Journal of neonatal-perinatal medicine最新文献

{"title":"Need for gastrostomy tube placement for premature infants born at 22- and 23-week gestational age: A single-center experience.","authors":"Julia Prakash, Raquel Garcia, Claire Barrette, Yodika Singh, Shenae Samuels, Xiaoqi Sun, Monica S Arroyo","doi":"10.1177/19345798261424782","DOIUrl":"10.1177/19345798261424782","url":null,"abstract":"<p><p>BackgroundPremature neonates are at risk for feeding difficulties, and despite early feeding therapy, some neonates require gastrostomy tube (GT) placement. This study aims to determine rates of GT placement in infants born at 22- and 23-weeks of gestation at our institution and to identify demographic and clinical risk factors associated with this outcome.MethodsInstitutional Review Board approval and de-identified data from January 1, 2018 to December 31, 2021 were analyzed in a REDCap database.ResultsGT was placed for 33 of the 72 neonates (45.8%). GT neonates had lower gestational ages (23.1 vs 23.4 weeks; <i>P</i> = 0.004), birth weights (532.5 vs 596.7 g; <i>P</i> = 0.003), and APGAR scores at 1 min (2 vs 3; <i>P</i> = 0.020) and 5 min (5 vs 7; <i>P</i> = 0.009). They also had a higher incidence of intraventricular hemorrhage (IVH) diagnosed in the first week of life (45.5% vs 30.8%; <i>P</i> = 0.041) than those without a GT.ConclusionDespite feeding therapy, a substantial proportion of 22- and 23-week neonates require alternative feeding methods at NICU discharge. Further research is needed to determine additional risk factors and interventions in this population.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"495-499"},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146165519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing blood carboxyhemoglobin levels as an early predictor of phototherapy in ABO incompatible newborns.","authors":"Cisem Dilbaz Akyuz, Sema Arayici, Belgin Akcan Paksoy, Basak Akyuz","doi":"10.1177/19345798261424781","DOIUrl":"10.1177/19345798261424781","url":null,"abstract":"<p><p>BackgroundThis study aimed to evaluate blood carboxyhemoglobin (COHb) levels as an indicator of hemolysis and as an early predictor of phototherapy requirement in newborns with blood type A or B born to mothers with blood type O.MethodsIn this prospective observational study, enrolled infants were divided into two groups: Group 1 comprised newborns with maternal blood type O and infant blood type A or B, while Group 2 consisted of newborns born to mothers without blood type O. Total serum bilirubin and carboxyhemoglobin levels were assessed from cord blood samples at birth and venous blood samples at 24 h of life and compared between groups. None of the infants required intravenous immunoglobulin therapy or blood transfusion.ResultsA total of 100 term infants were included. Mean carboxyhemoglobin levels in cord blood and at 24 h of life were significantly higher in Group 1 compared with Group 2 (0.55 vs 0.48, <i>p</i> = 0.04; 0.69 vs 0.36, <i>p</i> = 0.002, respectively). The onset of phototherapy occurred significantly earlier in Group 1 than in Group 2 (48 vs 90 h, <i>p</i> = 0.01).ConclusionElevated carboxyhemoglobin levels were observed in newborns with ABO incompatibility, and higher levels were associated with an earlier requirement for phototherapy.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"500-507"},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146165477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing drug development for the prevention of spontaneous preterm birth.","authors":"Christina Chang, Cameron Joyce, Mia Williams, An Massaro, Beth Boyer, Catherine Pilgrim-Grayson, Leyla Sahin, Lynne Yao, Janet Maynard, Christine Nguyen","doi":"10.1177/19345798261416363","DOIUrl":"10.1177/19345798261416363","url":null,"abstract":"<p><p>In the United States, one in 10 pregnancies results in preterm birth (PTB), making it the leading cause of infant morbidity and mortality. Following the 2023 withdrawal of Makena (hydroxy progesterone caproate) for lack of efficacy, clinicians currently lack FDA-approved options for women at risk of recurrent spontaneous PTB. Researchers and pharmaceutical companies may be hesitant to commit resources to develop therapies for PTB. This report summarizes a Food and Drug Administration-Duke Margolis Institute for Health Policy public workshop held in January 2024 to discuss challenges and opportunities for advancing drug development for the prevention of PTB. Participants-researchers, clinicians, industry