Journal of neonatal-perinatal medicine最新文献_第3页

Effects of protein intake on IGF1 and ROP. 蛋白质摄入对IGF1和ROP的影响。

Journal of neonatal-perinatal medicine Pub Date : 2025-06-23 DOI: 10.1177/19345798251351004

Divya Keerthy, Angela Holuba, David Bateman, Sudha Kashyap

{"title":"Effects of protein intake on IGF1 and ROP.","authors":"Divya Keerthy, Angela Holuba, David Bateman, Sudha Kashyap","doi":"10.1177/19345798251351004","DOIUrl":"https://doi.org/10.1177/19345798251351004","url":null,"abstract":"BackgroundInsulin-like growth factor 1 has been implicated in neural and retinal cell maturation. Optimizing insulin-like growth factor 1 may prevent morbidities, like retinopathy of prematurity. Our objective was to determine the effects of higher protein in parenteral nutrition for very low birth weight infants on insulin-like growth factor 1 and retinopathy of prematurity.MethodsThis was a post-hoc analysis of a prospective, double blind, randomized control trial of appropriate for gestational age, preterm infants (<1250 grams) randomized to high protein (N = 53) or conventional protein (N = 47) in early parenteral nutrition. Goal protein intake was 4 g/kg/d for high protein group and 3 g/kg/d for conventional protein group. Weekly insulin-like growth factor 1 and standard retinal examinations were evaluated.ResultsInsulin-like growth factor 1 was significantly associated with protein intake group controlling for postnatal age, gestational age and sex. Insulin-like growth factor 1 increased by 21.9% (p = 0.03) in the high protein group. Any retinopathy of prematurity or severe retinopathy of prematurity (grade ≥3 and/or plus disease) was not associated with group, actual daily protein intake or insulin-like growth factor 1. However, high protein group was associated with lower risk of plus disease (OR 0.17, p = 0.02). Infants with plus disease had 25% lower mean insulin-like growth factor 1 (p = 0.052).ConclusionHigher protein in parenteral nutrition was associated with increased insulin-like growth factor 1 and lower risk of plus disease in very low birth weight infants.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251351004"},"PeriodicalIF":0.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of probiotics supplementation in neonatal jaundice therapy: A systematic review. 补充益生菌在新生儿黄疸治疗中的作用：一项系统综述。

Journal of neonatal-perinatal medicine Pub Date : 2025-06-20 DOI: 10.1177/19345798251350382

Lisa Amelia Wijaya, Putu Wila Widiastuti, Ni Nyoman Metriani Nesa, I Gusti Ngurah Sanjaya Putra

{"title":"The effect of probiotics supplementation in neonatal jaundice therapy: A systematic review.","authors":"Lisa Amelia Wijaya, Putu Wila Widiastuti, Ni Nyoman Metriani Nesa, I Gusti Ngurah Sanjaya Putra","doi":"10.1177/19345798251350382","DOIUrl":"10.1177/19345798251350382","url":null,"abstract":"BackgroundNeonatal jaundice affects 60% of term and 80% of preterm newborns due to high levels of unconjugated bilirubin, leading to significant health issues. Currently, probiotics were used as a promising agent to enhance phototherapy outcomes.ObjectivesThe purpose of this systematic review is to assess the effect of probiotics supplementation in neonatal jaundice therapy.MethodsFour reviewers extracted randomized controlled trial (RCT) studies from Google Scholar, PubMed, and the Cochrane Library as per PRISMA guidelines. The risk of bias will be assessed using the Cochrane risk of bias tool for randomized trials (RoB 2). Inclusion criteria comprised term or preterm neonates diagnosed with any type of jaundice warranting phototherapy, outcome comparison between probiotic supplementation in phototherapy and control group. Study including healthy neonates, prophylaxis effect, non-RCT, and non-English studies were excluded in this study.ResultsNine out of 14 RCT studies showed significant reduction of total serum bilirubin levels with various duration after receiving probiotic supplementation during phototherapy. Some of RCT studies reported significant changes in indirect bilirubin levels, duration of phototherapy, duration of hospital stay. Moreover, there were four studies that found no significant changes on total serum bilirubin levels. No adverse effects or complications are found among those studies.ConclusionProbiotics supplementation in neonatal jaundice therapy was promising beneficial outcome for neonatal jaundice. Further research is required to confirm the consistency of therapeutic effects and adverse reactions.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251350382"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of implementing a clinical practice guideline for prophylactic indomethacin on reduction of severe IVH in extremely preterm infants. 实施预防性吲哚美辛临床实践指南对减少极早产儿严重IVH的影响。

Journal of neonatal-perinatal medicine Pub Date : 2025-06-19 DOI: 10.1177/19345798251349748

