Journal of neonatal-perinatal medicine最新文献_第2页

Maternal, placental and cord erythrocyte levels of long-chain polyunsaturated fatty acids in full-term and preterm pregnancy. 足月和早产儿母体、胎盘和脐带红细胞长链多不饱和脂肪酸水平。

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Journal of neonatal-perinatal medicine Pub Date : 2025-09-18 DOI: 10.1177/19345798251380113

Akshaya P Meher, Manasi Kathaley

{"title":"Maternal, placental and cord erythrocyte levels of long-chain polyunsaturated fatty acids in full-term and preterm pregnancy.","authors":"Akshaya P Meher, Manasi Kathaley","doi":"10.1177/19345798251380113","DOIUrl":"https://doi.org/10.1177/19345798251380113","url":null,"abstract":"BackgroundLong-chain polyunsaturated fatty acids (LCPUFAs) are biologically active fatty acids which regulate placental as well as fetal development. Abnormalities in these fatty acids have implications in adverse pregnancy outcomes like preterm birth. In the current study, we examined the maternal and cord erythrocyte LCPUFA levels along with the regional placental LCPUFA levels in women delivering preterm as compared with the women delivering at term.MethodsIn this cross-sectional study, we recruited 93 women delivering at term and 93 women delivering preterm. Fatty acid levels were analyzed from maternal erythrocyte, placental and cord erythrocyte samples. Samples from two different regions of placenta, maternal and fetal region were studied.ResultsWe observed lower (p = 0.001) cord erythrocyte docosahexaenoic acid (DHA) levels, lower (p = 0.000) maternal erythrocyte arachidonic acid (ARA) levels and higher (p = 0.002) cord erythrocyte ARA levels in women delivering preterm as compared to those delivering full-term. The placental DHA levels were higher (p = 0.002) on the maternal side of women delivering preterm as compared to women delivering full-term. There was a positive association (p = 0.000) between cord erythrocyte DHA levels with all the newborn characteristics. There was a negative association (p = 0.000) between placental DHA levels from the maternal side with all the newborn characteristics.ConclusionThe imbalance in the levels of maternal DHA and ARA in addition to differential pattern of DHA distribution across the maternal and fetal regions of the placenta may have affected materno-fetal transfer of these fatty acids, therefore responsible for the adverse fetal outcome.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251380113"},"PeriodicalIF":0.9,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of neonatal outcomes from mothers with and without COVID-19 in a tertiary referral hospital in Jakarta, Indonesia, neonatal COVID-19 in Indonesia. 印度尼西亚雅加达一家三级转诊医院感染COVID-19母亲和未感染COVID-19母亲的新生儿结局比较

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Journal of neonatal-perinatal medicine Pub Date : 2025-09-18 DOI: 10.1177/19345798251380123

Agnes Yuni Purwita Sari, Jully Neily Kasie, Yuyun Lisnawati, Erlina Burhan, Muhammad Farhan Maruli, Dara Ariqah Jibril

{"title":"Comparison of neonatal outcomes from mothers with and without COVID-19 in a tertiary referral hospital in Jakarta, Indonesia, neonatal COVID-19 in Indonesia.","authors":"Agnes Yuni Purwita Sari, Jully Neily Kasie, Yuyun Lisnawati, Erlina Burhan, Muhammad Farhan Maruli, Dara Ariqah Jibril","doi":"10.1177/19345798251380123","DOIUrl":"https://doi.org/10.1177/19345798251380123","url":null,"abstract":"BackgroundCoronavirus disease 2019 (COVID-19) in pregnant women and neonates may adversely affect neonatal outcome, but literature remains limited.MethodsThis is a retrospective analysis of all infants born to mothers with and without COVID-19 at an Indonesian national referral hospital between March and September 2020.ResultsA total of 393 neonates were delivered by 389 mothers, of whom 204 (52.4%) had COVID-19. Symptomatic and asymptomatic mothers with COVID-19 had similar seropositivity rates (53.6% vs 69.8%, p = 0.090). Neonates born to noninfected mothers were more likely to experience asphyxia at minute 1 of life (p = 0.005), to be diagnosed with TTN (p = 0.048) and sepsis (p = 0.022) and to require resuscitation (p = 0.008) than those born to infected mothers. Nine (2.4%) out of 377 tested infants were positive for SARS-CoV-2, of whom 4 had noninfected mothers. Neonates of mothers with symptomatic COVID-19 were less likely to be seropositive (30.0% vs 52.4%, p = 0.024) and more likely to acquire COVID-19 (p = 0.026) than those born to asymptomatically infected mothers.ConclusionThis study suggests that maternal COVID-19, particularly when occurring in late pregnancy, was not associated with an increase in acute neonatal complications.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251380123"},"PeriodicalIF":0.9,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of inotropic support on outcomes in congenital diaphragmatic hernia: A retrospective cohort study. 肌力支持对先天性膈疝预后的影响：一项回顾性队列研究。