representatives, families, and regulators-highlighted challenges that hinder the development of PTB therapies, including the limited understanding of PTB causes, ethical concerns for trials, and lack of consensus on appropriate outcome measures. A few of the emerging recommendations suggest that supporting basic science research to address knowledge gaps, such as elucidating the biological drivers and underlying mechanisms of spontaneous preterm birth (sPTB), as well as improving data quality and evidence and focusing on gestational age-specific clinical outcome endpoints could help move the needle forward in this area. Meeting participants also shared perspectives on research priorities, discussed optimizing study design for dose-finding, and strategized about funding and investments. Key recommendations included pursuing greater regulatory flexibility, innovative trial designs, expanding federal and philanthropic funding incentives to de-risk early-stage development, and strengthening data-sharing and research collaborations to accelerate translation of discoveries into therapies.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"451-458"},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145959605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of anemia and necrotizing enterocolitis in neonates: Systematic review and meta-analysis of transfusion thresholds, erythropoietin trials, and observational studies.","authors":"Dipen Vyas, Menaka Reddy, Aditya Patel, Caroline Minnick, Jeffrey Shenberger, Parvesh Mohan Garg","doi":"10.1177/19345798261416362","DOIUrl":"10.1177/19345798261416362","url":null,"abstract":"<p><p>BackgroundMeta-analyses of observational studies evaluating association between blood transfusion and necrotizing enterocolitis (NEC) have shown mixed results and an independent association between anemia and NEC requires further evaluation.ObjectiveTo investigate the association of NEC with anemia in preterm infants via meta-analysis of (1) randomized controlled trials (RCTs) evaluating transfusion thresholds and recombinant erythropoietin (rEpo)/darbepoetin and (2) case-control studies comparing hematocrit levels between NEC cases and controls.Data sourcesPubMed, Embase, Scopus, and the Cochrane Database were searched in August 2025, and the results were supplemented by other sources.Study selection(1) Transfusion threshold and rEpo RCTs evaluating NEC rates in preterm infants with lower hemoglobin (Hb) levels compared with higher Hb levels. (2) Case-control studies comparing hematocrit levels between NEC cases and controls.Primary outcomeThe incidence of any stage NEC in infants with low versus high Hb group.ResultsRCTs evaluating transfusion threshold (n = 4, 3307 participants) showed no difference in NEC incidence between the low versus high Hb group [OR: 1.14 (CI: 0.89, 1.46), <i>p</i> 0.647]. RCTs evaluating rEPO versus placebo (<i>n</i> = 11, 4173 participants) showed higher incidence of NEC in the low versus high Hb group [OR: 1.43 (CI: 1.13, 1.80), <i>p</i> 0.003]. Meta-analysis of case-control studies (<i>n</i> = 3, 1016 participants) showed association of lower hematocrit levels in NEC cases compared with controls (standardized mean difference -0.28; CI -0.56, -0.002; <i>p</i> 0.048).ConclusionOur analysis suggests an association between NEC and lower hemoglobin levels. Well-designed and adequately powered prospective studies are required to confirm our findings.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"459-472"},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12831413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145965942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe congenital toxoplasmosis with isolated central hypothyroidism: A rare case report.","authors":"K Abi El Aala, A Lalaoui, G Kassal, F Bennaoui, H C Ahmanna, H Jalal, N El Idrissi Slitine, F M R Maoulainine","doi":"10.1177/19345798261424780","DOIUrl":"10.1177/19345798261424780","url":null,"abstract":"<p><p>Congenital toxoplasmosis results from transplacental transmission of <i>Toxoplasma gondii</i> during maternal primary infection. While the classic triad-hydrocephalus, intracranial calcifications, and chorioretinitis-defines severe forms, hypothalamic-pituitary axis involvement is extremely rare. Endocrine complications, particularly central hypothyroidism, are seldom described in this context. We report a preterm newborn at 35 weeks' gestation, representing the first documented case of isolated central hypothyroidism associated