Eniko Szakmar, Sasha Harrison, Hoda Elshibiny, Chelsea Munster, Mohamed El-Dib

{"title":"Effect of implementing a clinical practice guideline for prophylactic indomethacin on reduction of severe IVH in extremely preterm infants.","authors":"Eniko Szakmar, Sasha Harrison, Hoda Elshibiny, Chelsea Munster, Mohamed El-Dib","doi":"10.1177/19345798251349748","DOIUrl":"https://doi.org/10.1177/19345798251349748","url":null,"abstract":"BackgroundProphylactic indomethacin in preterm infants has been associated with reduction of severe intraventricular hemorrhage (SIVH) but no improvement in neurodevelopmental outcome. Since January 2016, Brigham and Women's Hospital has implemented a clinical practice guideline (CPG) for prophylactic indomethacin to prevent SIVH. Our aim was to compare the predicted and observed rate of SIVH before and after CPG implementation. Second, to evaluate the association between indomethacin and development of SIVH.MethodsThis retrospective cohort study included infants born between 23 and 28 weeks of gestation. Variables were compared between before (pre-group) and after the CPG implementation (post-group). Risk categories for SIVH were defined as the following based on a validated model: low <15%, moderate ≥15% to <25%, and high risk ≥25%. Multivariate logistic regression model was applied to evaluate the association between SIVH and the administration of indomethacin.ResultsInfants in the post-group (n = 325) presented with lower Apgar scores, higher rate of necrotizing enterocolitis, abdominal surgery, and mortality comparing to pre-group (n = 424). The use of indomethacin for any reason was 44% in pre-group and 62% in post-group (p < 0.001). There was no significant difference in the predicted and observed rate of SIVH between the 2 groups in any risk categories. There was no association between the use of indomethacin and development of SIVH in multivariate regression models.ConclusionThe implementation of CPG for prophylactic indomethacin was not associated with reduction in the incidence of SIVH and no association was found between the use of indomethacin and development of SIVH.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251349748"},"PeriodicalIF":0.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human breast milk fortification with human milk fortifier vs preterm infant formula: A systematic review and meta-analysis. 母乳强化与母乳强化剂vs早产儿配方奶粉：一项系统回顾和荟萃分析。

Journal of neonatal-perinatal medicine Pub Date : 2025-06-19 DOI: 10.1177/19345798251350987

Ni Nyoman Berlian Aryadevi, Rosita Saumi Imanta Putri, Putri Maharani Tristanita Marsubrin

{"title":"Human breast milk fortification with human milk fortifier vs preterm infant formula: A systematic review and meta-analysis.","authors":"Ni Nyoman Berlian Aryadevi, Rosita Saumi Imanta Putri, Putri Maharani Tristanita Marsubrin","doi":"10.1177/19345798251350987","DOIUrl":"https://doi.org/10.1177/19345798251350987","url":null,"abstract":"BackgroundThe limited availability and high cost of human milk fortifier (HMF) in developing countries represent significant challenges. Preterm formula (PTF) fortification of breast milk is a potential alternative, but its safety and impact on growth are still uncertain. This study compares the safety and effect of breast milk fortification with PTF versus HMF on growth velocity in very low birth weight preterm infants.MethodsA thorough literature search was conducted in the PubMed, Scopus, Google Scholar, ClinicalTrials.gov, and Europe PMC databases up to March 24, 2024. Relevant randomized controlled trials (RCTs) studying fortifying breast milk with PTF or HMF were identified and their quality assessed using the Cochrane Risk of Bias 2 tool. Statistical analysis was performed in Review Manager Web, and certainty of evidence was assessed with GRADE.ResultsSix RCTs were included, of which one exhibited low bias risk, three had moderate concerns, and two were classed as high risk. The six RCTs, involving 434 preterm infants, revealed no significant differences in the gain of weight (SMD 0, 95% CI -0.19 to 0.19), length (MD -0.01 cm/wk, 95% CI -0.06 to 0.05), or head circumference (MD -0.01 cm/wk, 95% CI -0.06 to 0.04) between PTF and HMF. There were comparable risks of morbidities.ConclusionVery low certainty evidence suggests that breast milk fortification with PTF may be a safe alternative to HMF, with similar safety profiles and effects on growth.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251350987"},"PeriodicalIF":0.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New diagnostic criteria for clinical chorioamnionitis using only objective indicators: A retrospective study. 临床绒毛膜羊膜炎仅使用客观指标的新诊断标准：回顾性研究。

Journal of neonatal-perinatal medicine Pub Date : 2025-06-17 DOI: 10.1177/19345798251351002