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Journal of neonatal-perinatal medicine Pub Date : 2025-09-18 DOI: 10.1177/19345798251380168

Aimann Surak, Chloe Joynt, Eyad Bitar, Marcia Ergezinger, Lisa K Hornberger, Kumar Kumaran

{"title":"Impact of inotropic support on outcomes in congenital diaphragmatic hernia: A retrospective cohort study.","authors":"Aimann Surak, Chloe Joynt, Eyad Bitar, Marcia Ergezinger, Lisa K Hornberger, Kumar Kumaran","doi":"10.1177/19345798251380168","DOIUrl":"https://doi.org/10.1177/19345798251380168","url":null,"abstract":"IntroductionCongenital diaphragmatic hernia (CDH) has complex hemodynamic pathophysiology. There is a paucity of literature to predict outcomes based on the type of medications used for hemodynamic support.MethodsThis is a single-center retrospective cohort. Cases were categorized into different phenotypes: No dysfunction, right ventricle dysfunction, left ventricle dysfunction, and biventricular dysfunction. Medications used for hemodynamic support were categorized into inotropes and vasopressors based on type and dose.StatisticsMean, median, standard deviation, and percentages were used as appropriate. Contingency tables were constructed to compare the distribution of outcomes across different groups. Regression models analyzed the link between hemodynamic phenotype and outcomes.Results69 CDH cases between 2011 and 2023 were analyzed. The mean gestational age at birth was 38.0 weeks (SD 2.4), with a mean birth weight of 3109 g (SD 744 g). The distribution of hemodynamic phenotypes was as follows: No dysfunction phenotype: 43 infants (62.3%), RV phenotype: 7 infants (10.1%), LV phenotype: 7 infants (10.1%), and combined phenotype: 12 infants (17.4%). Inotropes were used in 26 infants (37.7%), vasopressors in 16 infants (23.2%), and a combination of inotropes and vasopressors in 19 infants (27.5%). Outcomes of interest were not different across the different hemodynamic phenotypes. Adjusted logistic regression analysis exploring the impact of LV dysfunction with vasopressor use found higher odds for death (OR = 4.8, p = 0.05).ConclusionInfants with CDH with LV dysfunction and vasopressor exposure are possibly at higher risk for mortality. This is an exploratory finding that warrants further investigation and research to establish the prognosis based on medications used for hemodynamic support.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251380168"},"PeriodicalIF":0.9,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between celiac and superior mesenteric arteries' Doppler flow parameters and risk of necrotizing enterocolitis in preterm infants. 乳糜和肠系膜上动脉多普勒血流参数与早产儿坏死性小肠结肠炎风险的关系

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Journal of neonatal-perinatal medicine Pub Date : 2025-09-13 DOI: 10.1177/19345798251377439

