Journal of neonatal-perinatal medicine最新文献_第2页

Diffusion tensor imaging and MR spectroscopy in the evaluation of neonatal encephalopathies. 弥散张量成像和磁共振光谱在新生儿脑病评估中的应用。

IF 0.9

Journal of neonatal-perinatal medicine Pub Date : 2026-05-01 Epub Date: 2025-09-22 DOI: 10.1177/19345798251380181

Adya Mehra, Priya Pattath Sankaran, Sheila S Mathai, Rajagopal Kadavigere, Prakashini Koteshwara

{"title":"Diffusion tensor imaging and MR spectroscopy in the evaluation of neonatal encephalopathies.","authors":"Adya Mehra, Priya Pattath Sankaran, Sheila S Mathai, Rajagopal Kadavigere, Prakashini Koteshwara","doi":"10.1177/19345798251380181","DOIUrl":"10.1177/19345798251380181","url":null,"abstract":"BackgroundNeonatal encephalopathy is a broad term encompassing many underlying pathologies, most commonly hypoxic-ischemic encephalopathy. Though this diagnosis has long been derived from relevant history, examination and lab parameters, this study aims to illustrate the diagnostic power of advanced radiological techniques such as MR Spectroscopy and Diffusion Tensor Imaging to objectively classify subjects based on disease severity and predict adverse outcomes.Methods41 cases of neonatal encephalopathy with MRI Brain were included in the study. NAA/Cr, NAA/Cho, Cho/Cr and Lac/Cr ratios in basal ganglia and white matter, and DTI parameters of FA, ADC and MD in five major tracts were recorded. Developmental milestones were assessed on follow up of the child at 6 months. Correlation of the MRS and DTI values with disease severity and status at follow up was done.ResultsThe ratios of NAA/Cr and Lac/Cr in basal ganglia and white matter showed strong positive correlation with the disease severity at onset. Lac/Cr also positively correlated with the abnormal outcome group. FA values in the posterior limbs of internal capsule, thalami and corpus callosum were seen to most consistently correlate with the abnormal outcome group, substantiating these objective and reproducible metrics that can be employed for neuro-prognostication across all etiologies of neonatal encephalopathy.ConclusionNeonatal encephalopathy is an umbrella term for conditions that can cause devastating neurological sequelae, which necessitates radiological pattern recognition for identification of etiology, and use of supplementary quantitative techniques such as MRS and DTI is endorsed for objective evaluation of clinical outcomes.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"274-287"},"PeriodicalIF":0.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12982549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of a quality improvement initiative on neonatal stabilization and admission patterns in a special care newborn unit in India. 质量改进倡议对新生儿稳定和入院模式在印度的特殊护理新生儿单位的影响。

IF 0.9

Journal of neonatal-perinatal medicine Pub Date : 2026-05-01 Epub Date: 2025-10-14 DOI: 10.1177/19345798251387331

Md Habibullah Sk, Bijan Saha, Anindya Kumar Saha

{"title":"Impact of a quality improvement initiative on neonatal stabilization and admission patterns in a special care newborn unit in India.","authors":"Md Habibullah Sk, Bijan Saha, Anindya Kumar Saha","doi":"10.1177/19345798251387331","DOIUrl":"https://doi.org/10.1177/19345798251387331","url":null,"abstract":"BackgroundTo reduce avoidable Special Newborn Care Unit (SNCU) admissions by 15% over a 4-month period through focused quality improvement (QI) interventions at a high-volume tertiary care hospital in Kolkata, India.MethodsThis QI study was conducted from August to November 2024. Baseline data revealed that 25% of weekly SNCU admissions were avoidable. A multidisciplinary team implemented evidence-based admission criteria, enhanced perinatal care practices, and strengthened postnatal monitoring. Key interventions included improved delivery room practices (respiratory support with CPAP, delayed cord clamping, early skin-to-skin contact, and early initiation of breastfeeding) and standardized triage protocols. Feeding support, prefeeding oromotor stimulation, antibiotic stewardship, and reverse transport to nearby SNCUs were also integrated. Four Plan-Do-Study-Act (PDSA) cycles supported infrastructure planning, staff training, protocol implementation, and sustainability.ResultsAvoidable admissions declined from 25% to 10% over 4-months. Bed occupancy dropped from a peak of 125% to 102%. Process indicators improved significantly: delayed cord clamping increased from 30% to 88%, early initiation of breastfeeding from 40% to 90%, and exclusive breastfeeding at discharge from 67% to 81%. Admissions for neonatal jaundice decreased following the implementation of updated AAP guidelines, with 21% of cases managed without phototherapy. Only five re-admissions (0.59%) and one emergency NICU transfer (0.13%) occurred.ConclusionsNeonatal care should extend beyond SNCU optimization to include strengthened delivery point and postnatal-ward practices. When integrated with protocol based SNCU management, this continuum helps reduce morbidity, ease overcrowding, enhance efficiency, and optimize resource utilization in high-burden, resource-limited settings.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":"19 3","pages":"313-322"},"PeriodicalIF":0.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147816362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neonatal calvarial osteomyelitis secondary to perinatal skin infection. 新生儿颅骨骨髓炎继发于围产期皮肤感染。

