Journal of neonatal-perinatal medicine最新文献

{"title":"Targeted developmental oral stimulation with the NTrainer system™ in infants with bronchopulmonary dysplasia reduces time to achieve oral feeding success.","authors":"Nkechi E Okotcha, Richard Tucker, Amy Embleton, Melanie Franchetti, Heather Brennan, Jill Maron","doi":"10.1177/19345798251330823","DOIUrl":"10.1177/19345798251330823","url":null,"abstract":"<p><p>Infants with bronchopulmonary dysplasia (BPD) are prohibited from oral feeding attempts during essential developmental windows due to their respiratory support, resulting in delayed oral feeding and prolonged length-of-stay (LOS). The NTrainer system™ (Cardinal Health) is an FDA approved device which provides patterned frequency-modulated oral stimulation, matures non-nutritive matures non-nutritive suck, and shortens time to oral feeding. Our objective was to use this device to improve oral feeding competency and shorten the duration to achieve full oral feeding in these infants.MethodsBPD infants received therapy between 32 and 35.5 weeks post-menstrual age (PMA). The primary outcome was PMA at full oral feedings. A contemporary, retrospective cohort of infants with BPD served as controls.ResultsInfants provided therapy achieved oral feeding at 38.5 weeks versus 39.6 weeks PMA in the control group (<i>p</i> = 0.03). Kaplan-Meier analyses revealed days-to-full-oral-feed was achieved earlier for the NTrainer™ group compared to controls (40 vs 61 days; log-rank test <i>p</i> = 0.08). With a hazard ratio of 1.57 (95% CI 0.93-2.65), the NTrainer™ group was 57% more likely to reach full oral feeds at an earlier PMA. LOS was not significantly different between groups.ConclusionsProviding NTrainer™ therapy to infants with BPD during essential developmental windows shortens time to oral feeding success. Although not statistically significant, any reduced LOS potentially has clinical and economic implications for both the family and health care systems.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"321-326"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal cholelithiasis, an unusual association with twin anemia and polycythemia sequence: A case report.","authors":"S Kaur, P Singh, K Yusuf","doi":"10.1177/19345798251337351","DOIUrl":"10.1177/19345798251337351","url":null,"abstract":"<p><p>Gallstones are rarely seen in preterm neonates with most cases reported in term singletons without any identifiable risk factors. Although most cases are self-resolving, neonatal gallstones can be associated with significant complications. We report a case of 34-week gestation monochorionic diamniotic twins with twin anemia-polycythemia sequence (TAPS) where the recipient twin presented with gallstones on the first day of life. To the best of our knowledge, this is the first case of gallstones in preterm twins following TAPS.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"395-398"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of newborn individualized developmental care and assessment program (NIDCAP) on pain caused by eye examination for ROP screening.","authors":"Naimeh Abbasi, Monir Ramezani, Mohammad Heidarzadeh, Naser Shoeibi","doi":"10.1177/19345798251330827","DOIUrl":"10.1177/19345798251330827","url":null,"abstract":"<p><p>BackgroundEye examination is one of the painful procedures for infants. Eye screening for retinopathy of prematurity (ROP) is an essential intervention to prevent visual impairment in preterm infants. However, Newborn Individualized Developmental Care and Assessment Program (NIDCAP) is a well-established framework for all of the interventions on premature infants, and pain management is the main subject of this program.PurposeThe aim of this study is to determine the effect of NIDCAP on the pain caused by eye examination for ROP screening.MethodsIn this non-randomized controlled clinical trial, 60 infants were classified in two groups (30 infants in the intervention group and 30 infants in the control group). The infants of the intervention group underwent NIDCAP protocols before, during, and after the examination and the infants of the control group received routine cares. Then, according to PIPP tool, level of pain in the two groups was evaluated.ResultsThe two groups were homogeneous in terms of demographic variables. The results showed that the interventions group experienced significantly lower increases in heart rate during exams (<i>p</i> = 0.001). The reduction of oxygen saturation during the examination in the intervention group was less than the control group, which was not statistically significant (<i>p</i> = 0.577). The two groups have no difference in behavioral status score during examination. While facial scores during the examination in the intervention group were significantly lower than the control group (<i>p</i> = 0.011). In terms of the total score of pain during examination, the newborns of the intervention group have a significantly lower pain score than the control group (<i>p</i> = 0.033).