M Sumino, T Yoshida, T Hirata, M Yamanaka

{"title":"New diagnostic criteria for clinical chorioamnionitis using only objective indicators: A retrospective study.","authors":"M Sumino, T Yoshida, T Hirata, M Yamanaka","doi":"10.1177/19345798251351002","DOIUrl":"https://doi.org/10.1177/19345798251351002","url":null,"abstract":"BackgroundChorioamnionitis is a significant perinatal infection that adversely affects maternal and neonatal outcomes. Diagnostic criteria, including Lencki's criteria, are frequently used; however, they include subjective indicators, limiting their clinical utility. We aimed to establish diagnostic criteria using only objective indicators.MethodsThis retrospective cohort study involved patients who delivered at our hospital and underwent placental pathological examination from 2003 to 2022. Based on the Blanc classification, patients were classified into the CAM II/III (stage 2 or 3) and CAM I (stage 1) groups, followed by between-group comparisons of maternal and neonatal outcomes. Diagnostic indicators were selected through multivariate logistic regression analysis and used to develop a diagnostic model. Receiver operating characteristic curves were generated to compare the diagnostic performances of the new and previous criteria.ResultsAmong 862 included patients, 538 and 324 were classified as CAM II/III and CAM I, respectively. The CAM II/III group showed significantly higher rates of neonatal acidosis and maternal postpartum hospitalization ≥10 days. In the new model, scores were assigned as follows: body temperature ≥38.5°C (2 points), C-reactive protein ≥1.0 mg/dL (2 points), white blood cell count ≥12 × 109/L (1 point), and nulliparity (1 point). A total score ≥4 points was considered the diagnostic threshold. The new criteria outperformed the existing criteria, with an area under the curve (AUC) value of 0.741 compared to 0.621 (p < 0.001).ConclusionsThe new criteria showed improved diagnostic accuracy for chorioamnionitis, which may facilitate early diagnosis and timely intervention for improved perinatal outcomes.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251351002"},"PeriodicalIF":0.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

'VACTERL-H in newborn: A rare case report'. 新生儿VACTERL-H：一例罕见病例报告。

Journal of neonatal-perinatal medicine Pub Date : 2025-06-17 DOI: 10.1177/19345798251349420

Walid Alhussin, Fathima Sabahath

{"title":"'VACTERL-H in newborn: A rare case report'.","authors":"Walid Alhussin, Fathima Sabahath","doi":"10.1177/19345798251349420","DOIUrl":"https://doi.org/10.1177/19345798251349420","url":null,"abstract":"BackgroundVACTERL association is a mnemonically useful acronym for a condition characterized by the sporadic, non-random association of specific birth defects in multiple organ systems. Described in the early 1970s, it is typically defined by the presence of three or more of these congenital malformations: vertebral defects, anal atresia, cardiac defects, tracheoesophageal fistulas, renal anomalies, and limb abnormalities. In addition to these core components, patients may also have other congenital anomalies. VACTERL association does not involve neuro-cognitive impairment unless; associated with hydrocephalus, known as VACTERL-H syndrome. VACTERL with hydrocephalus is an extremely rare disorder that affects males and females' children equally.Case descriptionThis report describes the case of a preterm 32 weeks gestation, Asian, male infant who was diagnosed with VACTERL associated with hydrocephalus (VACTERL-H).ConclusionVACTERL syndrome cases are seen very rarely. The diagnosis of VACTERL-H syndrome is primarily based upon a complete physical examination and a few specialized tests to ascertain the features of the syndrome. The treatment of VACTERL-H is directed towards the specific symptoms that are apparent in each individual, which often vary greatly. This case highlights the challenges in managing VACTERL-H syndrome in preterm, who presented with the most serious features of VACTERL. Hence, early diagnosis and early interventions are needed to prevent morbidity and mortality.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251349420"},"PeriodicalIF":0.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Laparotomy or peritoneal drain: Where does the evidence lead? 剖腹手术或腹膜引流：证据指向何处？

Journal of neonatal-perinatal medicine Pub Date : 2025-06-17 DOI: 10.1177/19345798251349434

Parvesh Mohan Garg, Jeffrey S Shenberger

引用次数: 0

Role of calprotectin in diagnosis of necrotizing enterocolitis and Doppler US in detecting its severity and outcome in neonates. 钙保护蛋白在新生儿坏死性小肠结肠炎诊断中的作用及多普勒超声检测其严重程度和预后。

Journal of neonatal-perinatal medicine Pub Date : 2025-06-17 DOI: 10.1177/19345798251349747

