapy. Several echocardiographic ductal markers have been evaluated for their predictive utility with a wide range of sensitivity (26%-100%) and specificity (6%-100%). Ductal diameter, left pulmonary artery (LPA) velocity, and left atrial to aortic width (La/Ao) ratio are the common markers being used routinely for PDA. This research was planned to assess the predictive utility of additional ductal echocardiographic markers in preterm newborns.MethodsIt was a prospective observational cohort study conducted in the tertiary care neonatal intensive care unit (NICU) at Lady Hardinge Medical College, Delhi. 50 very low birth weight newborns underwent four sequential Echo scans within the first 72 hrs; the first within 12 hours, and the next three scans at completed 24 hrs, 48 hrs, and 72 hrs of age. These newborns were then monitored for clinical signs of PDA up to 2 weeks of life.ResultsThe left atrial volume index (LAVI), left ventricle to aortic width (Lv/Ao ratio), left ventricular output/superior vena cava (LVO/SVC) flow ratio with different cut-off values at different hours of life, shunt pattern and altered blood flow in the anterior cerebral, and superior mesenteric vessels predicted persistence of ductus arteriosus.ConclusionThis study provides insights into the predictive utility of additional ductal echo markers apart from the routinely measured ones.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251343494"},"PeriodicalIF":0.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0