IF 0.9

Journal of neonatal-perinatal medicine Pub Date : 2026-05-01 Epub Date: 2025-08-27 DOI: 10.1177/19345798251372535

L Santos Gómez, E Fernández Morán, C Calvo Penín, S Amat Valero, N Vega Mata, S Rubín Roger, J M Vázquez Villa, B Fernández Colomer

引用次数: 0

Localized bullous drug reaction to cefotaxime leading to wet gangrene in a neonate: A case report. 头孢噻肟致新生儿湿性坏疽的局部大疱性药物反应1例报告。

IF 0.9

Journal of neonatal-perinatal medicine Pub Date : 2026-05-01 Epub Date: 2025-09-30 DOI: 10.1177/19345798251384933

K Krishna Kumar, Choudri Muzafar Paswal, Swasthi Kabi Satpathy, Gudipudi Sai Vamsi Manoj, Neeraj Gupta

{"title":"Localized bullous drug reaction to cefotaxime leading to wet gangrene in a neonate: A case report.","authors":"K Krishna Kumar, Choudri Muzafar Paswal, Swasthi Kabi Satpathy, Gudipudi Sai Vamsi Manoj, Neeraj Gupta","doi":"10.1177/19345798251384933","DOIUrl":"10.1177/19345798251384933","url":null,"abstract":"BackgroundBullous drug eruptions are rare but serious adverse reactions in neonates. Cefotaxime, a commonly used third-generation cephalosporin in neonatal intensive care, can rarely cause severe cutaneous adverse reactions.ResultsWe report a case of a term, large-for-gestational-age male neonate who developed bullous drug eruption following intravenous cefotaxime administration on Day 3 of life. The patient was initially admitted for decreased urine output and received prophylactic cefotaxime for suspected sepsis. Immediately after the fifth dose of intravenous cefotaxime, blister formation occurred over all five left toes distal to the IV cannula site. This progressed to gangrenous changes involving all five toes with erythematous discoloration extending to the metacarpophalangeal joints. Conservative management, including antibiotics and local wound care, resulted in gradual improvement, characterized by the formation of demarcation lines and the resolution of inflammation.ConclusionThis case highlights a rare but serious complication of cefotaxime use in neonates. Healthcare providers should be aware of this potential severe cutaneous adverse reaction, particularly when cefotaxime is administered via peripheral intravenous access. Early recognition and immediate discontinuation of the offending drug, along with conservative management, can lead to favorable outcomes.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"329-333"},"PeriodicalIF":0.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of non-adhesive suspension method for fixing umbilical lines on CLABSI in preterm neonates - A propensity score matched study. 非粘附悬浮液固定脐带对早产儿CLABSI的影响-倾向评分匹配研究。

IF 0.9

Journal of neonatal-perinatal medicine Pub Date : 2026-05-01 Epub Date: 2025-09-29 DOI: 10.1177/19345798251380176