Amira M Shalaby, Azhar Arabi Mohammed, Randa Abdelbadie Abdelaleem, Omran Khodary Qenawy, Abdellatif M Abdelmoeaz, Ismail L Mohamad, Deiaaeldin M Tamer

{"title":"Role of calprotectin in diagnosis of necrotizing enterocolitis and Doppler US in detecting its severity and outcome in neonates.","authors":"Amira M Shalaby, Azhar Arabi Mohammed, Randa Abdelbadie Abdelaleem, Omran Khodary Qenawy, Abdellatif M Abdelmoeaz, Ismail L Mohamad, Deiaaeldin M Tamer","doi":"10.1177/19345798251349747","DOIUrl":"https://doi.org/10.1177/19345798251349747","url":null,"abstract":"BackgroundNecrotizing enterocolitis (NEC) is a life-threatening gastrointestinal emergency in preterm neonates, with mortality exceeding 50% in severe cases. Early diagnosis remains challenging due to nonspecific clinical signs.ObjectivesThis study aimed to evaluate the diagnostic accuracy of fecal calprotectin (FCP) and assess Doppler ultrasound (US) for predicting disease severity and mortality.MethodsA case-control study of 54 neonates with NEC (Bell's Stages I-III) and 42 matched controls. FCP levels were measured within 48 hours of symptom onset and Doppler US was performed to evaluate bowel perfusion. It was done at Neonatal Intensive Care Unit (NICU) during the period from (January 2019 to December 2019).ResultsFecal calprotectin levels were significantly higher in NEC cases (362.6 ± 239.8 µg/g) compared to controls (61.9 ± 44.2 µg/g, p < 0.001). The optimal FCP cutoff was 176 µg/g (sensitivity 87%, specificity 97.6%). Doppler US showed decreased bowel perfusion in 77.8% of Stage III NEC cases, which strongly predicted mortality (OR 4.2, 95% CI 1.8-9.6).ConclusionFCP and Doppler US provide complementary, non-invasive methods for early NEC diagnosis and risk stratification. Their combined use could improve clinical decision-making in high-risk neonates.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251349747"},"PeriodicalIF":0.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perinatal palliative care in an infant with exencephaly: Supporting life beyond 3 years of age. 新生儿畸形的围产期姑息治疗：支持3岁以上的生命。

Journal of neonatal-perinatal medicine Pub Date : 2025-06-17 DOI: 10.1177/19345798251351003

G Bayo Varão, E Parravicini, A Aziz, S Brady

引用次数: 0

Implementing the practice of early skin-to-skin contact among infants ≥34 weeks gestation born by caesarean section: A quality improvement study. 在妊娠≥34周剖腹产婴儿中实施早期皮肤接触：一项质量改善研究

Journal of neonatal-perinatal medicine Pub Date : 2025-06-17 DOI: 10.1177/19345798251349219

Md Habibullah Sk, Saugata Chaudhuri, Bijan Saha

{"title":"Implementing the practice of early skin-to-skin contact among infants ≥34 weeks gestation born by caesarean section: A quality improvement study.","authors":"Md Habibullah Sk, Saugata Chaudhuri, Bijan Saha","doi":"10.1177/19345798251349219","DOIUrl":"https://doi.org/10.1177/19345798251349219","url":null,"abstract":"BackgroundSeparating mothers and newborns after caesarean delivery prevents early skin-to-skin contact (SSC), despite WHO recommendations to initiate SSC immediately at birth. Early SSC promotes breastfeeding success, enhances thermoregulation, reduces maternal postpartum complications, and fosters bonding. In our hospital, SSC was not practiced after caesarean deliveries, prompting this quality improvement (QI) initiative.MethodsConducted in the operating theatre of a tertiary care hospital over 4 months (January-April 2024), with a 3-month sustenance phase. Inborn infants ≥34 weeks gestation and ≥1.8 kg delivered via caesarean section, with good tone and breathing at birth, were eligible. Sequential Plan-Do-Study-Act (PDSA) cycles were implemented to introduce SSC within 5 minutes of birth, aiming for ≥90% compliance. Interventions included staff training, SSC protocol development, operating room reorganization, and maternal support during recovery.ResultsSSC compliance increased from 0% at baseline to 100% by cycle 4. Breastfeeding initiation improved from 48% to 95%, and exclusive breastfeeding at discharge increased from 77% to 97%. Deferred weighing and vitamin K administration rates increased from 10% to 100%.ConclusionThrough systematic interventions, we achieved and sustained 100% SSC compliance for caesarean births. This study demonstrates that with a structured, multidisciplinary approach, SSC can be successfully integrated into caesarean delivery routines, potentially enhancing maternal-infant bonding and early breastfeeding initiation.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251349219"},"PeriodicalIF":0.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0