</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"327-337"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Keep the PEEP: A quality improvement project assessing safety and feasibility of prolonged non-invasive positive end expiratory pressure.","authors":"E Sangillo, S Patel, K Nyman, E Cho, E Schofield, C H Driscoll","doi":"10.1177/19345798251339650","DOIUrl":"10.1177/19345798251339650","url":null,"abstract":"<p><p>IntroductionInfants born less than 32-week gestation are at increased risk of respiratory distress syndrome due to underdeveloped pulmonary alveoli. Despite known respiratory benefits associated with positive end expiratory pressure (PEEP), our staff expressed concern that prolonged exposure to PEEP would contribute to increased risk of pneumothorax and delayed initiation of oral feeding.​ This quality improvement project aimed to standardize PEEP use with a guideline for early initiation, continuation, and subsequent discontinuation in infants born at less than 32-week gestation.MethodsWe developed and implemented a \"Keep the PEEP\" guideline, which included recommendations for initiation of PEEP at delivery, continuation through 32-week post-menstrual age (PMA), and discontinuation. Data collection occurred between July 2019-July 2021 (pre-intervention) and July 2021-August 2023 (post-intervention). Data analysis included run charts for monthly compliance, and bivariate analysis of pre- and post-intervention data. Interventions included team member education and team engagement through auditing.ResultsWe achieved a median compliance of 100% with PEEP use through 32-week PMA. We found no statistically significant differences in a pre- versus post-intervention comparison of pneumothorax incidence [14 versus 13, <i>p</i> = 0.86], bronchopulmonary dysplasia (BPD) incidence [82 versus 68, <i>p</i> = 0.65], median post-menstrual age at first oral feed [34.1 versus 34.1, <i>p</i> = 0.56], or median length of stay [55 versus 43, <i>p</i> = 0.2].ConclusionsWe successfully implemented a new respiratory guideline to standardize PEEP use in our unit during the study period. Despite initial concerns, the incidence of pneumothorax and the median gestational age at initiation of oral feedings remained unchanged.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"362-368"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intentional delivery versus expectant management in preterm prelabour rupture of membranes at 28-34 weeks of gestation - A prospective observational study.","authors":"Srishty Mohanty, Sibananda Nayak, Vijay Kumar Krishnegowda, Debasish Nanda","doi":"10.1177/19345798251330832","DOIUrl":"10.1177/19345798251330832","url":null,"abstract":"<p><p>BackgroundPreterm prelabour rupture of membrane (PPROM) often precedes a significant number of preterm deliveries. However, the optimal timing of delivery in women with PPROM remains unclear.ObjectiveTo compare duration of neonatal intensive care between two management strategies - intentional delivery and expectant delivery, in women with PPROM between 28 and 34 weeks of gestation. Additionally, we also compared other crucial neonatal and maternal outcomes between the two groups.Materials/methodThis prospective observational study enrolled women aged over 18 years; singleton pregnancy complicated by PPROM occurring between 28 and 34 weeks of gestation. These women were managed either by intentional delivery (ID) or expectant management (ED), as per clinician discretion.ResultA total of 115 women were included in the study; 68 women underwent intentional delivery and 47 women by expectant management. Neonates born to mothers in the ID group had a significantly shorter hospital stay compared to those in the ED group (12.71 ± 13.89 vs. 20.02 ± 20.94, Mean difference 7.3 days, 95% CI: -0.9 to -13.7 days, <i>p</i> 0.026). The early onset neonatal sepsis was similar [11 (16.2%) in the ID group and 9 (19.1%) in the ED group, <i>p</i> 0.688 and other neonatal and maternal outcomes were also comparable between the two groups.ConclusionIn intentional management, the duration of neonatal hospital stay was shorter in comparison to the expectant management group, while there was no difference in other maternal and major neonatal outcomes. There was a clinician preference for expectant delivery with lower foetal weight.