Tsv Vahnita, Umamaheswari Balakrishnan, Prakash Amboiram, Saishree Pradhan

{"title":"Effect of non-adhesive suspension method for fixing umbilical lines on CLABSI in preterm neonates - A propensity score matched study.","authors":"Tsv Vahnita, Umamaheswari Balakrishnan, Prakash Amboiram, Saishree Pradhan","doi":"10.1177/19345798251380176","DOIUrl":"10.1177/19345798251380176","url":null,"abstract":"BackgroundFixing umbilical lines using medical adhesives raises concern of skin injury, creating a potential source of infection increasing the likelihood of central associated blood stream infection (CLABSI). Considering this, we adapted an alternate method of non-adhesive vertical suspension technique for fixation of umbilical lines. This study compared CLABSI rate between suspension method and conventional method.MethodsThis before-after design (observational study) included preterm neonates <32 weeks of gestational age (GA) who required umbilical line insertion. Suspension technique for fixation of umbilical lines was adopted from October, 2024. Based on the technique, neonates were grouped as ADHESIVE group (AG) admitted between October 2023 and September 2024, and SUSPENSION group (SG) admitted between October 2024 and March 2025. Propensity matching for GA formed a matched cohort of 60 neonates. Outcome of the study included comparison of CLABSI rate among two groups, and skin injury and displacement of umbilical lines in SG.ResultsOut of 60 matched neonates, 30 were included in the SG. CLABSI rate in the SG and AG was 6.2 and 30.1, respectively (RR- 0.20, 95% CI 0.004-1.83). According to McNemar's test SG had a significant lower CLABSI rate (p < 0.001).ConclusionThis study highlights the feasibility of the non-adhesive suspension technique as a method to fix umbilical catheter with no associated skin injury and displacement. Though there was no difference in CLABSI rate overall, with propensity matching for GA, this technique had lower CLABSI rate. Future larger studies are needed to evaluate efficacy of this technique.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"267-273"},"PeriodicalIF":0.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exclusive human milk for infants with gastroschisis: A systematic review and meta-analysis. 胃裂婴儿纯母乳治疗：系统回顾和荟萃分析。

IF 0.9

Journal of neonatal-perinatal medicine Pub Date : 2026-05-01 Epub Date: 2025-10-08 DOI: 10.1177/19345798251384981

Hareshan Suntharalingam, Jennifer Armstrong, Daniel Briatico, Esther Huisman, Prakesh S Shah, Michael H Livingston

{"title":"Exclusive human milk for infants with gastroschisis: A systematic review and meta-analysis.","authors":"Hareshan Suntharalingam, Jennifer Armstrong, Daniel Briatico, Esther Huisman, Prakesh S Shah, Michael H Livingston","doi":"10.1177/19345798251384981","DOIUrl":"10.1177/19345798251384981","url":null,"abstract":"BackgroundInfants with gastroschisis often experience prolonged stays in hospital as they transition from parenteral nutrition to enteral feeds. The purpose of this study was to assess the evidence for the use of exclusive human milk compared to formula in these patients.MethodsA structured search was performed using Medline, Embase, and Cochrane Central from inception until March 2025. We included comparative studies of infants with gastroschisis who received exclusive human milk versus supplemental or exclusive formula. Screening and data extraction were completed by two independent reviewers. Results from included studies were meta-analyzed using a random-effects model and reported as risk ratios (RR) with 95% confidence intervals (CI). Risk of bias assessments were performed using the Newcastle-Ottawa Scale. Outcomes included time to enteral autonomy, necrotizing enterocolitis, sepsis, cholestasis, and mortality. Certainty of evidence was summarized using Grading of Recommendations, Assessment, Development and Evaluations criteria.ResultsWe identified 3661 infants with gastroschisis from six retrospective cohort studies and one case-control study. Exclusive human milk was associated with a reduced risk of mortality (RR = 0.38, 95% CI: 0.15-0.99, I2 = 0%). There were no statistically significant differences between groups for necrotizing enterocolitis, cholestasis, or sepsis. These findings were supported by low quality evidence based on retrospective data.ConclusionsThe best available evidence suggests that exclusive breast milk is associated with reduced mortality compared to formula among infants with gastroschisis. This estimate is based on data from retrospective studies. Further research is needed to clarify the role of donor human milk.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"245-259"},"PeriodicalIF":0.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12982548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Kangaroo Mother Care on oxygen saturation histogram profiles among preterm infants: A prospective comparative study. 袋鼠妈妈护理对早产儿血氧饱和度直方图的影响：一项前瞻性比较研究。