with severe congenital toxoplasmosis. Neuroimaging revealed major triventricular hydrocephalus, multiple cystic formations, and cerebral calcifications consistent with toxoplasmic meningoencephalitis. Ocular examination showed bilateral cataracts, microphthalmia, and retinal detachment. Laboratory studies confirmed congenital toxoplasmosis by positive IgM/IgG serology and cerebrospinal fluid PCR. Endocrine assessment demonstrated central hypothyroidism with low TSH (0.012 mIU/L) and T4 (4.31 pmol/L) levels, while exploration of the other hypothalamic-pituitary axes was normal, suggesting selective thyrotropic axis dysfunction. Treatment included pyrimethamine, sulfadiazine, folinic acid, and levothyroxine replacement. The infant died on day 54 of life from a nosocomial infection.This case highlights an exceptional presentation of congenital toxoplasmosis associated with isolated central hypothyroidism. The findings suggest potential inflammatory or vascular damage to the hypothalamic-pituitary axis. Early recognition and hormone replacement therapy are essential to prevent further neurological impairment. Systematic endocrine evaluation is recommended in neonates with severe central nervous system involvement due to congenital toxoplasmosis.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"555-561"},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146220100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding the diagnostic lens: Whole exome sequencing in a neonate with arthrogryposis-renal dysfunction-cholestasis (ARC) syndrome.","authors":"Gayathri Sreenivasan, Jane Hedrick, Anita Ware, Melanie Leong","doi":"10.1177/19345798261483255","DOIUrl":"https://doi.org/10.1177/19345798261483255","url":null,"abstract":"<p><p>We report a term neonate who presented with early-onset conjugated hyperbilirubinemia, acholic stools, and imaging findings concerning for biliary atresia, including a contracted gallbladder and triangular cord sign on abdominal ultrasound. However, intraoperative cholangiography demonstrated normal bile flow. Persistently normal gamma-glutamyl transpeptidase (GGT), cholestasis, and renal tubular dysfunction prompted expanded evaluation. Whole-exome sequencing identified a pathogenic <i>VPS33B</i> variant, confirming Arthrogryposis-Renal dysfunction-Cholestasis (ARC) syndrome. Despite supportive management, his condition progressively declined, and he died at approximately 2 years of age following worsening cholestasis, reduced oral intake, and cardiorespiratory arrest at home. In this infant, the absence of arthrogryposis represented an incomplete and atypical phenotype at birth of an already rare condition. This case report and review of the literature expands the recognized clinical spectrum of ARC syndrome and underscores the importance of considering genetic etiologies in neonates with low-normal GGT cholestasis when conventional evaluation is inconclusive. Early integration of genomic testing may improve diagnostic accuracy, inform family counseling, and refine clinical decision-making in neonatal cholestasis.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798261483255"},"PeriodicalIF":1.0,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of structured antenatal breastfeeding counselling on early initiation of breastfeeding: A comparative study from Central India.","authors":"Priyanshi Panwar, Bharati P Choubey, Sharmila Ramteke, Anukrati Khare, Manjusha Goel","doi":"10.1177/19345798261483256","DOIUrl":"https://doi.org/10.1177/19345798261483256","url":null,"abstract":"<p><p>ObjectivesTo determine the effectiveness of structured antenatal breastfeeding counselling on early initiation of breastfeeding (EIBF) within 1 hour of birth and its determinants among mothers delivering at a tertiary-care hospital in central India.MethodsA prospective, non-randomized (quasi-experimental) study was conducted in the Department of Pediatrics, Bhopal, from June 2024 to September 2025. The intervention group included third-trimester antenatal women who received one to three structured counselling sessions on selected Anganwadi centre days, while the comparison group included postpartum mothers with no prior counselling. Counselling was based on the Facility-Based Newborn Care (FBNC) module. Data were collected using a pre-tested semi-structured questionnaire and analyzed using STATA v14.2. Differences between groups were assessed using the χ² test and t-test. Multivariable logistic regression was additionally used to identify independent