Raef Qeretli, Abdalkarim Alnajjar, Nadya Ben Fadel

{"title":"Association between celiac and superior mesenteric arteries' Doppler flow parameters and risk of necrotizing enterocolitis in preterm infants.","authors":"Raef Qeretli, Abdalkarim Alnajjar, Nadya Ben Fadel","doi":"10.1177/19345798251377439","DOIUrl":"10.1177/19345798251377439","url":null,"abstract":"BackgroundNecrotizing enterocolitis (NEC) remains a significant cause of morbidity and mortality in preterm neonates. Identifying early markers of impaired intestinal perfusion may aid detecting an association with the development of NEC. This study aims to evaluate the role of Doppler ultrasound of the superior mesenteric artery (SMA) and celiac artery (CA) and its association with NEC in preterm neonates.MethodsWe conducted a retrospective, single-center case-control study. Eligible infants were born at <29 weeks' gestation; we excluded those with chromosomal abnormalities, major anomalies, and those without Doppler assessments. NEC cases (Bell stage ≥II) were matched to controls on gestational age and birth weight. We compared SMA and CA Doppler parameters-peak systolic velocity (PSV), end-diastolic velocity (EDV) of NEC and control infants obtained at the end of the first and between 2nd and 3rd weeks of life.ResultsAmong 44 preterm infants (NEC = 21; controls = 23), Doppler assessment in the 1st week showed lower CA PSV in NEC versus controls (AMD = -27.7 cm/s [-53.58, -1.81]; p = 0.0371) after adjustment for PDA, birth weight, and gestational age. In weeks 2-3, and before NEC onset, NEC infants had lower SMA PSV (AMD = -35.7 cm/s [-68.5, -3.00]; p = 0.036) in models adjusted for PDA. No significant differences were found in CA parameters.ConclusionsReduced CA PSV during the first week of life, and reduced SMA PSV prior to NEC onset reflects impaired splanchnic perfusion preceding NEC and may be useful to clinicians in stratifying neonates at a risk of developing NEC in advance.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251377439"},"PeriodicalIF":0.9,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145053819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The utility of thymus and spleen ultrasound in the early prediction of neonatal sepsis. 胸腺脾超声在新生儿败血症早期预测中的应用。

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Journal of neonatal-perinatal medicine Pub Date : 2025-09-10 DOI: 10.1177/19345798251378077

F Öztürk, S Filiz, I Çetiner, B Yağcı, C Gürses, D Yapar

{"title":"The utility of thymus and spleen ultrasound in the early prediction of neonatal sepsis.","authors":"F Öztürk, S Filiz, I Çetiner, B Yağcı, C Gürses, D Yapar","doi":"10.1177/19345798251378077","DOIUrl":"https://doi.org/10.1177/19345798251378077","url":null,"abstract":"BackgroundThis investigation aimed to determine the utility of postnatal, ultrasonographically-derived dimensions of the thymus and spleen as imaging indicators for the prediction of early-onset neonatal sepsis (EOS).Material and MethodIn this case-control study, 30 term neonates diagnosed with Early-Onset Sepsis (EOS), based on European Medicines Agency (EMA) criteria, were compared to 30 healthy, matched control neonates. All participants underwent ultrasonography to quantify thymic and splenic dimensions. Receiver Operating Characteristic (ROC) curve analysis was employed to determine the optimal diagnostic cut-off value for thymic volume. Statistical significance was set at p < 0.05.ResultsBaseline demographics were comparable between patient and control groups (p > 0.05). A profound and statistically significant reduction in thymic volume (p < 0.001) was identified in the patient group compared to healthy controls, demonstrating a significant correlation with EOS, whereas spleen dimensions did not show a similar association. ROC analysis confirmed the high diagnostic accuracy of thymic volume (Area under the Curve [AUC]: 0.896; 95% CI: 0.813-0.978; p < 0.001). An optimal diagnostic threshold of ≤9 mL was established, yielding a sensitivity of 90.0% and a specificity of 83.3%. The corresponding Diagnostic Odds Ratio was 45.0, signifying a 45-fold increased odds of sepsis in neonates with a thymic volume below this value.ConclusionThymic volume is significantly reduced in neonates with Early-Onset Sepsis (EOS), making it a powerful, non-invasive diagnostic indicator. Serial ultrasonographic assessment of thymic volume holds promise for improving the diagnostic and prognostic management of neonatal sepsis. Spleen dimensions, however, showed limited utility as an early predictive indicator.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251378077"},"PeriodicalIF":0.9,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypoxic-ischaemic encephalopathy, perinatal stroke or both? A case report. 缺氧缺血性脑病、围产期中风还是两者兼而有之？一份病例报告。