IF 0.9

Journal of neonatal-perinatal medicine Pub Date : 2026-05-01 Epub Date: 2025-09-30 DOI: 10.1177/19345798251384953

V P Sathyamoorthy, Nishad Plakkal, Usha Devi

{"title":"Impact of Kangaroo Mother Care on oxygen saturation histogram profiles among preterm infants: A prospective comparative study.","authors":"V P Sathyamoorthy, Nishad Plakkal, Usha Devi","doi":"10.1177/19345798251384953","DOIUrl":"10.1177/19345798251384953","url":null,"abstract":"BackgroundPreterm infants often experience oxygen saturation (SpO2) instability due to immature respiratory control. While Kangaroo Mother Care (KMC) is known to improve cardiorespiratory stability, its impact on detailed SpO2 dynamics using histogram analysis has not been well studied.MethodsIn this prospective observational study, 120 paired sessions of KMC and off-KMC were analyzed in preterm infants (26 + 0 to 32 + 6 weeks gestation) admitted to a tertiary neonatal unit. Each session involved continuous SpO2 monitoring using Masimo Radical-7 oximeters. The primary outcome was the percentage of time with SpO2 ≤90%. Secondary outcomes included subgroup analyses by postmenstrual age (PMA) and respiratory support status.ResultsInfants spent less time with SpO2 ≤90% during KMC (median 10%, IQR: 7-17) compared to off-KMC (12%, IQR: 8-18), although not statistically significant (p = 0.06). A significant reduction was noted in infants on room air (median 9% vs 11%; p = 0.01). No significant difference was observed in those on CPAP, HFNC, or NIPPV. Infants with PMA >34 weeks showed an improvement in histogram trend during KMC, which was not statistically significant (p = 0.06).ConclusionsOverall, KMC showed a trend towards improved oxygen saturation patterns, although this was not statistically significant. Among stable preterm infants on room air without respiratory support, KMC was associated with a significant improvement.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"302-306"},"PeriodicalIF":0.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vasoactive support in asphyxiated neonates: Evidence, uncertainty, and clinical practice. 窒息新生儿的血管活性支持：证据、不确定性和临床实践。

IF 0.9

Journal of neonatal-perinatal medicine Pub Date : 2026-04-24 DOI: 10.1177/19345798261443963

Aimann Surak, Po-Yin Cheung, Georg M Schmölzer

{"title":"Vasoactive support in asphyxiated neonates: Evidence, uncertainty, and clinical practice.","authors":"Aimann Surak, Po-Yin Cheung, Georg M Schmölzer","doi":"10.1177/19345798261443963","DOIUrl":"https://doi.org/10.1177/19345798261443963","url":null,"abstract":"Perinatal asphyxia is a critical condition frequently associated with hemodynamic instability, often necessitating vasoactive support. Despite the established benefits of therapeutic hypothermia, significant mortality and long-term morbidity persist, particularly in severe cases. The objective of this narrative review is to critically evaluate the available evidence on vasoactive therapies in asphyxiated neonates, compare the hemodynamic effects of commonly used agents, and propose a physiology-based, phenotype-driven approach to cardiovascular management during therapeutic hypothermia. Available evidence remains limited and heterogeneous, with few high-quality studies specifically addressing this population. While commonly used vasoactive agents exert distinct physiologic effects, no single agent has demonstrated clear superiority in improving clinical outcomes. Current evidence supports an individualized, physiology-based approach to vasoactive therapy guided by the underlying hemodynamic phenotype and informed by multimodal monitoring. Further prospective studies are needed to define optimal therapeutic strategies and improve outcomes in this high-risk population.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798261443963"},"PeriodicalIF":0.9,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adverse outcomes associated with intubation in preterm infants in the delivery room setting. 早产婴儿在产房插管相关的不良后果。

IF 0.9

Journal of neonatal-perinatal medicine Pub Date : 2026-04-22 DOI: 10.1177/19345798261443966