predictors of EIBF after adjustment for measured sociodemographic and obstetric covariates. A <i>p</i>-value <0.05 was considered statistically significant.ResultsAmong 496 mothers analysed (246 intervention; 250 comparison), baseline characteristics were largely comparable. EIBF within 1 hour was achieved by 58.0% of counselled mothers compared with 42.0% of controls, demonstrating an absolute improvement of 16 percentage points (95% CI: 9.6-26.8; <i>p</i> < 0.001). Higher maternal education (<i>p</i> < 0.001), working status (<i>p</i> = 0.016), higher socioeconomic status (<i>p</i> < 0.001), urban residence (<i>p</i> < 0.001), multiparity (<i>p</i> < 0.001), absence of pregnancy-related complications (<i>p</i> = 0.010), receipt of ≥4 ANC visits (<i>p</i> < 0.001), vaginal delivery (<i>p</i> < 0.001), and absence of prelacteal feeding (<i>p</i> < 0.001) were significant facilitators of early initiation. After adjustment for these covariates in a multivariable logistic regression model, structured counselling remained an independent predictor of EIBF (adjusted OR 1.68, 95% CI 1.12-2.52; <i>p</i> = 0.012), as did graduate-level education, multiparity, ≥4 ANC visits, and vaginal delivery.ConclusionStructured antenatal breastfeeding counselling was independently associated with improved early initiation of breastfeeding in this non-randomized comparative study. These findings support incorporating structured counselling into antenatal care programmes, pending confirmation in larger, multi-centre, and ideally randomized trials.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798261483256"},"PeriodicalIF":1.0,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148840423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enteral feeding practices around neonatal packed red blood cell transfusion: A national survey of U.S. NICU providers.","authors":"Irfan Shehzad, Kelsey Coombs, Lesley Cottrell, Mahmoud Ali","doi":"10.1177/19345798261483251","DOIUrl":"https://doi.org/10.1177/19345798261483251","url":null,"abstract":"<p><p>IntroductionAnemia and packed red blood cell (PRBC) transfusion are common in preterm infants, and feeding management during transfusion remains uncertain.ObjectiveTo characterize current opinions and enteral feeding practices surrounding PRBC transfusion among U.S. NICU providers.MethodsWe conducted a voluntary, anonymous 10-item REDCap survey distributed through AAP SONPM and TECaN listservs; responses were analyzed descriptively.ResultsAmong 432 respondents, most were neonatologists in level III or IV NICUs. More than half reported a transfusion-related feeding guideline, yet practices varied widely. Most withheld or restricted feeds, with variation in interruption timing, refeeding, glucose monitoring, and diuretic use. NEC and transfusion-related acute gut injury were the main reasons for restriction.ConclusionFindings highlight substantial practice variation and persistent uncertainty, not a preferred feeding approach. Prospective multicenter studies are needed to guide safe, evidence-based peri-transfusion feeding practices.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798261483251"},"PeriodicalIF":1.0,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148808731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-dose 40% buccal dextrose gel for treatment of neonatal hypoglycemia: A randomized controlled trial.","authors":"Nagwa Mohamed Sabry Mahmoud, Aya Rabie Mohamed, Madeha Abdalla Sayed","doi":"10.1177/19345798261483257","DOIUrl":"https://doi.org/10.1177/19345798261483257","url":null,"abstract":"<p><p>BackgroundNeonatal hypoglycemia is a common, potentially serious postnatal metabolic disorder. This study evaluated the efficacy and safety of a single dose of 40% buccal dextrose gel versus standard care for achieving early euglycemia in at-risk neonates with a documented low baseline blood glucose.MethodsThis prospective randomized controlled trial was conducted at the Neonatal Intensive Care Unit, Minia University Hospital, Egypt (March-November 2024). Clinically stable, asymptomatic at-risk neonates (gestational age ≥34 weeks) with a documented low baseline blood glucose (below the maturity-specific operational threshold: <45 mg/dL for asymptomatic late-preterm/term infants and <30 mg/dL for preterm infants in the first 48 h) were randomized 1:1 to standard care alone or standard care plus a single 40% dextrose gel dose (0.5 mL/kg, buccal). The primary outcome was euglycemia (blood glucose ≥45 mg/dL) at 120 min, analyzed by