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"344-349"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A neonate with upper cervical spinal cord injury as a previously unrecognized complication of vacuum-assisted delivery and uterine fundal pressure.","authors":"S Watanabe, N Ohama, S Suga, E Kondo, T Hoshina, K Yoshino","doi":"10.1177/19345798251339661","DOIUrl":"10.1177/19345798251339661","url":null,"abstract":"<p><p>BackgroundNeonatal spinal cord injury is a rare complication of birth trauma which is typically reported after breech delivery and forceps delivery. Therefore, it is extremely difficult to recognize the occurrence of injury after vacuum-assisted delivery.Methods/ResultsWe report the case of a neonate with an upper cervical spinal cord injury that occurred during vacuum-assisted delivery accompanied by uterine fundal pressure. During delivery, the cardiotocogram showed persistent fetal bradycardia and a loss of baseline variability. The neonate was initially diagnosed with hypoxic-ischemic encephalopathy (HIE) and underwent therapeutic hypothermia therapy. However, after therapeutic hypothermia, upper cervical spinal cord injury and HIE were detected on head and cervical magnetic resonance imaging (MRI).ConclusionWhen a neonate born by vacuum-assisted delivery accompanied by uterine fundal pressure presents asphyxia, cervical MRI should be promptly considered to differentiate upper cervical spinal cord injury.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"386-389"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feeding practices for infants with gastroschisis: A survey of neonatal intensive care units in Canada.","authors":"Hareshan Suntharalingam, Daniel Briatico, Nathalie Carey, Ali McBryde, Erik Skarsgard, Esther Huisman, Michael H Livingston","doi":"10.1177/19345798251327370","DOIUrl":"10.1177/19345798251327370","url":null,"abstract":"<p><p>BackgroundFeeding practices for infants with gastroschisis are often based on institutional protocols, clinician judgement, and usual practice. The purpose of this study was to describe the range of feeding practices used in neonatal intensive care units across Canada.MethodsWe developed an 18-item survey with open-ended questions focused on feeding and nutrition among infants with gastroschisis. Clinicians from neonatal intensive care units that manage infants with gastroschisis were invited to participate. Interviews were completed via virtual meeting or email. Data were analyzed using descriptive statistics.ResultsSemi-structured interviews were conducted with 14 of 17 centers (82% response rate). Participants included neonatologists (12/14 centers) and dieticians (10/14 centers). Pediatric surgeons from 3/14 centers participated at the request of neonatologists. None of the centers reported using a gastroschisis feeding protocol routinely, although two centers noted occasional use of a protocol from another hospital, and another indicated that a gastroschisis feeding protocol is in development. All centers reported that patients with gastroschisis qualify for donor human milk if maternal breast milk is unavailable. Routine use of sham feeding, contrast studies, rectal irrigations, or motility agents was not reported. There was variation between centers regarding feeding advancement, type of formula used if breast milk is unavailable, use of probiotics, and strategies to introduce breastfeeding.ConclusionThere is variation in some but not all aspects of enteral feeding among infants with gastroschisis at neonatal intensive care units in Canada. The development of institutional feeding protocols and clinical practice guidelines may help standardize practice.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"312-320"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of COVID-19 on maternal mental health and social support in the postpartum period: A case-control study.","authors":"Khaoula Khemakhem, Chiraz Regaieg, Khadija Chiha, Maryam Chaabane, Amira Bouraoui, Donia Ben Touhemi, Nedia Hamida, Yousr Moalla","doi":"10.1177/19345798251354969","DOIUrl":"https://doi.org/10.1177/19345798251354969","url":null,"abstract":"<p><p>BackgroundThe main objectives of this study were to assess depression, fear of COVID-19, and perceived social support in postpartum mothers during both groups during the COVID-19 pandemic and to study their impact on the psychological state of affected mothers and their perception of social support.Study designThis was a case-control, and analytical cohort study spanning 2021, including mothers with and without COVID-19 in the perinatal period.ResultsA sample of 140 mothers was included (73 tested COVID-19 positive, and 67 tested COVID-19 negative). The prevalence of postpartum depression was 90.40% among mothers with COVID-19 against 77.60% in the control group (<i>p</i> = 0.002). The mean score of fear of COVID-19 was comparable between the two groups. The affected mothers perceived less entourage availability (<i>p</i> = 0.001), while the satisfaction feeling was almost the same.ConclusionThe implementation of mental health services in maternal and child health units can help to provide psychological support and reduce the symptoms of psychological distress in mothers.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251354969"},"PeriodicalIF":0.