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Journal of neonatal-perinatal medicine Pub Date : 2025-09-03 DOI: 10.1177/19345798251374939

Adilah W Ab Rahim, Assyifaa Bt Nik Mazian, Halimah Binti Abdul Halim, Azie Jumaatul Adawiyah Nabir, Siti Khadijah Mazli, Aliyyah Mohammad Khuzaini

{"title":"Hypoxic-ischaemic encephalopathy, perinatal stroke or both? A case report.","authors":"Adilah W Ab Rahim, Assyifaa Bt Nik Mazian, Halimah Binti Abdul Halim, Azie Jumaatul Adawiyah Nabir, Siti Khadijah Mazli, Aliyyah Mohammad Khuzaini","doi":"10.1177/19345798251374939","DOIUrl":"10.1177/19345798251374939","url":null,"abstract":"BackgroundPerinatal stroke is an acute focal brain infarction or haemorrhage occurring from birth to 28 postnatal days. Perinatal stroke typically presents with seizures within 72 h and conversely hypoxic-ischaemic encephalopathy (HIE) presents at birth with signs of encephalopathy.CaseThis case report presents a case of perinatal stroke which was initially treated as HIE. The mother presented in labour and had thick meconium-stained liquor. The patient was born with a poor Apgar score and metabolic acidosis. The patient did not fulfil criteria for cooling therapy, until he developed a focal seizure at 7 h of life. Subsequently, therapeutic hypothermia (TH) therapy was initiated with the diagnosis of neonatal encephalopathy. However, a Magnetic Resonance Imaging (MRI) of the brain performed later showed left posterior cerebral artery territory subacute infarct with haemorrhagic component at the left occipital lobe.ConclusionThe pathophysiology of perinatal stroke is similar to HIE which may lead to similar presentation at birth. Due to the difficulty in differentiating these two diseases, initiating therapeutic hypothermia for HIE is appropriate in this case. Utilisation of scoring tools may aid objective interpretation of MRI findings and prognostication of HIE.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251374939"},"PeriodicalIF":0.9,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of sequential functional echocardiography in predicting clinically apparent patent ductus arteriosus in preterm very low birth weight newborns: An observational study. 序贯功能超声心动图在预测早产儿极低出生体重新生儿临床明显动脉导管未闭中的作用：一项观察性研究。

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Journal of neonatal-perinatal medicine Pub Date : 2025-09-01 Epub Date: 2025-05-15 DOI: 10.1177/19345798251343494