intention-to-treat; infants requiring rescue intravenous dextrose before 120 minutes were counted as treatment failures.ResultsOf 120 screened neonates, 100 were randomized (50/group). By intention-to-treat, euglycemia at 120 minutes occurred in 82.0% (41/50) of the dextrose gel group versus 64.0% (32/50) of controls (absolute risk difference 18.0%, 95% CI 1.0-35.0; relative risk 1.28, 95% CI 1.00-1.64; number needed to treat = 6), a difference of borderline statistical significance (Pearson χ² p = 0.043; Fisher's exact <i>p</i> = 0.070). A secondary complete-case analysis (<i>n</i> = 90) showed a larger effect (91.1% vs 71.1%) but is potentially biased by exclusion of early treatment failures. Intravenous dextrose use during the study was numerically lower with gel (22.0% [11/50] vs 36.0% [18/50]; relative risk 0.61, 95% CI 0.32-1.16) but was not statistically significant. No intervention-related adverse events were observed during the 120-min study period.ConclusionsA single dose of 40% buccal dextrose gel improved early euglycemia in at-risk neonates by intention-to-treat analysis, with no intervention-related adverse events observed during the 120-min study period. These single-center findings are consistent with existing evidence and support further evaluation of buccal dextrose gel as a non-invasive first-line therapy, rather than establishing broad implementation.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798261483257"},"PeriodicalIF":1.0,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148808783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between jaundice treatment and conventional electroencephalography (EEG) changes with spectral analysis in infants.","authors":"Hasan Boskhabadi, Fabrice Wallois, Azadeh Darabi, Javad Mohamadi Taze Abadi","doi":"10.1177/19345798261475686","DOIUrl":"https://doi.org/10.1177/19345798261475686","url":null,"abstract":"<p><p>ObjectiveNeonatal hyperbilirubinemia (NHB) is a common clinical condition that may lead to long-term neurodevelopmental impairment due to bilirubin-induced neurotoxicity. The development of reliable methods for neurological monitoring in affected newborns remains a major challenge in neonatal care. This study aimed to evaluate the association between treatment and EEG changes on cerebral activity in infants with hyperbilirubinemia using conventional EEG.Methods & MaterialsThis prospective before-and-after study was conducted on neonates aged over 35 weeks of gestation who were diagnosed with hyperbilirubinemia. Demographic and clinical data, including neonatal age, sex, birth weight, presence of ABO incompatibility, and treatment modalities, were collected. Maternal data, including parity, mode of delivery, and maternal and neonatal blood groups, were also recorded.Conventional EEG was performed for all neonates during the first eight hours of hospitalization and repeated after therapeutic interventions, including phototherapy and, when indicated, exchange transfusion.ResultsA total of 26 neonates with hyperbilirubinemia were included in this study. The mean total serum bilirubin level before treatment was 23.01 ± 2.99 mg/dL.A statistically significant change in the EEG spectral power was observed before and after treatment in the frontal regions Fp1, Fp2, and Fz, particularly within the delta and beta frequency bands.Furthermore, the findings demonstrated that delta activity was significantly dominant in the Fp1, Fp2, and Fz regions both before and after treatment. In contrast, no dominant frequency bands were observed in the C3, O1, T3, C4, T4, Cz, and O2 regions either before or after treatment.ConclusionHyperbilirubinemia in neonates may be associated with alterations in cortical electrical activity as assessed by conventional EEG. In our study, delta band activity was significantly predominant in the frontal regions (Fp1, Fp2, and Fz) both before and after treatment. Moreover, delta band activity remained the predominant frequency in the frontal regions (Fp1, Fp2, and Fz) before and after treatment, suggesting persistent frontal cortical involvement despite treatment.Further studies with larger samples are recommended to clarify whether these EEG changes reflect a transient bilirubin effect or age-related maturation patterns.</p>","PeriodicalId":16537,"journal":{"name":"Journal of neonatal-perinatal medicine","volume":" ","pages":"19345798261475686"},"PeriodicalIF":1.0,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148758726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}