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Right atrial thrombus in neonates following hyperosmolar glucose infusion: A case series.","authors":"Prakash Duraisamy, Anand Nandakumar, Harikrishnan Kelamangalam NeelakantaKurup, Aswathy Rahul, Radhika Sujatha, Aishwarya Venugopal, Anupriya Ayshabai Vijayan, Meghna Nema","doi":"10.1177/19345798251354970","DOIUrl":"https://doi.org/10.1177/19345798251354970","url":null,"abstract":"<p><p>BackgroundCardiac thrombus in neonates is an uncommon but life-threatening condition that may result in significant morbidity and mortality. Factors such as invasive procedures, metabolic disturbances, and the use of high-osmolarity fluids can contribute to thrombus formation, particularly in critically ill neonates. This case series aims to highlight the clinical characteristics, potential risk factors, and outcomes of right atrial thrombus in neonates, with particular emphasis on the role of high-concentration glucose infusions administered through umbilical venous catheters.MethodsThis is a retrospective case series of five neonates who developed right atrial thrombus between January 2022 and December 2024.ResultsAll five neonates have a history of receiving high-concentration glucose infusions via umbilical venous catheters for hyperinsulinemic hypoglycemia before the development of right atrial thrombus. Unexplained tachycardia prompted the diagnosis, with echocardiography revealing thrombi. Three of them were successfully treated with anticoagulation, while the other two babies unfortunately succumbed to complications despite intensive treatment.ConclusionLarge cardiac thrombus in neonates leads to high mortality due to the risk of embolization and sepsis. High-concentration glucose infusion via umbilical venous catheter is a potential risk factor for cardiac thrombus formation in neonates. Early detection and appropriate intervention, including anticoagulation and thrombolysis, are crucial for preventing further complications and improving survival rates.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251354970"},"PeriodicalIF":0.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct microbiota profiles in non-survivors in preterm infants with surgical necrotizing enterocolitis: Insights from FFPE intestinal tissue analysis.","authors":"Pengbo Zhang, Padma P Garg, Liang Liu, Wei Zhang, Kylie Kavanagh, Avinash Shetty, Tim Howard, Neha Varshney, David Sawaya, Greg Hawkins, Drew J Schwartz, Parvesh Mohan Garg","doi":"10.1177/19345798251353777","DOIUrl":"https://doi.org/10.1177/19345798251353777","url":null,"abstract":"<p><p>BackgroundThe variant microbiome is associated with necrotizing enterocolitis (NEC). We aimed to analyze remnant formalin fixed paraffin-embedded (FFPE) intestine tissue for microbiome profiling in preterm infants with surgical NEC.MethodsWe analyzed FFPE small intestine tissues from 16 infants with NEC (8 survivors and 8 non-survivors). Extracted DNA from FFPE tissue blocks underwent 16S rRNA sequencing. We compared the microbiota profiles in survivors and non-survivors. Alpha- and beta diversity metrics were calculated using QIIME2. To assess differences in overall microbial community structure, we performed a Permutational Multivariate Analysis of Variance (PERMANOVA). The analysis was performed in MaAsLin2 R package to determine the specific microbial taxa whose relative abundances were significantly associated with survival status in a multivariable linear model.ResultsSequencing of FFPE extracted DNA resulted in high-quality sequence reads in 16 cases.AnalysisAnalysis of microbial communities from 16 cases revealed a significant association between microbiome structure and survival status. Beta diversity analysis demonstrated distinct clustering of microbiome profiles between survivor and non-survivor groups. Alpha diversity metrics further characterized these differences: the non-survivor group exhibited a more complex and even microbiota (Shannon entropy, <i>p</i> = 0.02; Pielou's evenness, <i>p</i> = 0.017), whereas the survivor group's microbiome was significantly richer in observed features (<i>p</i> = 0.004). Notably, this association was specific to survival outcome, as overall community structure did not significantly differ when grouped by histological features of disease severity such as necrosis, inflammation, or hemorrhage. Linear mixed effect models and direct comparisons further identified numerous taxa potentially associated with survival status.ConclusionFFPE intestinal tissue enabled retrospective and spatially relevant microbiota assessment at the disease site. The non-survivors had complex microbiota and had distinct bacterial communities compared to survivors. Our findings suggest that the gut microbiome is a key factor related to prognosis, independent of other measures of NEC severity.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798251353777"},"PeriodicalIF":0.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}