Anchala Bhardwaj, Arvind Saili, Dinesh Kumar Yadav, Ajay Kumar

{"title":"Role of sequential functional echocardiography in predicting clinically apparent patent ductus arteriosus in preterm very low birth weight newborns: An observational study.","authors":"Anchala Bhardwaj, Arvind Saili, Dinesh Kumar Yadav, Ajay Kumar","doi":"10.1177/19345798251343494","DOIUrl":"10.1177/19345798251343494","url":null,"abstract":"BackgroundThe prolonged ductal patency in preterm newborns despite being associated with short- and long-term morbidities has failed to show significant improvement in the long-term outcome with routine ductal treatment. Echocardiography has been shown to have a predictive and diagnostic role in identifying the significant patent ductus arteriosus (PDA) before its clinical detection and providing selective treatment for PDA to avoid unnecessary therapy or delay of necessary therapy. Several echocardiographic ductal markers have been evaluated for their predictive utility with a wide range of sensitivity (26%-100%) and specificity (6%-100%). Ductal diameter, left pulmonary artery (LPA) velocity, and left atrial to aortic width (La/Ao) ratio are the common markers being used routinely for PDA. This research was planned to assess the predictive utility of additional ductal echocardiographic markers in preterm newborns.MethodsIt was a prospective observational cohort study conducted in the tertiary care neonatal intensive care unit (NICU) at Lady Hardinge Medical College, Delhi. 50 very low birth weight newborns underwent four sequential Echo scans within the first 72 hrs; the first within 12 hours, and the next three scans at completed 24 hrs, 48 hrs, and 72 hrs of age. These newborns were then monitored for clinical signs of PDA up to 2 weeks of life.ResultsThe left atrial volume index (LAVI), left ventricle to aortic width (Lv/Ao ratio), left ventricular output/superior vena cava (LVO/SVC) flow ratio with different cut-off values at different hours of life, shunt pattern and altered blood flow in the anterior cerebral, and superior mesenteric vessels predicted persistence of ductus arteriosus.ConclusionThis study provides insights into the predictive utility of additional ductal echo markers apart from the routinely measured ones.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"423-430"},"PeriodicalIF":0.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation of the vasoactive-ventilation-renal score in extreme preterm neonates. 极端早产儿血管活性-通气-肾脏评分的验证。

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Journal of neonatal-perinatal medicine Pub Date : 2025-09-01 DOI: 10.1177/19345798251372550

Eyad Bitar, Renjini Lalitha, Matthew Hicks, Aimann Surak, Abbas Hyderi, Dawn Pepper, Po Yin Cheung, Kumar Kumaran

{"title":"Validation of the vasoactive-ventilation-renal score in extreme preterm neonates.","authors":"Eyad Bitar, Renjini Lalitha, Matthew Hicks, Aimann Surak, Abbas Hyderi, Dawn Pepper, Po Yin Cheung, Kumar Kumaran","doi":"10.1177/19345798251372550","DOIUrl":"https://doi.org/10.1177/19345798251372550","url":null,"abstract":"ObjectivesTo validate Vasoactive-Ventilation-Renal (VVR) score in extremely low gestational age neonates (ELGANs) as a predictor of mortality and morbidity by assessing its association with clinical outcomes.Study DesignThis was a secondary analysis of data from a randomized controlled trial including neonates born 230-286 weeks' gestation admitted to a Canadian tertiary-level neonatal intensive care unit between February 2019 and December 2021. VVR scores were measured at set intervals. Outcomes included mortality, intraventricular hemorrhage (IVH), bronchopulmonary dysplasia (BPD), necrotizing enterocolitis, patent ductus arteriosus, retinopathy of prematurity, mechanical ventilation duration, and length of hospital stay. Multivariate logistic regression analysis and receiver operating characteristic (ROC) curves were used to determine the association between VVR scores and clinical outcomes.ResultsData from 132 neonates were analyzed. The mean (SD) gestational age was 26.5 (1.5) weeks, and the mean (SD) birth weight was 933 (243) grams. A VVR score >48 was significantly associated with severe IVH (AOR: 5.8, 95% CI: 1.2-28.9, p = 0.03), BPD (AOR: 8.8, 95% CI: 1.1-72.4, p = 0.044), prolonged mechanical ventilation (>71 days) (AOR: 6.86, 95% CI: 1.6-30, p = 0.01), and extended hospital stay (>150 days) (AOR: 6.19, 95% CI: 1.4-26.4, p = 0.01). No significant associations were observed with mortality or other outcomes. ROC curves analysis demonstrated good predictive performance of VVR score at 7 days for these adverse outcomes.ConclusionThe VVR score at 7 days is a reliable predictor of significant adverse outcomes, including severe IVH and BPD, in ELGANs. Further studies in larger, diverse populations are warranted to confirm these findings.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251372550"},"PeriodicalIF":0.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

'VACTERL-H in newborn: A rare case report'. 新生儿VACTERL-H：一例罕见病例报告。

IF 0.9

Journal of neonatal-perinatal medicine Pub Date : 2025-09-01 Epub Date: 2025-06-17 DOI: 10.1177/19345798251349420