Benjamin Tang, Romeesa Khan, Justin Richards, Sandeep Shetty, Anay Kulkarni

{"title":"Adverse outcomes associated with intubation in preterm infants in the delivery room setting.","authors":"Benjamin Tang, Romeesa Khan, Justin Richards, Sandeep Shetty, Anay Kulkarni","doi":"10.1177/19345798261443966","DOIUrl":"https://doi.org/10.1177/19345798261443966","url":null,"abstract":"BackgroundInitiation of non-invasive ventilation (NIV) rather than delivery-room (DR) intubation reduces lung injury and bronchopulmonary dysplasia (BPD) in premature babies.MethodsWe performed a retrospective cohort study of infants born at 23 + 0 to <32 + 0 weeks' gestation at a single tertiary centre (St George's Hospital) from 2017 to 2024, excluding major congenital anomalies. Clinical data were extracted from BadgerNet and Cerner. Temporal trends in DR intubation and associations with neonatal outcomes were examined using univariable and multivariable analyses.ResultsA total of 717 infants were included. DR intubation rates declined from 66.3% in 2017 to 27.5% in 2024 (p < 0.001), with the large changes in infants >26 + 0 weeks' gestation and >500g birthweight. Compared with non-intubated infants, those intubated in the DR were of lower gestational age, lower birthweight, and were less likely to be from multiple pregnancies. DR intubation was associated with higher rates of intubation at 24 h and 7 days, oxygen dependency at 28 days and at discharge, as well as BPD, IVH, death, and longer durations of invasive and non-invasive ventilation. After adjustment, DR intubation remained independently associated with intubation at 24 h and 7 days, oxygen dependency at 28 days and at discharge, BPD, IVH, death, and longer invasive (+6.56 days) and non-invasive ventilation (+7.42 days), but not with severe BPD, ROP, or length of stay.ConclusionPreterm infants offered NIV from birth had improved respiratory outcomes. DR intubation rates fell substantially over the study period, particularly in infants 26 + 0 to <32 + 0 weeks' gestation and birthweight ≥500g. Although DR intubation likely reflects baseline immaturity and vulnerability, it remained independently associated with several adverse neonatal outcomes, supporting ongoing efforts to avoid unnecessary early invasive ventilation where feasible.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798261443966"},"PeriodicalIF":0.9,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology of early onset hyponatremia in extremely preterm neonates: A retrospective observational study. 极早产儿早发性低钠血症的流行病学：一项回顾性观察研究。

IF 0.9

Journal of neonatal-perinatal medicine Pub Date : 2026-04-22 DOI: 10.1177/19345798261443956

Namrata Todurkar, Susan Albersheim, Jeffrey N Bone, Li Wang, Cherry Mammen, Rajavel Elango

{"title":"Epidemiology of early onset hyponatremia in extremely preterm neonates: A retrospective observational study.","authors":"Namrata Todurkar, Susan Albersheim, Jeffrey N Bone, Li Wang, Cherry Mammen, Rajavel Elango","doi":"10.1177/19345798261443956","DOIUrl":"https://doi.org/10.1177/19345798261443956","url":null,"abstract":"BackgroundExtremely preterm neonates undergo significant serum sodium (Na) changes in the first few days after birth. The objectives of this study were to describe the epidemiology of early onset hyponatremia, examine the investigations and interventions chosen, and assess the association of early onset hyponatremia with sodium and fluid intake in extremely preterm neonates.MethodsRetrospective study of 100 extremely preterm neonates admitted between 2018 and 2019; data was collected 1-14 days post-birth. Early onset hyponatremia was defined as: hyponatremia within first 14 days, with mild (serum Na 130-134), moderate (Na 126-129), and severe (Na ≤125 mmol/L).ResultsEarly onset hyponatremia prevalence was 85%. Amongst mild hyponatremia, 23% progressed to moderate, 21% to severe hyponatremia. Repeat Na was ordered in 84%, Na intake increased in 57%, fluid intake reduced in 7% in the 24-h following hyponatremia. Higher cumulative weight gain and fluid intake >171 ml/kg/day had higher moderate/severe hyponatremia after 7 days. Na intake higher than 5 mmol/L (OR = 1.03) and increased fluid intake (OR = 1.00) did not reduce hyponatremia risk.ConclusionsEarly onset hyponatremia is common in extremely preterm neonates. Early recognition of mild hyponatremia is critical in preventing progression to moderate-severe hyponatremia. Fluid management in the early days of life of extremely preterm neonates should prioritize weight loss and Na balance while providing adequate nutrition.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798261443956"},"PeriodicalIF":0.9,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0