Walid Alhussin, Fathima Sabahath

{"title":"'VACTERL-H in newborn: A rare case report'.","authors":"Walid Alhussin, Fathima Sabahath","doi":"10.1177/19345798251349420","DOIUrl":"10.1177/19345798251349420","url":null,"abstract":"BackgroundVACTERL association is a mnemonically useful acronym for a condition characterized by the sporadic, non-random association of specific birth defects in multiple organ systems. Described in the early 1970s, it is typically defined by the presence of three or more of these congenital malformations: vertebral defects, anal atresia, cardiac defects, tracheoesophageal fistulas, renal anomalies, and limb abnormalities. In addition to these core components, patients may also have other congenital anomalies. VACTERL association does not involve neuro-cognitive impairment unless; associated with hydrocephalus, known as VACTERL-H syndrome. VACTERL with hydrocephalus is an extremely rare disorder that affects males and females' children equally.Case descriptionThis report describes the case of a preterm 32 weeks gestation, Asian, male infant who was diagnosed with VACTERL associated with hydrocephalus (VACTERL-H).ConclusionVACTERL syndrome cases are seen very rarely. The diagnosis of VACTERL-H syndrome is primarily based upon a complete physical examination and a few specialized tests to ascertain the features of the syndrome. The treatment of VACTERL-H is directed towards the specific symptoms that are apparent in each individual, which often vary greatly. This case highlights the challenges in managing VACTERL-H syndrome in preterm, who presented with the most serious features of VACTERL. Hence, early diagnosis and early interventions are needed to prevent morbidity and mortality.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"501-507"},"PeriodicalIF":0.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of implementing a clinical practice guideline for prophylactic indomethacin on reduction of severe IVH in extremely preterm infants. 实施预防性吲哚美辛临床实践指南对减少极早产儿严重IVH的影响。

IF 0.9

Journal of neonatal-perinatal medicine Pub Date : 2025-09-01 Epub Date: 2025-06-19 DOI: 10.1177/19345798251349748

Eniko Szakmar, Sasha Harrison, Hoda Elshibiny, Chelsea Munster, Mohamed El-Dib

{"title":"Effect of implementing a clinical practice guideline for prophylactic indomethacin on reduction of severe IVH in extremely preterm infants.","authors":"Eniko Szakmar, Sasha Harrison, Hoda Elshibiny, Chelsea Munster, Mohamed El-Dib","doi":"10.1177/19345798251349748","DOIUrl":"10.1177/19345798251349748","url":null,"abstract":"BackgroundProphylactic indomethacin in preterm infants has been associated with reduction of severe intraventricular hemorrhage (SIVH) but no improvement in neurodevelopmental outcome. Since January 2016, Brigham and Women's Hospital has implemented a clinical practice guideline (CPG) for prophylactic indomethacin to prevent SIVH. Our aim was to compare the predicted and observed rate of SIVH before and after CPG implementation. Second, to evaluate the association between indomethacin and development of SIVH.MethodsThis retrospective cohort study included infants born between 23 and 28 weeks of gestation. Variables were compared between before (pre-group) and after the CPG implementation (post-group). Risk categories for SIVH were defined as the following based on a validated model: low <15%, moderate ≥15% to <25%, and high risk ≥25%. Multivariate logistic regression model was applied to evaluate the association between SIVH and the administration of indomethacin.ResultsInfants in the post-group (n = 325) presented with lower Apgar scores, higher rate of necrotizing enterocolitis, abdominal surgery, and mortality comparing to pre-group (n = 424). The use of indomethacin for any reason was 44% in pre-group and 62% in post-group (p < 0.001). There was no significant difference in the predicted and observed rate of SIVH between the 2 groups in any risk categories. There was no association between the use of indomethacin and development of SIVH in multivariate regression models.ConclusionThe implementation of CPG for prophylactic indomethacin was not associated with reduction in the incidence of SIVH and no association was found between the use of indomethacin and development of SIVH.","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"449-455"},"PeriodicalIF":0.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0